Factors Causing Infertility in Women Diagnosed with Endometriosis

Rosales, Andres Alejandro Lepe, Rodríguez, Jose Armando López, Mendoza, Alejandro Arias, Medina, Araceli López, González, Erika Mora, Rocía Alvídrez Rodríguez
2022 · doi:10.5281/zenodo.7229253 · W6950644315
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-13 ⓘ

This review examines the multifactorial mechanisms linking endometriosis to infertility, including oxidative stress, altered steroidogenesis, inflammatory interleukins, and pelvic or genetic factors affecting oocyte development.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by gpt-5.6-luna, 2026-08-12 · read from full text ⓘ

This paper reviews proposed mechanisms underlying infertility in women with endometriosis, focusing on ectopic endometrial tissue and its effects on pelvic, ovarian, and genetic factors. It discusses oxidative stress, altered aromatase P450 activity and steroidogenesis, impaired follicular and oocyte development, and inflammatory mediators including TNF-α, IL-1β, IL-6, IL-8, and IL-10. The paper emphasizes that infertility is multifactorial and that the mechanisms remain uncertain, while presenting several biological explanations; it does not describe a specific study population or experimental methodology. This paper is centrally about endometriosis — the proposed biological factors linking the disease to infertility.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a pathology that commonly prevails in more than 50% of women as a cause of dysmenorrhea and infertility and we can define it as the presence of endometrial glands and stroma outside of it, that is, ectopic endometrial tissue that is mostly located in the ovaries, Douglas pouch, uterosacral ligaments and other anatomical sites. Infertility associated with endometriosis is a multifactorial disease and there is no certainty about the mechanisms by which it is developed, however there are several theories that could provide an explanation. Oxidative stress is one of the factors that contribute to infertility where a chain of events is created that culminates in the alteration of the number of oocyte recovery and the number of mature oocytes. Dysregulation of aromatase P450 production in steroidogenesis causes a decrease in estrogen production altering follicular and oocyte development. There are also interleukins associated with infertility of which TNF-α, interleukin-1β, IL-6, IL-8, IL-10 and others stand out. On the other hand, there are several biological explanations that are related to the causal link between endometriosis and infertility, some of them include factors of the pelvic cavity, ovarian and genetic factors.
Full text 1,840 characters · extracted from oa-doi-fallback · click to expand
Factors Causing Infertility in Women Diagnosed with Endometriosis Authors/Creators - 1. Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México. - 2. Universidad Anáhuac. México. - 3. Escuela Superior de Medicina del Instituto Politécnico Nacional - 4. Universidad Autónoma de Ciudad Juárez. Ciudad Juarez, Chihuahua, México - 5. Universidad Anáhuac. México - 6. Universidad Autónoma de Chihuahua. Chihuahua, México. Description Endometriosis is a pathology that commonly prevails in more than 50% of women as a cause of dysmenorrhea and infertility and we can define it as the presence of endometrial glands and stroma outside of it, that is, ectopic endometrial tissue that is mostly located in the ovaries, Douglas pouch, uterosacral ligaments and other anatomical sites. Infertility associated with endometriosis is a multifactorial disease and there is no certainty about the mechanisms by which it is developed, however there are several theories that could provide an explanation. Oxidative stress is one of the factors that contribute to infertility where a chain of events is created that culminates in the alteration of the number of oocyte recovery and the number of mature oocytes. Dysregulation of aromatase P450 production in steroidogenesis causes a decrease in estrogen production altering follicular and oocyte development. There are also interleukins associated with infertility of which TNF-α, interleukin-1β, IL-6, IL-8, IL-10 and others stand out. On the other hand, there are several biological explanations that are related to the causal link between endometriosis and infertility, some of them include factors of the pelvic cavity, ovarian and genetic factors. Files 16.pdf Files (432.7 kB) | Name | Size | Download all | |---|---|---| | md5:ffeffa12d5028f071bd5d0d645f6f3ac | 432.7 kB | Preview Download |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisdysmenorrheainfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-10T11:08:42.831752+00:00
License: CC0 · commercial use OK