Post Danazol Amenorrhoea

Ian S. Fraser, I S Fraser
Clinical reproduction and fertility · 1985 · vol. 40(1) , pp. 48–50 · doi:10.1097/00006254-198501000-00015 · PMID:6428735 · W2430440842
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Following danazol treatment, four women experienced amenorrhoea longer than 6 months, with two showing a temporary, unusually high FSH rise and excessive GnRH response.

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Abstract

Four women out of 242 experienced amenorrhoea in excess of 6 months duration following danazol treatment. Two of these exhibited an unusual monotropic rise of FSH into the post menopausal range for 4-5 months following the end of therapy. This was associated with an excessive response to GnRH injection. The mechanism of this temporary FSH rise is unknown. A causal association of the amenorrhoea and monotropic FSH rise following danazol therapy is unproven but seems likely.

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Condition tags

endometriosis

MeSH descriptors

Amenorrhea Danazol Pregnadienes Adolescent Adult Amenorrhea Amenorrhea Danazol Danazol Endometriosis Endometriosis Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Pregnadienes Time Factors Uterine Neoplasms Uterine Neoplasms

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Source provenance

europepmc
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openalex
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