Acceptance and tolerability of 75 g Pregnancy Oral Glucose Tolerance Test in Pregnancy
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This study found that pregnant women found the 75g oral glucose tolerance test acceptable and well-tolerated despite issues with taste, duration, and nausea, though many preferred the 50g glucose challenge test.
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This preprint studied acceptance and tolerability of the 75 g two-hour pregnancy oral glucose tolerance test (POGTT) among pregnant females attending a combined endocrine and obstetrics antenatal clinic at Gosford Hospital, NSW, using a prospective questionnaire-based design. The questionnaire assessed inconveniences related to fasting, test duration, and gastrointestinal and other side effects, and compared reported experiences between the 75 g POGTT and a prior or current 50 g glucose challenge test (GCT). Among 98 respondents, the most inconvenient factors were the taste of Glucogel (54%) and test duration (45%), with nausea (42%) and fasting requirement (18%) also reported; overall, 69% reported an overall experience with the test as having no issues. The paper acknowledges that it is a preprint and not peer reviewed, and its findings are based on questionnaire self-report from a single clinical setting. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
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Abstract
Abstract Background: Gestational diabetes mellitus (GDM) is increasing in prevalence but there are various debatable issues around the diagnostic methods and criteria. Universal screening and 2-hour 75 g pregnancy oral glucose tolerance test (POGTT) is now widely accepted in Australia barring a few places.A questionnaire based study was planned to determine the acceptance and tolerability of 75 g POGTT in pregnant females and compare with 50 g glucose challenge test (GCT). Methods: A questionnaire based prospective study was conducted of the pregnant females attending the combined endocrine and obstetrics antenatal clinic at Gosford Hospital, NSW. The questionnaire tried to analyse the issues encountered by patients with regard to requirement of fasting, duration of the test as well as gastrointestinal and other side effects experienced during the test. Moreover, the respondents were also asked to rate their experience with 75 g POGTT vs. 50 g GCT if they had this in previous or current pregnancy. The attitude of the respondents towards various side effects was explored as well. Results: The completed questionnaire was received from 98 pregnant females attending the clinic. The most inconvenient factors during the POGTT were the taste of Glucogel (54%, 53/98) and duration of the test (45%, 44/98) , followed nausea (42%, 41/98) and requirement for fasting (18 %, 18/98). Almost half (46%, 45/98) had had a 50 g GCT previously. Of those, more had no issues with 50 g GCT compared to 75 g POGTT (76% vs. 47%, P=0.006) and there was a tendency of less issues of the duration of the test (20% vs. 40%, P=0.065). Conclusions: This study, reassuringly found that in spite its complexity and longer duration of test, 75 g POGTT was reasonably well accepted and tolerated.
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Acceptance and tolerability of 75 g Pregnancy Oral Glucose Tolerance Test in Pregnancy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Acceptance and tolerability of 75 g Pregnancy Oral Glucose Tolerance Test in Pregnancy Santosh Kumar Chaubey, Henrik Falhammar This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.14227/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Gestational diabetes mellitus (GDM) is increasing in prevalence but there are various debatable issues around the diagnostic methods and criteria. Universal screening and 2-hour 75 g pregnancy oral glucose tolerance test (POGTT) is now widely accepted in Australia barring a few places.A questionnaire based study was planned to determine the acceptance and tolerability of 75 g POGTT in pregnant females and compare with 50 g glucose challenge test (GCT). Methods: A questionnaire based prospective study was conducted of the pregnant females attending the combined endocrine and obstetrics antenatal clinic at Gosford Hospital, NSW. The questionnaire tried to analyse the issues encountered by patients with regard to requirement of fasting, duration of the test as well as gastrointestinal and other side effects experienced during the test. Moreover, the respondents were also asked to rate their experience with 75 g POGTT vs. 50 g GCT if they had this in previous or current pregnancy. The attitude of the respondents towards various side effects was explored as well. Results: The completed questionnaire was received from 98 pregnant females attending the clinic. The most inconvenient factors during the POGTT were the taste of Glucogel (54%, 53/98) and duration of the test (45%, 44/98) , followed nausea (42%, 41/98) and requirement for fasting (18 %, 18/98). Almost half (46%, 45/98) had had a 50 g GCT previously. Of those, more had no issues with 50 g GCT compared to 75 g POGTT (76% vs. 47%, P=0.006) and there was a tendency of less issues of the duration of the test (20% vs. 40%, P=0.065). Conclusions: This study, reassuringly found that in spite its complexity and longer duration of test, 75 g POGTT was reasonably well accepted and tolerated. Maternal & Fetal Medicine Figures Figure 1 Full Text Tables Table 1 Experience of 75 g oral glucose tolerance test in pregnant women with gestational diabetes No issues Inconvenient but tolerable Intolerable 1.Convenience with fasting requirement 80 (82%) 18 (18%) 0 (0%) 2.Convenience with duration of test 54 (55%) 40 (41%) 4 (4%) 3. Taste of GlucoGel 45 (46%) 38 (39%) 15 (15%) 4. Nausea soon after taking GlucoGel 57 (58%) 33 (34%) 8 (8%) 5.Overall experience with test 68 (69%) 26 (27%) 4 (4%) 6. Acceptability of repeat OGTT in future pregnancies 68 (69%) 21 (21%) 9 (9%) Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4924","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":150758,"identity":"fbf2f4d4-d395-43c6-a085-0b6e0a13c593","order_by":1,"name":"Santosh Kumar Chaubey","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7ElEQVRIiWNgGAWjYDCCAwxsYJKBgY3xAZDk4SNFC7MBSAsbKVrYJEACBLXw3T787MHPtjtyBuePpVV+zbGTYWNgfvjoBh4tkufSzA17254ZG9xIO3Zbdlsy0GFsxsY5eLQYnOFhk+BtO5y44QZ7223JbcxALTxs0oS0SP5tO1y/4fzxtmLJbfXEaZEG2pJgcCDtGOPHbYcJa5E8w2YmLXPumeHMG2nJ0ozbjvOwMRPwC98Z5meSb8ruyPOdP2b48ee2ant+9uaHj/FpgQOFAwwMzDwgFjMxykFAvoGBgfEHsapHwSgYBaNgRAEAvFBLPWE0C4UAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-5009-6261","institution":"Gosford Hospital","correspondingAuthor":true,"prefix":"","firstName":"Santosh","middleName":"Kumar","lastName":"Chaubey","suffix":""},{"id":150759,"identity":"789c4444-32eb-4a03-9042-1db7e2179c47","order_by":2,"name":"Henrik Falhammar","email":"","orcid":"","institution":"Royal Darwin Hospital, Darwin, NT","correspondingAuthor":false,"prefix":"","firstName":"Henrik","middleName":"","lastName":"Falhammar","suffix":""}],"badges":[],"createdAt":"2019-09-06 14:22:55","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.14227/v1","doiUrl":"https://doi.org/10.21203/rs.2.14227/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":89049,"identity":"03588207-d191-46aa-a750-f47e8b433494","added_by":"auto","created_at":"2019-09-17 20:24:46","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":33849,"visible":true,"origin":"","legend":"Questionnaire given to the females attending the combined Endocrine-Obstetric Antenatal Clinic. \nPanel A: Tolerability of 75 g oral pregnancy oral glucose tolerance test (POGTT).\n\nQ 1: Did you feel unwell and needed help from lab staff during the test? \n1= No, 2= Yes\nQ 2: Vomiting soon after taking GlucoGel? \n1= No, 2=Yes \nQ 3: Fainting before, during or 1 hour after test?\n1= No, 2=Yes\nQ 4: Did you have 1 hour 50 g glucose challenge test in current or previous pregnancy? If yes, how is your experience with 75 g POGTT in comparison to 50 g glucose challenge test?\n1= No issues \n2= Issues with longer duration of test\n3= Issues with larger amount GlucoGel.\n\nPanel B: Acceptance of 75 g POGTT.\nQ 5: How was your experience with various aspects of 75 g POGTT - please tick the appropriate boxes, below.","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/69d142b8-bd39-4866-9277-7c6bf5d574f2/v1/Fig 1.jpg"},{"id":794836,"identity":"46ec2b03-df3a-4793-bd69-6cb76bc74a0f","added_by":"auto","created_at":"2020-03-31 14:35:26","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":93517,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4924/v1/manuscript.pdf"},{"id":124101,"identity":"00ad1462-fe0d-4a52-8a94-a843cf6b59a5","added_by":"auto","created_at":"2019-10-14 12:09:37","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":163711,"visible":true,"origin":"","legend":"","description":"","filename":"GDMstudyAug19MainPDF.pdf","url":"https://assets-eu.researchsquare.com/files/69d142b8-bd39-4866-9277-7c6bf5d574f2/v1/GDM study Aug 19 Main PDF.pdf"},{"id":89051,"identity":"9c1189f9-73ea-4bf7-98b1-6fd339e91426","added_by":"auto","created_at":"2019-09-17 20:24:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":220697,"visible":true,"origin":"","legend":"","description":"","filename":"GDMstudyAug19MainPDF.pdf","url":"https://assets-eu.researchsquare.com/files/69d142b8-bd39-4866-9277-7c6bf5d574f2/v1/Manuscript.pdf"},{"id":13473367,"identity":"29d1807d-8a15-4faf-9d54-092af66d3d7e","added_by":"auto","created_at":"2021-09-16 21:19:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":275181,"visible":true,"origin":"","legend":"","description":"","filename":"GDMstudyAug19MainPDF.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4924/v1_covered.pdf"}],"financialInterests":"","formattedTitle":"Acceptance and tolerability of 75 g Pregnancy Oral Glucose Tolerance Test in Pregnancy","fulltext":[{"header":"Full Text","content":"\u003cp\u003eThis preprint is available for \u003ca href='/article/rs-4924/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cb\u003eTable 1\u003c/b\u003e Experience of 75 g oral glucose tolerance test in pregnant women with gestational diabetes \u003c/p\u003e\u003ctable style=\"margin-left: .15in; background: #CED7E7; border-collapse: collapse; border: none;\" width=\"640\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 46.5pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-bottom: solid white 3.0pt; background: #499BC9; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.5pt;\" width=\"161\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: none; background: #499BC9; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.5pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003eNo issues\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: none; background: #499BC9; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.5pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003eInconvenient but tolerable\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: solid black 2.25pt; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: solid black 2.25pt; background: #499BC9; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.5pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003eIntolerable \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 46.0pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border-top: none; border-left: solid white 1.0pt; border-bottom: solid white 1.0pt; border-right: solid #BFBFBF 1.0pt; background: #CEDDEB; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.0pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e1.Convenience with fasting requirement\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: solid #BFBFBF 1.0pt; background: #E6E6E6; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.0pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e80 (82%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: solid #BFBFBF 1.0pt; background: #E6E6E6; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e18 (18%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid #BFBFBF 1.0pt; border-right: solid #BFBFBF 1.0pt; background: #E6E6E6; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 46.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%; tab-stops: 1.0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e0 (0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 74.45pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-top: none; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e2.Convenience with duration of test\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e54 (55%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e40 (41%)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e4 (4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 45.0pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-top: none; background: #CEDDEB; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;3. Taste of GlucoGel\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #CEDDEB; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e45 (46%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #CEDDEB; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e38 (39%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #CEDDEB; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e15 (15%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 74.45pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-top: none; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e4. Nausea soon after taking GlucoGel\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e57 (58%)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e33 (34%)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e8 (8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 45.0pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-top: none; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e5.Overall experience with test\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e68 (69%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e26 (27%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 45.0pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e4 (4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 74.45pt;\"\u003e\n\u003ctd style=\"width: 120.75pt; border: solid white 1.0pt; border-top: none; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"161\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;6. Acceptability of repeat OGTT in future pregnancies\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 119.25pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"159\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e68 (69%)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e21 (21%)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.15pt; border-top: none; border-left: none; border-bottom: solid white 1.0pt; border-right: solid white 1.0pt; background: #E8EEF5; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 74.45pt;\" width=\"160\"\u003e\n\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e9 (9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.2.14227/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.14227/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: Gestational diabetes mellitus (GDM) is increasing in prevalence but there are various debatable issues around the diagnostic methods and criteria. Universal screening and 2-hour 75 g pregnancy oral glucose tolerance test (POGTT) is now widely accepted in Australia barring a few places.A questionnaire based study was planned\u0026nbsp;to\u0026nbsp;determine the acceptance and tolerability of 75 g POGTT in pregnant females and compare with 50 g glucose challenge test (GCT).\u003c/p\u003e\u003cp\u003eMethods: A questionnaire based prospective study was conducted of the pregnant females attending the combined endocrine and obstetrics antenatal clinic at\u0026nbsp;Gosford Hospital, NSW. The questionnaire tried to analyse the issues encountered by patients with regard to requirement of fasting, duration of the test as well as gastrointestinal and other side effects experienced during the test. Moreover, the respondents were also asked to rate their experience with 75 g POGTT vs. 50 g GCT if they had this in previous or current pregnancy. The attitude of the respondents towards various side effects was explored as well.\u003c/p\u003e\u003cp\u003eResults: The completed questionnaire was received from 98 pregnant females attending the clinic. The most inconvenient factors during the POGTT were\u0026nbsp;the taste of Glucogel (54%, 53/98) and duration of the test (45%, 44/98) , followed\u0026nbsp;nausea (42%, 41/98) and requirement for fasting (18 %, 18/98).\u0026nbsp;\u0026nbsp;Almost half (46%, 45/98) had had a 50 g GCT previously. Of those, more had no issues with 50 g GCT compared to 75 g POGTT (76% vs. 47%, P=0.006) and there was a tendency of less issues of the duration of the test (20% vs. 40%, P=0.065).\u003c/p\u003e\u003cp\u003eConclusions: This study, reassuringly found that in spite its complexity and longer duration of test, 75 g POGTT was reasonably well accepted and tolerated.\u003c/p\u003e","manuscriptTitle":"Acceptance and tolerability of 75 g Pregnancy Oral Glucose Tolerance Test in Pregnancy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-09-17 20:24:46","doi":"10.21203/rs.2.14227/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"31a34572-0284-492a-9cf9-ceb5de904d26","owner":[],"postedDate":"September 17th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":25274,"name":"Maternal \u0026 Fetal Medicine"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-09-17 20:24:46","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4924","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-4924","version":["v1"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}
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