Expressions of CA125 and antibody to transferrin in patients with endometriosis

Aim:To investigate the expressions and diagnostic values of CA125 and antibody to transferrin(TFAb)in serum and peritoneal fluid from patients with endometriosis(EMT).Methods:CA125 and TFAb in serum and peritoneal fluid from 52 patients with EMT(25 patients with stage Ⅰ,Ⅱ and 27 patients with stage Ⅲ,Ⅳ)and 40 controls were measured by ELISA.Results:The levels of CA125 in serum and peritoneal fluid from patients with EMT were higher than those in the control group(χ2=21.997 and 45.551,P0.001).The levels of CA125 in serum and peritoneal fluid increased with stage-level rise(P0.05).The positive rates of CA125 and TFAb in serum and peritoneal fluid among the groups were different significantly(χ2=18.945,40.926 and 59.916,59.919,P0.05).The sensitivity and specificity were up to 94.2% and 100.0% respectively when the CA125 combined with TFAb were used to diagnose EMT.Conclusion:CA125 and TFAb levels in serum and peritoneal fluid is useful for EMT diagnosis,and combined determination of CA125 and TFAb in serum or peritoneal fluid can improve the diagnostic accuracy.