Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil

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This retrospective cohort study analyzed clinical characteristics of 204 patients hospitalized with infective endocarditis at a tertiary hospital in São Paulo, Brazil, and examined in-hospital mortality plus predictors of readmission and mortality up to six months after discharge. Most cases were healthcare-associated (62.3%), with Staphylococcus aureus the predominant pathogen, and mortality was significantly associated with complications including heart failure and septic shock. Independent risk factors for hospital readmission were diabetes mellitus and acute kidney injury, while overall mortality was high (50.9%); the main limitation is reliance on retrospective chart data. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Objective: To analyze the clinical characteristics of patients with infective endocarditis (IE) admitted to a tertiary hospital in Brazil, in-hospital mortality and predictors of readmission and mortality up to six months after hospital discharge. Method: Retrospective cohort study, with data collected from medical records of patients with diagnosis of infective endocarditis hospitalized during the study period. To comparative statistical analysis patients were divided into two groups, according to the outcome: survival and death. Results: 204 patients participated in the study. Healthcare-associated infective endocarditis accounted for 62.3% of cases, with Staphylococcus aureus as the predominant pathogen. Mortality was significantly associated with complications such heart failure and septic shock (p < 0.001). Diabetes mellitus (OR 7,76; p < 0.001) and acute kidney injury (OR 7,99; p=0,016) were independent risk factors for hospital readmission (OR 7,76; p < 0.001). Overall mortality was 50.9%. Conclusion: Short-term mortality was high. Healthcare-associated infections were predominant, and complications and comorbidities significantly affect mortality in IE patients. Identifying high-risk patients and optimizing management may improve outcomes.
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Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil | SciELO Preprints window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-3TT8HYRH0Y'); Open Menu Registrar-se Acesso English Español Ir para o conteúdo principal Ir para o menu de navegação principal Ir para o rodapé Preprints Submissão Áreas do Conhecimento Ciências Agrárias Ciências Biológicas Ciências da Saúde Ciências Exatas e da Terra Ciências Humanas Ciências Sociais Aplicadas Engenharias Linguística, letras e artes Educação em Revista Memórias do Instituto Oswaldo Cruz 47º Encontro Anual da ANPOCS 48º Encontro Anual da ANPOCS 49º Encontro Anual da ANPOCS Sobre Sobre o Servidor Declaração de Privacidade Atualizações do Sistema Contato FAQ Ética no SciELO Preprints Avaliação de preprints Anotações em preprints (via Hypothesis) Avalie um preprint Notícias Início / Ciências da Saúde Preprint / Versão 1 Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil article.authors6a13947870593 Juliana Barros Becker Universidade Federal de São Paulo image/svg+xml .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0002-4960-9074 Valdir Ambrósio Moisés Universidade Federal de São Paulo image/svg+xml Dulce Aparecida Barbosa Universidade Federal de São Paulo image/svg+xml .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0002-9912-4446 DOI: https://doi.org/10.1590/SciELOPreprints.11228 Palavras-chave: Endocarditis, cross infection, epidemiology, hospital mortality, Staphylococcus, Methicillin-resistant Staphylococcus aureus Resumo Objective : To analyze the clinical characteristics of patients with infective endocarditis (IE) admitted to a tertiary hospital in Brazil, in-hospital mortality and predictors of readmission and mortality up to six months after hospital discharge. Method : Retrospective cohort study, with data collected from medical records of patients with diagnosis of infective endocarditis hospitalized during the study period. To comparative statistical analysis patients were divided into two groups, according to the outcome: survival and death. Results: 204 patients participated in the study. Healthcare-associated infective endocarditis accounted for 62.3% of cases, with Staphylococcus aureus as the predominant pathogen. Mortality was significantly associated with complications such heart failure and septic shock (p < 0.001). Diabetes mellitus (OR 7,76; p < 0.001) and acute kidney injury (OR 7,99; p=0,016) were independent risk factors for hospital readmission (OR 7,76; p < 0.001). Overall mortality was 50.9%. Conclusion: Short-term mortality was high. Healthcare-associated infections were predominant, and complications and comorbidities significantly affect mortality in IE patients. Identifying high-risk patients and optimizing management may improve outcomes. Downloads Os dados de download ainda não estão disponíveis. PDF (Inglês) Postado 13/02/2025 Como Citar Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil. (2025). 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