Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B.

Zhou XP, Hu XL, Zhu YM, Fan Qu, Sun SJ, Qian YL
Asian journal of andrology · 2011 · doi:10.1038/aja.2010.164 · PMID:21399651 · PMC3739335
OA: closed CC-BY-NC-SA-4.0
📄 Open PDF Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-18 ⓘ

This study found that hepatitis B infection in men is associated with reduced semen quality and lower implantation and clinical pregnancy rates following intracytoplasmic sperm injection, though it does not affect outcomes of in vitro fertilization.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-18 · read from full text ⓘ

This study evaluated the impact of hepatitis B virus infection on semen parameters and assisted reproductive technology outcomes in a cohort of 916 Chinese men seeking fertility treatment. The researchers compared HBV-positive individuals against matched controls, analyzing data from both intracytoplasmic sperm injection and in vitro fertilization cycles. Results indicated that HBV-infected men had significantly lower semen volume, sperm count, motility, and morphology, along with reduced implantation and clinical pregnancy rates following ICSI, though IVF outcomes remained comparable between groups. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

In this study, we aimed to determine the effects of hepatitis B virus (HBV) infection on sperm quality and the outcome of assisted reproductive technology (ART). A total of 916 men (457 HBV-positive and 459 HBV-negative) seeking fertility assistance from January 2008 to December 2009 at the Women's Hospital in the School of Medicine at Zhejiang University were analysed for semen parameters. Couples in which the men were hepatitis B surface antigen (HBsAg)-seropositive were categorized as HBV-positive and included 587 in vitro fertilisation (IVF) and 325 intracytoplasmic sperm injection (ICSI) cycles from January 2004 to December 2009; negative controls were matched for female age, date of ova retrieval, ART approach used (IVF or ICSI) and randomized in a ratio of 1:1 according to the ART treatment cycles (587 for IVF and 325 for ICSI). HBV-infected men exhibited lower semen volume, lower total sperm count as well as poor sperm motility and morphology (P < 0.05) when compared to control individuals. Rates of two-pronuclear (2PN) fertilisation, high-grade embryo acquisition, implantation and clinical pregnancy were also lower among HBV-positive patients compared to those of HBV-negative patients after ICSI and embryo transfer (P 0.05). Logistic regression analysis showed that HBV infection independently contributed to increased rates of asthenozoospermia and oligozoospermia/azoospermia (P < 0.05) as well as decreased rates of implantation and clinical pregnancy in ICSI cycles (P < 0.05). Our results suggest that HBV infection in men is associated with poor sperm quality and worse ICSI and embryo transfer outcomes but does not affect the outcome of IVF and embryo transfer.
Full text 2,730 characters · extracted from oa-doi-fallback · click to expand
| Volume 13, Issue 3 (May 2011) 13, 465–469; 10.1038/aja.2010.164 Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B Xu-Ping Zhou1, Xiao-Ling Hu1, Yi-Min Zhu2, Fan Qu3, Sai-Jun Sun2 and Yu-Li Qian2 1 Key Laboratory of Women’s Reproductive Health of Zhejiang Province, Hangzhou 310006, China 2 Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China 3 Department of Reproductive Endocrinology, The First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310006, China Correspondence: Dr YM Zhu, ([email protected]) Received 26 July 2010; Revised 13 October 2010; Accepted 16 November 2010; Published online 14 March 2011. | Abstract | | In this study, we aimed to determine the effects of hepatitis B virus (HBV) infection on sperm quality and the outcome of assisted reproductive technology (ART). A total of 916 men (457 HBV-positive and 459 HBV-negative) seeking fertility assistance from January 2008 to December 2009 at the Women’s Hospital in the School of Medicine at Zhejiang University were analysed for semen parameters. Couples in which the men were hepatitis B surface antigen (HBsAg)-seropositive were categorized as HBV-positive and included 587 in vitro fertilisation (IVF) and 325 intracytoplasmic sperm injection (ICSI) cycles from January 2004 to December 2009; negative controls were matched for female age, date of ova retrieval, ART approach used (IVF or ICSI) and randomized in a ratio of 1:1 according to the ART treatment cycles (587 for IVF and 325 for ICSI). HBV-infected men exhibited lower semen volume, lower total sperm count as well as poor sperm motility and morphology (P<0.05) when compared to control individuals. Rates of two-pronuclear (2PN) fertilisation, high-grade embryo acquisition, implantation and clinical pregnancy were also lower among HBV-positive patients compared to those of HBV-negative patients after ICSI and embryo transfer (P0.05). Logistic regression analysis showed that HBV infection independently contributed to increased rates of asthenozoospermia and oligozoospermia/azoospermia (P<0.05) as well as decreased rates of implantation and clinical pregnancy in ICSI cycles (P<0.05). Our results suggest that HBV infection in men is associated with poor sperm quality and worse ICSI and embryo transfer outcomes but does not affect the outcome of IVF and embryo transfer. Keywords: hepatitis B virus; infection; infertility; intracytoplasmic sperm injection; in vitro fertilisation; male infertility; sperm; sperm motility PDF | PDF | 中文摘要 | | | | | Browse: 5402 | |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-10-04T09:26:46.659050+00:00
unpaywall
last seen: 2026-08-13T06:47:16.638238+00:00
License: CC-BY-NC-SA-4.0