Self-judgment on emotional items modulates memory resources in breast cancer patients: a longitudinal MRI study

Self-judgment on emotional items modulates memory resources in breast cancer patients: a longitudinal MRI study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Self-judgment on emotional items modulates memory resources in breast cancer patients: a longitudinal MRI study Gina Joue, Joy Perrier, Jacques Dayan, Mikaël Naveau, Nastassja Morel, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4772428/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Breast-cancer (BC) patients (PT) frequently report memory problems pre-and post-cancer treatments that are not always corroborated by memory tests. We hypothesized that self-reported problems actually coincide with structural brain changes and that the discrepancy partly stems from BC-related distressed self-image and stress that alter arousal at memory encoding. To detect such subtle changes before/after treatments, we leveraged on known memory advantages related to self-image and stress in a longitudinal MRI study: the self-reference effect (SRE; better memory for what concerns oneself) and the negativity effect (NE; better memory for items with emotionally negative associations). We tested women with non-metastatic BC, before and one year after chemotherapy, and age-matched healthy women (HC) at similar time lapses. Neither group had clinical anxiety or depression. At each visit, participants completed an episodic memory fMRI task involving attributing character traits to themselves or someone else. Overall memory accuracy and SRE were similar between groups, but only HC showed NE. PT showed greater activity for self-judged positive traits in brain regions implicated in self-representation and emotional memory regulation. Functional connectivity and structural changes in these regions varied with self-representation and anxiety, but multivariate analyses with unsupervised machine learning suggest differences only partially characterize PT. Biological sciences/Cancer/Breast cancer Biological sciences/Neuroscience/Cognitive neuroscience Biological sciences/Neuroscience/Learning and memory Biological sciences/Neuroscience/Learning and memory/Hippocampus Full Text Additional Declarations No competing interests reported. Supplementary Files joue.EAsubmselfJudgmtsuppl.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4772428","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":342654786,"identity":"8416d198-2428-4e73-b384-87c232f81893","order_by":0,"name":"Gina 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