Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy

Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy Masanobu Kumon, Shunsuke Nakae, Kazuhiro Murayama, Takema Kato, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-27275/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Background: Isocitrate dehydrogenase (IDH) wild-type gliomas tend to be pathologically defined as glioblastomas. We previously reported that, unlike IDH -mutant gliomas, IDH wild-type gliomas showed significantly lower ratios of myoinositol to total choline (i.e., the Ins/Cho ratio) on magnetic resonance (MR) spectroscopy. Given that IDH -mutant gliomas also have much better prognoses than IDH wild-type gliomas, we hypothesized that this lower Ins/Cho ratio is associated with malignancy in adults with supratentorial gliomas. Therefore, we calculated the Ins/Cho ratios of patients with supratentorial IDH wild-type gliomas and investigated their progression free survival (PFS) and overall survival (OS) to determine its utility as a prognostic marker. Methods: We classified IDH wild-type gliomas (n = 30) into two groups based on the Ins/Cho ratios, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations. Results: Compared with the group with high Ins/Cho ratios, the group with low Ins/Cho ratios had shorter PFS (P = 0.020) and OS (P = 0.037) durations. Multivariate analysis demonstrated that the Ins/Cho ratio correlated significantly with PFS (hazard ratio 0.34, P = 0.027). Conclusion: We conclude that the preoperative Ins/Cho ratio can be used as a novel prognostic factor for IDH wild-type gliomas. Neurosurgery glioma IDH wild-type magnetic resonance spectroscopy myoinositol Figures Figure 1 Background Gliomas, which are diagnosed based on pathological and genetic findings, are among the most common brain tumors [1-4]. Extensive, surgical resection is the preferred initial therapeutic strategy to improve prognosis [5, 6]; however, such an approach also increases the risk of brain dysfunction because either the border between the tumor and normal brain tissue is unclear or because tumors infiltrate invasively into adjacent healthy brain tissue. Therefore, the ability to predict tumor malignancy preoperatively could help surgeons to plan optimal surgical strategies. Magnetic resonance (MR) spectroscopy enables us to quantify tumor metabolites noninvasively by analyzing their spectra, and thus, it is widely used for preoperative diagnosis of brain tumors [7]. We previously examined tumor metabolites in adult supratentorial gliomas and reported that the myoinositol to total choline (Ins/Cho) ratios in isocitrate dehydrogenase (IDH) wild-type gliomas were significantly lower than in IDH -mutant gliomas [8]. Given that total choline is thought to represent cell density [9], we presumed that lower ratios indicate myoinositol consumption in a glioma cell. Myoinositols are sugar alcohol in phospholipids of the intracellular membrane [10], and they are produced through food digestion or by hydrolysis or dephosphorylation of the intracellular membrane [10-12]. In astrocytes, myoinositols contribute to adjusting osmotic pressure in response to changes in intracranial pressure [13]. Most supratentorial gliomas harboring wild-type IDH are pathologically classified as glioblastomas and tend to have dismal prognoses [1-3]. Molecular factors that contribute to this poor prognosis have been identified based on genetic subtype, including TERT promoter mutations, copy number aberrations (e.g., +7, 10q and 9p21), and epigenetic changes (e.g., histone H3) [14-18]. However, such information is only available after surgical resection, and we ideally need a method for predicting outcomes in patients suspected of having glioblastomas before surgery. Based on the observation that supratentorial gliomas with IDH mutations have better outcomes than those with wild-type IDH [1, 2, 3], we hypothesized that low Ins/Cho ratios in IDH wild-type gliomas can be used as a prognostic marker for this genetic subtype of glioma. In the present study, we calculated Ins/Cho ratios by MR spectroscopy for adults with supratentorial IDH wild-type gliomas to investigate the ratio’s association with prognosis, its correlation with previously reported prognostic factors, and whether it could be used as a preoperative prognostic factor. Materials And Methods Study design We retrospectively investigated 30 cases of newly diagnosed IDH wild-type glioma in patients analyzed by MR spectroscopy between 2013 and 2018 at Fujita Health University hospital. Patients who had already received treatment before MR spectroscopy or who were younger than 20 years old were excluded. The primary outcomes were the progression free survival (PFS) and the overall survival (OS). PFS was calculated from the date of first operation to the date of confirmed recurrence. OS was calculated from the date of first resection to the date of death. Patient information was last updated in April 2019 for follow-up purposes. All resected tissues were assessed by neuropathologists according to the WHO classification [1]. MR spectroscopy A single-voxel 1 H-MR spectroscopy with point-resolved spectroscopy sequence was performed with a 3 Tesla (T) scanner (Ingenia 3T; Philips Healthcare, Best, The Netherlands) using a dS Head coil and Vantage Titan 3T (Canon Medical Systems Corporation, Otawara, Japan) using a 16 or a 32-channel coil. In each patient, 1 H-MR spectroscopy was performed using the following parameters: repetition time (TR)/echo time (TE), 2000/144 and 35 ms; number of excitation (NEX), 128; bandwidth, 1.61 HZ/point; voxel of interest (VOI) size for metabolic measurements, 15 × 15 × 15 mm. T2 weighted images in 3 directions for setting the VOI were determined for each patient by means of the following parameters: repetition time (TR)/echo time (TE), 4250/82 ms; acquisition matrix size, 416 × 344; reconstruction matrix, 640 × 640; field of view (FOV), 230 × 230 mm; slice thickness, 4.0 mm; slice gap, 0.8 mm; number of excitation (NEX), 1; reduction factor 1.9. The VOI was selected by a board certified neuroradiologist (K.M) with an experience of 10–15 years’ to include the VOIs inside the lesion based on T2 weighted images in 3 directions. When the tumor contains necrotic and cystic components, these components were included within VOI to accurately evaluate tumor characteristics. In 1 H-MR spectroscopy, myoinositol and total choline were measured with short TE (TE = 35 ms) and long TE (TE = 144 ms) respectively [19, 20, 21] because of their relaxation time in T2, and mean concentration of MR spectroscopy values were analyzed by automatic quantification program (LCModel; Stephen Provencher, Oakville, Ontario, Canada) [22]. Evaluation of IDH mutation status We evaluated IDH mutations using the Sanger method, with codon 132 in IDH1 and codon 172 in IDH 2 analyzed by polymerase chain reaction (PCR). Briefly, DNA was extracted from resected frozen tissue and formalin-fixed and paraffin-embedded tissue (FFPE), using DNeasy blood and tissue kits (QIAGEN, Hulsterweg, Netherland) and an REPLI-g FFPE Kit (QIAGEN).The reaction mixtures for PCR comprised DNA, primers, 10PCR buffer, 10mM dNTP mix (Thermo Fisher Scientific, Waltham, MA, USA ), 50 mM MGCL₂, and PLATINUM TagDNA polymerase (Thermo Fisher Scientific). After we confirmed the DNA bands of the PCR products in electrophoresis, we added BigDye Sequencing Buffer (Thermo Fisher Scientific), Ready Reaction Mix (Thermo Fisher Scientific), and the same primer to the PCR products, and repeated the PCR. Sequencing was performed with a BigDye Terminator version 3.1 Cycle Sequencing Kit (Thermo Fisher Scientific) and results were analyzed on an ABI 3100 (Applied Biosystems, Waltham, MA, USA ). Next generation sequencing analysis and comparison of Copy number aberration We analyzed samples that met our inclusion criteria and classified them by Ins/Cho ratio into high and low and a low ratio groups. We prepared diluted genomic DNA for subsequent experiments. After whole genome amplification using a SurePlex DNA Amplification System (Illumina, San Diego, CA, USA), library preparation was performed with a Nextera XT DNA Library Preparation Kit (Illumina). Sequencing analysis was conducted with a VeriSeq PGS Kit-MiSeq (Illumina), and results were analyzed with BlueFuse Multi Software (Illumina). In all cases, chromosomes were divided into 2500 windows of approximately 1 Mb in size. Statistical analysis We used Fisher's exact test and the MannWhitney U test to compare age at onset, sex, laterality, MIB-1 index, and pathology between the two groups. PFS and OS were analyzed using the KaplanMeier method and compared with the log-rank test. Cox proportional hazards models were used to determine the relationship between the Ins/Cho ratio and prognosis. Given that most patients were treated with surgery, temozolomide and radiotherapy, and bevacizumab, we selected the following as explanatory factors in the multivariate analysis: gross total resection; subtotal resection, which was defined as >90% resection; temozolomide and radiotherapy; bevacizumab; and the Ins/Cho ratio. All statistical analyses were conducted using EZR [23]. Results Relation of patient and pathology characteristics with the Ins/Cho ratio The mean and median values of the Ins/Cho ratios for the 30 patients included in this cohort were 0.75 and 0.67, respectively. We opted for 0.7 as the cutoff value and classified those patients into high (≥0.7) and low (<0.7) Ins/Cho ratio groups (n = 13 and 17, respectively). Tables 1 and 2 show the patient characteristics, pathologies, Ins/Cho ratios, and postoperative therapies. Case comprised 25 glioblastoma, two gliosarcomas, three astrocytomas. Two of three astrocytomas gained chromosome 7 and/or loss of chromosome 10q, but the other was not associated with them. There were no statistically significant differences in sex, age at onset, laterality, MIB-1 index, or grade Ⅳ WHO classification between the two groups. Overall, eight patients underwent reoperation, six patients underwent additional chemotherapy, and seven patients had no treatment after recurrence. Table 1. Characteristics and treatments of patients Case Age, sex Pathology Recurrence PFS Follow-up terms Outcome Ins/Cho First operation / Postoperative therapies / therapies after recurrence 1 42F GBM, Gr Ⅳ Yes 9 22 Dead 0.573 GTR / TMZ + RT / TMZ + RT + BEV+ other chemotherapies + operation 2 43M GBM, Gr Ⅳ Yes 5 12 Dead 0.475 PR / TMZ + RT / BEV + another chemotherapy + operation 3 43F GBM, Gr Ⅳ Yes 1 31 Dead 0.507 GTR / No treatment / TMZ + RT + BEV + other chemotherapies + operations 4 44M GBM, Gr Ⅳ Yes 10 14 Dead 0.167 GTR / TMZ + RT + BEV / other chemotherapy 5 46F GBM, Gr Ⅳ Yes 3 12 Dead 0.450 GTR / TMZ + RT / TMZ + RT + BEV + other chemotherapy 6 62M GBM, Gr Ⅳ Yes 14 49 Dead 0.516 Biopsy / TMZ + RT / TMZ + RT + BEV + operation 7 62M GS, Gr Ⅳ Yes 26 58 Alive 1.149 STR / TMZ + RT / TMZ + RT + operation 8 63F GBM, Gr Ⅳ Yes 17 36 Alive 1.149 GTR / TMZ + RT / TMZ + RT + BEV 9 67M GBM, Gr Ⅳ Yes 2 2 Alive 0.044 PR / TMZ + RT / BEV 10 67M GBM, Gr Ⅳ Yes 9 10 Alive 0.816 PR / TMZ + RT + BEV / TMZ 11 68F GBM, Gr Ⅳ Yes 8 8 Dead 0.227 GTR / TMZ + RT / No treatment 12 68M GBM, Gr Ⅳ NO 6 10 Alive 1.182 STR / TMZ + RT / No treatment 13 69F GBM, Gr Ⅳ Yes 1 12 Dead 2.054 GTR / No treatment / TMZ + RT + BEV 14 69F GBM, Gr Ⅳ Yes 12 20 Dead 0.655 GTR / TMZ + RT / BEV 15 70M GBM, Gr Ⅳ NO 3 11 Dead 0.854 GTR / TMZ + RT / No treatment 16 71M DA, Gr Ⅱ Yes 9 39 Dead 1.702 Biopsy / TMZ + RT / operation 17 72M GBM, Gr Ⅳ Yes 1 22 Dead 0.451 GTR / TMZ + RT / TMZ + RT + BEV 18 72F DA, Gr Ⅱ Yes 4 7 Alive 0.952 PR / No treatment / No treatment 19 73F GBM, Gr Ⅳ Yes 1 23 Dead 0.405 STR / No treatment / TMZ + RT + BEV + operation 20 74M GBM, Gr Ⅳ Yes 2 20 Dead 0.758 GTR / TMZ + RT / TMZ + BEV 21 74M GBM, Gr Ⅳ Yes 1 20 Dead 0.240 GTR / TMZ + RT / TMZ + BEV + another chemotherapy + Operation 22 74M GBM, Gr Ⅳ Yes 10 19 Alive 0.893 STR / TMZ + RT + BEV / TMZ + RT + BEV 23 75F GBM, Gr Ⅳ NO 6 6 Alive 0.405 GTR / TMZ + RT 24 76F AA, Gr Ⅲ Yes 1 24 Dead 0.635 Biopsy / TMZ + RT / TMZ + BEV 25 77M GS, Gr Ⅳ Yes 13 14 Dead 0.695 GTR / TMZ + BEV / No treatment 26 80F GBM, Gr Ⅳ NO 39 39 Alive 1.176 PR / TMZ + RT 27 81M GBM, Gr Ⅳ Yes 2 3 Dead 0.692 Biopsy / TMZ + BEV / No treatment 28 81M GBM, Gr Ⅳ Yes 4 4 Alive 1.397 GTR / No treatment 29 85M GBM, Gr Ⅳ Yes 2 5 Alive 0.279 Biopsy / TMZ + BEV +RT / TMZ 30 86F GBM, Gr Ⅳ Yes 21 24 Dead 1.111 STR / TMZ / BEV Data show the patient and treatment details after the first operation and after recurrence for supratentorial IDH wild-type glioma (n=30). Pathology was diagnosed according to the WHO classification 2016. Abbreviations: AA, anaplastic astrocytoma; BEV, bevacizumab; DA, diffuse astrocytoma; F, female; GBM, glioblastoma; Gr, grade; GS, gliosarcoma; GTR, Gross total resection; Ins/Cho, ratio of myoinositol to total choline; IDH, isocitrate dehydrogenase; M, male; PFS, progression free survival; PR, Partial resection; RT, radiotherapy; STR, Subtotal resection; TMZ, temozolomide. Table 2. Comparison of patient characteristics by Ins/Cho ratio threshold Ins/Cho ratio≥0.7 (n = 13) Ins/Cho ratio<0.7 (n = 17) P value Male, n 8 9 0.72 Age at onset, median (years) 71 69 0.38 Left side, n 8 7 0.46 MIB-1 index, median 38 46 0.41 Grade Ⅳ, n 11 16 0.57 Abbreviations: Grade Ⅳ, grade Ⅳ in WHO Classification; Ins/Cho, ratio of myoinositol to total choline; n, number of patients. PFS and OS analysis We compared prognosis by the Ins/Cho ratio. During follow-up, tumor recurrence occurred in 94% of patients with low Ins/Cho ratio (i.e., 16/17) and in 77% with high Ins/Cho ratio (i.e., 10/13). Moreover, 82% (14/17) of patients with low ratios and 38% (5/13) with high ratios died. Figures 1a and 1b show that the PFS and OS in those with high ratios were significantly shorter than in those with low ratios, indicating higher recurrence and mortality rates in the patients with low Ins/Cho ratios (P = 0.020 and 0.037, respectively). In the multivariate analysis, Cox proportional hazards models revealed that the Ins/Cho ratio was significantly associated with PFS (hazard ratio 0.34, P = 0.027), which suggested that the Ins/Cho ratio was useful outcome predictor, especially for PFS. These data are summarized in Tables 3a and 3b. Table 3a. Multivariate analysis of PFS Explanatory factor Hazard ratio (95% CI) P value GTR or STR 0.84 (0.36 - 2.0) 0.68 Use of BEV 0.76 (0.26 - 2.2) 0.62 Both use of TMZ and RT 0.52 (0.20 - 1.4) 0.18 Ins/Cho ratio 0.34 (0.13 - 0.88) 0.027 Table 3b. Multivariate analysis of OS Explanatory factor Hazard ratio (95% CI) P value GTR or STR 1.6 (0.44 - 5.6) 0.48 Use of BEV 0.91 (0.28 - 3.0) 0.88 Both use of TMZ and RT 0.70 (0.22 - 2.2) 0.55 Ins/Cho ratio 0.33 (0.10 - 1.1) 0.067 Tables 3a and 3b show the results of multivariate analysis: we chose GTR or STR, BEV, TMZ and RT, and the Ins/Cho ratio as explanatory factors and analyzed their relevance to PFS and OS. Abbreviations: BEV, bevacizumab; GTR, Gross total resection; Ins/Cho, ratio of myoinositol to total choline; OS, overall survival; PFS, progression free survival; RT, radiotherapy; STR, subtotal resection; TMZ, temozolomide. Analysis of copy number aberration by next generation sequencing We included 20 cases in the next generation sequencing, analyzing nine samples in the group with high Ins/Cho ratios (≥0.7) and 11 samples in the group with low Ins/Cho ratios (<0.7). The overall noise value was <0.3. Analysis focused on regions where specific genes exist that are associated with poor prognosis in glioblastoma, including 7p11.2 ( EGFR ), 9p21.3 ( p16 ), 10q23.3 ( PTEN ) [15, 16]. Gain of 7p11.2 was detected in seven cases with high ratios and in six cases with low ratios, loss of 9p21.3 was detected in four cases with high ratios and in three cases with low ratios, and loss of 10q23.3 was detected in four cases with high ratios and in three cases with low ratios (Table 4). There were no significant differences between the groups in any other window. Table 4. Comparison of copy number aberrations by Ins/Cho ratio Ins/Cho ratio ≥0.7 (n = 9) Ins/Cho ratio <0.7 (n = 11) P value + 7p11.2 7 (78%) 6 (55%) 0.37 − 9p21.3 4 (44%) 3 (27%) 0.64 − 10q23.3 4 (44%) 3 (27%) 0.64 Copy number aberrations identified by next generation sequencing are compared by the Ins/Cho ratio. We defined an effective change of gain or loss when the average value of a window was >2.5 or <1.5. Abbreviations: Ins/Cho, ratio of myoinositol to total choline. Discussion In this study, we demonstrated that a high Ins/Cho ratio on MR spectroscopy was associated with a better prognosis than a low Ins/Cho ratio according to KaplanMeier curves. The Ins/Cho ratio was significantly associated with PFS by KaplanMeier and multivariate analysis. Of the three cases in which the Ins/Cho ratios exceeded 1.0 and that started the Stupp regimen soon after maximum safe resection, the PFS durations were 26, 17, and ≥39 months (Cases 7, 8, and 26, respectively). Given that total choline in MR spectroscopy reveals cell density [9], low myoinositol levels are considered associated with poor prognosis. Indeed, a recent cohort study of recurrent glioblastoma treated with bevacizumab reported that a high myoinositol value on MR spectroscopy was associated with a good prognosis [24]. Given all these results, we considered that myoinositol affects as a second messenger and has antitumor effects. Myoinositols are located in glial cells, especially in astrocytes [25], and regulate intracranial osmotic pressure [13]. Phosphatidylinositol 3-phosphate, which contains myoinositols in its structure, is produced by intracellular membrane metabolism [10] and activates the PI3K-Akt pathway as a second messenger [26]. Activation of this pathway may cause a poorer prognosis in patients with a low Ins/Cho ratio by prompting cell proliferation and myoinositol consumption. As shown in a previous study, oral administration of myoinositols can inhibit malignant transformation of tumor cells in patients suffering non - small-cell lung cancer, in which the PI3K-Akt pathway is important [27]. Other researchers also reported that myoinositols have antitumor effects that result from their phosphorylated metabolites, such as inositol 1,3,4,5,6 - pentaphosphate and inositol hexaphosphate, which can induce tumor cell apoptosis [28, 29]. These previous studies suggest that malignancy in IDH wild-type gliomas with low Ins/Cho ratios is associated with a simple reduction in antitumor effects. However, multivariate analysis only showed that the Ins/Cho ratio was significantly associated with PFS and not OS (Figure 1, Table 3). We assumed that the therapeutic strategies used after recurrence affected these results in the multivariate analyses. Indeed, some patients chose both surgical resection and additional chemotherapy (13%), whereas other patients opted for no additional therapy after recurrence (23%), potentially affecting outcomes. Notably, all patients younger than 50 years at diagnosis were in the group with a low Ins/Cho ratio, and 60% of these chose surgical resection and chemotherapy (Table 1). Two of these patients (cases 1 and 3) survived for approximately 2 years despite having low Ins/Cho ratios (0.57 and 0.51, respectively). By contrast, 20% of patients older than 60 years at diagnosis underwent surgical resection, and only 4% of these chose additional chemotherapy. Patients who opted for no therapy after recurrence had short survival time (e.g., cases 15 and 27) despite having relatively high Ins/Cho ratios (0.85 and 0.69, respectively). Copy number analysis by next generation sequencing revealed no significant correlations between the Ins/Cho ratio and chromosomal areas, despite the association of specific copy number aberrations with glioblastoma (Table 4). Previous studies have shown that such copy number aberrations are an early stage of tumorigenesis in glioblastoma [15, 30, 31], and our results suggest that low myoinositol levels are less likely to be caused by decreased myoinositol synthesis due to chromosomal change and gene expression. Rather, the low myoinositol levels can be considered to result from consumption due to tumor growth. This study is limited by its retrospective cohort design and lack of control of therapeutic strategies (e.g., resection extent by tumor location, postoperative bevacizumab use, and radiological dosages) or postoperative complications (e.g., delayed wound healing or high-fever affected the start of adjuvant therapy). These factors could have significantly affected the clinical courses and outcomes. We must now investigate more cases to clarify the putative correlations between the Ins/Cho ratio and patient prognosis. Conclusions The noninvasive Ins/Cho ratio can serve as a novel prognostic marker for adults with supratentorial IDH wild-type gliomas, providing useful preoperative information in patients with suspected glioblastomas. However, we can only speculate on why myoinositols are associated with patient outcomes, and questions around this will be targeted in future research. Abbreviations FFPE: formalin-fixed and paraffin-embedded tissue IDH: isocitrate dehydrogenase Ins/Cho ratio: ratio of myoinositol to total choline MR: Magnetic resonance spectroscopy OS: overall survival PCR: polymerase chain reaction PFS: progression free survival VOI: voxel of interest Declarations Ethical approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethical review board of Fujita Health University (HG19-017). Consent for publication All authors read and approved the final manuscript. Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no conflict of interest. Funding This study was funded by a Grant-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology in Japan (# 16K20029 to S.N.). Authors' contributions MK is the author and who conducted this study. TK, HS, HK conducted the copy number analysis and drafted the manuscript. KM and YO analyzed metabolites of glioma in this study and drafted the manuscript. MA and SY diagnosed tissue pathologically according to the WHO classification. SN, SO, JI, MH, and YH revised and edited the manuscript. Acknowledgements We would like to thank Ms. Fujiko Sueishi for technical support. References Louis DN , Perry A , Reifenberger G , von Deimling A , Figarella-Branger D , Cavenee WK , Ohgaki H , Wiestler OD , Kleihues P , Ellison DW . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. 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Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy. NMR Biomed . 1997, 10:2-12. https://doi.org/10.1002/(SICI)1099-1492(199701)10:13.0.CO;2-N . Abel K , Anderson RA , Shears SB . Phosphatidylinositol and inositol phosphate metabolism. J Cell Sci. 2001, 114:2207-2208. Groenen PM , Merkus HM , Sweep FC , Wevers RA , Janssen FS , Steegers-Theunissen RP . Kinetics of myo-inositol loading in women of reproductive age. Ann Clin Biochem . 2003, 40:79-85. https://doi.org/10.1258/000456303321016213 . Dinicola S , Minini M , Unfer V , Verna R , Cucina A , Bizzarri M . Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders. Int J Mol Sci . 2017, 18: 2187. https://doi.org/10.3390/ijms18102187 . Cordoba J , Gottstein J , Blei AT . Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain Hepatology . 1996, 24:919-923. https://doi.org/10.1002/hep.510240427 . Simon M , Hosen I , Gousias K , Rachakonda S , Heidenreich B , Gessi M , Schramm J , Hemminki K , Waha A , Kumar R . TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro Oncol . 2015, 17:45-52. https://doi.org/10.1093/neuonc/nou158 . Lopez-Gines C , Cerda-Nicolas M , Gil-Benso R , Pellin A , Lopez-Guerrero JA , Callaghan R , Benito R , Roldan P , Piquer J , Llacer J , Barbera J . Association of chromosome 7, chromosome 10 and EGFR gene amplification in glioblastoma multiforme. Clin Neuropathol . 2005, 24:209-218. Feng J , Kim ST , Liu W , Kim JW , Zhang Z , Zhu Y , Berens M , Sun J , Xu J . An integrated analysis of germline and somatic, genetic and epigenetic alterations at 9p21.3 in glioblastoma. Cancer . 2012, 118:232-240. https://doi.org/10.1002/cncr.26250 . Meyronet D , Esteban-Mader M , Bonnet C , Joly MO , Uro-Coste E , Amiel-Benouaich A , Forest F , Rousselot-Denis C , Burel-Vandenbos F , Bourg V , Guyotat J , Fenouil T , Jouvet A , Honnorat J , Ducray F . Characteristics of H3 K27M-mutant gliomas in adults. Neuro Oncol . 2017, 19:1127-1134. https://doi.org/10.1093/neuonc/now274 Kuwahara K, Ohba S, Nakae S, Hattori N, Pareira ES, Yamada S, Sasaki H, Abe M, Hasegawa M, Hirose Y. Clinical, histopathological, and molecular analyses of IDH-wild-type WHO grade II-III gliomas to establish genetic predictors of poor prognosis. Brain Tumor Pathol. 2019 36:135-143. https://doi.org/10.1007/s10014-019-00348-9 . Govindaraju V , Young K , Maudsley AA . Proton NMR chemical shifts and coupling constants for brain metabolites. NMR 2000 13:129-153. DOI: 10.1002/1099-1492(200005)13:33.0.co;2-v . Li Y , Lafontaine M , Chang S , Nelson SJ . Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma. ACS Chem Neurosci. 2018 9:130-137. doi: 10.1021/acschemneuro.7b00286. Epub 2017 Oct 16. Wilson M , Andronesi O , Barker PB , Bartha R , Bizzi A , Bolan PJ , Brindle KM , Choi IY , Cudalbu C , Dydak U , Emir UE , Gonzalez RG , Gruber S , Gruetter R , Gupta RK , Heerschap A , Henning A , Hetherington HP , Huppi PS , Hurd RE , Kantarci K , Kauppinen RA , Klomp DWJ , Kreis R , Kruiskamp MJ , Leach MO , Lin AP , Luijten PR , Marjańska M , Maudsley AA , Meyerhoff DJ , Mountford CE , Mullins PG , Murdoch JB , Nelson SJ , Noeske R , Öz G , Pan JW , Peet AC , Poptani H , Posse S , Ratai EM , Salibi N , Scheenen TWJ , Smith ICP , Soher BJ , Tkáč I , Vigneron DB , Howe FA . Magn Reson Med. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. 2019 82:527-550. doi: 10.1002/mrm.27742. Epub 2019 Mar 28. Provencher SW . Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed . 2001, 14:260-264. https://doi.org/10.1002/nbm.698 . Kanda Y . Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant . 2013, 48:452-458. https://www.nature.com/articles/bmt2012244 . Steidl E , Pilatus U , Hattingen E , Steinbach JP , Zanella F , Ronellenfitsch MW , Bähr O . Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study. PLoS One . 2016, 11:e0168113. https://doi.org/10.1371/journal.pone.0168113 . Brand A , Richter-Landsberg C , Leibfritz D . Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci . 1993, 15:289-298. https://doi.org/10.1159/000111347 . Maehama T , Dixon JE . The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem . 1998, 273:13375-13378. https://doi.org/ 10.1074/jbc.273.22.13375. Han W , Gills JJ , Memmott RM , Lam S , Dennis PA . The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Cancer Prev Res (Phila) . 2009, 2:370-376. https://doi.org/ 1158/1940-6207.CAPR-08-0209 . Piccolo E , Vignati S , Maffucci T , Innominato PF , Riley AM , Potter BV , Pandolfi PP , Broggini M , Iacobelli S , Innocenti P , Falasca M . Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene . 2004, 23:1754-1765.https://doi.org/ 10.1038/sj.onc.1207296 . Singh RP , Agarwal C , Agarwal R . Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis . 2003, 24:555-563. https://doi.org/10.1093/carcin/24.3.555 . Ozawa T , Riester M , Cheng YK , Huse JT , Squatrito M , Helmy K , Charles N , Michor F , Holland EC . Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. Cancer Cell . 2014, 26:288-300. https://doi.org/ 1016/j.ccr.2014.06.005. Huse JT , Aldape KD . The evolving role of molecular markers in the diagnosis and management of diffuse glioma. Clin Cancer Res . 2014, 20:5601-5611. https://doi.org/ 1158/1078-0432.CCR-14-0831. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-27275","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":683051,"identity":"59669e3c-6ca1-46d6-a6a1-eaebcf79a5cc","order_by":0,"name":"Masanobu Kumon","email":"","orcid":"https://orcid.org/0000-0003-0566-532X","institution":"Department of Neurosurgery, Fujita Health University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Masanobu","middleName":"","lastName":"Kumon","suffix":""},{"id":683052,"identity":"95400293-5f8e-43e6-bbc3-20c03538bb16","order_by":1,"name":"Shunsuke 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University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hiroki","middleName":"","lastName":"Kurahashi","suffix":""},{"id":683063,"identity":"dfd47116-3408-4de1-b453-35de9127b7b4","order_by":12,"name":"Yuichi Hirose","email":"","orcid":"","institution":"Fujita Health University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yuichi","middleName":"","lastName":"Hirose","suffix":""}],"badges":[],"createdAt":"2020-05-06 21:24:16","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-27275/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-27275/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":1359646,"identity":"1dc12b0a-4b08-4f5f-a103-7c5269d8328f","added_by":"auto","created_at":"2020-06-18 15:34:23","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":35704,"visible":true,"origin":"","legend":"Comparison of PFS (a) and OS (b) between the group with a high Ins/Cho ratio (n = 13) and that with a low ratio (n = 17). Analysis was by the Kaplan–Meier method, using the log-rank test. Abbreviations: Ins/Cho, ratio of myoinositol to total Choline; OS, overall survival; PFS, progression free survival.","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-27275/v2/Figure1.jpg"},{"id":15667619,"identity":"e688cc2b-604b-42f0-9fa7-85dfbf5ecf70","added_by":"auto","created_at":"2021-11-18 13:44:04","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":660124,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-27275/v2/7476b9ae-0a6c-4ea5-9a0c-9542c093527b.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eMyoinositol to total choline ratio in \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eGliomas, which are diagnosed based on pathological and genetic findings, are among the most common brain tumors [1-4]. Extensive, surgical resection is the preferred initial therapeutic strategy to improve prognosis [5, 6]; however, such an approach also increases the risk of brain dysfunction because either the border between the tumor and normal brain tissue is unclear or because tumors infiltrate invasively into adjacent healthy brain tissue. Therefore, the ability to predict tumor malignancy preoperatively could help surgeons to plan optimal surgical strategies.\u003c/p\u003e\n\u003cp\u003eMagnetic resonance (MR) spectroscopy enables us to quantify tumor metabolites noninvasively by analyzing their spectra, and thus, it is widely used for preoperative diagnosis of brain tumors [7]. We previously examined tumor metabolites in adult supratentorial gliomas and reported that the myoinositol to total choline (Ins/Cho) ratios in isocitrate dehydrogenase (IDH) wild-type gliomas were significantly lower than in \u003cem\u003eIDH\u003c/em\u003e-mutant gliomas [8]. Given that total choline is thought to represent cell density [9], we presumed that lower ratios indicate myoinositol consumption in a glioma cell. Myoinositols are sugar alcohol in phospholipids of the intracellular membrane [10], and they are produced through food digestion or by hydrolysis or dephosphorylation of the intracellular membrane [10-12]. In astrocytes, myoinositols contribute to adjusting osmotic pressure in response to changes in intracranial pressure [13].\u003c/p\u003e\n\u003cp\u003eMost supratentorial gliomas harboring wild-type \u003cem\u003eIDH\u003c/em\u003e are pathologically classified as glioblastomas and tend to have dismal prognoses [1-3]. Molecular factors that contribute to this poor prognosis have been identified based on genetic subtype, including \u003cem\u003eTERT\u003c/em\u003e promoter mutations, copy number aberrations (e.g., +7, 10q and 9p21), and epigenetic changes (e.g., histone H3) [14-18]. However, such information is only available after surgical resection, and we ideally need a method for predicting outcomes in patients suspected of having glioblastomas before surgery. Based on the observation that supratentorial gliomas with \u003cem\u003eIDH\u003c/em\u003e mutations have better outcomes than those with wild-type \u003cem\u003eIDH\u003c/em\u003e [1, 2, 3], we hypothesized that low Ins/Cho ratios in\u003cem\u003e IDH\u003c/em\u003e wild-type gliomas can be used as a prognostic marker for this genetic subtype of glioma.\u003c/p\u003e\n\u003cp\u003eIn the present study, we calculated Ins/Cho ratios by MR spectroscopy for adults with supratentorial \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas to investigate the ratio\u0026rsquo;s association with prognosis, its correlation with previously reported prognostic factors, and whether it could be used as a preoperative prognostic factor.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy design \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe retrospectively investigated 30 cases of newly diagnosed \u003cem\u003eIDH\u003c/em\u003e wild-type glioma in patients analyzed by MR spectroscopy between 2013 and 2018 at Fujita Health University hospital. Patients who had already received treatment before MR spectroscopy or who were younger than 20 years old were excluded.\u003c/p\u003e\n\u003cp\u003eThe primary outcomes were the progression free survival (PFS) and the overall survival (OS). PFS was calculated from the date of first operation to the date of confirmed recurrence. OS was calculated from the date of first resection to the date of death. Patient information was last updated in April 2019 for follow-up purposes. All resected tissues were assessed by neuropathologists according to the WHO classification [1]. \u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMR \u003c/strong\u003e\u003cstrong\u003espectroscopy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA single-voxel \u003csup\u003e1\u003c/sup\u003eH-MR spectroscopy with point-resolved spectroscopy sequence was performed with a 3 Tesla (T) scanner (Ingenia 3T; Philips Healthcare, Best, The Netherlands) using a dS Head coil and Vantage Titan 3T (Canon Medical Systems Corporation, Otawara, Japan) using a 16 or a 32-channel coil. In each patient, \u003csup\u003e1\u003c/sup\u003eH-MR spectroscopy was performed using the following parameters: repetition time (TR)/echo time (TE), 2000/144 and 35 ms; number of excitation (NEX), 128; bandwidth, 1.61 HZ/point; voxel of interest (VOI) size for metabolic measurements, 15 \u0026times; 15 \u0026times; 15 mm. T2 weighted images in 3 directions for setting the VOI were determined for each patient by means of the following parameters: repetition time (TR)/echo time (TE), 4250/82 ms; acquisition matrix size, 416 \u0026times; 344; reconstruction matrix, 640 \u0026times; 640; field of view (FOV), 230 \u0026times; 230 mm; slice thickness, 4.0 mm; slice gap, 0.8 mm; number of excitation (NEX), 1; reduction factor 1.9. The VOI was selected by a board certified neuroradiologist (K.M) with an experience of 10\u0026ndash;15 years\u0026rsquo; to include the VOIs inside the lesion based on T2 weighted images in 3 directions. When the tumor contains necrotic and cystic components, these components were included within VOI to accurately evaluate tumor characteristics. In \u003csup\u003e1\u003c/sup\u003eH-MR spectroscopy, myoinositol and total choline were measured with short TE (TE = 35 ms) and long TE (TE = 144 ms) respectively [19, 20, 21] because of their relaxation time in T2, and mean concentration of MR spectroscopy values were analyzed by automatic quantification program (LCModel; Stephen Provencher, Oakville, Ontario, Canada) [22].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEvaluation of \u003cem\u003eIDH\u003c/em\u003e mutation status \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe evaluated\u003cem\u003e IDH\u003c/em\u003e mutations using the Sanger method, with codon 132 in \u003cem\u003eIDH1\u003c/em\u003e and codon 172 in \u003cem\u003eIDH 2\u003c/em\u003e analyzed by polymerase chain reaction (PCR). Briefly, DNA was extracted from resected frozen tissue and formalin-fixed and paraffin-embedded tissue (FFPE), using DNeasy blood and tissue kits (QIAGEN, Hulsterweg, Netherland) and an REPLI-g FFPE Kit (QIAGEN).The reaction mixtures for PCR comprised DNA, primers, 10PCR buffer, 10mM dNTP mix (Thermo Fisher Scientific, Waltham, MA, \u003cstrong\u003eUSA\u003c/strong\u003e), 50 mM MGCL₂, and PLATINUM TagDNA polymerase (Thermo Fisher Scientific). After we confirmed the DNA bands of the PCR products in electrophoresis, we added BigDye Sequencing Buffer (Thermo Fisher Scientific), Ready Reaction Mix (Thermo Fisher Scientific), and the same primer to the PCR products, and repeated the PCR. Sequencing was performed with a BigDye Terminator version 3.1 Cycle Sequencing Kit (Thermo Fisher Scientific) and results were analyzed on an ABI 3100 (Applied Biosystems, Waltham, MA, \u003cstrong\u003eUSA\u003c/strong\u003e).\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eNext generation sequencing analysis and comparison of Copy number aberration\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe analyzed samples that met our inclusion criteria and classified them by Ins/Cho ratio into high and low and a low ratio groups. We prepared diluted genomic DNA for subsequent experiments. After whole genome amplification using a SurePlex DNA Amplification System (Illumina, San Diego, CA, USA), library preparation was performed with a Nextera XT DNA Library Preparation Kit (Illumina). Sequencing analysis was conducted with a VeriSeq PGS Kit-MiSeq (Illumina), and results were analyzed with BlueFuse Multi Software (Illumina). In all cases, chromosomes were divided into 2500 windows of approximately 1 Mb in size.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe used Fisher's exact test and the MannWhitney \u003cem\u003eU\u003c/em\u003e test to compare age at onset, sex, laterality, MIB-1 index, and pathology between the two groups. PFS and OS were analyzed using the KaplanMeier method and compared with the log-rank test. Cox proportional hazards models were used to determine the relationship between the Ins/Cho ratio and prognosis. Given that most patients were treated with surgery, temozolomide and radiotherapy, and bevacizumab, we selected the following as explanatory factors in the multivariate analysis: gross total resection; subtotal resection, which was defined as \u0026gt;90% resection; temozolomide and radiotherapy; bevacizumab; and the Ins/Cho ratio. All statistical analyses were conducted using EZR [23].\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eRelation of patient and pathology characteristics with the Ins/Cho ratio \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe mean and median values of the Ins/Cho ratios for the 30 patients included in this cohort were 0.75 and 0.67, respectively. We opted for 0.7 as the cutoff value and classified those patients into high (\u0026ge;0.7) and low (\u0026lt;0.7) Ins/Cho ratio groups (n = 13 and 17, respectively). Tables 1 and 2 show the patient characteristics, pathologies, Ins/Cho ratios, and postoperative therapies. Case comprised 25 glioblastoma, two gliosarcomas, three astrocytomas. Two of three astrocytomas gained chromosome 7 and/or loss of chromosome 10q, but the other was not associated with them. There were no statistically significant differences in sex, age at onset, laterality, MIB-1 index, or grade Ⅳ WHO classification between the two groups. Overall, eight patients underwent reoperation, six patients underwent additional chemotherapy, and seven patients had no treatment after recurrence.\u003c/p\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;margin-top:12.0pt;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eTable 1. Characteristics and treatments of patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.3e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border: 1pt solid windowtext;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eCase\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAge, sex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePathology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eRecurrence\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePFS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eFollow-up terms\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eOutcome\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 38.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-top: none;border-left: 1pt solid windowtext;border-bottom: 1.5pt double windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 35.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eFirst operation / Postoperative therapies / therapies after recurrence\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e42F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.573\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT / TMZ + RT + BEV+ other chemotherapies + operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e43M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.475\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePR / TMZ + RT / BEV + another chemotherapy + operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e43F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.507\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / No treatment / TMZ + RT + BEV + other chemotherapies + operations\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e44M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.167\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT + BEV / other chemotherapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e46F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.450\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT / TMZ + RT + BEV + other chemotherapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e62M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.516\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBiopsy / TMZ + RT / TMZ + RT + BEV + operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e62M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGS, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.149\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eSTR / TMZ + RT / TMZ + RT + operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e63F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.149\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT / TMZ + RT + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e67M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.044\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePR / TMZ + RT / BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e67M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.816\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePR / TMZ + RT + BEV / TMZ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e68F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.227\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eNo treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e68M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eNO\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.182\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eSTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eNo treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e69F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2.054\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / No treatment /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eTMZ + RT + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e69F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.655\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eBEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e70M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eNO\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.854\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eNo treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e71M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDA, Gr Ⅱ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.702\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBiopsy / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eoperation\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e72M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.451\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eTMZ + RT + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e72F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDA, Gr Ⅱ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.952\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePR / No treatment /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eNo treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e73F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.405\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eSTR / No treatment /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eTMZ + RT + BEV +\u0026nbsp;operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e74M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.758\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT /\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eTMZ + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e74M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.240\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT / TMZ + BEV + another chemotherapy + Operation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e74M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.893\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eSTR / TMZ + RT + BEV / TMZ + RT + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e75F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eNO\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.405\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + RT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e76F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAA, Gr Ⅲ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.635\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBiopsy / TMZ + RT / TMZ + BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e77M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGS, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.695\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / TMZ + BEV / No treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e80F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eNO\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.176\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003ePR / TMZ + RT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e81M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.692\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBiopsy / TMZ + BEV / No treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e81M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.397\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR / No treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e85M\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAlive\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.279\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBiopsy / TMZ + BEV +RT / TMZ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.2pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e86F\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGBM, Gr\u0026nbsp;Ⅳ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eYes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eDead\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.111\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 432.1pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"font-family: Helvetica; font-size: 13px; color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eSTR / TMZ / BEV\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:justify;line-height:200%;'\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eData show the patient and treatment details after the first operation and after recurrence for\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003esupratentorial\u003cem\u003e\u0026nbsp;IDH\u003c/em\u003e wild-type glioma\u0026nbsp;(n=30).\u0026nbsp;Pathology was diagnosed according to the WHO classification 2016. Abbreviations: AA, anaplastic astrocytoma; BEV, bevacizumab; DA, diffuse astrocytoma; F, female; GBM, glioblastoma; Gr, grade; GS, gliosarcoma;\u0026nbsp;GTR,\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;Gross total resection;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho,\u0026nbsp;ratio of\u0026nbsp;myoinositol to total choline;\u0026nbsp;IDH,\u0026nbsp;isocitrate dehydrogenase; M, male; PFS, progression free survival; PR, Partial resection; RT, radiotherapy;\u0026nbsp;STR,\u0026nbsp;\u003c/span\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003eSubtotal\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003eresection;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003eTMZ, temozolomide. \u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\u003cbr\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eTable 2. Comparison of patient characteristics by Ins/Cho\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003eratio threshold\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:439.65pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio\u0026ge;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e(n = 13)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio\u0026lt;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e(n = 17)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eMale, n\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;border: none;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eAge at onset, median (years)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e71\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eLeft side, n\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eMIB-1 index, median\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGrade Ⅳ, n\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.55pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;height: 27pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"font-family: Helvetica; font-size: 13px; color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.57\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;line-height:200%;'\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eAbbreviations: Grade Ⅳ, grade Ⅳ in WHO Classification; Ins/Cho, ratio of myoinositol to total choline; n, number of patients.\u003c/span\u003e\u003c/p\u003e\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003ePFS and OS analysis \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe compared prognosis by the Ins/Cho ratio. During follow-up, tumor recurrence occurred in 94% of patients with low Ins/Cho ratio (i.e., 16/17) and in 77% with high Ins/Cho ratio (i.e., 10/13). Moreover, 82% (14/17) of patients with low ratios and 38% (5/13) with high ratios died. Figures 1a and 1b show that the PFS and OS in those with high ratios were significantly shorter than in those with low ratios, indicating higher recurrence and mortality rates in the patients with low Ins/Cho ratios (P = 0.020 and 0.037, respectively). In the multivariate analysis, Cox proportional hazards models revealed that the Ins/Cho ratio was significantly associated with PFS (hazard ratio 0.34, P = 0.027), which suggested that the Ins/Cho ratio was useful outcome predictor, especially for PFS. These data are summarized in Tables 3a and 3b.\u003c/p\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS Gothic\";text-align:justify;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eTable 3a. Multivariate analysis of PFS\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:375.65pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eExplanatory factor\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eHazard ratio (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR or STR\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.84 (0.36\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e2.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eUse of BEV\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.76 (0.26\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e2.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBoth use of TMZ and RT\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.52 (0.20\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.34 (0.13\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.88)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.027\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS Gothic\";text-align:justify;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003eTable 3b. Multivariate analysis of OS\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:375.65pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eExplanatory factor\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eHazard ratio (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eGTR or STR\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.6 (0.44\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e5.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eUse of BEV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.91 (0.28\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e3.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eBoth use of TMZ and RT\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.70 (0.22\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e2.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.4pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.33 (0.10\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; background: white;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e1.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.067\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:justify;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eTables 3a and 3b show the results of multivariate analysis: we chose GTR or STR, BEV, TMZ and RT, and the Ins/Cho ratio as explanatory factors and analyzed their relevance to PFS and OS. Abbreviations: BEV, bevacizumab;\u0026nbsp;GTR,\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%; font-weight: normal;\"\u003e\u0026nbsp;Gross total resection;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho, ratio of\u0026nbsp;myoinositol to total choline; OS,\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eoverall survival; PFS, progression free survival; RT, radiotherapy; STR, subtotal resection; TMZ, temozolomide. \u003c/span\u003e\u003c/p\u003e\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eAnalysis of copy number aberration by next generation sequencing \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe included 20 cases in the next generation sequencing, analyzing nine samples in the group with high Ins/Cho ratios (\u0026ge;0.7) and 11 samples in the group with low Ins/Cho ratios (\u0026lt;0.7). The overall noise value was \u0026lt;0.3. Analysis focused on regions where specific genes exist that are associated with poor prognosis in glioblastoma, including 7p11.2 (\u003cem\u003eEGFR\u003c/em\u003e), 9p21.3 (\u003cem\u003ep16\u003c/em\u003e), 10q23.3 (\u003cem\u003ePTEN\u003c/em\u003e) [15, 16]. Gain of 7p11.2 was detected in seven cases with high ratios and in six cases with low ratios, loss of 9p21.3 was detected in four cases with high ratios and in three cases with low ratios, and loss of 10q23.3 was detected in four cases with high ratios and in three cases with low ratios (Table 4). There were no significant differences between the groups in any other window.\u003c/p\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003eTable 4. Comparison of copy number aberrations by Ins/Cho ratio\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;width:439.45pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio \u0026ge;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e(n = 9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eIns/Cho ratio \u0026lt;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e(n = 11)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS Gothic\";text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003e+\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e7p11.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e7 (78%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e6 (55%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026minus;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e9p21.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4 (44%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3 (27%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 200%;\"\u003e\u0026minus;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 200%;\"\u003e10q23.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e4 (44%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 141.75pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e3 (27%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 26.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:center;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003e0.64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:\"MS PGothic\",sans-serif;text-align:justify;line-height:200%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px;\"\u003e\u003cspan style=\"font-family: Helvetica;\"\u003e\u003cspan style=\"line-height: 200%;\"\u003eCopy number aberrations identified by next generation sequencing are compared by the Ins/Cho ratio. We defined an effective change of gain or loss when the average value of a window was \u0026gt;2.5 or\u0026nbsp;\u0026lt;1.5. Abbreviations: Ins/Cho, ratio of\u0026nbsp;myoinositol to total choline.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 200%; font-family: Helvetica; color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, we demonstrated that a high Ins/Cho ratio on MR spectroscopy was associated with a better prognosis than a low Ins/Cho ratio according to KaplanMeier curves. The Ins/Cho ratio was significantly associated with PFS by KaplanMeier and multivariate analysis. Of the three cases in which the Ins/Cho ratios exceeded 1.0 and that started the Stupp regimen soon after maximum safe resection, the PFS durations were 26, 17, and \u0026ge;39 months (Cases 7, 8, and 26, respectively). Given that total choline in MR spectroscopy reveals cell density [9], low myoinositol levels are considered associated with poor prognosis. Indeed, a recent cohort study of recurrent glioblastoma treated with bevacizumab reported that a high myoinositol value on MR spectroscopy was associated with a good prognosis [24]. Given all these results, we considered that myoinositol affects as a second messenger and has antitumor effects. Myoinositols are located in glial cells, especially in astrocytes [25], and regulate intracranial osmotic pressure [13]. Phosphatidylinositol 3-phosphate, which contains myoinositols in its structure, is produced by intracellular membrane metabolism [10] and activates the PI3K-Akt pathway as a second messenger [26]. Activation of this pathway may cause a poorer prognosis in patients with a low Ins/Cho ratio by prompting cell proliferation and myoinositol consumption. As shown in a previous study, oral administration of myoinositols can inhibit malignant transformation of tumor cells in patients suffering non\u003cstrong\u003e-\u003c/strong\u003esmall-cell lung cancer, in which the PI3K-Akt pathway is important [27]. Other researchers also reported that myoinositols have antitumor effects that result from their phosphorylated metabolites, such as \u003cstrong\u003einositol 1,3,4,5,6\u003c/strong\u003e\u003cstrong\u003e-\u003c/strong\u003epentaphosphate and \u003cstrong\u003einositol\u003c/strong\u003e hexaphosphate, which can induce tumor cell apoptosis [28, 29]. These previous studies suggest that malignancy in \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas with low Ins/Cho ratios is associated with a simple reduction in antitumor effects.\u003c/p\u003e\n\u003cp\u003eHowever, multivariate analysis only showed that the Ins/Cho ratio was significantly associated with PFS and not OS (Figure 1, Table 3). We assumed that the therapeutic strategies used after recurrence affected these results in the multivariate analyses. Indeed, some patients chose both surgical resection and additional chemotherapy (13%), whereas other patients opted for no additional therapy after recurrence (23%), potentially affecting outcomes. Notably, all patients younger than 50 years at diagnosis were in the group with a low Ins/Cho ratio, and 60% of these chose surgical resection and chemotherapy (Table 1). Two of these patients (cases 1 and 3) survived for approximately 2 years despite having low Ins/Cho ratios (0.57 and 0.51, respectively). By contrast, 20% of patients older than 60 years at diagnosis underwent surgical resection, and only 4% of these chose additional chemotherapy. Patients who opted for no therapy after recurrence had short survival time (e.g., cases 15 and 27) despite having relatively high Ins/Cho ratios (0.85 and 0.69, respectively).\u003c/p\u003e\n\u003cp\u003eCopy number analysis by next generation sequencing revealed no significant correlations between the Ins/Cho ratio and chromosomal areas, despite the association of specific copy number aberrations with glioblastoma (Table 4). Previous studies have shown that such copy number aberrations are an early stage of tumorigenesis in glioblastoma [15, 30, 31], and our results suggest that low myoinositol levels are less likely to be caused by decreased myoinositol synthesis due to chromosomal change and gene expression. Rather, the low myoinositol levels can be considered to result from consumption due to tumor growth.\u003c/p\u003e\n\u003cp\u003eThis study is limited by its retrospective cohort design and lack of control of therapeutic strategies (e.g., resection extent by tumor location, postoperative bevacizumab use, and radiological dosages) or postoperative complications (e.g., delayed wound healing or high-fever affected the start of adjuvant therapy). These factors could have significantly affected the clinical courses and outcomes. We must now investigate more cases to clarify the putative correlations between the Ins/Cho ratio and patient prognosis.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe noninvasive Ins/Cho ratio can serve as a novel prognostic marker for adults with supratentorial \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas, providing useful preoperative information in patients with suspected glioblastomas. However, we can only speculate on why myoinositols are associated with patient outcomes, and questions around this will be targeted in future research.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eFFPE: formalin-fixed and paraffin-embedded tissue\u003c/p\u003e\n\u003cp\u003eIDH: isocitrate dehydrogenase\u003c/p\u003e\n\u003cp\u003eIns/Cho ratio: ratio of myoinositol to total choline\u003c/p\u003e\n\u003cp\u003eMR: Magnetic resonance spectroscopy\u003c/p\u003e\n\u003cp\u003eOS: overall survival\u003c/p\u003e\n\u003cp\u003ePCR: polymerase chain reaction\u003c/p\u003e\n\u003cp\u003ePFS: progression free survival\u003c/p\u003e\n\u003cp\u003eVOI: voxel of interest\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthical approval and consent to participate: \u003c/strong\u003eAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethical review board of Fujita Health University (HG19-017).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors read and approved the final manuscript.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interest.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was funded by a Grant-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology in Japan (# 16K20029 to S.N.).\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMK is the author and who conducted this study. TK, HS, HK conducted the copy number analysis and drafted the manuscript. KM and YO analyzed metabolites of glioma in this study and drafted the manuscript. MA and SY diagnosed tissue pathologically according to the WHO classification. SN, SO, JI, MH, and YH revised and edited the manuscript.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank Ms. Fujiko Sueishi for technical support.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Louis%20DN%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eLouis DN\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Perry%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003ePerry A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Reifenberger%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eReifenberger G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=von%20Deimling%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003evon Deimling A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Figarella-Branger%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eFigarella-Branger D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cavenee%20WK%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eCavenee WK\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ohgaki%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eOhgaki H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wiestler%20OD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eWiestler OD\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kleihues%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eKleihues P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ellison%20DW%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27157931\"\u003eEllison DW\u003c/a\u003e. 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href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yung%20WK%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYung WK\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Salama%20SR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSalama SR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cooper%20LA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCooper LA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Rheinbay%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRheinbay E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Miller%20CR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMiller CR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Vitucci%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVitucci M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Morozova%20O%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMorozova O\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Robertson%20AG%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRobertson AG\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Noushmehr%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNoushmehr H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Laird%20PW%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLaird PW\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cherniack%20AD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCherniack AD\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Akbani%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAkbani R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Huse%20JT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHuse JT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ciriello%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCiriello G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Poisson%20LM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePoisson LM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Barnholtz-Sloan%20JS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBarnholtz-Sloan JS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Berger%20MS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBerger MS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Brennan%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBrennan C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Colen%20RR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eColen RR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Colman%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eColman H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Flanders%20AE%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFlanders AE\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Giannini%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGiannini C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Grifford%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGrifford M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Iavarone%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eIavarone A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jain%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJain R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Joseph%20I%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJoseph I\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKim J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kasaian%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKasaian K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mikkelsen%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMikkelsen T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Murray%20BA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMurray BA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=O'Neill%20BP%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eO'Neill BP\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pachter%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePachter L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Parsons%20DW%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eParsons DW\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sougnez%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSougnez C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sulman%20EP%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSulman EP\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Vandenberg%20SR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVandenberg SR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Van%20Meir%20EG%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVan Meir EG\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=von%20Deimling%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003evon Deimling A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZhang H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Crain%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCrain D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lau%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLau K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mallery%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMallery D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Morris%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMorris S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Paulauskis%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePaulauskis J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Penny%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePenny R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shelton%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eShelton T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sherman%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSherman M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yena%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYena P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Black%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBlack A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bowen%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBowen J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Dicostanzo%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDicostanzo K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gastier-Foster%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGastier-Foster J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Leraas%20KM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLeraas KM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lichtenberg%20TM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLichtenberg TM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pierson%20CR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePierson CR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ramirez%20NC%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRamirez NC\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Taylor%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTaylor C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Weaver%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWeaver S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wise%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWise L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zmuda%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZmuda E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Davidsen%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDavidsen T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Demchok%20JA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDemchok JA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Eley%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eEley G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ferguson%20ML%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFerguson ML\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hutter%20CM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHutter CM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mills%20Shaw%20KR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMills Shaw KR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ozenberger%20BA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eOzenberger BA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sheth%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSheth M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sofia%20HJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSofia HJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tarnuzzer%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTarnuzzer R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20Z%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWang Z\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYang L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zenklusen%20JC%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZenklusen JC\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ayala%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAyala B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Baboud%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBaboud J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Chudamani%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eChudamani S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jensen%20MA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJensen MA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLiu J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pihl%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePihl T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Raman%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRaman R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wan%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWan Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wu%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWu Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ally%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAlly A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Auman%20JT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAuman JT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Balasundaram%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBalasundaram M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Balu%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBalu S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Baylin%20SB%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBaylin SB\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Beroukhim%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBeroukhim R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bootwalla%20MS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBootwalla MS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bowlby%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBowlby R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bristow%20CA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBristow CA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Brooks%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBrooks D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Butterfield%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eButterfield Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Carlsen%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCarlsen R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Carter%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCarter S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Chin%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eChin L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Chu%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eChu A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Chuah%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eChuah E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cibulskis%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCibulskis K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Clarke%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eClarke A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Coetzee%20SG%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCoetzee SG\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Dhalla%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDhalla N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Fennell%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFennell T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Fisher%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFisher S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gabriel%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGabriel S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Getz%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGetz G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gibbs%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGibbs R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Guin%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGuin R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hadjipanayis%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHadjipanayis A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hayes%20DN%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHayes DN\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hinoue%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHinoue T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hoadley%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHoadley K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Holt%20RA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHolt RA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hoyle%20AP%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHoyle AP\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jefferys%20SR%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJefferys SR\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jones%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJones S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jones%20CD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJones CD\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kucherlapati%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKucherlapati R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lai%20PH%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLai PH\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lander%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLander E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lee%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLee S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lichtenstein%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLichtenstein L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ma%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMa Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Maglinte%20DT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMaglinte DT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mahadeshwar%20HS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMahadeshwar HS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Marra%20MA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMarra MA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mayo%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMayo M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Meng%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMeng S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Meyerson%20ML%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMeyerson ML\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mieczkowski%20PA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMieczkowski PA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Moore%20RA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMoore RA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mose%20LE%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMose LE\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mungall%20AJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMungall AJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pantazi%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePantazi A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Parfenov%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eParfenov M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Park%20PJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePark PJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Parker%20JS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eParker JS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Perou%20CM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePerou CM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Protopopov%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eProtopopov A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ren%20X%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRen X\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Roach%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRoach J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sabedot%20TS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSabedot TS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Schein%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSchein J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Schumacher%20SE%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSchumacher SE\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Seidman%20JG%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSeidman JG\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Seth%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSeth S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shen%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eShen H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Simons%20JV%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSimons JV\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sipahimalani%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSipahimalani P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Soloway%20MG%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSoloway MG\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Song%20X%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSong X\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sun%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSun H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tabak%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTabak B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tam%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTam A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tan%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTan D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tang%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTang J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Thiessen%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eThiessen N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Triche%20T%20Jr%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTriche T Jr\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Van%20Den%20Berg%20DJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVan Den Berg DJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Veluvolu%20U%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVeluvolu U\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Waring%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWaring S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Weisenberger%20DJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWeisenberger DJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wilkerson%20MD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWilkerson MD\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wong%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWong T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wu%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWu J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Xi%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eXi L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Xu%20AW%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eXu AW\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYang L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zack%20TI%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZack TI\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZhang J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Aksoy%20BA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAksoy BA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Arachchi%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eArachchi H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Benz%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBenz C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bernard%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBernard B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Carlin%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCarlin D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cho%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCho J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=DiCara%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDiCara D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Frazer%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFrazer S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Fuller%20GN%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFuller GN\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gao%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGao J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gehlenborg%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGehlenborg N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Haussler%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHaussler D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Heiman%20DI%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHeiman DI\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Iype%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eIype L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jacobsen%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJacobsen A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ju%20Z%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJu Z\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Katzman%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKatzman S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20H%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKim H\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Knijnenburg%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKnijnenburg T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kreisberg%20RB%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKreisberg RB\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lawrence%20MS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLawrence MS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lee%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLee W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Leinonen%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLeinonen K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lin%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLin P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ling%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLing S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLiu W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLiu Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLiu Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lu%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLu Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mills%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMills G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ng%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNg S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Noble%20MS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNoble MS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Paull%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePaull E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Rao%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRao A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Reynolds%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eReynolds S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Saksena%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSaksena G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sanborn%20Z%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSanborn Z\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sander%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSander C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Schultz%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSchultz N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Senbabaoglu%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSenbabaoglu Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shen%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eShen R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shmulevich%20I%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eShmulevich I\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sinha%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSinha R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Stuart%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eStuart J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sumer%20SO%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSumer SO\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sun%20Y%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSun Y\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Tasman%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTasman N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Taylor%20BS%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eTaylor BS\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Voet%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eVoet D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Weinhold%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWeinhold N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Weinstein%20JN%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eWeinstein JN\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYang D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Yoshihara%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eYoshihara K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zheng%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZheng S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZhang W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Zou%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eZou L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Abel%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAbel T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Sadeghi%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSadeghi S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cohen%20ML%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCohen ML\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Eschbacher%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eEschbacher J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hattab%20EM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHattab EM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Raghunathan%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRaghunathan A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Schniederjan%20MJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSchniederjan MJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Aziz%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eAziz D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Barnett%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBarnett G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Barrett%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBarrett W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bigner%20DD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBigner DD\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Boice%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBoice L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Brewer%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eBrewer C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Calatozzolo%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCalatozzolo C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Campos%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCampos B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Carlotti%20CG%20Jr%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCarlotti CG Jr\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Chan%20TA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eChan TA\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cuppini%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCuppini L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Curley%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCurley E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cuzzubbo%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eCuzzubbo S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Devine%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDevine K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=DiMeco%20F%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDiMeco F\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Duell%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eDuell R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Elder%20JB%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eElder JB\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Fehrenbach%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFehrenbach A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Finocchiaro%20G%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFinocchiaro G\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Friedman%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFriedman W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Fulop%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eFulop J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gardner%20J%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eGardner J\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hermes%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHermes B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Herold-Mende%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eHerold-Mende C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Jungk%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eJungk C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Kendler%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eKendler A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lehman%20NL%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLehman NL\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lipp%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLipp E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20O%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eLiu O\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mandt%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMandt R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=McGraw%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMcGraw M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mclendon%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMclendon R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=McPherson%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eMcPherson C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Neder%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNeder L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Nguyen%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNguyen P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Noss%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNoss A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Nunziata%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eNunziata R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ostrom%20QT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eOstrom QT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Palmer%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePalmer C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Perin%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePerin A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pollo%20B%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePollo B\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Potapov%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePotapov A\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Potapova%20O%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003ePotapova O\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Rathmell%20WK%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRathmell WK\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Rotin%20D%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eRotin D\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Scarpace%20L%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eScarpace L\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Schilero%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSchilero C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Senecal%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eSenecal K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shimmel%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=26061751\"\u003eShimmel K\u003c/a\u003e, \u003ca 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Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Comparison+between++short+and+long+echo+time+magnetic+resonance+spectroscopic+imag%EF%BF%BDing+at+3T+and+7T+for+evaluating+brain+metabolites+in+patients+with++glioma.+A\"\u003eACS Chem Neurosci.\u003c/a\u003e 2018 9:130-137. doi: 10.1021/acschemneuro.7b00286. Epub 2017 Oct 16.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Wilson%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=30919510\"\u003eWilson M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Andronesi%20O%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=30919510\"\u003eAndronesi O\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Barker%20PB%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=30919510\"\u003eBarker PB\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bartha%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=30919510\"\u003eBartha R\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Bizzi%20A%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=30919510\"\u003eBizzi A\u003c/a\u003e, \u003ca 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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=10.1074%2Fjbc.273.22.13375\"\u003eJ Biol Chem\u003c/a\u003e. 1998, 273:13375-13378.\u003ca href=\"https://doi.org/\"\u003ehttps://doi.org/\u003c/a\u003e10.1074/jbc.273.22.13375.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Han%20W%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=19336734\"\u003eHan W\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Gills%20JJ%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=19336734\"\u003eGills JJ\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Memmott%20RM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=19336734\"\u003eMemmott RM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Lam%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=19336734\"\u003eLam S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Dennis%20PA%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=19336734\"\u003eDennis PA\u003c/a\u003e. The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=The+chemopreventive+agent+myoinositol+inhibits+Akt+and+extracellular+signal-regulated+kinase+in+bronchial+lesions+from+heavy+smokers.13375\"\u003eCancer Prev Res (Phila)\u003c/a\u003e. 2009, 2:370-376. https://doi.org/\u003ca href=\"https://dx.doi.org/10.1158%2F1940-6207.CAPR-08-0209\"\u003e1158/1940-6207.CAPR-08-0209\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Piccolo%20E%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003ePiccolo E\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Vignati%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eVignati S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Maffucci%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eMaffucci T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Innominato%20PF%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eInnominato PF\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Riley%20AM%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eRiley AM\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Potter%20BV%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003ePotter BV\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Pandolfi%20PP%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003ePandolfi PP\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Broggini%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eBroggini M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Iacobelli%20S%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eIacobelli S\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Innocenti%20P%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eInnocenti P\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Falasca%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=14755253\"\u003eFalasca M\u003c/a\u003e. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/14755253\"\u003eOncogene\u003c/a\u003e. 2004, 23:1754-1765.https://doi.org/\u003ca href=\"https://doi.org/10.1038/sj.onc.1207296\"\u003e10.1038/sj.onc.1207296\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Singh%20RP%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=12663518\"\u003eSingh RP\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Agarwal%20C%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=12663518\"\u003eAgarwal C\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Agarwal%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=12663518\"\u003eAgarwal R\u003c/a\u003e. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Inositol+hexaphosphate+inhibits+growth%2C+and+induces+G1+arrest+and+apoptotic+death+of+prostate+carcinoma+DU145+cells%3A+modulation+of+CDKI-CDK-cyclin+and+pRb-related+protein-E2F+complexes.\"\u003eCarcinogenesis\u003c/a\u003e. 2003, 24:555-563. \u003ca href=\"https://doi.org/10.1093/carcin/24.3.555\"\u003ehttps://doi.org/10.1093/carcin/24.3.555\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Ozawa%20T%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eOzawa T\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Riester%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eRiester M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Cheng%20YK%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eCheng YK\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Huse%20JT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eHuse JT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Squatrito%20M%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eSquatrito M\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Helmy%20K%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eHelmy K\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Charles%20N%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eCharles N\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Michor%20F%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eMichor F\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Holland%20EC%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25117714\"\u003eHolland EC\u003c/a\u003e. Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/25117714\"\u003eCancer Cell\u003c/a\u003e. 2014, 26:288-300. \u003ca href=\"https://doi.org/\"\u003ehttps://doi.org/\u003c/a\u003e1016/j.ccr.2014.06.005.\u003c/li\u003e\n\u003cli\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Huse%20JT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25398843\"\u003eHuse JT\u003c/a\u003e, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Aldape%20KD%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=25398843\"\u003eAldape KD\u003c/a\u003e. The evolving role of molecular markers in the diagnosis and management of diffuse glioma. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/25398843\"\u003eClin Cancer Res\u003c/a\u003e. 2014, 20:5601-5611. \u003ca href=\"https://doi.org/\"\u003ehttps://doi.org/\u003c/a\u003e1158/1078-0432.CCR-14-0831.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"glioma, IDH wild-type, magnetic resonance spectroscopy, myoinositol","lastPublishedDoi":"10.21203/rs.3.rs-27275/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-27275/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Isocitrate dehydrogenase (IDH) wild-type gliomas tend to be pathologically defined as glioblastomas. We previously reported that, unlike\u003cem\u003e IDH\u003c/em\u003e-mutant gliomas, \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas showed significantly lower ratios of myoinositol to total choline (i.e., the Ins/Cho ratio) on magnetic resonance (MR) spectroscopy. Given that \u003cem\u003eIDH\u003c/em\u003e-mutant gliomas also have much better prognoses than \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas, we hypothesized that this lower Ins/Cho ratio is associated with malignancy in adults with supratentorial gliomas. Therefore, we calculated the Ins/Cho ratios of patients with supratentorial \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas and investigated their progression free survival (PFS) and overall survival (OS) to determine its utility as a prognostic marker.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eWe classified \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas (n = 30) into two groups based on the Ins/Cho ratios, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Compared with the group with high Ins/Cho ratios, the group with low Ins/Cho ratios had shorter PFS (P = 0.020) and OS (P = 0.037) durations. Multivariate analysis demonstrated that the Ins/Cho ratio correlated significantly with PFS (hazard ratio 0.34, P = 0.027). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eWe conclude that the preoperative Ins/Cho ratio can be used as a novel prognostic factor for \u003cem\u003eIDH\u003c/em\u003e wild-type gliomas.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-06-18 15:34:23","doi":"10.21203/rs.3.rs-27275/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-05-11 19:36:24","doi":"10.21203/rs.3.rs-27275/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5dbfdfd4-8118-420e-92ad-0fb78218205a","owner":[],"postedDate":"June 18th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":123988,"name":"Neurosurgery"}],"tags":[],"updatedAt":"2020-07-23T14:10:09+00:00","versionOfRecord":[],"versionCreatedAt":"2020-06-18 15:34:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-27275","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-27275","identity":"rs-27275","version":["v2"]},"buildId":"rHA-KDH7Qsr4HCuvH75dn","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}