Surgical Insights in the Management of Complex Facial Plexiform Neurofibromas

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This paper describes the authors’ surgical management experience with two complex facial plexiform neurofibroma (FPNF) cases in patients with neurofibromatosis type 1, alongside a review of relevant information on the condition. The central finding is that complete surgical resection is difficult to achieve because the tumors are infiltrative and are associated with high recurrence rates, as illustrated by the two case experiences. The authors note that their report is based on only two cases and presented as a preprint without peer review, limiting generalizability. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Surgical Insights in the Management of Complex Facial Plexiform Neurofibromas | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Clinical Case Reports This is a preprint and has not been peer reviewed. Data may be preliminary. 16 May 2026 V1 Latest version Share on Surgical Insights in the Management of Complex Facial Plexiform Neurofibromas Authors : Giovanny Pérez Ortiz E [email protected] , Francisco Del Valle-Díaz [email protected] , Javier Vilá Ortiz 0009-0002-7394-5737 [email protected] , Edgar Del Toro Diez [email protected] , Antonio Bures-Rodríguez [email protected] , and Jorge Aldrich Novoa [email protected] Authors Info & Affiliations https://doi.org/10.22541/authorea.15003413/v1 Under Review Clinical Case Reports Peer review timeline 25 views 23 downloads Contents Abstract Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objectives: Facial plexiform neurofibromas (FPNF) are infiltrative tumors in neurofibromatosis type 1 (NF1) patients that cause aesthetic deformities, functional impairments, and potential malignant transformation. Complete surgical resection remains challenging due to infiltrative growth and high recurrence rates. This study presents surgical management experience with two complex FPNF cases and reviews relevant Information & Authors Information Version history V1 Version 1 16 May 2026 Peer review timeline Under Review Clinical Case Reports 16 May 2026 Submission Checks Completed Collection Clinical Case Reports Authors Affiliations Giovanny Pérez Ortiz E [email protected] Universidad de Puerto Rico Escuela de Medicina, San Juan, United States, 00936-5067 View all articles by this author Francisco Del Valle-Díaz [email protected] Universidad de Puerto Rico Escuela de Medicina, San Juan, United States, 00936-5067 View all articles by this author Javier Vilá Ortiz 0009-0002-7394-5737 [email protected] Universidad de Puerto Rico Escuela de Medicina, San Juan, United States, 00936-5067 View all articles by this author Edgar Del Toro Diez [email protected] View all articles by this author Antonio Bures-Rodríguez [email protected] View all articles by this author Jorge Aldrich Novoa [email protected] Universidad de Puerto Rico Escuela de Medicina, San Juan, United States, 00936-5067 View all articles by this author Metrics & Citations Metrics Article Usage 25 views 23 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Giovanny Pérez Ortiz E, Francisco Del Valle-Díaz, Javier Vilá Ortiz, et al. Surgical Insights in the Management of Complex Facial Plexiform Neurofibromas. Authorea . 16 May 2026. DOI: https://doi.org/10.22541/authorea.15003413/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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last seen: 2026-05-20T01:45:00.602351+00:00