IGFBP-1 and glycodelin serum levels before and after hysterectomy with and without bilateral oophorectomy in premenopausal women

Dolores Foth, Margitta Meisel, Frank Nawroth, W Straube, Thomas Römer
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2001 · vol. 100(1) , pp. 55–61 · doi:10.1016/s0301-2115(01)00460-2 · PMID:11728658 · W2165747078
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This study measured serum levels of IGFBP-1 and glycodelin in premenopausal women before and after hysterectomy with or without bilateral oophorectomy.

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Abstract

ObjectivesThe aim of our study was to investigate the role of the intact endometrium and ovaries for serum levels of insulin-like growth factor binding protein-1 (IGFBP-1) and glycodelin.Study designIn 35 premenopausal patients with a planned hysterectomy, serum measurements of IGFBP-1 and glycodelin were done before surgery and 1, 3, 5, and 10 days after surgery. Patients were divided into three groups according to the kind and time of operation: (1) hysterectomy with bilateral adnexectomy in the luteal phase and (2) hysterectomy without adnexectomy in the follicular phase or (3) the luteal phase.ResultsIGFBP-1-we could not show any differences in IGFBP-1 serum levels before and after hysterectomy with or without bilateral oophorectomy. Glycodelin-hysterectomized and oophorectomized patients showed decreasing serum levels up to day 3. After day 5, circulating concentrations of glycodelin increased continuously but remained below pre-operative levels. In both non-adnexectomized groups we saw a reduction up to day 5 but a rise at day 10. None of the results reached statistical significance.ConclusionThe results indicate that endometrium and ovary are not the only sources of IGFBP-1 and glycodelin.

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