A Retrospective Study on the Clinical Effect of Uterine Artery Embolization Combined with Cervical Double Balloon for Patients with Complete Placenta Previa Undergoing Pregnancy Termination in the Second Trimester

A Retrospective Study on the Clinical Effect of Uterine Artery Embolization Combined with Cervical Double Balloon for Patients with Complete Placenta Previa Undergoing Pregnancy Termination in the Second Trimester | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Retrospective Study on the Clinical Effect of Uterine Artery Embolization Combined with Cervical Double Balloon for Patients with Complete Placenta Previa Undergoing Pregnancy Termination in the Second Trimester Ruobing Li, Shuguo Du, Jing Peng, Xuan Zheng, Shiyao Wu, Hongwen Ma, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-646236/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Pregnancy termination in the second trimester is a complex and delicate situation for patients with complete placenta previa (CPP), which has less been reported. The objective of this research was to investigate and evaluate the clinical effect of uterine artery embolization(UAE) combined with cervical double balloon(CDB) for patients with CPP. Methods We conducted a retrospective study based on a large medical center. The medical records of patients who were diagnosed with CPP and treated UAE combined with CDB for termination in the second trimester in our hospital from January 2017 and March 2021 were retrospectively reviewed. The clinical outcomes were analyzed. Results A total of 11 patients with CPP were included in this study. Prenatal diagnosis of CPP was realized by trans-vaginal ultrasound. The average age was 34.2 years old, and the gestational week was 21.6 weeks. Of the selected patients, 3 cases (3/11) had previous caesarean delivery, 5 cases were at older maternal age (≥35 years old), 10 cases underwent emergency UAE for prenatal bleeding equal or up to 400 mL and 1 case underwent prophylactic UAE for placenta percreta, and all cases underwent CDB to promote cervical ripening. It was worth noting that 5 cases (5/11) of selected patients underwent curettage to take out fetus and placenta. The uterus preservation was achieved in all 11 patients. The complications associated with conservative management included prenatal hemorrhaging (10/11), blood transfusion (5/11), fever (2/11), and septicemia (1/11). The mean dilation of cervix was from 0cm to 1.9cm, the length of cervix was from 3.5cm to 0.6cm and the Bishop scores were from 1.5 to 7.3 after using CDB, the changes of cervical conditions were statistically significant (p＜0.05). The levels of WBC and CRP were higher after termination with medicine+UAE+CDB and/or curettage. Conclusion The adjuvant therapy of UAE, CDB, and/curettage step by step is a preferred choice for patients with CPP who underwent pregnancy termination in the second trimester. Maternal & Fetal Medicine Sexual & Reproductive Medicine uterine artery embolization (UAE) complete placenta previa (CPP) second trimester termination of pregnancy cervical double balloon (CDB) Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-646236","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":36201905,"identity":"37307a1c-1b3b-44cd-aff1-d60766896fcd","order_by":0,"name":"Ruobing Li","email":"","orcid":"","institution":"Wuhan University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Ruobing","middleName":"","lastName":"Li","suffix":""},{"id":36201906,"identity":"b66777c1-eb57-43c6-bfae-81a0112a531d","order_by":1,"name":"Shuguo Du","email":"","orcid":"","institution":"Maternal and child health hospital of hubei province, affiliated hospital of tongji medical college, huazhong university of science and technology","correspondingAuthor":false,"prefix":"","firstName":"Shuguo","middleName":"","lastName":"Du","suffix":""},{"id":36201907,"identity":"33c922ff-4dfa-4a4f-afd8-4e06a743f5c3","order_by":2,"name":"Jing Peng","email":"","orcid":"","institution":"Maternal and child health hospital of hubei province, affiliated hospital of tongji medical college, huazhong university of science and technology","correspondingAuthor":false,"prefix":"","firstName":"Jing","middleName":"","lastName":"Peng","suffix":""},{"id":36201908,"identity":"47929ebe-f956-4375-bd31-1a248aeab746","order_by":3,"name":"Xuan Zheng","email":"","orcid":"","institution":"Wuhan University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Xuan","middleName":"","lastName":"Zheng","suffix":""},{"id":36201909,"identity":"72c59419-1997-4c95-9b75-651a9d08ee85","order_by":4,"name":"Shiyao Wu","email":"","orcid":"","institution":"Wuhan University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Shiyao","middleName":"","lastName":"Wu","suffix":""},{"id":36201910,"identity":"b499f868-78ae-4bd9-b94d-485a3cc59d88","order_by":5,"name":"Hongwen Ma","email":"","orcid":"","institution":"Maternal and child health hospital of hubei province, affiliated hospital of tongji medical college, huazhong university of science and technology","correspondingAuthor":false,"prefix":"","firstName":"Hongwen","middleName":"","lastName":"Ma","suffix":""},{"id":36201911,"identity":"29e6ff73-22f1-4e0e-8c9f-0eb824086221","order_by":6,"name":"Hui Yang","email":"","orcid":"","institution":"Maternal and child health hospital of hubei province, affiliated hospital of tongji medical college, huazhong university of science and 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01:59:03","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-646236/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-646236/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":13652482,"identity":"32f798bd-0450-421f-8406-8a91cd024091","added_by":"auto","created_at":"2021-09-17 09:49:43","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":450884,"visible":true,"origin":"","legend":"","description":"","filename":"6.225.3111UAE.pdf","url":"https://assets-eu.researchsquare.com/files/rs-646236/v1_covered.pdf"},{"id":10957844,"identity":"6c074d35-b3df-4af8-8ab3-f16d839e1ada","added_by":"auto","created_at":"2021-06-30 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pregnancy, cervical double balloon (CDB)","lastPublishedDoi":"10.21203/rs.3.rs-646236/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-646236/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground \u003c/strong\u003e\u003c/p\u003e\u003cp\u003ePregnancy termination in the second trimester is\u0026nbsp;a complex and delicate situation\u0026nbsp;for patients with complete placenta previa\u0026nbsp;(CPP), which has less been reported. The objective of this research was to investigate and evaluate the clinical effect of uterine artery embolization(UAE)\u0026nbsp;combined with cervical double balloon(CDB)\u0026nbsp;for patients with CPP. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods \u003c/strong\u003e\u003c/p\u003e\u003cp\u003eWe conducted a retrospective study based on\u0026nbsp;a large medical center. The medical records of patients who were diagnosed with CPP\u0026nbsp;and treated UAE combined with CDB\u0026nbsp;for\u0026nbsp;termination in the second trimester in our hospital from January 2017 and March 2021 were retrospectively reviewed. The clinical outcomes\u0026nbsp;were analyzed.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults \u003c/strong\u003e\u003c/p\u003e\u003cp\u003eA total of 11 patients with\u0026nbsp;CPP were included in this study. Prenatal diagnosis of CPP\u0026nbsp;was realized\u0026nbsp;by trans-vaginal\u0026nbsp;ultrasound. The average age was 34.2 years old,\u0026nbsp;and\u0026nbsp;the gestational week was 21.6 weeks. Of the selected patients,\u0026nbsp;3 cases (3/11) had previous caesarean\u0026nbsp;delivery, 5 cases were at older maternal age\u0026nbsp;(≥35 years old),\u0026nbsp;10 cases underwent\u0026nbsp;emergency\u0026nbsp;UAE\u0026nbsp;for prenatal bleeding equal or up to 400 mL and 1 case underwent\u0026nbsp;prophylactic UAE for placenta percreta, and\u0026nbsp;all cases\u0026nbsp;underwent CDB to promote cervical ripening. It was worth noting that 5 cases (5/11) of\u0026nbsp;selected patients underwent\u0026nbsp;curettage to take out fetus and placenta. The uterus preservation was achieved in all 11 patients. The complications associated with conservative management included prenatal hemorrhaging (10/11), blood transfusion (5/11), fever (2/11), and septicemia (1/11). The mean dilation of cervix was from 0cm to 1.9cm, the length of cervix was from 3.5cm to 0.6cm and the Bishop scores were from 1.5 to 7.3 after using CDB, the changes of cervical conditions were statistically significant\u0026nbsp;(p＜0.05). The levels of WBC\u0026nbsp;and\u0026nbsp;CRP were higher after termination\u0026nbsp;with medicine+UAE+CDB and/or curettage. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion \u003c/strong\u003e\u003c/p\u003e\u003cp\u003eThe adjuvant\u0026nbsp;therapy of UAE, CDB, and/curettage step by step is a\u0026nbsp;preferred choice for patients with CPP who underwent pregnancy termination in the second trimester.\u003c/p\u003e","manuscriptTitle":"A Retrospective Study on the Clinical Effect of Uterine Artery Embolization Combined with Cervical Double Balloon for Patients with Complete Placenta Previa Undergoing Pregnancy Termination in the Second Trimester","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-06-30 14:37:00","doi":"10.21203/rs.3.rs-646236/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3c969f0d-7176-4dd9-8889-2847af793e0e","owner":[],"postedDate":"June 30th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":5383865,"name":"Maternal \u0026 Fetal Medicine"},{"id":5383866,"name":"Sexual \u0026 Reproductive Medicine"}],"tags":[],"updatedAt":"2021-11-24T12:14:06+00:00","versionOfRecord":[],"versionCreatedAt":"2021-06-30 14:37:00","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-646236","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-646236","identity":"rs-646236","version":["v1"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}