Comparison of total nerve fiber density and sympathetic nerve fiber density in peritoneal endometriotic specimens and healthy peritoneum.

Yanchun Liang (213593), Wei Wang (17594), Jiaming Huang (840570), Hao Tan (117484), Tianyu Liu (529994), Chunliang Shang (840571), Duo Liu (758674), Luyan Guo (442591), Shuzhong Yao (840572)
2016 · doi:10.1371/journal.pone.0146027.g003 · W6885682820
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The study compared total nerve fiber density and sympathetic nerve fiber density in peritoneal endometriotic specimens against healthy peritoneal tissue from control subjects. Researchers utilized immunohistochemical staining with Anti-PGP 9.5 for total nerves and Anti-TH for sympathetic fibers to quantify innervation levels across different anatomical regions associated with the disease. The results indicated a statistically significant increase in both total and sympathetic nerve densities within the endometriotic lesions and their immediate vicinity compared to the normal peritoneum. This paper is centrally about endometriosis — specifically the characterization of aberrant sympathetic innervation in peritoneal endometriotic lesions.

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Abstract

(A) Total nerve fibers were positively stained by Anti-PGP 9.5 antibody. Comparison of the total nerve fiber density (NFD, NF/mm2) of endometriosis-associated nerve of peritoneal endometriosis (EAN-PEM), NFD of para-endometriotic nerve of peritoneal endometriosis (PEN-PEM) and NFD of nerve of peritoneum of control (N-PC). (B) Sympathetic nerve fibers were positively stained by Anti-TH antibody. Comparison of endometriosis-associated sympathetic NFD of peritoneal endometriosis (ESAN-PEM), para-endometriotic sympathetic NFD of peritoneal endometriosis (PESN-PEM) and sympathetic NFD of peritoneum of control (SN-PC). *P<0.05.
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Potential Role of Semaphorin 3A and Its Receptors in Regulating Aberrant Sympathetic Innervation in Peritoneal and Deep Infiltrating Endometriosis Fig 3 Comparison of total nerve fiber density and sympathetic nerve fiber density in peritoneal endometriotic specimens and healthy peritoneum. (A) Total nerve fibers were positively stained by Anti-PGP 9.5 antibody. Comparison of the total nerve fiber density (NFD, NF/mm2) of endometriosis-associated nerve of peritoneal endometriosis (EAN-PEM), NFD of para-endometriotic nerve of peritoneal endometriosis (PEN-PEM) and NFD of nerve of peritoneum of control (N-PC). (B) Sympathetic nerve fibers were positively stained by Anti-TH antibody. Comparison of endometriosis-associated sympathetic NFD of peritoneal endometriosis (ESAN-PEM), para-endometriotic sympathetic NFD of peritoneal endometriosis (PESN-PEM) and sympathetic NFD of peritoneum of control (SN-PC). *P<0.05.

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endometriosis

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