Minimal deviation mucinous adenocarcinoma (‘adenoma malignum’) of the uterine corpus

Kaoru Abiko, Tsukasa Baba, M Ogawa, Madoka Ogawa, Yoshiki Mikami, Takashi Koyama, Masaki Mandai, Ikuo Konishi
Pathology international · 2009 · vol. 60(1) , pp. 42–47 · doi:10.1111/j.1440-1827.2009.02473.x · PMID:20055951 · W1905463172
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This case describes a rare mucinous adenocarcinoma of the uterine corpus with a gastric phenotype, mimicking minimal deviation adenocarcinoma of the cervix, and discusses its diagnostic and management implications.

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Abstract

Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms. A case is described of a 56-year-old postmenopausal woman who presented with mucinous vaginal discharge. Imaging demonstrated thickened myometrium due to adenomyosis. Serum CA19-9 levels were elevated to 486 U/mL. Microscopic examination of hysterectomy specimens indicated highly differentiated mucinous adenocarcinoma diffusely infiltrating the portion of adenomyosis of the corpus. In some areas endometrial glands of adenomyosis were replaced by benign-looking mucinous metaplasia. The uterine cervix showed no abnormalities. HIK1083 and MUC6 immunohistochemistry indicated a gastric phenotype of the tumor, as seen in cases of prototypical minimal deviation adenocarcinoma (MDA) of the cervix. In summary, mucinous endometrial adenocarcinoma rarely shows features similar to MDA of the cervix. This case provokes a discussion on diagnostic and management strategy, and histogenesis of mucinous neoplasm of the endometrium.

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Condition tags

adenomyosis

MeSH descriptors

Adenocarcinoma, Mucinous Uterine Cervical Neoplasms Uterine Neoplasms Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Biomarkers Female Humans Hysterectomy Immunophenotyping Middle Aged Uterine Cervical Neoplasms Uterine Cervical Neoplasms Uterine Neoplasms Uterine Neoplasms

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