Expressions of ER,PR,and HOXA-11 in human endometrium during window period

Aim: To investigate the expressions of ER,PR and HOXA-11 in human endometrium during window period. Methods: Using immunohistochemical staining and RT-PCR the expressions of ER,PR and HOXA-11 in human endometrium during the window period were detected. According to pregnancy or not after IVF-ET,78 cases of infertility patients with tubal factors were divided into pregnant group( n = 86) and non-pregnant group( n = 67). Results: The expressions of PR and HOXA-11 in the glandular epithelium of the pregnant group were significantly lower than those of the non-pregnant group( P 0. 001),while in the stromal cells were significantly higher than those of the non-pregnant group( P 0. 001). The expressions of ER,PR and HOXA-11 mRNA of the pregnant group were higher than those of the nonpregnant group( P 0. 05). There was correlation between level of P and PR,HOXA-11 in glandular epithelial( P 0. 05).Conclusion: The down-regulated expressions of PR and HOXA-11 in glandular epithelial cells and the up-regulated expressions of PR and HOXA-11 in mesenchymal cells may be the reasons which lead to the decrease of endometrial receptivity.