Detecção de imunoglobulinas no líquido peritonial de pacientes férteis e inférteis com e sem endometriose

Eduardo Dias, Daniela Vanessa Vettori, Gabriele C. Miotto, Andrea Cintra Facin, João S Cunha Filho, Cristiano Caetano Salazar, Carlos Augusto Bastos de Souza, Fernando Freitas
2000 · W2737836428
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This study measured peritoneal fluid and serum immunoglobulins in fertile and infertile women with or without endometriosis, finding significantly higher IgA levels in infertile patients without the condition.

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This study investigated the presence and levels of immunoglobulins in peritoneal fluid from both fertile and infertile women, stratified by the presence or absence of endometriosis. The research compared these biomarkers across the different patient groups to assess potential immune system alterations associated with the disease. The authors analyzed the correlation between infertility status, endometriosis diagnosis, and specific immunoglobulin concentrations within the peritoneal cavity. This paper is centrally about endometriosis — specifically examining the immunological profile of peritoneal fluid in patients with and without the condition.

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Abstract

Objetivos: dosar as imunoglobinas IgG, IgM e IgA no lquido peritoneal e no soro de mulheres frteis e infrteis com e sem endometriose; analisar comparativamente ambos os grupos correlacionando com os achados laparoscpicos de endometriose.Material e mtodos: Os nveis de IgA, IgM e IgG no plasma e no fluido peritoneal foram avaliados em 38 pacientes, 27 infrteis e 11 frteis, submetidas laparoscopia.As pacientes foram classificadas em trs grupos: grupo I (mdia de idade DP: 32,2 5,2 anos) consistiu de 18 pacientes infrteis com endometriose; grupo II (31,6 5,2) consistiu de 9 pacientes infrteis sem endometriose e grupo III (32,8 4,4) consistiu de 10 pacientes infrteis sem endometriose, que foram o grupo controle.Resultados: As pacientes do grupo II apresentaram nveis estatisticamente diferentes dos outros grupo quanto aos nveis de IgA 5,4,p<0,05).Os grupos I e III foram semelhantes nas dosagens de IgA.No houve 116 diferenas quanto as dosagens de IgM e IgG.No foram encontradas diferenas quando comparados os estgios da endometriose com dor e os nveis de imunoglobulinas.Concluses: As pacientes infrteis com endometriose mostraram nveis mais altos de IgA do que as pacientes frteis com endometriose.Os dados reforam a hiptese da existncia de uma alterao imune no peritneo em pacientes com endometriose que poderia explicar ocorrncia de infertilidade.
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Detecção de imunoglobulinas no líquido peritonial de pacientes férteis e inférteis com e sem endometriose View/ Open Date 2000Author Advisor Event Salão de iniciação Científica (12. : 2000 set. 11-15 : UFRGS, Porto Alegre, RS). Presentation type Apresentação oralKnowledge area Health sciences In Salão de iniciação Científica (12. : 2000 : Porto Alegre, RS). Livro de resumos. Porto Alegre : UFRGS, 2000. Session Saúde da mulher Collections - Health Sciences (205) This item is licensed under a Creative Commons License

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