O Elo Silencioso: Desvendando a Conexão Sistêmica entre Endometriose e Distúrbios Temporomandibulares na Era da Dor Crônica Feminina

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This integrative review identifies shared pathophysiological mechanisms between endometriosis and temporomandibular disorders, including hormonal dysfunction and inflammation, to propose an integrated clinical care model for managing this high-prevalence comorbidity.

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This integrative literature review examines the shared pathophysiological mechanisms linking endometriosis and temporomandibular disorders, highlighting a significantly higher prevalence of TMD in women with endometriosis compared to the general population. The authors identify common drivers including hormonal dysfunction, chronic systemic inflammation involving cytokines like TNF-α and IL-6, and central nervous system sensitization, which are further amplified by psychosocial comorbidities such as anxiety and pain catastrophizing. Based on these overlapping etiologies, the paper proposes an integrated, multidisciplinary clinical approach that incorporates rapid screening tools for early identification and management of this distress. This paper is centrally about endometriosis — specifically exploring its systemic connection to temporomandibular disorders through shared inflammatory and neurological pathways.

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Abstract

Objective: To review the evidence on the shared pathophysiological mechanisms between endometriosis and temporomandibular disorders (TMD) and to propose an integrated care model. Methods: An integrative literature review was conducted in the PubMed, SciELO, and Web of Science databases. Results: The prevalence of TMD in women with endometriosis (45-77%) is drastically higher than in the general population (5-12%). Shared mechanisms include hormonal dysfunction (estrogen receptor polymorphisms and progesterone resistance), chronic systemic inflammation (TNF-α, IL-6, IL-1β), and central nervous system sensitization. Psychosocial comorbidities, such as anxiety and pain catastrophizing, significantly amplify pain perception. Rapid screening tools demonstrate clinical feasibility for early identification of this distress. Conclusion: The connection between endometriosis and TMD is supported by a common pathophysiological basis, requiring a multidisciplinary and integrated clinical approach for effective management.
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Objective

To review the evidence on the shared pathophysiological mechanisms between endometriosis and temporomandibular disorders (TMD) and to propose an integrated care model. Methods: An integrative literature review was conducted in the PubMed, SciELO, and Web of Science databases. Results: The prevalence of TMD in women with endometriosis (45-77%) is drastically higher than in the general population (5-12%). Shared mechanisms include hormonal dysfunction (estrogen receptor polymorphisms and progesterone resistance), chronic systemic inflammation (TNF-α, IL-6, IL-1β), and central nervous system sensitization. Psychosocial comorbidities, such as anxiety and pain catastrophizing, significantly amplify pain perception. Rapid screening tools demonstrate clinical feasibility for early identification of this distress. Conclusion: The connection between endometriosis and TMD is supported by a common pathophysiological basis, requiring a multidisciplinary and integrated clinical approach for effective management. Files Desvendando_a_Conexao_Sistemica_entre_Endrometriose_e_Disturbios..._revista-abous-edicao1.pdf Files (133.8 kB) | Name | Size | Download all | |---|---|---| | md5:d7825a3936ebc671f2ab08d3b734867b | 133.8 kB | Preview Download | Additional details Dates - Issued - 2025-11-22

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