ORLA combined with telerehabilitation in patients with subacute poststroke aphasia: A randomized controlled trial

ORLA combined with telerehabilitation in patients with subacute poststroke aphasia: A randomized controlled trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article ORLA combined with telerehabilitation in patients with subacute poststroke aphasia: A randomized controlled trial Li Gan, Litao Huang, Lijuan Li, Xin Yang, Lijiao Meng, Zijian Pang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5735439/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Scientific Reports → Version 1 posted 6 You are reading this latest preprint version Abstract BACKGROUND: Oral reading for language in aphasia (ORLA) therapy coupled with telerehabilitation (TR) is a promising adjunct to therapy for aphasia. METHODS:This single-center, randomized, single-blind, 6-month trial aimed to evaluate whether ORLA combined with TR demonstrates comparable efficacy to conventional ORLA offline rehabilitation for improving comprehensive language ability in subacute aphasia patients, while assessing longitudinal treatment effects. Enrolled patients were randomized 1:1:1 into: Group A (medium-high intensity ORLA TR）：Group B (low intensity ORLA TR）Group C (medium-high intensity ORLA offline). All groups received a 6-month, 90-hour intervention comprising three treatment phases. The primary outcome was change in Aphasia Quotient (AQ) at baseline and 4 weeks, 3 months, and 6 months post-treatment. Secondary outcomes included quality of life and language subscale scores at the same timepoints. RESULTS: A total of 42 participants were analyzed,Group A demonstrated a non-significant mean difference of -0.62 (95% CI, -5.00 to 6.23; P=0.83) in AQ compared to Group C.A statistically significant difference in the Stroke Aphasia Quality of Life-39 Scale (SAQOL-39) scores between Group A and Group C (mean difference: -8.19; 95% CI [-12.39, -3.99]; P 0.05 for all comparisons). CONCLUSIONS: ORLA combined with TR demonstrated comparable efficacy to conventional ORLA offline rehabilitation, serving as a viable alternative for home-based speech rehabilitation in subacute aphasia patients. This TR approach improved both comprehensive language ability and quality of life, with sustained treatment effects over time. First registration date: August 18, 2023 (retrospective registration, Chinese Clinical Trial Registry number: ChiCTR2300074870). Health sciences/Health care Health sciences/Medical research aphasia ischemic stroke language telerehabilitation Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementalMaterial.doc 4.04SupplementalMaterial.pdf Cite Share Download PDF Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 12 May, 2025 Reviews received at journal 30 Apr, 2025 Reviewers agreed at journal 23 Apr, 2025 Reviewers invited by journal 20 Apr, 2025 Submission checks completed at journal 18 Apr, 2025 First submitted to journal 03 Apr, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5735439","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":445460054,"identity":"6d190103-b564-4323-acad-1d271f799a14","order_by":0,"name":"Li Gan","email":"","orcid":"","institution":"Department of Adult Speech and Swallowing Therapy, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM","correspondingAuthor":false,"prefix":"","firstName":"Li","middleName":"","lastName":"Gan","suffix":""},{"id":445460055,"identity":"4a4dd8f9-93b0-4efc-aa41-7190035924b2","order_by":1,"name":"Litao 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trial","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"aphasia, ischemic stroke, language, telerehabilitation","lastPublishedDoi":"10.21203/rs.3.rs-5735439/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5735439/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBACKGROUND:\u0026nbsp;Oral reading for language in\u0026nbsp;aphasia (ORLA) therapy coupled with telerehabilitation (TR) is a promising adjunct to therapy for aphasia.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMETHODS:This single-center, randomized, single-blind, 6-month trial aimed to evaluate whether ORLA combined with TR demonstrates comparable efficacy to conventional ORLA offline rehabilitation for improving comprehensive language ability in subacute aphasia patients, while assessing longitudinal treatment effects. Enrolled patients were randomized 1:1:1 into: Group A (medium-high intensity ORLA TR）：Group B (low intensity ORLA TR）Group C (medium-high intensity ORLA offline). All groups received a 6-month, 90-hour intervention comprising three treatment phases. The primary outcome was change in Aphasia Quotient (AQ) at baseline and 4 weeks, 3 months, and 6 months post-treatment. Secondary outcomes included quality of life and language subscale scores at the same timepoints.\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eRESULTS:\u0026nbsp;A total of 42 participants were analyzed,Group A demonstrated a non-significant mean difference of -0.62 (95% CI, -5.00 to 6.23; P=0.83) in AQ compared to Group C.A statistically significant difference in the Stroke Aphasia Quality of Life-39\u0026nbsp;Scale (SAQOL-39) scores between Group A and Group C (mean difference: -8.19; 95% CI [-12.39, -3.99]; P \u0026lt; 0.001). Group A vs. Group C: No statistically significant differences were observed in any of the aforementioned language subskills\u0026nbsp;between Group A and Group C\u0026nbsp;(P\u0026gt;0.05 for all comparisons).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eCONCLUSIONS: ORLA combined with TR demonstrated comparable efficacy to conventional ORLA offline rehabilitation, serving as a viable alternative for home-based speech rehabilitation in subacute aphasia patients. This TR approach improved both comprehensive language ability and quality of life, with sustained treatment effects over time. First registration date: August 18, 2023 (retrospective registration, Chinese Clinical Trial Registry number: ChiCTR2300074870).\u003c/p\u003e","manuscriptTitle":"ORLA combined with telerehabilitation in patients with subacute poststroke aphasia: A randomized controlled trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-23 11:08:47","doi":"10.21203/rs.3.rs-5735439/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-05-12T09:37:37+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-04-30T10:53:00+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"215728236252522301238833505663724407015","date":"2025-04-23T08:13:30+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-04-21T00:44:33+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-04-18T10:13:49+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-04-04T03:18:59+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"203362f2-3015-4a21-aad6-ff0ce017a942","owner":[],"postedDate":"April 23rd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":47419919,"name":"Health sciences/Health care"},{"id":47419920,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2025-07-07T16:11:30+00:00","versionOfRecord":{"articleIdentity":"rs-5735439","link":"https://doi.org/10.1038/s41598-025-06258-5","journal":{"identity":"scientific-reports","isVorOnly":false,"title":"Scientific Reports"},"publishedOn":"2025-07-01 15:57:56","publishedOnDateReadable":"July 1st, 2025"},"versionCreatedAt":"2025-04-23 11:08:47","video":"","vorDoi":"10.1038/s41598-025-06258-5","vorDoiUrl":"https://doi.org/10.1038/s41598-025-06258-5","workflowStages":[]},"version":"v1","identity":"rs-5735439","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5735439","identity":"rs-5735439","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}