Iatrogenic parasitic myoma and iatrogenic adenomyoma after laparoscopic morcellation: A mini-review

The authors have declared no conflict of interest

Myoma was the initial surgical indication for myomectomy or hysterectomy in all cases of IPM, except in 3 cases in which the initial indication of hysterectomy was not stated. In 7 of 10 cases (70%), when the myoma location was indicated, a posterior location in the uterine wall was cited. Myomectomy was performed for large uterine myomas (>5 cm) in all cases when their size was described (fibroids measuring 8.3 ± 2.2 cm). A myoma size exceeding 6 cm was described in 9 cases (29%); in 25 cases, the data were not available, and in 2 cases, the myoma size was measured at 5 cm ( Table 1 ). The initial surgical procedure (myomectomy/hysterectomy) was performed by laparoscopy in 88.8% of cases (n = 32) and by laparotomy in 11% of cases (n = 4) in women aged 23–50 years. In the laparoscopic group, 78.8% (n = 25) of the procedures were myomectomies, whereas 21.8% (n = 7) were hysterectomies (3 cases of total hysterectomy and 4 cases of subtotal hysterectomy). When the laparoscopic approach was performed, an electromechanical morcellator was used in 90% of cases (n = 29). In the other 3 cases, manual morcellation with a cold knife was performed. Manual morcellation was described even in the abdominal approach (n = 3). The interval between the initial surgery and the diagnosis of IPM or IA varied depending on symptoms. For asymptomatic cases, the average time was longer (6.2 years) than that for the symptomatic case (4.2 years). In the Kho and Nezat [29] series, the average time between the previous abdominal surgery and surgery during which an IPM was diagnosed was 75 months. In this review overall, 63.8% of patients presenting with IMP were asymptomatic at the time of the diagnosis, while Van der Meulen et al. [35] reported that 21.7% of patients were asymptomatic, in both parasitic myoma and adenomyoma cases. Common symptoms of IPM include abdominal discomfort, fatigue, backache, dyspareunia, and urinary/bowel complaints. Table 1 Initial pathologic characteristics and surgery performed in cases of iatrogenic parasitic myoma and iatrogenic adenomyoma. References (year) n Initial pathology Myomas n° Location Size (cm) U/M weight Surgery Morcellator used La Coursiere et al. (2005) [16] 1 Myoma 5 NA 6 205 g LTH Yes Paul and Koshy (2006) [21] 1 Myoma 1 Posterior 9 NA LM Yes Rakesh et al. (2007) [22] 1 Myoma 1 NA NA NA LM Yes Rakesh et al. (2007) [23] 2 Myoma 1 Posterior 10 390 g > ut LM > 3 years LTH Yes 920 g Myoma 1 Posterior 5 135 g > ut LM −8 years Yes 300 g LASHnR + excision Takeda et al. (2007) [24] 1 Myoma 1 Intraligamental NA NA LM Yes Thian YL et al. (2009) [12] 1 Myoma 1 Posterior 9.7 NA LM Yes? Moon HS et al. (2008) [25] 1 Myoma 1 Posterior 6.3 NA LM Yes Rakesh et al. (2009) [26] 1 Myoma 1 Posterior 10 620 g LM Yes Epstein JH et al. (2009) [27] 1 Myoma 1 Anterior 5 NA LM Yes Wada-Hiraike et al. (2009) [28] 1 Myoma 1 Posterior 9.3 NA LAM Cold knife Kho KA (2009) [29] 12 Myoma NA NA LM, AM Yes (6) + 2 cold knife Larrain et al. (2010) [15] 4 Myoma 1 1 NA NA LM Yes 1 1 NA 600 g LM Yes 1 NA LTH Yes 1 NA LTH Yes Cuccinela et al. (2011) [17] 4 1 Myoma NA NA LM + 2 years TAH Yes 1 Myoma NA NA LM Yes 1 Myoma NA NA LM + 2 years TAH Yes 1 Myoma NA NA LM Yes Sesti F (2011) [30] 1 Myoma 5 NA NA GLM Cold knife Yanazume et al. (2012) [31] 1 Myoma 10 Fundal NA AM No Takeda A (2012) [32] 1 Myoma 1 Posterior 11 262 g GLM Cold knife Leren et al. (2012) [33] 3 NA NA NA NA NA LASH Yes UtroSCT 1 NA LH Yes Ehdaivand et al. (2014) [34] 2 Myoma NA NA NA NA LM Yes Initial pathologic characteristics and surgery performed in cases of iatrogenic parasitic myoma and iatrogenic adenomyoma. There was no relationship between the size of IPM and symptomatic patients, as asymptomatic cases were described with 8–10-cm parasitic myomas [12] , [23] , [30] , and a 15-mm parasitic myoma was described as causing pelvic or abdominal pain [17] . Pain was usually described in cases of IPM located in the pelvic region [15] , [16] , [26] . These iatrogenic lesions were identified by vaginal ultrasound and more accurately by magnetic resonance imaging (MRI). Masses similar to uterine myoma were observed in the cases of IPM. The location of these iatrogenic pathologies may be on any abdominal organ or peritoneal area, especially if an electromechanical morcellator is used. However, the majority of IPMs were found in the pelvis (67.7%), along the gastrointestinal tract, and less frequently in the upper abdomen, along the urinary tract, or along the trocar or abdominal scar. Cuccinela et al. [17] identified the pelvic location of IPMs by movement of the fragments to the lower part of the abdomen. Kho and Nezhat [29] noted that the most likely locations of IPMs are in the pelvis. The number of IPMs varies depending on the type of morcellation. After mechanical morcellation, one lesion is usually cited. In cases in which an electrical morcellator is used, the number can reach up to seven or more. This difference could be explained by the fact that when manual morcellation is used, the tissue fragments are larger and can be seen easily, which is not the case in electromechanical morcellation due to the force of the rotating blade, causing very small fragments to be dispersed away from the field. The size of nodules varies from 3 mm to 30 cm. Concerning intraoperative macroscopic analysis of the lesions, the majority of IPMs were not described as causing an inflammatory reaction or adhesions (69.2%, n = 18/26 of available data). In two case reports and in one series, there were no available data regarding the adhesions. All cases of IPM were confirmed by histological findings to be composed only of smooth muscles ( Table 2 ). The pathogenesis of IPM is still not clearly understood. Pieces of the endometrium, such as the myometrium, can implant and proliferate [36] . According to Kho and Nezat [29] , the greater risk factor for the development of parasitic myomas is the presence of a uterine leiomyoma. It was shown that myomas >6.5 cm had a significantly higher proportion of abnormal karyotypes than myomas 6.5 cm could have a higher implantation and growth potential. In this review, 29% (9 cases) of the laparoscopic myomectomies that were performed were for fibroids >6 cm, whereas in 2 cases, the size of the fibroid was <6 cm; in 20 cases, no data were provided. A posterior location of uterine myomas was frequently described for the previous laparoscopic myomectomy, and this position may have made the surgical intervention more difficult, contributing to the formation of IPMs. Table 2 Clinical characteristics and intraoperative data for iatrogenic parasitic myoma. References (Year) Symptoms Interval (years) Iatrogenic myomas N° Location of iatrogenic lesions Size of the developed nodules CA125 Adhesions Anatomopathology LaCoursiere et al. (2005) [16] DPP, pelvic pain, dysuria 1 5 Pelvis 0.4–0.7 cm NA Yes Leiomyoma, fibrosis, cervical and endocervical tissue Paul and Koshy (2006) [21] DPP, pelvic pain 2, 5 Nr Parietal peritoneum at the trocar site, uterine fundus, paracolic gutter NA NA NA (no) Leiomyoma Rakesh et al. (2007) [22] Asymptomatic 5 2 Right dome diaphragm + rectovaginal septum 5 cm, 3 cm NA No Leiomyoma Rakesh et al. (2007) [23] Pain and mass 3 3 Pelvis > liver, sigmoid colon broad pedicle; lateral pelvic wall; urinary bladder left paraumbilical region: sigmoid colon and left lateral abdominal wall 15 cm, 7 cm, 8 cm Leiomyoma Abdominal mass 6 1 10 cm Leiomyoma Takeda et al. (2007) [24] Asymptomatic 6 1 Omentum, round ligament, vesicouterine peritoneum, peritoneum NA NA Leiomyoma Thian YL et al. (2009) [12] Asymptomatic 1 50 Right adnexa, umbilical nodule, peritoneal cavity, colon 8, 4, 2 cm N Leiomyomas Moon HS et al. (2008) [25] Mass, left lower quadrant of the abdomen 3 1 Abdominal wall (subfascial area) 3 cm NA No Leiomyoma Rakesh S et al. (2009) [26] Abdominal pain 3 2 Pouch D + right lumbar region 6, 7 cm NA Leiomyoma Epstein JH et al. (2009) [27] Pelvic pain 1, 5 2 Omentum, sigmoid 3, 8 cm NA NA (no) Leiomyoma Wada-Hiraike et al. (2009) [28] Mass, left lower quadrant of the abdomen 4 1 Rectus muscle at the suprapubic incisional scar 10 cm NA Desmoid tumour Kho KA (2009) [29] NA NA Larrain et al. (2010) [15] Pelvic mass 16 1 Pouch of Douglas 3 cm NA No Calcified leiomyoma Pelvic mass 8 1 Pouch of Douglas 7 cm NA No Leiomyoma Pelvic pain, pelvic mass 6 1 Presacral peritoneum 6 cm N Yes Adenomyosis Vaginal mass 3 1 Vaginal scar 5 cm NA No Leiomyoma Cuccinela et al. (2011) [17] Pelvic pain, abdominal masses 7 3 15–60 mm NA NA (no) Leiomyoma Asymptomatic 2 1 Pelvic peritoneum, along the gastrointestinal tract 18 mm NA NA (no) Leiomyoma DPP, left side tenderness 9 5 4–35 mm NA NA (no) Leiomyoma Asymptomatic 6 2 43–60 mm NA NA (no) Leiomyoma Sesti F (2011) [30] Palpable masses of the abdominal wall 10 6 Abdominal wall: umbilical area, rectus muscles, left abdominal region 0.3–10 cm NA No Leiomyoma Yanazume et al. (2012) [31] Painful subcutaneous mass 16 1 Abdominal subcutaneous adipose tissue 12 cm N No Leiomyoma Takeda A (2012) [32] Asymptomatic 2 1 Vesicouterine pouch 1, 4 cm NA NA (no) Leiomyoma Leren et al. (2012) [33] Pain, mass in the abdomen 3, 6–8 1–12 Peritoneum, abdominal wall, colon transversum, caecum, in the pelvic abdominal wall, rectum, cervix and small intestine, pouch of Douglas N51 NoNo Leiomyoma 1–11 cm kU/L Yes Leiomyoma + adenomyoma Ehdaivand et al. (2014) [34] Asymptomatic 0, 15–1,7 1 Omentum NA NA Yes Leiomyoma NA Peritoneal sites NA No Leiomyoma LM, laparoscopic myomectomy; LTH, laparoscopic total hysterectomy; LASHnR, laparoscopic subtotal nonradical hysterectomy; LAM, laparoscopically assisted myomectomy; GLM, gasless laparoscopic myomectomy; AM, abdominal myomectomy; NA, not available; N, normal; UTROSCT, uterine tumour resembling ovarian sex cord tumour. Clinical characteristics and intraoperative data for iatrogenic parasitic myoma. LM, laparoscopic myomectomy; LTH, laparoscopic total hysterectomy; LASHnR, laparoscopic subtotal nonradical hysterectomy; LAM, laparoscopically assisted myomectomy; GLM, gasless laparoscopic myomectomy; AM, abdominal myomectomy; NA, not available; N, normal; UTROSCT, uterine tumour resembling ovarian sex cord tumour. As with uterine myoma [39] , the theory of response to injury may explain the pathogenesis of IPM. Experimental data on mice showed that primary myoma cells are able to form xenograft tumour. Associated stromal cells, such as myoma-derived fibroblasts or microvasculature endothelial cells, could account for tumour formation by providing a supportive tumour stroma or a microvascular network [40] . Huang et al. [41] suggested that increased angiogenesis and cell proliferation occur in implanted xenografted myomas (compared with primary myomas) and are involved in the pathogenesis of iatrogenic myomas. Kho and Nezat [29] described the parasitic myoma as follows: after administration of gonadotropin-releasing hormone, which restricts blood supply to the myoma, a subserosal or pedunculated myoma may lose its uterine blood supply and parasitise to an adjacent organ. In the review of Van der Meulen et al. [18] , the duration of steroid exposure seems to be a risk factor that contributes to the development of either IPM or IA. All patients in this review had a premenopausal status at the time of the first surgery (myomectomy or hysterectomy). Even if leiomyomatosis peritonealis disseminata is described after a surgical procedure, it may not be an iatrogenic condition. In this pathology, the pathogenesis differs from the clinical picture, and the evolution is different from IPM. Regarding this pathology that developed after a surgical procedure, in the majority of cases, morcellation was not performed; other theories could explain this pathology as being caused by hormonal or genetic factors [42] . Even in asymptomatic patients, removal of this iatrogenic pathology is necessary because the risk of malignant transformation is higher than that with uterine myoma (2–5% [43] versus 2.33–3.6 per 1000 hysterectomies for uterine myoma [44] ), as genetic disorders in this tumour are more frequent.

This article does not contain any studies with human or animal subjects

All described cases of IA (n = 10) were found after total (n = 1) or subtotal hysterectomy (n = 9) with morcellation ( Table 3 ). The hysterectomy was performed for a large uterus with myomas or a large uterus with myomas and adenomyosis weighing 211.6 ± 5 g in women aged 39–48 years. The average interval between hysterectomy and symptoms of IA varied within 7.42 ± 1.03 years. Common symptoms of IA included abdominal discomfort, moderate-to-severe deep dyspareunia, and pelvic mass. Pelvic pain was described in all cases, mostly due to the existence of adhesions and nerve involvement. Dyspareunia was another common symptom in patients with this entity, explained by rectal retraction and the presence of adhesions. Clinical examination was painful when the pouch of Douglas and lateral Cul-de-sac were explored, and vaginal examination showed the presence of retrocervical or laterocervical masses. The preoperative blood sample analysis showed elevated CA 125 in 9 cases (90%). Pelvic MRI showed an irregular mass overhanging the cervix, extending up into the pelvis, pressing against the rectum or rectosigmoid, or a pelvic mass fixed to the vaginal vault. These heterogeneous masses were composed of hypo- and hyperintense signals on T2-weighted images. Gadolinium injection evidenced vascularisation of the lesions. Hyperintense signals on T1-weighted images with saturation of fatty tissue suggested the presence of old blood. Table 3 Initial pathology and initial surgery performed in the case of iatrogenic adenomyoma. References (Year) N° c Initial pathology U/M weight Surgery Morcellator used Hilger et al. (2006) [14] 1 Myomas 225 g LASHnR Yes Donnez et al. (2007) [13] 8 Myomas + ADM 210 ± 59 g LASHnR/R Yes Larrain et al. (2010) [15] 1 Myomas - LH Yes Initial pathology and initial surgery performed in the case of iatrogenic adenomyoma. Laparoscopic excision was proposed for patients with retrocervical masses filling the pouch of Douglas. The number of lesions varied between 1 and 2, which was not the case for IPM, which had seven lesions in one case. The iatrogenic nodule size measured 34.5 ± 28.7 mm. Despite the use of an electromechanical morcellator in the case of IA masses, the usual location was in the pelvic area, especially in the retrocervical zone. A macroscopic inflammatory reaction was observed, creating retraction of the surrounding organs, such as the cervix and rectum. Adhesions between the pelvic masses and the rectum were found in all cases. Extensive dissection of the rectum and pararectal fossa were required to isolate the lesions. During resection of the masses, bluish lesions were identified corresponding to haemorrhagic spots observed on MRI. In the physiology of adhesion formation, the inflammatory process is commonly implicated [45] , and adenomyosis is associated with a more inflammatory reaction than uterine fibroids. Additionally, the junctional zone is more inflammatory for the peritoneum. In peritoneal endometriosis, according to Sampson’s theory, viable endometrial cells are able to implant, proliferate and create an inflammatory reaction [46] . The experimental baboon model confirmed these data with more adhesions after grafting the endometrium or endometrium and junctional zone, as the inflammatory response is more important in IAs than in myomatous lesions [13] . Histological examination of the excised iatrogenic lesions confirmed smooth muscle hyperplasia infiltrated by endometrial glands and stroma. An inflammatory reaction was also observed around the dilated glands, probably due to old blood retention in the lumen of these glands ( Table 4 ). Table 4 Clinical characteristics and intraoperative data for iatrogenic adenomyoma. References (Year) Symptoms Interval (years) Adenomyoma N° Location of novel pathology Size of developed nodules CA125 Adhesions Anatomopathology Hilger et al. (2006) [14] Pelvic pain, pelvic mass 5 2 Cervical stump, rectosigmoidal junction, near the right ovary 3,2, 4 cm High Yes Adenomyosis Donnez et al. (2007) [13] Pelvic pain, DPP 2–9 1 for each case Latero- and retrocervical masses 2–8 cm N/high Yes Adenomyosis Larrain et al. (2010) [15] Pelvic pain, pelvic mass 6 1 Presacral peritoneum 6 cm N Yes Adenomyosis LH, laparoscopic hysterectomy; LASHnR, laparoscopic subtotal nonradical hysterectomy; NA, not available; N, normal; DPP, dyspareunia; ADM, adenomyosis. Clinical characteristics and intraoperative data for iatrogenic adenomyoma. LH, laparoscopic hysterectomy; LASHnR, laparoscopic subtotal nonradical hysterectomy; NA, not available; N, normal; DPP, dyspareunia; ADM, adenomyosis. Concerning IA, all cases were described after morcellation of an adenomyotic uterus. We thus agreed with Donnez et al. [36] that retained uterine fragments containing both endometrium and myometrium are able to survive in the peritoneal cavity, resulting in adenomyotic lesions. The most important difference between IPMs and IAs is the presence of endometrium associated with subendometrial myometrium (junctional zone). When this association is found in forgotten specimens, these iatrogenic lesions are able to develop tumours characterised by dense tissue composed of smooth muscle hyperplasia with isolated foci of endometrial mucosa and stroma. Experimental studies conducted by Donnez et al. [36] on baboons showed that 20–24 months after grafting of the myometrium alone, smooth muscle lesions associated with fibrotic tissue were found in all cases except one. After grafting the endometrium together with the junctional zone and total uterine thickness, novel lesions composed of endometrial glands and stroma associated with smooth muscle hyperplasia were found. Induced nodular endometriotic lesions were significantly larger and showed a stronger invasion process when tissue specimens containing the junctional zone were grafted. Adenomyosis was the initial indication for LASH in the Donnez et al. [36] series, which means that the junctional zone was larger with a higher risk of having more junctional zone fragments able to induce the formation of iatrogenic adenomyosis. Based on an experimental model [47] , the adhesion of human endometrial cells to mouse peritoneum was increased by treatment with pro-inflammatory cytokines, and surgical intervention creates an inflammatory reaction because of peritoneal damage, crush-induced ischaemia, suture ligation, coagulation, or CO 2 use [45] . In cases of uterine morcellation, both types of iatrogenic lesions may develop, but IA lesions were more commonly described. The duration of steroid exposure seems to be a risk factor in the case of IPM, and all patients were in the premenopausal period at the time of first surgery. Removal of this iatrogenic pathology is necessary because of the risk of malignant transformation. Rabischong [48] described one case with atypical endometrial hyperplasia as an initial pathology without this atypia. Methods to avoid these iatrogenic complications may include laparoscopic morcellation in a bag, as suggested by Kanade et al. [49] , or culdotomy or mini-laparotomy with manual morcellation within a specimen bag [50] . There are no limitations of in-bag morcellation, with the possibility of use even with single-site access. Morcellation in a bag is proposed for myomas and for the uterus and does not require additional advanced surgical skills. In cases of uterine morcellation (subtotal or total hysterectomy), the use of a bag may systematically include conditions without anatomopathological modifications, such as uterine prolapse [51] . In 2016, the FDA approved the first bag for contained morcellation [52] . However, an in vitro study demonstrated that the risk of leakage and tissue dissemination still exists, depending on the insufflation pressure and material type of the bag [53] , and the case of Süleyman Salman confirmed this issue [54] . Another in vivo study showed that some types of bags seem to be safe [55] , [56] , but the existing bags were not designed for power morcellation and, thus, risk spillage in the case of multiport laparoscopy. The authors of that study suggested that the absence of leakage be assessed by visual inspection. Akdemir et al. [57] proposed the use of surgical gloves for enclosed morcellation in cases of multiport laparoscopy to decrease tissue spillage, but the myoma size is a limiting factor for this in-bag morcellation technique. In addition to the concern of spreading malignant cells, morcellation raises new challenges in the pathological interpretation of disrupted tissue specimens. Pathologic evaluation of morcellated uteri is more challenging, and there is a possibility that smaller uterine tumours would be missed. Furthermore, the complexity of this technique may require more advanced training to ensure safety in the hands of novice users [58] . In the review titled “Contained Morcellation: Review of Current Methods and Future Directions”, the authors concluded that there is currently no available method for tissue extraction that completely eliminates the risk of cellular dissemination [59] . The FDA discouraged the use of laparoscopic power morcellation to avoid the spread and worsened clinical outcomes of unsuspected uterine malignancy with a first safety communication warning in April 2014 [60] , [61] . Following this communication regarding power morcellation, utilization of minimally invasive hysterectomy and morcellation decreased [35] . In patients with a history of uncontained uterus or myoma morcellation who report pelvic symptoms, IPM or adenomyoma should be considered in the differential diagnosis.

Retained uterine or myoma fragments after laparoscopic surgery are able to survive and grow in the peritoneal cavity under hormonal steroid exposure when the uterine blood supply is lost. The lack of systematic follow-up after laparoscopic morcellation could result in an underestimation of the incidence because many cases are asymptomatic. Iatrogenic myoma and adenomyoma have a possible different pathogenetic mechanism, but both pathologies have a common point : they originate after a surgical procedure involving morcellation. In-bag morcellation might decrease the incidence of these iatrogenic conditions and is technical feasible but has some limitations and risks. When a morcellator is used, a thorough inspection of the peritoneal cavity and the observation of no leakage from the bag are required. In addition, the patient should be informed concerning this potential, rare iatrogenic complication and the remaining risk potential of in-bag morcellation as well as provided balanced information on alternative treatment options, particularly when a laparoscopic approach is employed . Although the studies discussed in this review provide a good understanding of the risk factors of IPM and adenomyoma, other prospective data collection is necessary to establish other risk factors in addition to morcellator use to develop an algorithm for patient selection for laparoscopic morcellation of the uterus or myoma, with the aim of improving patient safety.

Laparoscopy has become the surgical treatment of choice for several benign pathologies [1] . It has many advantages, such as magnification of the pelvis, short hospitalisation, rapid recovery, low rate of infection, and good cosmetic results [2] , [3] , [4] . Additionally, hysterectomy is one of the most common gynaecological procedures, with approximately 600,000 hysterectomies performed per year in the US [5] . Laparoscopic subtotal/supracervical hysterectomy (LASH) is a surgical option when hysterectomy is indicated in the absence of cervical or endometrial malignant pathology [6] . This technique has many advantages, such as low perioperative morbidity, and faster postoperative recovery [7] . However, leiomyoma is still the most common indication for hysterectomy [8] , [9] . Both LASH and laparoscopic myomectomy are surgical procedures that could be proposed in cases of uterine myoma, depending on the patient’s age and their wish to preserve fertility. Both techniques require laparoscopic tissue extraction through small incisions to avoid the need for a mini-laparotomy. Intra-abdominal fragmentation is performed with the use of a morcellator. Since 1993, with the development of the Steiner morcellator [10] , several systems of electromechanical morcellation have become available. A rapidly circulating sharp cylinder with a coring knife/cutter at its intra-abdominal end is placed inside the trocar sleeve and is rotated by an electrical micro-engine attached to the trocar. Cylindrical tissue blocks are cut out of the main specimen in a stepwise fashion and removed from the peritoneal cavity through the cannula [11] . Morcellation can induce different sizes of tissue specimens. Fragments that are microscopic or even larger may be unnoticed and may remain in the abdominal cavity, tract incisions, or trocars, resulting in the appearance of an unrecognized pathology such as iatrogenic parasitic myoma (IPM) [12] or iatrogenic adenomyoma (IA) [2] , [13] , [14] , [15] , [16] . The incidence of retained uterine fragments remains unknown because this complication of morcellation is underestimated due to the small series and because the majority of such pathologies are published as case reports. In the largest series, the incidence of IPM was 1.2% [17] , and that of IA was 0.57% [13] . In the Van der Meulen et al. [18] review, the incidence was 0.12% to 0.94%. The majority of case reports and series have been published in the last few decades after electromechanical morcellator introduction. Many types of morcellators (motor coring, motor peeling, or bipolar cutting as the working principle) with four types of blade diameters (12, 13, 15, and 20 mm) and increased morcellation rates (6.2–40.4 g/min) [19] were available from 1993 to 2014 (after the FDA warning concerning morcellator use) [20] . Following this communication regarding power morcellation, the utilization of minimally invasive hysterectomy and morcellation decreased. However, asymptomatic cases of IPM are not reported, and these cases will likely be diagnosed and reported in the next period. This article aimed to review the literature on parasitic myoma and adenomyoma and to compare these diseases in terms of clinical, paraclinical, surgical, and prognostic factors. Available articles were reviewed using PubMed/ MEDLINE and ScienceDirect resources, and the differences between these two entities were analysed. Thirty-six cases of IPM (13 case reports and 5 case series) and 10 cases of IA (2 case reports and one series) were found ( Fig. 1 ). Fig. 1 Flow chart for literature search. Flow chart for literature search.