Antiprogestines

Antiprogestins are steroid compounds that have a high ability to bind to progesterone cell receptors and thus prevent their binding to endogenous steroid hormone. The first achievements in the search for progesterone antagonists were obtained in the laboratories of well-known companies Roussel-Uclaf and Schering AG, where hundreds of Hp-arylsteroid derivatives were synthesized, of which the most common were mifepristone (RU 38486), lilopristone (ZK 08734), onapriston (ZK 08200 ) At present, antiprogestins are used as implantation inhibitors, contraceptives, drugs used in Itsenko-Cushing's disease. In most cases, antiprogestins are administered to women of active reproductive age.