Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?

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Have things changed after the 2014/2015 Ebola outbreak?", "datePublished": "2019-06-06T13:36:55", "dateModified": "2020-01-09T15:46:12", "author": [ { "@type": "Person", "name": "Tom Sesay" }, { "@type": "Person", "name": "Olga Denisiuk" }, { "@type": "Person", "name": "Rony Zachariah" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": "Background: Sierra Leone was severely affected by the 2014/2015 Ebola outbreak which is likely to have had longer term repercussions on the health system including on paediatric morbidity and mortality. We thus assessed under-five morbidity and mortality for malaria, acute respiratory Infections (ARI)/pneumonia, watery diarrhoea and measles during the post-Ebola period in Sierra Leone and compared this with the pre- and intra-Ebola periods. Methods: This was a retrospective cross-sectional study using program data from the District Health Information system (DHIS2) and sourced from 14 districts in Sierra Leone. It included under-five children from 1,250 health facilities country-wide. Study periods included: before (June 1 st, 2013-April 30 th, 2014); during (June 1 st, 2014-April 30 th, 2015); and after Ebola (June 1 st, 2016-April 30 th, 2017). Results: Malaria, ARI/pneumonia and diarrhoea consultations declined during Ebola but recovered to pre-Ebola levels in the post-Ebola period. During the post-Ebola period, there was a highly significant reduction in case-fatality for the first three morbidities compared to the pre-Ebola period (P<0.0001). Average number of measles cases increased from 48/month in the pre-Ebola period to 568/month (12-fold increase) post-Ebola. Although there was no difference in measles case-fatality between the pre- and post-Ebola periods, case-fatality post-Ebola was significantly lower than during Ebola (Relative Risk: 0.05, 95% confidence interval 0.02-0.15, P<0.0001). Conclusions: Consultations for under-five children at health facilities in Sierra Leone recovered to pre-Ebola levels and case-fatality for common childhood illnesses declined significantly. This is a change for the better. However, the high level of reported measles cases in the post-Ebola period indicates gaps in immune status and needs focused attention." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/8-796", "name": "Paediatric morbidity and mortality in Sierra Leone. Have things changed..." } } ] } Home Browse Paediatric morbidity and mortality in Sierra Leone. Have things changed... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Sesay T, Denisiuk O and Zachariah R. Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.12688/f1000research.18552.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Research Article Revised Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] Tom Sesay 1 , Olga Denisiuk 2 , Rony Zachariah https://orcid.org/0000-0002-2915-9328 3 Tom Sesay 1 , Olga Denisiuk 2 , Rony Zachariah https://orcid.org/0000-0002-2915-9328 3 PUBLISHED 09 Jan 2020 Author details Author details 1 Child Health and Immunization Programme, Ministry of Health and Sanitation, Freetown, Sierra Leone 2 Alliance for Public Health, Kiev, Ukraine 3 Special Programme for Research and Training in Tropical Diseases (WHO/TDR), Geneva, Switzerland Tom Sesay Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Olga Denisiuk Roles: Data Curation, Formal Analysis, Methodology, Software, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Rony Zachariah Roles: Conceptualization, Formal Analysis, Funding Acquisition, Methodology, Resources, Software, Supervision, Validation, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Emerging Diseases and Outbreaks gateway. This article is included in the TDR gateway. This article is included in the Ebola Virus collection. Abstract Background: Sierra Leone was severely affected by the 2014/2015 Ebola outbreak which is likely to have had longer term repercussions on the health system including on paediatric morbidity and mortality. We thus assessed under-five morbidity and mortality for malaria, acute respiratory Infections (ARI)/pneumonia, watery diarrhoea and measles during the post-Ebola period in Sierra Leone and compared this with the pre- and intra-Ebola periods. Methods: This was a retrospective cross-sectional study using program data from the District Health Information system (DHIS2) and sourced from 14 districts in Sierra Leone. It included under-five children from 1,250 health facilities country-wide. Study periods included: before (June 1 st , 2013-April 30 th , 2014); during (June 1 st , 2014-April 30 th , 2015); and after Ebola (June 1 st , 2016-April 30 th , 2017). Results: Malaria, ARI/pneumonia and diarrhoea consultations declined during Ebola but recovered to pre-Ebola levels in the post-Ebola period. During the post-Ebola period, there was a highly significant reduction in case-fatality for the first three morbidities compared to the pre-Ebola period ( P <0.0001). Average number of measles cases increased from 48/month in the pre-Ebola period to 568/month (12-fold increase) post-Ebola. Although there was no difference in measles case-fatality between the pre- and post-Ebola periods, case-fatality post-Ebola was significantly lower than during Ebola (Relative Risk: 0.05, 95% confidence interval 0.02-0.15, P <0.0001). Conclusions: Consultations for under-five children at health facilities in Sierra Leone recovered to pre-Ebola levels and case-fatality for common childhood illnesses declined significantly. This is a change for the better. However, the high level of reported measles cases in the post-Ebola period indicates gaps in immune status and needs focused attention. READ ALL READ LESS Keywords Sustainable Development Goals, Outbreak response, Universal Health Coverage, Operational Research, SORT IT Corresponding Author(s) Tom Sesay ( [email protected] ) Close Corresponding author: Tom Sesay Competing interests: No competing interests were disclosed. Grant information: The programme was funded by the Special Programme for Research and Training in Tropical Diseases hosted at the World Health Organization (TDR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2020 World Health Organisation. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License , which permits copying, adaptation and distribution in any medium or format for any purpose, provided the original work is properly cited, a link is provided to the license, and any changes made are indicated. Any such copying, adaptation and distribution must not in any way suggest that World Health Organisation endorses you or your use. How to cite: Sesay T, Denisiuk O and Zachariah R. Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.12688/f1000research.18552.2 ) First published: 06 Jun 2019, 8 :796 ( https://doi.org/10.12688/f1000research.18552.1 ) Latest published: 09 Jan 2020, 8 :796 ( https://doi.org/10.12688/f1000research.18552.2 ) Revised Amendments from Version 1 We have made some minor edits to formatting and grammar. In addition, in response to reviewers, we have added clarifications in the introductory paragraph on recovery or improvement. We added t-tests to the methods description and disaggregated the analysis of monthly consultation trends across time periods by disease condition. Therefore, Figure 1 now has four components, one for each of the conditions. We added in Table 1 which presents the results of the t-tests for differences in mean monthly consultations for the four conditions. Finally, in the discussion section, we added points on lack of representation in our data and findings of longer term changes in the health system; a description of our finding on the reductions in case fatality from malaria, ARI/pneumonia and watery diarrhoea; an elaboration on the possible explanations for the decline in immunization services; as well as recommendations for future research. We have made some minor edits to formatting and grammar. In addition, in response to reviewers, we have added clarifications in the introductory paragraph on recovery or improvement. We added t-tests to the methods description and disaggregated the analysis of monthly consultation trends across time periods by disease condition. Therefore, Figure 1 now has four components, one for each of the conditions. We added in Table 1 which presents the results of the t-tests for differences in mean monthly consultations for the four conditions. Finally, in the discussion section, we added points on lack of representation in our data and findings of longer term changes in the health system; a description of our finding on the reductions in case fatality from malaria, ARI/pneumonia and watery diarrhoea; an elaboration on the possible explanations for the decline in immunization services; as well as recommendations for future research. See the authors' detailed response to the review by Sara Hersey See the authors' detailed response to the review by Justin Lessler READ REVIEWER RESPONSES Introduction In 2017, a cross-sectional study 1 documented country-wide morbidity for four common childhood illnesses: malaria, acute respiratory infections (ARI)/pneumonia, watery diarrhoea and measles. There were two main findings. First, during the Ebola outbreak, health facility visits for malaria, ARI/pneumonia and watery diarrhoea dropped significantly nation-wide, without returning to pre-Ebola levels post-outbreak. As these morbidities have similar symptom patterns as Ebola, people may have avoided accessing formal health services to avoid being considered “an Ebola case”. Second, measles cases increased dramatically by six-fold during Ebola and the immediate post-Ebola periods. This was attributed to cessation of measles vaccination activities during the Ebola outbreak. The outbreak was declared over in November 2015. Since then, there have been considerable investments into the health system by Government and development partners. One of the limitations of the 2017 study 1 was that it only included the immediate six-month period after the Ebola outbreak, which might have been too early to assess health system recovery or possible improvement. It is now expected that the country would have fully recovered from the outbreak, but there has been no formal evaluation in this regard. We thus conducted a similar country-wide study assessing morbidity and mortality for the same childhood illnesses using a longer post-Ebola period and compared this data with the pre- and intra Ebola periods. Methods This was a retrospective analysis using routine program data from the District Health Information system (DHIS2) and sourced from all 14 districts in Sierra Leone (see Underlying data 2 ). The study setting was described in detail before 1 . In brief, the health infrastructure is tiered into tertiary hospitals, district hospitals and Peripheral Health Units (PHUs). PHUs include Community Health Centres (CHCs), Community Health Posts (CHPs) and Maternal and Child Health Posts (MCHPs). The Ministry of Health and Sanitation provides free primary health care for children under five across 1,250 health facilities nationwide. The study population included all children under-five years attending public health facilities nationwide. No children were excluded. Study periods included: before (June 1 st 2013-April 30 th 2014); during (June 1 st 2014-April 30 th 2015); and after Ebola (June 1st 2016-April 30th 2017). We exported data on health facility visits and mortality for malaria, ARI/pneumonia, watery diarrhoea and measles from the DHIS2 to Microsoft excel (2016) for analysis. Differences between groups were assessed using Pearson’s X 2 test (Chi square) for the case fatality and t-tests for the average monthly consultations. Levels of significance were set at P ≤ 0.05. Ethics and consent Ethics approval was obtained from the Sierra Leone Ethics and Scientific Review Board (dated 14 December 2018) and the Union Ethics Advisory Group (International Union against Tuberculosis and Lung Disease, Paris, France; EAG number: 68/18). As the study used anonymous data, there was no need for informed consent. Results Country-wide trend in out-patient consultations for under-five morbidities Figure 1 shows country-wide trends in outpatient consultations for malaria, ARI/pneumonia, watery diarrhoea and measles. Consultations followed a seasonal pattern with an overall decline during Ebola. In the post-Ebola period (assessed six months after the end of the outbreak), consultations reached pre-Ebola levels. In contrast, measles increased during the last six months of the Ebola outbreak and this trend continued into the post-Ebola period. Average numbers of measles cases were 48/month in the pre-Ebola period, increasing to 87/month in the Ebola period and 568/month (12-fold increase) post-Ebola. Measles cases peaked in March 2017 with 853 cases. Figure 1. Trends in consultations for childhood morbidities in the pre-Ebola (1 June 2013–30 April 2014), intra-Ebola (1 June 2013–30 April 2014), and post- Ebola (1 June 2016–30 April 2017) periods, Sierra Leone. a ): Malaria consultations in the pre-Ebola, intra-Ebola and post-Ebola periods. b ) ARI/Pneumonia consultations in the pre-Ebola, intra-Ebola and post-Ebola periods. c ) Watery diarrhea consultations in the pre-Ebola, intra-Ebola and post-Ebola periods. d ) Measles consultations in the pre-Ebola, intra-Ebola and post-Ebola periods. Table 1 shows that the observed differences of the pre-Ebola period relative to both the intra-Ebola and post-Ebola periods were statistically significant for all morbidities. Table 1. Difference in mean monthly consultations for four morbidities between the pre-Ebola (1 June 2013–30 April 2014) period and the intra-Ebola (1 June 2013–30 April 2014) and post- Ebola (1 June 2016–30 April 2017) periods, Sierra Leone. Condition Pre/Intra-Ebola Pre/Post-Ebola Difference 95% CI P -value Difference 95% CI P -value ARI/Pneumonia -17,771 (-17,804 to -17,738) p<0.0001 1,661 (1,628 to 1,693) p<0.0001 Malaria -24,071 (-24,060 to -23,973) p<0.0001 6,117 (6,093 to 6,161) p<0.0001 Measles 39 (31 to 47) p<0.0001 520 (508 to 532) p<0.0001 Watery Diarrhoea -6,900 (-6,926 to -6,874) p<0.0001 320 (301 to 339) p<0.0001 CI: Confidence Interval Morbidity and case-fatality for four under-five morbidities Table 2 shows numbers of cases, deaths and case-fatality (per 1,000) for malaria, ARI/pneumonia, watery diarrhoea and measles. During the post-Ebola period, there was a highly significant reduction in case-fatality for the first three morbidities compared to the pre-Ebola period ( P <0.0001). Table 2. Morbidity and case-fatality for four under five morbidities before, during and after the Ebola outbreak in Sierra Leone 1 . Pre-Ebola Ebola Post-Ebola P -value 2 n n n Malaria Cases 989,068 724,881 1056354 Deaths 2,564 1,205 2,112 Deaths/1000 2.6 1.7 2.0 <0.0001 ARI/Pneumonia Cases 717,345 521,860 735,836 Deaths 849 794 568 Deaths/1000 1.2 1.5 0.8 <0.0001 Watery Diarrhoea Cases 200,006 124,100 203,520 Deaths 361 150 242 Deaths/1000 1.8 1.2 1.2 <0.0001 Measles Cases 525 962 6,245 Deaths 1 16 6 Deaths/1000 1.9 16.6 1.0 0.5 1 Pre-Ebola: June 1 st 2013 – April 30 th 2014; Ebola: June 1 st 2014 – April 30 th 2015; Post-Ebola: June 1 st 2016 – April 30 th 2017. 2 Chi-square comparing the pre-Ebola and post-Ebola periods. For measles, there was a total of 525 cases pre-Ebola, 962 cases during Ebola and 6,245 cases post-Ebola. Although there was no difference in measles case-fatality between the pre- and post-Ebola periods, case-fatality post-Ebola was significantly lower than during Ebola (Relative Risk: 0.05, 95% confidence interval 0.02–0.15, P <0.0001). Discussion This study shows that health facility consultations for malaria, ARI/Pneumonia and watery diarrhoea recovered to pre-Ebola levels and were accompanied by significant country-wide reductions in case-fatality compared to the pre-Ebola period. Despite a dramatic increase in measles cases post-Ebola, there was a significant mortality reduction, suggesting overall improvements in clinical care. A study strength is that we included data from 1,250 health facilities and for similar periods before, during and after the outbreak. A limitation is that our data did not include private health facilities resulting in possible underestimation of disease burden. In addition, our post-Ebola period was limited to 2017, which may not be representative of long-term changes in systems strengthening. There were two key findings. First, the reductions in case fatality from malaria, ARI/pneumonia and watery diarrhoea could be associated with post- Ebola health system investments with improved health seeking behaviour. The post-Ebola recovery plan 3 of the Government of Sierra Leone with enhanced financial, technical and training support from partners may also have contributed. Furthermore, community health worker activities including early identification and referrals of ill children were promoted which in turn would contribute to reducing mortality. Second, increased measles cases during and after Ebola could be attributed to vaccination service cessation during Ebola in line with the recommendation to avoid invasive procedures as a way of minimizing Ebola-related occupational risks 4 . Many children would have missed their measles vaccination, resulting in a reduction in herd immunity as well as an accumulation of unvaccinated children. Measles coverage among children under two years in 2017 (post-Ebola) stood at 80% 5 while pre-Ebola this was at a low 78.6% 6 . This implies that measles vaccination coverage was already below the desired level prior to Ebola, worsened during Ebola and remained below desired levels after Ebola. The decline in immunization services during the Ebola period may have triggered a measles outbreak; however the resumption of immunization services would have contributed to the reduction of the cases in the post-Ebola period. This calls for strategies to increase immunisation coverage to at least 95% 7 , 8 and to increase in the coverage of the second measles dose taken at 15 months of age. Future research may consider including additional time periods of 2018-2019 to understand the longer term changes of health systems strengthening efforts on service delivery. In conclusion, consultations of under-five children at health facilities in Sierra Leone recovered to pre-Ebola levels and case-fatality for common childhood illnesses declined significantly. This is a change for the better. However, the high level of reported measles cases in the post-Ebola period needs focused attention. Data availability Source data The Sierra Leone Health Management Information Systems, the District Health Information System 2 (DHIS2), is accessible with a Ministry of Health and Sanitation (MOHS) login through https://sl.dhis2.org/ . The Directorate of Policy, Planning, and Information (DPPI) can be contacted to arrange access through Dr. Francis Smart ( [email protected] ), Director, DPPI, MOHS. Underlying data Repository: Dataset 1. Sesay_Tom_SORTIT2_paed_data. https://doi.org/10.17605/OSF.IO/SYP7G 2 This project contains the following underlying data: Sesay_T_casefatality_data.xlsx (case fatality data) Sesay_T_morbidity_data.xlsx (morbidity data) Sesay_T_paed_datadictionary.xlsx (data dictionary) Data are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). Acknowledgement This research was conducted through the Structured Operational Research and Training Initiative (SORT IT), a global partnership coordinated by the Special Programme for Research and Training in Tropical Diseases at the World Health Organization (WHO/TDR) and implemented with partners. The training model is based on a course developed jointly by the International Union Against Tuberculosis and Lung Disease (The Union) and Medécins sans Frontières (MSF). The specific SORT IT programme which resulted in this publication was jointly developed and implemented by: WHO/TDR, the Sierra Leone Ministry of Health and Sanitation, WHO Sierra Leone and the Centre for Operational Research, The Union, Paris, France, Alliance for Public Health, Ukraine; Institute of Tropical Medicine, Antwerp, Belgium; and Sustainable Health Systems, Freetown, Sierra Leone. Faculty Opinions recommended References 1. Sesay T, Denisiuk O, Shringarpure KK, et al. : Paediatric care in relation to the 2014-2015 Ebola outbreak and general reporting of deaths in Sierra Leone. Public Health Action. 2017; 7 (Suppl 1): S34–S9. PubMed Abstract | Publisher Full Text | Free Full Text 2. Sesay T: Sesay_Tom_SORTIT2_paed_data. 2019. http://www.doi.org/10.17605/OSF.IO/SYP7G 3. National Ebola Recovery Strategy for Sierra Leone, 2015-2017. (Accessed 20th February 2019). Reference Source 4. Takahashi S, Metcalf CJ, Ferrari MJ, et al. : Reduced vaccination and the risk of measles and other childhood infections post-Ebola. Science. 2015; 347 (6227): 1240–2. PubMed Abstract | Publisher Full Text | Free Full Text 5. MICS: Sierra Leone multiple indictor cluster survey 2017, Survey findings report, Statistics Sierra Leone. (Accessed 20nd February, 2019). Reference Source 6. Statistics Sierra Leone (SSL) and ICF International: Sierra Leone Demographic and Health Survey 2013. Freetown, Sierra Leone and Rockville, Maryland, USA: SSL and ICF International. 2014. Reference Source 7. Truelove SA, Moss WJ, Lessler J: Mitigating measles outbreaks in West Africa post-Ebola. Expert Rev Anti Infect Ther. 2015; 13 (11): 1299–301. PubMed Abstract | Publisher Full Text 8. Luquero FJ, Pham-Orsetti H, Cummings DA, et al. : A long-lasting measles epidemic in Maroua, Cameroon 2008-2009: mass vaccination as response to the epidemic. J Infect Dis. 2011; 204 Suppl 1 : S243–51. PubMed Abstract | Publisher Full Text | Free Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 06 Jun 2019 ADD YOUR COMMENT Comment Author details Author details 1 Child Health and Immunization Programme, Ministry of Health and Sanitation, Freetown, Sierra Leone 2 Alliance for Public Health, Kiev, Ukraine 3 Special Programme for Research and Training in Tropical Diseases (WHO/TDR), Geneva, Switzerland Tom Sesay Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Olga Denisiuk Roles: Data Curation, Formal Analysis, Methodology, Software, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Rony Zachariah Roles: Conceptualization, Formal Analysis, Funding Acquisition, Methodology, Resources, Software, Supervision, Validation, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The programme was funded by the Special Programme for Research and Training in Tropical Diseases hosted at the World Health Organization (TDR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Article Versions (2) version 2 Revised Published: 09 Jan 2020, 8:796 https://doi.org/10.12688/f1000research.18552.2 version 1 Published: 06 Jun 2019, 8:796 https://doi.org/10.12688/f1000research.18552.1 Copyright © 2020 World Health Organisation. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License , which permits copying, adaptation and distribution in any medium or format for any purpose, provided the original work is properly cited, a link is provided to the license, and any changes made are indicated. Any such copying, adaptation and distribution must not in any way suggest that World Health Organisation endorses you or your use. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Sesay T, Denisiuk O and Zachariah R. Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.12688/f1000research.18552.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 09 Jan 2020 Revised Views 0 Cite How to cite this report: Arendt V. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74704 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74704 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 15 Dec 2020 Vic Arendt , Service National des Maladies Infectieuses, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg Approved VIEWS 0 https://doi.org/10.5256/f1000research.23885.r74704 This article reports the impact of the West African Ebola outbreak in Sierra Leone (from early 2014-late 2015) on the number of consultations for common childhood diseases at 1250 health facilities as well as case fatality rates for these diseases. ... Continue reading READ ALL This article reports the impact of the West African Ebola outbreak in Sierra Leone (from early 2014-late 2015) on the number of consultations for common childhood diseases at 1250 health facilities as well as case fatality rates for these diseases. The conclusions are highly relevant regarding the recovery of the health system and the attendance to these facilities after the end of the Ebola epidemic. Regarding the figures of mortality, the conclusion that the case fatality between pre and post-ebola periods decreased significantly is clear. Strange enough, however, the mortality from malaria and diarrheal diseases from the pre to intra-ebola period also decreased a lot and it would be useful to comment on this. Could this be because of mass drug administration for malaria during the outbreak 1 or could it be due to underreporting fever-related death due to fear of being suspected as Ebola cases or other explanations? Or decreased social contacts during the epidemic leading to a decrease in diarrheal diseases? Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Aregawi M, Smith SJ, Sillah-Kanu M, Seppeh J, et al.: Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone. Malar J . 2016; 15 : 480 PubMed Abstract | Publisher Full Text Competing Interests: No competing interests were disclosed. Reviewer Expertise: infectious diseases I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Arendt V. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74704 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74704 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Lynen L. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74709 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74709 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 30 Nov 2020 Lutgarde Lynen , Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium Approved VIEWS 0 https://doi.org/10.5256/f1000research.23885.r74709 This is a follow-up study on the impact of the West-African Ebola outbreak on health seeking behavior for common childhood illnesses and their case-fatality in Sierra Leone. It is important to report on these indirect impacts of outbreaks on ... Continue reading READ ALL This is a follow-up study on the impact of the West-African Ebola outbreak on health seeking behavior for common childhood illnesses and their case-fatality in Sierra Leone. It is important to report on these indirect impacts of outbreaks on population health and hopefully lessons can be learnt for future epidemics, in how to mitigate these. The authors have sufficiently addressed the comments of the reviewers in the first round. The results are clear and are correctly discussed. I have no further comments. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Infectious Diseases I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Lynen L. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74709 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74709 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Pyakurel P. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74702 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74702 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 25 Nov 2020 Prajjwal Pyakurel , School of Public Health and Community Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal Approved VIEWS 0 https://doi.org/10.5256/f1000research.23885.r74702 First, during the Ebola outbreak, health facility visits for malaria, ARI/pneumonia and watery diarrhoea dropped significantly nation-wide, without returning to pre-Ebola levels post-outbreak. (Please explain the reason). The outbreak was declared over ... Continue reading READ ALL First, during the Ebola outbreak, health facility visits for malaria, ARI/pneumonia and watery diarrhoea dropped significantly nation-wide, without returning to pre-Ebola levels post-outbreak. (Please explain the reason). The outbreak was declared over in November 2015. Since then, there have been considerable investments into the health system by Government and development partners. (In terms of what?) We thus conducted a similar country-wide study assessing morbidity and mortality for the same childhood illnesses using a longer post-Ebola period. (Can you specify what a longer period means?) Is DHIS2 is the latest version? (Has it been upgraded?) Could you discuss the transition period of recovery from Pre-Ebola to Ebola period and how the health system worked during that period so that the reader could correlate with your findings? Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Pyakurel P. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74702 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74702 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Stewart A. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74706 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74706 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 17 Nov 2020 Alex Stewart , College of Life and Environmental Science, University of Exeter, Exeter, UK Approved VIEWS 0 https://doi.org/10.5256/f1000research.23885.r74706 This is a revised version of a paper examining rates of consultations for childhood illnesses and deaths before, during and after the Ebola outbreak in Sierra Leone. The authors have responded fully to the reviewers' comments on the first submission. ... Continue reading READ ALL This is a revised version of a paper examining rates of consultations for childhood illnesses and deaths before, during and after the Ebola outbreak in Sierra Leone. The authors have responded fully to the reviewers' comments on the first submission. I have no further comment to make. The paper is clear, the results justify the conclusions, and there are considerable implications for health services both in Ebola and other outbreak and pandemic situations. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: I taught with Rony Zachariah in November 2019 in Nepal on a one week SORT IT course. I have not had social contact with him before or after. Reviewer Expertise: Public Health, Health Protection, Environmental public health, Iodine deficiency. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Stewart A. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74706 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74706 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Hersey S. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r58461 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-58461 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 30 Jan 2020 Sara Hersey , US Centers for Disease Control and Prevention (CDC), Washington, DC, USA Approved VIEWS 0 https://doi.org/10.5256/f1000research.23885.r58461 I confirm that I have read this submission and believe that I have an ... Continue reading READ ALL Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Hersey S. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r58461 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-58461 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 06 Jun 2019 Views 0 Cite How to cite this report: Lessler J. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52585 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v1#referee-response-52585 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 28 Oct 2019 Justin Lessler , Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.20306.r52585 "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on ... Continue reading READ ALL "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results: Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Specific notes: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Discussion, "First, the reductions in case fatality...": There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Epidemiology, statistics, infectious disease dynamics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Lessler J. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52585 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v1#referee-response-52585 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 09 Jan 2020 Tom Sesay , Ministry of Health and sanitation, Sierra Leone 09 Jan 2020 Author Response Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. ... Continue reading Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. Reviewer comment: "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. Response: Thank you for this comment. 2. Reviewer comment: While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results. Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Response: Thank you for this point. We have performed t-tests for the differences in the mean monthly cases of the intra-Ebola and post-Ebola periods relative to the pre-Ebola period at a level of significance of 5%. We have also updated the figures by disease condition, which better displays the differences between the periods. 3. Reviewer comment: Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Response: We have taken note of this comment and, accordingly, removed comments that could be considered as speculations. 4. Reviewer comment: Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Response: We have included the basic statistical tests to test the statistical significance of differences between periods, as mentioned above. 5. Reviewer comment: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Response: This comment is noted, and we have added in a phrase on possible improvements. 6. Reviewer comment: Discussion, "First, the reductions in case fatality...” There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Response: The reductions in case fatality were indicated by a Chi-square test of the difference between the pre-Ebola and the post-Ebola period which showed a significant reduction in case fatality in the post- Ebola period. 7. Reviewer comment: Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Response: We have included a t-test of the average monthly measles cases, which showed significant increase in the number of measles cases between the pre-Ebola and post-Ebola periods. 8. Reviewer comment: Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Response: We have ensured that the relevant statistical tests have been completed, with corresponding results to support the conclusions. Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. Reviewer comment: "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. Response: Thank you for this comment. 2. Reviewer comment: While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results. Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Response: Thank you for this point. We have performed t-tests for the differences in the mean monthly cases of the intra-Ebola and post-Ebola periods relative to the pre-Ebola period at a level of significance of 5%. We have also updated the figures by disease condition, which better displays the differences between the periods. 3. Reviewer comment: Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Response: We have taken note of this comment and, accordingly, removed comments that could be considered as speculations. 4. Reviewer comment: Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Response: We have included the basic statistical tests to test the statistical significance of differences between periods, as mentioned above. 5. Reviewer comment: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Response: This comment is noted, and we have added in a phrase on possible improvements. 6. Reviewer comment: Discussion, "First, the reductions in case fatality...” There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Response: The reductions in case fatality were indicated by a Chi-square test of the difference between the pre-Ebola and the post-Ebola period which showed a significant reduction in case fatality in the post- Ebola period. 7. Reviewer comment: Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Response: We have included a t-test of the average monthly measles cases, which showed significant increase in the number of measles cases between the pre-Ebola and post-Ebola periods. 8. Reviewer comment: Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Response: We have ensured that the relevant statistical tests have been completed, with corresponding results to support the conclusions. Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 09 Jan 2020 Tom Sesay , Ministry of Health and sanitation, Sierra Leone 09 Jan 2020 Author Response Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. ... Continue reading Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. Reviewer comment: "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. Response: Thank you for this comment. 2. Reviewer comment: While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results. Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Response: Thank you for this point. We have performed t-tests for the differences in the mean monthly cases of the intra-Ebola and post-Ebola periods relative to the pre-Ebola period at a level of significance of 5%. We have also updated the figures by disease condition, which better displays the differences between the periods. 3. Reviewer comment: Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Response: We have taken note of this comment and, accordingly, removed comments that could be considered as speculations. 4. Reviewer comment: Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Response: We have included the basic statistical tests to test the statistical significance of differences between periods, as mentioned above. 5. Reviewer comment: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Response: This comment is noted, and we have added in a phrase on possible improvements. 6. Reviewer comment: Discussion, "First, the reductions in case fatality...” There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Response: The reductions in case fatality were indicated by a Chi-square test of the difference between the pre-Ebola and the post-Ebola period which showed a significant reduction in case fatality in the post- Ebola period. 7. Reviewer comment: Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Response: We have included a t-test of the average monthly measles cases, which showed significant increase in the number of measles cases between the pre-Ebola and post-Ebola periods. 8. Reviewer comment: Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Response: We have ensured that the relevant statistical tests have been completed, with corresponding results to support the conclusions. Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. Reviewer comment: "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. Response: Thank you for this comment. 2. Reviewer comment: While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results. Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Response: Thank you for this point. We have performed t-tests for the differences in the mean monthly cases of the intra-Ebola and post-Ebola periods relative to the pre-Ebola period at a level of significance of 5%. We have also updated the figures by disease condition, which better displays the differences between the periods. 3. Reviewer comment: Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Response: We have taken note of this comment and, accordingly, removed comments that could be considered as speculations. 4. Reviewer comment: Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Response: We have included the basic statistical tests to test the statistical significance of differences between periods, as mentioned above. 5. Reviewer comment: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Response: This comment is noted, and we have added in a phrase on possible improvements. 6. Reviewer comment: Discussion, "First, the reductions in case fatality...” There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Response: The reductions in case fatality were indicated by a Chi-square test of the difference between the pre-Ebola and the post-Ebola period which showed a significant reduction in case fatality in the post- Ebola period. 7. Reviewer comment: Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Response: We have included a t-test of the average monthly measles cases, which showed significant increase in the number of measles cases between the pre-Ebola and post-Ebola periods. 8. Reviewer comment: Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Response: We have ensured that the relevant statistical tests have been completed, with corresponding results to support the conclusions. Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Hersey S. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52581 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v1#referee-response-52581 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 08 Oct 2019 Sara Hersey , US Centers for Disease Control and Prevention (CDC), Washington, DC, USA Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.20306.r52581 The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area ... Continue reading READ ALL The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Infectious disease epidemiology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Hersey S. Reviewer Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52581 ) The direct URL for this report is: https://f1000research.com/articles/8-796/v1#referee-response-52581 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 09 Jan 2020 Tom Sesay , Ministry of Health and sanitation, Sierra Leone 09 Jan 2020 Author Response Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded ... Continue reading Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded as below. 1. Reviewer comment: The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. Response: Thank you for recognising the importance of this study and its contribution to knowledge about the impact of the 2014/15 Ebola outbreak. 2. Reviewer comment: The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Response: Thank you for this recommendation which we do understand and accept. We do acknowledge the need for further research into the sustainability of the early post-Ebola gains in a much longer post-Ebola period. However, the objective of this study was to assess whether the investments in the health system had an impact on service delivery in the post-Ebola period, as defined in the manuscript. In addition, the ethical approval obtained for this study was only for the periods mentioned in the paper. This, however, is an area we will be interested to investigate in the near future. We have added a recommendation to this effect in the discussion section. 3. Reviewer comment: Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. Response: We agree with your recommendation, and accordingly have completed the analysis separately by the disease conditions. We have amended the Figure 1 based on this. 4. Reviewer comment: The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Response: We do agree with this recommendation. We have removed the recommendation to extend the cut off age for vaccination and added the recommendation to increase the coverage of the second measles dose at 15 months. Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded as below. 1. Reviewer comment: The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. Response: Thank you for recognising the importance of this study and its contribution to knowledge about the impact of the 2014/15 Ebola outbreak. 2. Reviewer comment: The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Response: Thank you for this recommendation which we do understand and accept. We do acknowledge the need for further research into the sustainability of the early post-Ebola gains in a much longer post-Ebola period. However, the objective of this study was to assess whether the investments in the health system had an impact on service delivery in the post-Ebola period, as defined in the manuscript. In addition, the ethical approval obtained for this study was only for the periods mentioned in the paper. This, however, is an area we will be interested to investigate in the near future. We have added a recommendation to this effect in the discussion section. 3. Reviewer comment: Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. Response: We agree with your recommendation, and accordingly have completed the analysis separately by the disease conditions. We have amended the Figure 1 based on this. 4. Reviewer comment: The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Response: We do agree with this recommendation. We have removed the recommendation to extend the cut off age for vaccination and added the recommendation to increase the coverage of the second measles dose at 15 months. Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 09 Jan 2020 Tom Sesay , Ministry of Health and sanitation, Sierra Leone 09 Jan 2020 Author Response Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded ... Continue reading Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded as below. 1. Reviewer comment: The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. Response: Thank you for recognising the importance of this study and its contribution to knowledge about the impact of the 2014/15 Ebola outbreak. 2. Reviewer comment: The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Response: Thank you for this recommendation which we do understand and accept. We do acknowledge the need for further research into the sustainability of the early post-Ebola gains in a much longer post-Ebola period. However, the objective of this study was to assess whether the investments in the health system had an impact on service delivery in the post-Ebola period, as defined in the manuscript. In addition, the ethical approval obtained for this study was only for the periods mentioned in the paper. This, however, is an area we will be interested to investigate in the near future. We have added a recommendation to this effect in the discussion section. 3. Reviewer comment: Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. Response: We agree with your recommendation, and accordingly have completed the analysis separately by the disease conditions. We have amended the Figure 1 based on this. 4. Reviewer comment: The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Response: We do agree with this recommendation. We have removed the recommendation to extend the cut off age for vaccination and added the recommendation to increase the coverage of the second measles dose at 15 months. Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded as below. 1. Reviewer comment: The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. Response: Thank you for recognising the importance of this study and its contribution to knowledge about the impact of the 2014/15 Ebola outbreak. 2. Reviewer comment: The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Response: Thank you for this recommendation which we do understand and accept. We do acknowledge the need for further research into the sustainability of the early post-Ebola gains in a much longer post-Ebola period. However, the objective of this study was to assess whether the investments in the health system had an impact on service delivery in the post-Ebola period, as defined in the manuscript. In addition, the ethical approval obtained for this study was only for the periods mentioned in the paper. This, however, is an area we will be interested to investigate in the near future. We have added a recommendation to this effect in the discussion section. 3. Reviewer comment: Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. Response: We agree with your recommendation, and accordingly have completed the analysis separately by the disease conditions. We have amended the Figure 1 based on this. 4. Reviewer comment: The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Response: We do agree with this recommendation. We have removed the recommendation to extend the cut off age for vaccination and added the recommendation to increase the coverage of the second measles dose at 15 months. Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 06 Jun 2019 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 4 5 6 Version 2 (revision) 09 Jan 20 read read read read read Version 1 06 Jun 19 read read Sara Hersey , US Centers for Disease Control and Prevention (CDC), Washington, USA Justin Lessler , Johns Hopkins Bloomberg School of Public Health, Baltimore, USA Alex Stewart , University of Exeter, Exeter, UK Prajjwal Pyakurel , B.P. Koirala Institute of Health Sciences, Dharan, Nepal Lutgarde Lynen , Institute of Tropical Medicine Antwerp, Antwerp, Belgium Vic Arendt , Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Arendt V. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 15 Dec 2020 | for Version 2 Vic Arendt , Service National des Maladies Infectieuses, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg 0 Views copyright © 2020 Arendt V. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This article reports the impact of the West African Ebola outbreak in Sierra Leone (from early 2014-late 2015) on the number of consultations for common childhood diseases at 1250 health facilities as well as case fatality rates for these diseases. The conclusions are highly relevant regarding the recovery of the health system and the attendance to these facilities after the end of the Ebola epidemic. Regarding the figures of mortality, the conclusion that the case fatality between pre and post-ebola periods decreased significantly is clear. Strange enough, however, the mortality from malaria and diarrheal diseases from the pre to intra-ebola period also decreased a lot and it would be useful to comment on this. Could this be because of mass drug administration for malaria during the outbreak 1 or could it be due to underreporting fever-related death due to fear of being suspected as Ebola cases or other explanations? Or decreased social contacts during the epidemic leading to a decrease in diarrheal diseases? Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Aregawi M, Smith SJ, Sillah-Kanu M, Seppeh J, et al.: Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone. Malar J . 2016; 15 : 480 PubMed Abstract | Publisher Full Text Competing Interests No competing interests were disclosed. Reviewer Expertise infectious diseases I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Arendt V. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74704) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74704 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Lynen L. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 30 Nov 2020 | for Version 2 Lutgarde Lynen , Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium 0 Views copyright © 2020 Lynen L. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This is a follow-up study on the impact of the West-African Ebola outbreak on health seeking behavior for common childhood illnesses and their case-fatality in Sierra Leone. It is important to report on these indirect impacts of outbreaks on population health and hopefully lessons can be learnt for future epidemics, in how to mitigate these. The authors have sufficiently addressed the comments of the reviewers in the first round. The results are clear and are correctly discussed. I have no further comments. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Infectious Diseases I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Lynen L. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74709) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74709 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Pyakurel P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 25 Nov 2020 | for Version 2 Prajjwal Pyakurel , School of Public Health and Community Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal 0 Views copyright © 2020 Pyakurel P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions First, during the Ebola outbreak, health facility visits for malaria, ARI/pneumonia and watery diarrhoea dropped significantly nation-wide, without returning to pre-Ebola levels post-outbreak. (Please explain the reason). The outbreak was declared over in November 2015. Since then, there have been considerable investments into the health system by Government and development partners. (In terms of what?) We thus conducted a similar country-wide study assessing morbidity and mortality for the same childhood illnesses using a longer post-Ebola period. (Can you specify what a longer period means?) Is DHIS2 is the latest version? (Has it been upgraded?) Could you discuss the transition period of recovery from Pre-Ebola to Ebola period and how the health system worked during that period so that the reader could correlate with your findings? Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Pyakurel P. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74702) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74702 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Stewart A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 17 Nov 2020 | for Version 2 Alex Stewart , College of Life and Environmental Science, University of Exeter, Exeter, UK 0 Views copyright © 2020 Stewart A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This is a revised version of a paper examining rates of consultations for childhood illnesses and deaths before, during and after the Ebola outbreak in Sierra Leone. The authors have responded fully to the reviewers' comments on the first submission. I have no further comment to make. The paper is clear, the results justify the conclusions, and there are considerable implications for health services both in Ebola and other outbreak and pandemic situations. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests I taught with Rony Zachariah in November 2019 in Nepal on a one week SORT IT course. I have not had social contact with him before or after. Reviewer Expertise Public Health, Health Protection, Environmental public health, Iodine deficiency. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Stewart A. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r74706) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-74706 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2020 Hersey S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 30 Jan 2020 | for Version 2 Sara Hersey , US Centers for Disease Control and Prevention (CDC), Washington, DC, USA 0 Views copyright © 2020 Hersey S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Hersey S. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.23885.r58461) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v2#referee-response-58461 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2019 Lessler J. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 28 Oct 2019 | for Version 1 Justin Lessler , Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 0 Views copyright © 2019 Lessler J. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results: Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Specific notes: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Discussion, "First, the reductions in case fatality...": There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise Epidemiology, statistics, infectious disease dynamics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 09 Jan 2020 Tom Sesay, Ministry of Health and sanitation, Sierra Leone Author Response to Reviewer Report for Version 1 from Justin Lessler 28 Oct 2019 Thank you for your thoughtful review of the manuscript and your suggestions. We have responded as below. 1. Reviewer comment: "Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?" provides a straight forward analysis of changes in reports of, and mortality from, four diseases before, during and after the 2014/2015 Ebola outbreak based on data from DHIS2 in Sierra Leone. The report provides simple, but important, statistics on morbidity and mortality for malaria, ARI/pneumonia, watery diarrhea, and measles. Response: Thank you for this comment. 2. Reviewer comment: While the data and analysis is important, I have some significant concerns with the statistical analysis and interpretation of the results. Statistics: While the use of chi-squared test to identify that significant differences in mortality exist is appropriate, it only is being used to compare pre- and post Ebola periods and does not help with evaluation of the size of the changes. I would suggest the authors instead select a reference period and report relative rates and confidence intervals, so the data can be better understood. Further, the authors do not perform statistical tests to support some of their statements, some of which are noted below. More tests for differences in reported rates between periods and some analysis of changes in the Ebola period would better support their conclusions. Response: Thank you for this point. We have performed t-tests for the differences in the mean monthly cases of the intra-Ebola and post-Ebola periods relative to the pre-Ebola period at a level of significance of 5%. We have also updated the figures by disease condition, which better displays the differences between the periods. 3. Reviewer comment: Interpretation: The authors make several statements in the discussion and abstract that do not correspond to the analyses done. For instance, they make statements regarding trends in case reports, but perform no statistical test as to whether between period changes in reports are significant. Further, in some cases they frame speculation as a key finding of the paper, such as when they attribute changes to community confidence in the health system. Such speculations need to be clearly framed as such. Response: We have taken note of this comment and, accordingly, removed comments that could be considered as speculations. 4. Reviewer comment: Overall, this paper could be made far stronger and more valuable with the addition of just a few additional basic statistical analyses that were more aligned with the conclusions the authors which to highlight in the discussion. This analysis could likely be done while preserving the admirable conciseness and brevity of the paper. Response: We have included the basic statistical tests to test the statistical significance of differences between periods, as mentioned above. 5. Reviewer comment: Introduction, "to early to assess...": Could this not just be recovery, but also improvements, as significant investments followed the Ebola outbreak. Response: This comment is noted, and we have added in a phrase on possible improvements. 6. Reviewer comment: Discussion, "First, the reductions in case fatality...” There is not really any evidence for this association in the paper, it should be, at the very least, more clear this is speculation. Response: The reductions in case fatality were indicated by a Chi-square test of the difference between the pre-Ebola and the post-Ebola period which showed a significant reduction in case fatality in the post- Ebola period. 7. Reviewer comment: Discussion, "Second, increased measles cases...": If this is going to be said it needs to be better supported by the statistical analysis in the paper. Response: We have included a t-test of the average monthly measles cases, which showed significant increase in the number of measles cases between the pre-Ebola and post-Ebola periods. 8. Reviewer comment: Discussion, "In conclusion, consultations...": This was not explicitly tested in the analysis, so I am not sure it can be concluded. Response: We have ensured that the relevant statistical tests have been completed, with corresponding results to support the conclusions. View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Lessler J. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52585) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/8-796/v1#referee-response-52585 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2019 Hersey S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 08 Oct 2019 | for Version 1 Sara Hersey , US Centers for Disease Control and Prevention (CDC), Washington, DC, USA 0 Views copyright © 2019 Hersey S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Infectious disease epidemiology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 09 Jan 2020 Tom Sesay, Ministry of Health and sanitation, Sierra Leone Author Response to Reviewer Report for Version 1 from Sara Hersey 08 Oct 2019 Thank you for your thoughtful review of the manuscript and your insightful suggestions. We have responded as below. 1. Reviewer comment: The authors of this paper have looked at trends in the pediatric morbidity and mortality prior to, during and after the 2014-15 Ebola outbreak in West Africa. The impact of large scale outbreaks on health systems remains a critical area of research, and the authors should be congratulated in contributing to this area of work. The comments below are intended to better contextualize the analysis and conclusions proposed by the authors. Response: Thank you for recognising the importance of this study and its contribution to knowledge about the impact of the 2014/15 Ebola outbreak. 2. Reviewer comment: The authors divide the paper into three distinct time periods, with ‘post-Ebola’ defined as beginning in June 2016 and extending through April 2017. While the end of the Ebola outbreak in Sierra Leone was declared in November 2015, there continued to be additional Ebola clusters in the country and the region into the ‘post-Ebola’ study period. The policy of mandatory Ebola testing for all deaths also continued until June 2016. During the ‘post-Ebola’ time period in the paper, there was an enormous influx of funding to improve health systems at both the facility and community levels that was organized under the Presidential Recovery Plan. This funding supported the national and sub-national health systems but was also supplemented by NGO and other non-governmental health services. By the end of 2017, there were substantial reductions in the funds available for health systems and service delivery. The continued specter of Ebola transmission and the rapid scale-up in health resources likely had both negative and positive impacts on health systems utilization that are difficult to quantify. The authors have documented significantly lower case fatality rates for three diseases than the pre-Ebola time period which would support the conclusion that there was regained community trust in the health services. However, those services were not the same ones available prior to the Ebola outbreak and the services are difficult to maintain with reduced external resources. In order to compare the pre and post-Ebola periods, I would recommend that the analysis be extended to the immediate post-Ebola period included in this paper as well as a longer-term post-Ebola period through 2018 which would better capture the more sustainable health system in Sierra Leone rather than the one served by a short-term, high-volume influx of external funding. Response: Thank you for this recommendation which we do understand and accept. We do acknowledge the need for further research into the sustainability of the early post-Ebola gains in a much longer post-Ebola period. However, the objective of this study was to assess whether the investments in the health system had an impact on service delivery in the post-Ebola period, as defined in the manuscript. In addition, the ethical approval obtained for this study was only for the periods mentioned in the paper. This, however, is an area we will be interested to investigate in the near future. We have added a recommendation to this effect in the discussion section. 3. Reviewer comment: Aside from the clear spikes in measles consultations, Figure 1 is difficult to interpret when displayed by time period. The differences may be more impactful if compared by disease instead. Response: We agree with your recommendation, and accordingly have completed the analysis separately by the disease conditions. We have amended the Figure 1 based on this. 4. Reviewer comment: The analysis supports the conclusion that measles surged during and post-Ebola and this is backed up by other research and program documentation. However, it does not necessarily support the recommendation to extend the cut off age for vaccination. The recommendation to conduct laboratory confirmation for measles is also not necessarily supported by the data presented. Is this because a number of the measles outbreaks were determined to be rubella which is currently not on the vaccine schedule? If yes, this should be documented by the data. What would be the impact on measles morbidity if there was increased diagnostic versus syndromic management of measles? Response: We do agree with this recommendation. We have removed the recommendation to extend the cut off age for vaccination and added the recommendation to increase the coverage of the second measles dose at 15 months. View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Hersey S. Peer Review Report For: Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak? [version 2; peer review: 5 approved, 1 approved with reservations] . F1000Research 2020, 8 :796 ( https://doi.org/10.5256/f1000research.20306.r52581) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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