Regulatory role of LncRNA CASC15 in malignant tumors

It has been reported that long non-coding RNA (lncRNA) is closely related to tumor development and chemotherapy resistance. Cancer susceptibility candidate 15 (CASC15) is a cancer-related lncRNA located on chromosome 6p22.3 which is abnormally expressed in different malignant tumors. CASC15 is involved in a variety of biological processes, such as cell growth, migration and invasion. Various studies have shown that CASC15 is expected to become a novel biomarker and therapeutic target for cancer. In this review, we summarize the regulatory function and mechanism of CASC15 in malignant tumors, as well as its potential value in the diagnosis and treatment of tumors.