Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and Molecular docking studies

Abstract A series of novel oxadiazole functionalized pyridopyrimidine derivatives prepared starting from 6-methyl/ethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 1. These compound 1 on reaction with sulphuric acid and obtained compound 2, further compound 2 on reaction with chloroacetamide followed by reaction with EMME coupling and further cyclization to obtain compound 5. Compound 5 on reaction with hydrazide hydrate and obtained hydrazide derivatives 6. Compound 6 on reaction with diverse substituted aromatic acids to get oxadiazole derivatives 7a-l. All the final compounds 7a-l evaluated for anti cancer activity against four human cancer cell lines such as HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22) and promising compounds 7d and 7k have been identified and evaluated for molecular docking interactions.