New insights in the pathogenesis of endometriosis: the role of stem cells

D.А. Kosova, Leipzig Aleksandrov, A.I. Davydov, А.P. Nikonov, А.И. Ищенко, A.I. Ishchenko, М.B. Ageev, М.N. Zholobova, М.V. Berishvili, G.F. Proklova, Evgeniya A. Svidinskaya, M.B. Khabarova
In: Voprosy ginekologii, akušerstva i perinatologii · 2024 · vol. 23(6) , pp. 75–80 · doi:10.20953/1726-1678-2024-6-75-80 · W4407135933
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review examines the stem cell hypothesis for endometriosis pathogenesis, exploring their origin, required capabilities for lesion formation, and potential diagnostic implications if identified.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This paper is a review analyzing the hypothesis that stem cells contribute to the pathogenesis of endometriosis, with potential origins including the uterine endometrium and red bone marrow. It argues that stem cells that form ectopic endometriotic foci would need to migrate, attach, promote angiogenesis at implantation, and differentiate into both glandular and stromal cells. The authors state that, despite many studies, the specific cells responsible for developing endometrioid lesions have not yet been identified, which limits the ability to predict disease course or therapy efficacy based on a defined progenitor. This paper is centrally about endometriosis — it focuses on the proposed role and characteristics of stem cells in the development of ectopic endometrial lesions.

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Abstract

This review analyzes the hypothesis of the role of stem cells in the pathogenesis of endometriosis. The source of these cells can be both the uterine endometrium itself and the red bone marrow. Stem cells forming ectopic foci must have several features: the ability to migrate, attach and potentiate angiogenesis at the site of implantation, as well as differentiate into both glandular and stromal cells. Despite numerous studies, the cells responsible for the development of endometrioid lesions have not yet been identified. If an ectopic endometrial progenitor cell is found, it will be possible to use its features to predict the course of disease and the efficacy of therapy. Key words: endometriosis, endometrium, stem cells, side population cells
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New insights in the pathogenesis of endometriosis: the role of stem cells Daria A. Kosova / Leonid S. Aleksandrov / Aleksandr I. Davydov / Anatoliy I. Ishchenko / Andrey P. Nikonov / Anton A. Ishchenko / Mikhail B. Ageev / Maria N. Zholobova / Manana V. Berishvili / Guzel F. Proklova / Evgenya A. Svidinskaya / Marina B. Khabarova / This review analyzes the hypothesis of the role of stem cells in the pathogenesis of endometriosis. The source of these cells can be both the uterine endometrium itself and the red bone marrow. Stem cells forming ectopic foci must have several features: the ability to migrate, attach and potentiate angiogenesis at the site of implantation, as well as differentiate into both glandular and stromal cells. Despite numerous studies, the cells responsible for the development of endometrioid lesions have not yet been identified. If an ectopic endometrial progenitor cell is found, it will be possible to use its features to predict the course of disease and the efficacy of therapy. Key words: endometriosis, endometrium, stem cells, side population cells For citation: Kosova D.A., Aleksandrov L.S., Davydov A.I., Ishchenko A.I., Nikonov A.P., Ishchenko A.A., Ageev M.B., Zholobova M.N., Berishvili M.V., Proklova G.F., Svidinskaya E.A., Khabarova M.B. New insights in the pathogenesis of endometriosis: the role of stem cells. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2024; 23(6): 75–80. (In Russian). DOI: 10.20953/1726-1678-2024-6-75-80

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