The anti-inflammatory and anti-nociceptive activities of Patrinia villosa and its mechanism on the proinflammatory cytokines of rats with pelvic inflammation.

Zheng Y, Jin Y, Zhu HB, Xu ST, Xia YX, Huang Y
African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012 · doi:10.4314/ajtcam.v9i3.1 · PMID:23983359 · PMC3746661
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Patrinia villosa exhibited strong anti-inflammatory and anti-nociceptive effects in rat models of pelvic inflammation by significantly reducing serum levels of IL-6, IL-8, and TNF-alpha.

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This study investigated the anti-inflammatory and analgesic properties of Patrinia villosa using rat models of pelvic inflammation and general edema. Researchers administered the extract to rats and measured serum levels of proinflammatory cytokines, including IL-6, IL-8, and TNF-alpha, alongside standard pain and swelling assays. The results demonstrated that Patrinia villosa significantly reduced inflammatory markers and nociceptive responses compared to control groups, with efficacy in lowering specific cytokines exceeding that of dexamethasone. Relevance to endometriosis: listed as a potential therapeutic agent for pelvic inflammation and associated pain, though the paper's main focus is on general pelvic inflammatory disease rather than endometriosis or adenomyosis specifically.

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Abstract

This study explores the anti-inflammatory and anti-nociceptive activities of Patrinia villosa, a Chinese medicinal plant, and to explore its effects on the proinflammatory cytokines of the rats with pelvic inflammation model. The animals were randomly divided into Patrinia villosa group (PV group), dexamethasone group (DEX group), and model-control group (CON group) to perform an ear edema test, a carrageenin-induced paw edema test, a cotton pellet-induced granuloma formation test, and an acetic acid-induced writhing test. The model rats with pelvic inflammation were established, and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) in each group was detected with the Enzyme-Linked ImmunoSorbent Assay (ELISA). The results of the ear edema test, carrageenin-induced paw edema test, cotton pellet-induced granuloma formation test, and acetic acid-induced writhing test all showed that Patrinia villosa had strong anti-inflammatory and anti-nociceptive effects. In the experiment using model rats with pelvic inflammation, we found that the serum levels of IL-6, IL-8 and TNF-α in PV and DEX group were all significantly lower than those of the CON group, and the serum levels of IL-6 and IL-8 in PV group were significantly lower than those of the DEX group. Patrinia villosa, with its strong anti-inflammatory and anti-nociceptive activities, can be used to treat pelvic inflammation and to relieve the associated pain.
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Journal / African Journal of Traditional, Complementary and Alternative Medicines / Vol. 9 No. 3 (2012) / Articles This study explores the anti-inflammatory and anti-nociceptive activities of Patrinia villosa, a Chinese medicinal plant, and to explore its effects on the proinflammatory cytokines of the rats with pelvic inflammation model. The animals were randomly divided into Patrinia villosa group (PV group), dexamethasone group (DEX group), and model-control group (CON group) to perform an ear edema test, a carrageenin-induced paw edema test, a cotton pellet-induced granuloma formation test, and an acetic acid-induced writhing test. The model rats with pelvic inflammation were established, and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-á) in each group was detected with the Enzyme-Linked ImmunoSorbent Assay (ELISA). The results of the ear edema test, carrageenin-induced paw edema test, cotton pellet-induced granuloma formation test, and acetic acid-induced writhing test all showed that Patrinia villosa had strong anti-inflammatory and anti-nociceptive effects. In the experiment using model rats with pelvic inflammation, we found that the serum levels of IL-6, IL-8 and TNF-á in PV and DEX group were all significantly lower than those of the CON group, and the serum levels of IL-6 and IL-8 in PV group were significantly lower than those of the DEX group. Patrinia villosa, with its strong anti-inflammatory and anti-nociceptive activities, can be used to treat pelvic inflammation and to relieve the associated pain. eISSN: 0189-6016

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