Beyond principlism: Practical strategies for ethical AI use in research practices

The rapid adoption of generative artificial intelligence (AI) in scientific research, particularly large language models (LLMs), has outpaced the development of ethical guidelines, leading to a “Triple-Too” problem: too many high-level ethical initiatives, too abstract principles lacking contextual and practical relevance, and too much focus on restrictions and risks over benefits and utilities. Existing approaches—principlism (reliance on abstract ethical principles), formalism (rigid application of rules), and technological solutionism (overemphasis on technological fixes)—offer little practical guidance for addressing ethical challenges of AI in scientific research practices. To bridge the gap between abstract principles and day-to-day research practices, a user-centered, realism-inspired approach is proposed here. It outlines five specific goals for ethical AI use: 1) understanding model training and output, including bias mitigation strategies; 2) respecting privacy, confidentiality, and copyright; 3) avoiding plagiarism and policy violations; 4) applying AI beneficially compared to alternatives; and 5) using AI transparently and reproducibly. Each goal is accompanied by actionable strategies and realistic cases of misuse and corrective measures. I argue that ethical AI application requires evaluating its utility against existing alternatives rather than isolated performance metrics. Additionally, I propose documentation guidelines to enhance transparency and reproducibility in AI-assisted research. Moving forward, we need targeted professional development, training programs, and balanced enforcement mechanisms to promote responsible AI use while fostering innovation. By refining these ethical guidelines and adapting them to emerging AI capabilities, we can accelerate scientific progress without compromising research integrity.