Arid1ad/d mice exhibited an altered decidualization.

Tae Hoon Kim (128536), Jung-Yoon Yoo (462528), Zhong Wang (132073), John P. Lydon (476343), Shikha Khatri (797131), Shannon M. Hawkins (251961), Richard E. Leach (797132), Asgerally T. Fazleabas (462533), Steven L. Young (513583), Bruce A. Lessey (582244), Bon Jeong Ku (143640), Jae-Wook Jeong (143654)
2015 · doi:10.1371/journal.pgen.1005537.g003 · W6960748332
Lab / animal OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-09 · read from full text ⓘ

The study investigates the role of ARID1A in endometrial function by comparing its expression in infertile women with and without endometriosis. Researchers found that ARID1A levels were significantly lower in patients with endometriosis, suggesting a link between this gene and the condition. In mouse models, deletion of Arid1a resulted in impaired decidualization, characterized by decreased uterine weight ratios and reduced expression of key marker genes like Bmp2, Fst, and Fkbp5. This paper is centrally about endometriosis — specifically examining how ARID1A deficiency contributes to altered endometrial function and decidualization defects associated with the disease.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

(A) The ARID1A expression were lower in infertile women with endometriosis (n = 6) compared to women without endometriosis (n = 6). (B) The decidualization is highly induced in Arid1af/f mice (a) but not Arid1ad/d mice. Arrow heads indicate stimulated horns. (b). The uterine weight ratio was significantly decreased in Arid1ad/d mice as compared to Arid1af/f (C) Histology of control and stimulated horn in Arid1af/f (a and c) and Arid1ad/d mice (b and d) at day 5, respectively (D) The expression of decidualization marker genes, Bmp2, Fst and Fkbp5 was measured in the uteri of control and stimulated horn. The results represent the mean ± SEM of three independent RNA sets. **, p < 0.01; ***, p < 0.001.
Full text 834 characters · extracted from oa-doi-fallback · click to expand
ARID1A Is Essential for Endometrial Function during Early Pregnancy Fig 3 Arid1ad/d mice exhibited an altered decidualization. (A) The ARID1A expression were lower in infertile women with endometriosis (n = 6) compared to women without endometriosis (n = 6). (B) The decidualization is highly induced in Arid1af/f mice (a) but not Arid1ad/d mice. Arrow heads indicate stimulated horns. (b). The uterine weight ratio was significantly decreased in Arid1ad/d mice as compared to Arid1af/f (C) Histology of control and stimulated horn in Arid1af/f (a and c) and Arid1ad/d mice (b and d) at day 5, respectively (D) The expression of decidualization marker genes, Bmp2, Fst and Fkbp5 was measured in the uteri of control and stimulated horn. The results represent the mean ± SEM of three independent RNA sets. **, p < 0.01; ***, p < 0.001.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-13T20:13:29.559147+00:00
License: CC0 · commercial use OK