Arid1ad/d mice exhibited an altered decidualization.

Tae Hoon Kim (128536), Jung-Yoon Yoo (462528), Zhong Wang (132073), John P. Lydon (476343), Shikha Khatri (797131), Shannon M. Hawkins (251961), Richard E. Leach (797132), Asgerally T. Fazleabas (462533), Steven L. Young (513583), Bruce A. Lessey (582244), Bon Jeong Ku (143640), Jae-Wook Jeong (143654)
2015 · doi:10.1371/journal.pgen.1005537.g003 · W6960748332
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Abstract

(A) The ARID1A expression were lower in infertile women with endometriosis (n = 6) compared to women without endometriosis (n = 6). (B) The decidualization is highly induced in Arid1af/f mice (a) but not Arid1ad/d mice. Arrow heads indicate stimulated horns. (b). The uterine weight ratio was significantly decreased in Arid1ad/d mice as compared to Arid1af/f (C) Histology of control and stimulated horn in Arid1af/f (a and c) and Arid1ad/d mice (b and d) at day 5, respectively (D) The expression of decidualization marker genes, Bmp2, Fst and Fkbp5 was measured in the uteri of control and stimulated horn. The results represent the mean ± SEM of three independent RNA sets. **, p < 0.01; ***, p < 0.001.
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ARID1A Is Essential for Endometrial Function during Early Pregnancy Fig 3 Arid1ad/d mice exhibited an altered decidualization. (A) The ARID1A expression were lower in infertile women with endometriosis (n = 6) compared to women without endometriosis (n = 6). (B) The decidualization is highly induced in Arid1af/f mice (a) but not Arid1ad/d mice. Arrow heads indicate stimulated horns. (b). The uterine weight ratio was significantly decreased in Arid1ad/d mice as compared to Arid1af/f (C) Histology of control and stimulated horn in Arid1af/f (a and c) and Arid1ad/d mice (b and d) at day 5, respectively (D) The expression of decidualization marker genes, Bmp2, Fst and Fkbp5 was measured in the uteri of control and stimulated horn. The results represent the mean ± SEM of three independent RNA sets. **, p < 0.01; ***, p < 0.001.

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endometriosis

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