Emergency Surgery Admissions and The COVID-19 Pandemic: Did The First Wave Really Change Our Practice? Results of An ACOI/WSES International Audit On 6263 Patients.

Emergency Surgery Admissions and The COVID-19 Pandemic: Did The First Wave Really Change Our Practice? 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Results of An ACOI/WSES International Audit On 6263 Patients. Giovanni D. Tebala, Marika S. Milani, Mark Bignell, Giles Bond-Smith, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1106929/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 7 You are reading this latest preprint version Abstract Introduction The COVID-19 pandemic is having a deep impact on emergency surgical services, with a significant reduction of patients admitted into emergency surgical units world widely. Reliable figures of this reduction have not been produced yet. Our international audit aimed at giving a precise snapshot of the absolute and relative changes of emergency surgical admissions at the outbreak of the pandemic. Materials and methods Datasets of patients admitted as general surgical emergencies into 45 internationally distributed emergency surgical units during the months of March and April 2020 (Covid-19 pandemic outbreak) were collected and compared with those of patients admitted into the same units during the months of March and April 2019 (pre-Covid-19). Primary endpoint was to evaluate the relative variation of the presentation symptoms and discharge diagnoses between the two study periods. Secondary endpoint was to identify the possible change of therapeutic strategy during the same two periods. Results Forty-four centres participated sent their anonymised data to the study hub, for a total of 6263 patients. Of these, 3810 were admitted in the pre-Covid period and 2453 in the Covid period, for a 35.6% absolute reduction. The most common presentation was abdominal pain, whose incidence did not change between the two periods, but in the Covid period patients presented less frequently with anal pain, hernias, anaemia and weight loss. ASA 1 and low frailty patients were admitted less frequently, while ASA>1 and frail patients showed a relative increase. The type of surgical access did not change significantly, but lap-to-open conversion rate halved between the two study periods. Discharge diagnoses of appendicitis and diverticulitis reduced significantly, while bowel ischaemia and perianal ailments had a significant relative increase. Conclusions Our audit demonstrates a significant overall reduction of emergency surgery admissions at the outbreak of the Covid-19 pandemic with a minimal change of the proportions of single presentations, diagnoses and treatments. These findings may open the door to new ways of managing surgical emergencies without engulfing the already busy hospitals. Critical Care & Emergency Medicine Surgery emergency surgery Covid-19 admission Figures Figure 1 Introduction The Covid-19 pandemic has radically changed our life and work. In particular, it is having a significant and long-lasting impact on healthcare. Each and every health system underwent radical changes to adapt to the growing number of emergency admissions for respiratory syndromes, most of which needed intensive care, and every Country produced their own guidelines and policies to deal with this unexpected disaster. Most elective services have been stopped, with some differences among Countries, but emergency admissions had to be treated anyway, although with reduced resources. A common government advice was to avoid attending the Emergency Department if not strictly necessary, to leave room for more severe cases of Covid-19-associated respiratory failure and to avoid Covid-19 cross-infection. This caused a perceived reduction of all the non-Covid emergency admissions, in particular those of surgical remit. However, the general perception among surgeons was that the many causes for emergency presentation did not reduce proportionally. Aim of our international audit was to have a snapshot of the absolute and relative change of surgical emergency admissions during the first wave of the Covid-19 pandemic. Limiting our audit to the outbreak of the pandemic – instead of considering the whole course – allowed us to analyse the impact of the worldwide infection at its maximum, when most Countries were not yet prepared to respond. Materials And Methods We analysed data of patients admitted into Emergency Surgery Units in the months of March and April 2020 and compared them with same datasets of patients admitted in the months of March and April 2019. March-April 2020 were the first two months of the global pandemic in Europe. The control period March-April 2019 was chosen as a significant match to avoid seasonal biases. A short version of the protocol of this retrospective audit was disseminated by email to Emergency Surgical units in Europe. The units that confirmed their interest in participating to this study were emailed the full protocol and an empty database to collect their anonymised demographic and clinical data. Only adult patients admitted to the Surgical Emergency Units have been included. Patients aged <18 and those with <80% of complete data have been excluded. Single patients’ data have been accessed only by those who have anyway daily access to that information for their clinical work. Data from each unit have been collected under the responsibility of the Principal Local Investigator (PLI), anonymised and sent by secure encrypted email to the Study Coordinator (SC). Thereafter, data have been centrally coded, collected into an encrypted electronic database (Microsoft Excel for Mc v.16.54) and analysed with a statistical package (StatPlus Mac Pro 8.0.1.0). No patient could be identified in the main central database. Frequency variables have been compared by the Pearson Chi-square test. Continuous variables have been tested for distribution and skewness and then compared by one-way analysis of variance (ANOVA). Values of p<0.05 have been considered significant. Primary endpoint of the study was to evaluate the relative variation of the presentation symptoms and discharge diagnoses between the two study periods. Secondary endpoint was to identify the possible change of therapeutic strategy during the same two periods. Missing data have been excluded listwise. This may account for minimal numeric discrepancies in the calculation of frequencies. The factors who had more than 10% of missing data have been excluded from the analysis. Values in the text, tables and figures are approximated to the tenths. Ethical committee approval was not considered to be necessary due to the retrospective nature of the study and the fact that sensible data were all fully anonymised by the local research team before being transmitted and analysed by the central team. However, the study was approved by the Comitato Etico ATS Sardegna on 22.12.2020 and was approved and endorsed by the World Society of Emergency Surgery (WSES) and the Association of Italian Hospital Surgeons (ACOI – Associazione dei Chirurghi Ospedalieri Italiani). Results Forty-five centres participated in the study (39 from Italy, 2 from UK, 2 from Spain, 1 from Portugal, 1 from France) for a total of 6263 patients. Results are listed in Tables 1 to 5 and in Figure 1. Only the most significant are hereby reported. Table 1 reports the characteristics of the patients enrolled in the study. In March-April 2019 the participating units admitted 3810 patients, whereas during the Covid-19 first wave they admitted 2453 patients, for a 35.6% absolute reduction. Therefore, in evaluating the reduction of single items, a reduction of or around 35.6% is considered to be due to the overall reduction of admissions, whereas a variation of more than -35.6% may signify a relative reduction of that single factor and a reduction of less than -35.6% means that that single factor had a relative increase. In case of positive variation, it means that that item has had a significant relative increase. Age of admitted patients and gender distribution did not change between the two periods (59.1±21.1 vs 59.9±20.3, p=NS, and 1875/1935 vs 1211/1242, p=NS, respectively). The most frequent reason for admission was “abdominal pain” in both periods, with a reduction of 38%. This is still consistent with the general reduction of admissions. However, some causes of presentation reduced much more than expected. This is the case with “anal pain” (-57%), “anaemia” (-73.3%), “hernias” (-44.4%), “anorexia/weight loss” (-57.1%) and “wound complications” (-80%). Other presentations reduced much less or, unexpectedly, increased, such as “bowel obstruction” (-19.1%), “GI bleeding” (-7.8%) and “dysphagia” (+11.1%). The number of ASA 1 patients decreased of 52.6%, while patients in poorer general conditions were admitted more often (variation: ASA 2, -28.5%, ASA 3, -25.4%, ASA 4, -14.1%, ASA 5, 0%). This trend has been confirmed by evaluating the Frailty Score. Patients with no or minimal frailty (1-2) were admitted less frequently (-43.4% reduction between 2019 and 2020), whereas more frail patients were admitted more frequently (-26.5% reduction, which means a relative increase with respect to the -36.5% overall reduction of admissions). Table 2 shows the treatment of the patients and their outcomes. The type of treatment (medical vs surgical vs interventional) and the surgical access (laparoscopic vs open vs laparoscopic converted to open) did not change much during the two study periods. However, the rate of laparoscopy-to-open conversion halved between the two periods (not statistically significant, though). To assess if the unbalanced distribution of participating units would add a significant bias, a comparison between Italian and non-Italian centres has been performed. It showed that Italian surgeons were more prone to treat their patients with surgery in both periods with respect to their non-Italian counterparts (in 2019, 68.5% vs 48.7%, in 2020, 70.7% vs 42.6%, p=0.000). Furthermore, while non-Italian centres showed a small relative reduction of the surgical approach (from 48.7% of all treatments to 42.6%, variation=-12.6%) (and a contemporaneous increase of non-operative management), the attitude of Italian units showed a minimal relative increase in the surgical approach (from 68.5% of all treatments to 70.7%, variation=+3.2%), but this difference was not statistically significant. In the general series, some subspecialties had a more significant reduction (p=0.006). For instance, chest and abdominal wall surgery reduced more (respectively, -62.9% and -46.6%), while upper GI had a relative increase (-17.6%). Total length of stay was 7.8±10.5 days in the first period and 7.7±10.0 days in the second period (p=NS). The percent reduction of the reoperations was consistent with the overall reduction of cases (p=NS), but reduction of readmissions was significantly more than expected (-44.8%, p=0.059). Table 3 examines the surgical access in the most common operations. Appendicectomies and cholecystectomies were performed by laparoscopy in the vast majority of cases (81.6% in 2019 and 83.0% in 2020 and 81.9% in 2019 and 76.4% in 2020, respectively). Hernia repairs, large bowel resections and small bowel resections have been more frequently performed by open surgery (92.2% vs 91.9%, 84.6% vs 87.4% and 96.5% vs 96.1%, respectively). There was no significant difference of approach between the two periods of the study. Tables 4 and 5 and Figure 1 deal with discharge diagnosis. The most frequent discharge diagnoses were acute appendicitis, acute cholecystitis and small bowel obstruction (SBO). The overall incidence of the different diagnoses changed significantly between the two study periods (p<0.0001). While the incidence of admission for “acute appendicitis” reduced by 41.5% (much more than expected) and for “acute diverticulitis” reduced by 49.6%, other diagnoses, such as “bowel ischaemia” and “haemorrhoids/rectal prolapse” reduced less significantly (respectively, -8.9% and -7.1%), thus showing a relative growth, and others even had an absolute increase (IBD +10%, stoma complications +168.8%, enteric fistulas +50%, oesophagogastric strictures +1050%). An analysis of the most frequent diagnoses (acute pancreatitis, hot gallbladder, acute appendicitis, diverticulitis and small bowel obstruction) whose results are depicted in Figure 1, did not showed any relative change. The treatment of acute pancreatitis, hot gallbladder, acute appendicitis and diverticulitis did not change significantly, but SBO was treated surgically much less frequently (63.6% in 2019, 55.2% in 2020 – p=0.02324). Discussion Covid-19 is a worldwide pandemic affecting all Countries and taking by surprise every national healthcare system at its onset. Fortunately, due to immunization policies and containment guidelines, possibly helped by the natural weakening of the virus, the second and third waves of infection have been slightly less severe than the first and thankfully now the infection is reducing, at least in the western Countries. In most cases, social isolation has been used to control the spread of the virus. In some Countries, like the UK, this has meant an almost complete cessation of elective surgical work with significantly reduced capacity within primary care due to a combination of strict triage of patients and sickness within the workforce. Other governments and scientific societies have produced different guidelines, leading to different outcomes, mostly regarding the reduction of elective surgical operations. Sometimes, medical guidelines have been too drastic and widely controversial [1] also because with the aim of creating room for Covid-19 patients they reduced the capacity for elective and non-Covid emergency patients. On the contrary, we believe, in agreement with other Authors [2], that therapeutic indications should not change during this pandemic, because in our role of doctors in “developed” Countries we are morally bound to maintain high standards of care despite the pandemic [3]. It would be expected that this reduction in capacity would result in an increase in attendances across emergency services within secondary care, but this has failed to materialize with a reduction in attendances in all emergency departments including surgical emergency units. Our audit demonstrated an overall reduction in surgical emergency admission of about 36%, while average age and gender distribution did not change significantly. Few Italian Authors have reported a much more significant reduction on the basis of their own local experience [4-6], while a study from Australia reported a minimal reduction in overall emergency cases of only 12%, and a subgroup analysis of the general surgery emergencies shows a variation of -14% [7]. These disparities can be due to the different national guidelines, but the variations between the pre-Covid era and the first months of the Covid outbreak always present with a minus sign. The reason for this general reduction of admissions, that reflects a general reduction of presentations to the Emergency Departments, is not utterly clear, but it may be due to the government policies of self-isolation with the aim to avoid overstretching the health system or probably just to the fear of being infected while attending the hospital [5]. However, it is not clear also if this reduction is associated with an actual decrease of the incidence of emergency pathologies – possibly explained by a healthier lifestyle during lockdown – or if it is because patients with fewer symptoms and no systemic illness decided to stay at home and possibly self-medicate. In this last case, we would expect that the admitted patients were in poorer general conditions. In fact, our data showed a significant reduction of ASA 1 patients (-52%), while ASA 5 patients did not reduce at all. Also in percentage, ASA 1 patients passed from 29% to 21% of all admitted patients, while ASA 3 and 4 patients passed from 29% and 8% to 32% and 10% respectively. Same results were found by analyzing the frailty score, where score 1-2 patients went from 54% to 48% and score >2 went from 46% to 53%. Expectedly, these findings confirm that patients in poorer general conditions were more likely to attend the hospital during lockdown with respect to healthier ones. It could be surely argued that the suggestion to “stay at home as much as possible” to save precious resources for more severe Covid patients might have caused the presentation of patients in more advanced stages of the disease. This may possibly be the case with acute cholecystitis and acute appendicitis [8] and more generally with peritonitis [9]. Our study did not consider the degree of severity of each of the analysed conditions, but if we take the therapeutic approach as an indirect index of severity, we could state that in our experience there was no difference in severity of the presentations between the pre-Covid and the Covid eras (Table 5). The indications for surgery did not change during the first lockdown, despite suggestions and guidelines. However, this may be a biased conclusion, because most of the patients included into the analysis are from Italy and in that Country the guidelines were not so restrictive as elsewhere, where they suggested conservative non-operative management as much as possible against surgery. In fact, our data suggest that Italian surgeons were more aggressive in that they tended to use surgery much more frequently than their non-Italian colleagues in both periods of the study, with no change of attitude during the pandemic, while non-Italian units became even more conservative. This difference is not statistically significant and does not affect the overall results of our audit but shows a different cultural approach to surgical emergencies in terms of different criteria of admissions – where Italian surgeons tend to admit patients who more likely would need surgery – or different choices of treatment strategy – where non-Italian units, possibly considering local factors, prefer conservative management as much as possible. Interesting data came from the observation that patients with small bowel obstruction (SBO) were treated with surgery much less frequently during the pandemic, thus confirming the suggestion of evidence and guidelines [10]. While other diagnoses, such as appendicitis, are generally not a therapeutic dilemma, our audit showed that our treatment of patients with SBO may be too often too aggressive. In fact, while in the pre-Covid era patients with SBO were treated by surgery still in almost 64% of cases, during the Covid lockdown surgery was considered necessary in 55% of patients (Table 5). We believe that this percentage can be further reduced as soon as the above reported results are incorporated in new policies and guidelines on the treatment of SBO possibly reinforcing the role of non-operative management. Also, the kind of access (laparoscopic vs open vs laparoscopic converted to open) did not change significantly, but the comparative analysis showed that during the first Covid lockdown 40% were treated laparoscopically, against 43% of the pre-Covid period, showing a 5% relative reduction. Interestingly, there were less lap-to-open conversions during the Covid period, probably as an unwanted consequence of restricted indications to laparoscopy, as some hasty guidelines suggested. These results were confirmed also at the subgroup analysis by type of operation for the most common procedures (Table 3). Many Authors suggested avoiding laparoscopy on the ground that it could be considered “unsafe” due to the risk of inhalation of surgical plume. We agree that the inhalation of surgical smoke can potentially be an occupational health issue due to chemical risk, but in the specific situation of the Covid pandemic, there is still no clear evidence suggesting transmission of viral particles through the surgical smoke [11]. Probably a stricter selection of patient led to a reduced rate of readmission (overall -16%, from 9% to less than 8%), but this can also be due to the gradual introduction, during the first lockdown, of social restrictions in terms of more difficult access to hospital care, so that patients who previously would be admitted for a postoperative complication, were preferably treated at home during the Covid lockdown. The distribution of the various discharge diagnosis changed significantly during the Covid period with respect to the pre-Covid era (Table 4). Some of the changes we have highlighted during our audit can be due to normal variations, but some other are clearly not random but somehow related to the Covid pandemic or, better, to our response to it. This is for instance the case with acute appendicitis and acute diverticulitis, that had an absolute reduction of 42% and 50% respectively. As previously discussed, it is not clear if this reduction reflects a true fall of the incidence of these disorders or if it is due to a strict selection of the patients to be admitted, while less severe cases could be treated at home. This should open a frank discussion aimed at reviewing our criteria of surgical admission. In fact, if we could demonstrate that more patients can be easily treated at home with the same results of in-patients, we would introduce a huge improvement of resource utilization in our already very stretched national health systems. Initiative like the “Hospital At Home” scheme should be widely applied also to surgical emergency patients [12]. Other diseases likely reduced due to more people staying at home, and therefore hopefully having better diets and lifestyles, as it may be the case with symptomatic gallstones and gastro-oesophageal reflux, both reduced by more than 50%. On the contrary, other diagnoses became more frequent. We confirmed the common perception that the incidence of symptomatic haemorrhoids and rectal prolapse increased significantly during the first lockdown. This can be explained with the more sedentary life and the reduction of physical workout. On the contrary, the significant increase of stoma complications (+168.8%) demonstrated in our audit may be a direct consequence of the temporary closure of non-vital health services. A much more extensive investigation would be necessary to explain the relative increase of cases of bowel ischaemia as it is well known that Covid infection can cause microvascular thrombosis [13], but an increase of cases of unexplained bowel ischaemia during the Covid period has been demonstrated also in patients who resulted negative at naso-pharyngeal swab and broncho-alveolar lavage [14]. This in-depth analysis is beyond the scope of this work. Significant strength of this paper is its wide sample size, yielding clear and significant data on emergency surgical admissions during the first wave of Covid-19 pandemic as compared with the same period of the previous year. The characteristics of admitted patients have been reported and analysed thoroughly. This paper has also some limitations. First, it is supposed to give only a snapshot of the first two months of pandemic, but the Covid-19 infection did not break out at the same time in different Countries, therefore the choice of March-April may be arbitrary. Second, the fact that most of participating centres were in Italy might have introduced a selection bias linked to the different national policies and guidelines, but, as discussed above, this is not statistically significant. Conclusions In conclusion, this paper demonstrates a significant overall reduction of emergency surgical admissions during the first lockdown, with a minimal but significant change of the proportions of the single presentations and diagnoses. Further large studies may be necessary to find out if the reduction of surgical emergency admissions reflects a true reduction of incidence or it is just the evidence that more patients were treated non-operatively at home with the same results than during an hospital admission. Assuming that the reduction of admissions is due to more patients being treated at home, this opens the door to new ways to manage surgical emergencies while reducing the pressure on the already stretched resources of our health systems. Clearly, new policies in this sense must be supported by a growing cooperation between patients (=customers), health professionals and policy-makers, all committed towards a more sustainable and evidence-based healthcare. Abbreviations ACOI: Associazione dei Chirurghi Ospedalieri Italiani ANOVA: Analysis of Variance ASA: American Society of Anaesthesiologists NS: not significant GI: gastrointestinal IBD: Inflammatory Bowel Disease PI: Principal Investigator PLI: Principal Local Investigator SBO: small bowel obstruction SC: Study Coordinator WSES: World Society of Emergency Surgery Declarations Authors’ contributions: Conceptualisation and study plan: GDT, MSM, MB, GBS, CL, RC, SDS, FC, MS and PM Study coordinator: GDT Principal investigator: MB Local data collection and anonymisation: CovidICE-International Collaborative* Central data collection and analysis: GDT and MSM Interpretation of data: GDT, MSM, MB, GBS, CL, RC, SDS, FC, MS and PM WSES relationships: GDT, RC, SDS and FC ACOI relationships: GDT, MS and PM Manuscript drafting: GDT and MSM Manuscript final version approval: All Authors including the CovidICE-International Collaborative Funding No funding was available for this study Availability of data and material: The dataset generated and analysed during the current study are available from the corresponding Author upon reasonable request Ethics approval and consent to participate Formal ethical committee approval was not deemed to be necessary due to the retrospective nature and anonymised nature of the audit. However, the study was approved by the Comitato Etico ATS Sardegna on 22.12.2020 and was sponsored by the World Society of Emergency Surgery and by the Associazione dei Chirurghi Ospedalieri Italiani. Consent for publication Not applicable Competing interests The authors declare that they have no competing interests. All authors certify that they have no affiliations with or involvement in any organisation or entity with any financial or non-financial interest in the subject matter or materials discussed in this manuscript. References 1. Tebala GD, Bond-Smith G. Guidelines and recommendations during the Covid-19 pandemic: a word of caution. Am J Surg 2020;220:1526-1527 2. Aranda-Narvaez JM, Tallon-Aguilar L, Pareja-Ciurò F, Martin-Martin G, Gonzales-Sanchez AJ, Rey-Simo I, Tamayo-Medel G, Yanez-Benitez C Costa-Navarro D, Monton-Condon S, Navarro-Soto S, Turegano-Fuentes F, Perez-Diaz MD, Ceballo-Esparragon J, Jover-Navalon JM, Balibrea JM, Morales-Conde S. 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Dig Liver Dis 2020;52:1090-1091 Tables Table 1. Characteristics of the patients and variations between the two periods of the study. Factor 2019* 2020* Absolute variation § p TOTAL 3810 2453 -35.6% Age 59.1±21.1 59.9±20.3 +1.4% 0.11676 Gender (F/M) 1875/1935 1211/1242 -35.4% / -35.8% 0.90435 Presentation Abdominal pain 2709 (71.1%) 1680 (68.5%) -38.0% 0.00552 Bowel obstruction 183 (4.8%) 148 (6.0%) -19.1% GI bleeding 154 (4.0%) 142 (5.8%) -7.8% Anorexia/Weight loss 7 (0.2%) 3 (0.1%) -57.1% Jaundice 113 (3.0%) 67 (2.7%) -40.7% Diarrhoea/Vomit 92 (2.4%) 63 (2.6%) -31.5% Dysphagia 9 (0.2%) 10 (0.4%) +11.1 Non-trauma haemoperitoneum 4 (0.1%) 2 (0.1%) -50.0% Anal pain 114 (3.0%) 49 (2.0%) -57.0% Fever 24 (0.6%) 19 (0.8%) -20.8% Anaemia 15 (0.4%) 4 (0.2%) -73.3% Hernia 169 (4.4%) 94 (3.8%) -44.4% Skin issue 60 (1.6%) 51 (2.1%) -15.0% Wound complications 10 (0.3%) 2 (0.1%) -80% Postop complications 43 (1.1%) 34 (1.4%) -20.9% Breast pain 5 (0.5%) 7 (0.3%) +40.0% Chest pain 40 (1.0%) 26 (1.1%) -35% Ischaemic limb 12 (0.3%) 12 (0.5%) 0% Non traumatic shock 17 (0.4%) 17 (0.7%) 0% Abnormal radiology 6 (0.2%) 2 (0.1%) -66.7% Other 24 (0.6%) 21 (0.9%) -12.5% Missing 0 0 Smoking No 2616 (72.7%) 1428 (61.5%) -45.4% <0.0001 Yes 833 (23.2%) 599 (25.8%) -28.1% Ex 147 (4.1%) 296 (12.7%) +101.4% Missing 214 130 ASA 1 1007 (29.0%) 477 (20.6%) -52.6% <0.0001 2 1167 (33.6%) 834 (36.0%) -28.5% 3 1004 (28.9%) 749 (32.4%) -25.4% 4 277 (8.0%) 238 (10.3%) -14.1% 5 16 (0.5%) 16 (0.7%) 0% Missing 339 139 Frailty score 1-2 2060 (54.1%) 1165 (47.5%) -43.4% 2 1750 (45.9%) 1287 (52.5%) -26.5% Missing 0 1 *: values are reported as: total number (relative percentage in the column) §: values represent the absolute variation of cases between March-April 2019 and March-April 2020 Table 2. Treatment of the patients and its outcome and variations between the two periods of the study. Factor 2019* 2020* Absolute variation § p Treatment Medical 1175 (30.8%) 808 (33.0%) -31.2% 0.12282 Surgical 2391 (62.8%) 1505 (61.4%) -37.1% Interventional 244 (6.4%) 137 (5.6%) -43.9% Missing 0 3 Surgical access Laparoscopic 952 (42.7%) 559 (40.4%) -41.3% 0.11324 Open 1257 (56.4%) 818 (59.1%) -34.9% Lap converted to open 19 (0.8%) 6 (0.4%) -68.4% Missing 171 107 Lap-to-open conversion 19/971 (2.0%) 6/565 (1.1%) -45.0% 0.18140 Surgical subspecialty Colorectal 1307 (54.9%) 809 (53.9%) -38.1% 0.00603 Upper GI 85 (3.6%) 70 (4.7%) -17.6% HPB 416 (17.5%) 256 (17.1%) -38.5% Abdominal wall 281 (11.8%) 150 (10.0%) -46.6% I&D of abscesses 138 (5.8%) 98 (6.5%) -29.0% Chest 35 (1.5%) 13 (0.9%) -62.9% Vascular 21 (0.9%) 11 (0.7%) -47.6% Urology/Gynae 14 (0.6%) 7 (0.5%) -50.0% Other 82 (3.4%) 87 (5.8%) +6.1% Missing 12 4 Length of stay 7.8±10.5 7.7±10.0 -1.5% 0.65716 Reoperation No 3457 (96.6%) 2334 (96.6%) -32.5% 0.93414 Yes 120 (3.4%) 82 (3.4%) -31.7% Missing 233 37 Readmission No 3398 (91.0%) 2247 (92.4%) -33.9% 0.05906 Yes 335 (9.0%) 185 (7.6%) -44.8% Missing 77 21 *: values are reported as: total number (relative percentage in the column) §: values represent the absolute variation of cases between March-April 2019 and March-April 2020 Table 3. Surgical access for the most common operations. * “Hernia repair” includes inguinal, femoral, umbilical, ventral and incisional hernias. Access 2019 2020 p Appendicectomy Laparoscopic 434 (81.6%) 249 (83.0%) 0.36888 Open 91 (17.1%) 50 (16.7%) Lap to open 7 (1.3%) 1 (0.3%) Cholecystectomy Laparoscopic 321 (81.9%) 188 (76.4%) 0.24021 Open 68 (17.3%) 56 (22.8%) Lap to open 3 (0.8%) 2 (0.8%) Hernia repair* Laparoscopic 22 (7.8%) 12 (8.1%) 0.91902 Open 259 (92.2%) 136 (91.9%) Lap to open 0 0 Large bowel resection Laparoscopic 40 (14.6%) 24 (11.6%) 0.49189 Open 231 (84.6%) 180 (87.4%) Lap to open 2 (0.7%) 2 (1.0%) Small bowel resection Laparoscopic 3 (1.8%) 4 (3.0%) 0.57322 Open 165 (96.5%) 122 (96.1%) Lap to open 3 (1.8%) 1 (0.8%) Table 4. Discharge diagnosis in the two periods of the study. Diagnosis 2019* 2020* Absolute variation § P Acute appendicitis 609 (16.0%) 356 (14.5%) -41.5% <0.0001 Acute cholecystitis 445 (11.7%) 310 (12.6%) -30.3% Small bowel obstruction 379 (9.9%) 232 (9.5%) -38.8% Complicated diverticulitis 268 (7.0%) 135 (5.5%) -49.6% Complicated inguinal hernia 199 (5.2%) 110 (4.5%) -44.7% Acute pancreatitis 174 (4.6%) 121 (4.5%) -30.5% Complicated colon cancer 155 (4.1%) 114 (4.5%) -26.5% Complicated gastritis / peptic ulcer 134 (3.5%) 88 (3.6%) -34.2% Complicated ventral hernia 132 (3.5%) 84 (3.4%) -36.4% CBD stones 129 (3.4%) 76 (3.1%) -41.1% Gallstones 124 (3.3%) 61 (2.5%) -50.8% Non-specific abdominal pain 112 (2.9%) 71 (2.9%) -36.6% Perianal abscess/fistula/fissure 101 (2.7%) 69 (2.8%) -31.7% Superficial collection 66 (1.7%) 52 (2.1%) -21.2% Advanced cancer (any) 62 (1.6%) 28 (1.1%) -54.8% Bowel ischaemia 56 (1.5%) 51 (2.1%) -8.9% Constipation 45 (1.2%) 9 (0.4%) -80% Small bowel cancer 38 (1.0%) 30 (1.2%) -21.1% UTI / orchitis / epididymitis / torsion 30 (0.8%) 20 (0.8%) -33.3% Postop bleeding 30 (0.8%) 1 (0.04%) -96.7% Upper GI cancer 30 (0.8%) 17 (0.7%) -43.3% Haemorrhoids/Prolapse 28 (0.7%) 26 (1.1%) -7.1% Ischaemic limb 28 (0.7%) 21 (0.5%) -57.1% Spontaneous PNX 28 (0.7%) 12 (0.5%) -57.1% Pancreatic cancer 25 (0.7%) 8 (1.2%) -68.0% Anastomotic leak 24 (0.6%) 19 (0.8%) -0.8% Sigmoid/Caecal volvulus 22 (0.6%) 17 (0.7%) -22.7% GORD / Hiatus hernia 22 (0.6%) 11 (0.4%) -50.0% Goitre 22 (0.6%) 20 (0.8%) -9.1% Anaemia 22 (0.6%) 21 (0.9%) -4.5% IBD 20 (0.5%) 22 (0.9%) +10.0% Deep SSI 18 (0.5%) 6 (0.2%) -66.7% Abdominal abscess 18 (0.5%) 19 (0.8%) +5.6% Stoma complication 16 (0.4%) 43 (1.8%) +168.8% Spontaneous haemoperitoneum 16 (0.4%) 6 (0.2%) -62.5% Iatrogenic GI perforation 13 (0.3%) 9 (0.4%) -30.8% Hepatobiliary cancer 11 (0.3%) 7 (0.3%) -36.4% Benign large bowel obstruction 10 (0.3%) 10 (0.4%) 0% Biliary fistula 8 (0.2%) 2 (0.1%) -75.0% Superficial SSI 8 (0.2%) 6 (0.2%) -25.0% Kidney stone 8 (0.2%) 3 (0.1%) -62.5% PID / Endometriosis 8 (0.2%) 3 (0.1%) -62.5% Medical sepsis 7 (0.2%) 3 (0.1%) -57.1% Unspecified peritonitis 5 (0.1%) 2 (0.1%) -60.0% Breast infection 5 (0.1%) 6 (0.2%) +20.0% Aortic aneurysm 4 (0.1%) 2 (0.1%) -50.0% Enteric fistula 4 (0.1%) 6 (0.2%) +50.0% Liver abscess 4 (0.1%) 4 (0.2%) 0% GIST 4 (0.1%) 4 (0.2%) 0% Oesophageal varices 3 (0.1%) 4 (0.2%) +33.3% Small bowel perforation 3 (0.1%) 0 -100.0% Small bowel/large bowel bleeding 3 (0.1%) 3 (0.1%) 0% Upper GI stricture 2 (0.1%) 23 (0.9%) +1050.0% Meckel 2 (0.1%) 1 (0.04%) -50.0% Spleen/liver ischaemia, bleeding, cyst 2 (0.1%) 6 (0.2%) -200.0% Gallstone ileus 2 (0.1%) 0 -100.0% Infective colitis/enteritis 0 1 (0.04%) +100.0% Bladder perforation 0 1 (0.04%) Other 67 (1.8%) 70 (2.8%) +4.5% Missing 0 0 *: values are reported as: total number (relative percentage in the column) §: values represent the absolute variation of cases between March-April 2019 and March-April 2020 Table 5. Treatment per diagnosis per year Treatment 2019 2020 p Acute pancreatitis Medical 132 (75.9%) 96 (79.3%) 0.48247 Surgical 27 (15.5%) 19 (15.7%) Interventional 15 (8.6%) 6 (5.0%) Hot gallbladder Medical 202 (28.8%) 136 (30.6%) 0.81865 Surgical 401 (57.2%) 248 (55.7%) Interventional 98 (14.0%) 61 (13.7%) Acute appendicitis Medical 53 (8.5%) 32 (8.8%) 0.97813 Surgical 567 (91.2%) 329 (90.9%) Interventional 2 (0.3%) 1 (0.3%) Diverticulitis Medical 159 (59.3%) 73 (54.1%) 0.49189 Surgical 99 (36.9%) 58 (43.0%) Interventional 10 (3.7%) 4 (3.0%) Small bowel obstruction Medical 131 (34.6%) 103 (44.4%) 0.02324 Surgical 241 (63.6%) 128 (55.2%) Interventional 7 (1.8%) 2 (0.5%) Additional Declarations No competing interests reported. Supplementary Files Appendix.docx Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 21 Dec, 2021 Reviews received at journal 07 Dec, 2021 Reviewers agreed at journal 05 Dec, 2021 Reviewers invited by journal 04 Dec, 2021 Editor assigned by journal 24 Nov, 2021 Submission checks completed at journal 24 Nov, 2021 First submitted to journal 23 Nov, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1106929","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":65633744,"identity":"c7e4c5b8-a2b2-494b-b236-5764c805d6a6","order_by":0,"name":"Giovanni D. Tebala","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDElEQVRIiWNgGAWjYDACZgjFA8RsDAwFDHJgNmMDVAyvFjaQFgMGY8Ja4ACqJbGBkBZ5d+ZjEj933JFhkG8+9uCHgV16v0TuAebCHXUMBmcOYNVieJgtTbL3zDOgw9jSDXsMknNnzshLYJ555jCDwdkG7FqaeYwNeNsOA7XwmEnwGDDnbriRY8DM23aAweA8doeBtBj+BWvh/yb5x6A+3QCipQ6nFnlmHsPHUFvYpHkMDidAtTDjdJgBM1viY1mgFja2NHNjGYPjhjN73hgcBhkiicP78v2HDxx823bYnp/58LOHbyqq5fnZc0D21snxnUnAbgvMJDZkUZAgzoiUx+7eUTAKRsEoGAVIAABBD1K8KBppdAAAAABJRU5ErkJggg==","orcid":"","institution":"Oxford University Hospitals NHS Foundation Trust","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Giovanni","middleName":"D.","lastName":"Tebala","suffix":""},{"id":65633745,"identity":"78ca5b71-0f12-482e-8add-7ee42db5d604","order_by":1,"name":"Marika S. Milani","email":"","orcid":"","institution":"Causa Pia Luvini Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Marika","middleName":"S.","lastName":"Milani","suffix":""},{"id":65633747,"identity":"da953aa6-eaea-482e-a73c-3ca763da69d2","order_by":2,"name":"Mark Bignell","email":"","orcid":"","institution":"Oxford University Hospitals NHS Foundation Trust","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mark","middleName":"","lastName":"Bignell","suffix":""},{"id":65633748,"identity":"b536a74b-977e-4816-b990-08bf4f51212b","order_by":3,"name":"Giles Bond-Smith","email":"","orcid":"","institution":"Oxford University Hospitals NHS Foundation Trust","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Giles","middleName":"","lastName":"Bond-Smith","suffix":""},{"id":65633749,"identity":"2781d482-75d1-42d8-a4dc-0a0ab0c830e8","order_by":4,"name":"Chris Lewis","email":"","orcid":"","institution":"Oxford University Hospitals NHS Foundation Trust","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chris","middleName":"","lastName":"Lewis","suffix":""},{"id":65633750,"identity":"853f1a4b-d9a5-4ce2-89f5-ee63d9360202","order_by":5,"name":"Roberto Cirocchi","email":"","orcid":"","institution":"University of Perugia","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Roberto","middleName":"","lastName":"Cirocchi","suffix":""},{"id":65633751,"identity":"d8cdc296-2aea-4901-ae51-466677fe785d","order_by":6,"name":"Salomone Di Saverio","email":"","orcid":"","institution":"Madonna del Soccorso Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Salomone","middleName":"Di","lastName":"Saverio","suffix":""},{"id":65633752,"identity":"c7aabf50-f624-4ccc-9b62-5a7265433be0","order_by":7,"name":"Fausto Catena","email":"","orcid":"","institution":"“M.Bufalini” Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Fausto","middleName":"","lastName":"Catena","suffix":""},{"id":65633754,"identity":"5d5ea87a-c566-43c6-8936-8ec2098726d3","order_by":8,"name":"Marco Scatizzi","email":"","orcid":"","institution":"S.Maria Annunziata Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Marco","middleName":"","lastName":"Scatizzi","suffix":""},{"id":65633756,"identity":"1c207d5b-afbc-43f9-b4df-ed1a8e20855f","order_by":9,"name":"Pierluigi Marini","email":"","orcid":"","institution":"S.Camillo-Forlanini Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Pierluigi","middleName":"","lastName":"Marini","suffix":""}],"badges":[],"createdAt":"2021-11-23 11:14:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1106929/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1106929/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":16027785,"identity":"5a62b2d4-7a69-4823-81e4-7d228f7a57ba","added_by":"auto","created_at":"2021-11-30 16:49:58","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":13450,"visible":true,"origin":"","legend":"Most common diagnoses (p=0.23745). \n“Hot gallbladder” includes acute cholecystitis and refractory biliary colic\n“Diverticulitis“ includes complicated and uncomplicated acute diverticulitis\n“SBO” is small bowel obstruction\n","description":"","filename":"fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-1106929/v1/11f1de37a4b3191c05cbd70c.png"},{"id":16027786,"identity":"e0b4021c-e128-49b3-bb40-30c742696a40","added_by":"auto","created_at":"2021-11-30 16:50:06","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":398410,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1106929/v1/b3465637-1043-4bcf-be04-197011fa9495.pdf"},{"id":16027784,"identity":"b771dbdc-f8c2-49dd-81d1-83c3fa5b005d","added_by":"auto","created_at":"2021-11-30 16:49:58","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":16378,"visible":true,"origin":"","legend":"","description":"","filename":"Appendix.docx","url":"https://assets-eu.researchsquare.com/files/rs-1106929/v1/815831bb9fdb5fb6ca41d354.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eEmergency Surgery Admissions and The COVID-19 Pandemic: Did The First Wave Really Change Our Practice? Results of An ACOI/WSES International Audit On 6263 Patients.\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eThe Covid-19 pandemic has radically changed our life and work. In particular, it is having a significant and long-lasting impact on healthcare. Each and every health system underwent radical changes to adapt to the growing number of emergency admissions for respiratory syndromes, most of which needed intensive care, and every Country produced their own guidelines and policies to deal with this unexpected disaster. Most elective services have been stopped, with some differences among Countries, but emergency admissions had to be treated anyway, although with reduced resources. A common government advice was to avoid attending the Emergency Department if not strictly necessary, to leave room for more severe cases of Covid-19-associated respiratory failure and to avoid Covid-19 cross-infection. This caused a perceived reduction of all the non-Covid emergency admissions, in particular those of surgical remit. However, the general perception among surgeons was that the many causes for emergency presentation did not reduce proportionally. Aim of our international audit was to have a snapshot of the absolute and relative change of surgical emergency admissions during the first wave of the Covid-19 pandemic. Limiting our audit to the outbreak of the pandemic \u0026ndash; instead of considering the whole course \u0026ndash; allowed us to analyse the impact of the worldwide infection at its maximum, when most Countries were not yet prepared to respond.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003eWe analysed data of patients admitted into Emergency Surgery Units in the months of March and April 2020 and compared them with same datasets of patients admitted in the months of March and April 2019. March-April 2020 were the first two months of the global pandemic in Europe. The control period March-April 2019 was chosen as a significant match to avoid seasonal biases.\u003c/p\u003e\n\u003cp\u003eA short version of the protocol of this retrospective audit was disseminated by email to Emergency Surgical units in Europe. The units that confirmed their interest in participating to this study were emailed the full protocol and an empty database to collect their anonymised demographic and clinical data. Only adult patients admitted to the Surgical Emergency Units have been included. Patients aged \u0026lt;18 and those with \u0026lt;80% of complete data have been excluded. Single patients\u0026rsquo; data have been accessed only by those who have anyway daily access to that information for their clinical work. Data from each unit have been collected under the responsibility of the Principal Local Investigator (PLI), anonymised and sent by secure encrypted email to the Study Coordinator (SC). Thereafter, data have been centrally coded, collected into an encrypted electronic database (Microsoft Excel for Mc v.16.54) and analysed with a statistical package (StatPlus Mac Pro 8.0.1.0). No patient could be identified in the main central database.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFrequency variables have been compared by the Pearson Chi-square test. Continuous variables have been tested for distribution and skewness and then compared by one-way analysis of variance (ANOVA). Values of p\u0026lt;0.05 have been considered significant.\u003c/p\u003e\n\u003cp\u003ePrimary endpoint of the study was to evaluate the relative variation of the presentation symptoms and discharge diagnoses between the two study periods.\u003c/p\u003e\n\u003cp\u003eSecondary endpoint was to identify the possible change of therapeutic strategy during the same two periods.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMissing data have been excluded listwise. This may account for minimal numeric discrepancies in the calculation of frequencies. The factors who had more than 10% of missing data have been excluded from the analysis.\u003c/p\u003e\n\u003cp\u003eValues in the text, tables and figures are approximated to the tenths.\u003c/p\u003e\n\u003cp\u003eEthical committee approval was not considered to be necessary due to the retrospective nature of the study and the fact that sensible data were all fully anonymised by the local research team before being transmitted and analysed by the central team. However, the study was approved by the Comitato Etico ATS Sardegna on 22.12.2020 and was approved and endorsed by the World Society of Emergency Surgery (WSES) and the Association of Italian Hospital Surgeons (ACOI \u0026ndash; Associazione dei Chirurghi Ospedalieri Italiani).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eForty-five centres participated in the study (39 from Italy, 2 from UK, 2 from Spain, 1 from Portugal, 1 from France) for a total of 6263 patients. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults are listed in Tables 1 to 5 and in Figure 1. Only the most significant are hereby reported.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 1 reports the characteristics of the patients enrolled in the study. In March-April 2019 the participating units admitted 3810 patients, whereas during the Covid-19 first wave they admitted 2453 patients, for a 35.6% absolute reduction. Therefore, in evaluating the reduction of single items, a reduction of or around 35.6% is considered to be due to the overall reduction of admissions, whereas a variation of more than -35.6% may signify a relative reduction of that single factor and a reduction of less than -35.6% means that that single factor had a relative increase. In case of positive variation, it means that that item has had a significant relative increase.\u003c/p\u003e\n\u003cp\u003eAge of admitted patients and gender distribution did not change between the two periods (59.1\u0026plusmn;21.1 vs 59.9\u0026plusmn;20.3, p=NS, and 1875/1935 vs 1211/1242, p=NS, respectively). The most frequent reason for admission was \u0026ldquo;abdominal pain\u0026rdquo; in both periods, with a reduction of 38%. This is still consistent with the general reduction of admissions. However, some causes of presentation reduced much more than expected. This is the case with \u0026ldquo;anal pain\u0026rdquo; (-57%), \u0026ldquo;anaemia\u0026rdquo; (-73.3%), \u0026ldquo;hernias\u0026rdquo; (-44.4%), \u0026ldquo;anorexia/weight loss\u0026rdquo; (-57.1%) and \u0026ldquo;wound complications\u0026rdquo; (-80%). Other presentations reduced much less or, unexpectedly, increased, such as \u0026ldquo;bowel obstruction\u0026rdquo; (-19.1%), \u0026ldquo;GI bleeding\u0026rdquo; (-7.8%) and \u0026ldquo;dysphagia\u0026rdquo; (+11.1%).\u003c/p\u003e\n\u003cp\u003eThe number of ASA 1 patients decreased of 52.6%, while patients in poorer general conditions were admitted more often (variation: ASA 2, -28.5%, ASA 3, -25.4%, ASA 4, -14.1%, ASA 5, 0%). This trend has been confirmed by evaluating the Frailty Score. Patients with no or minimal frailty (1-2) were admitted less frequently (-43.4% reduction between 2019 and 2020), whereas more frail patients were admitted more frequently (-26.5% reduction, which means a relative increase with respect to the -36.5% overall reduction of admissions).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 2 shows the treatment of the patients and their outcomes. The type of treatment (medical vs surgical vs interventional) and the surgical access (laparoscopic vs open vs laparoscopic converted to open) did not change much during the two study periods. However, the rate of laparoscopy-to-open conversion halved between the two periods (not statistically significant, though).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTo assess if the unbalanced distribution of participating units would add a significant bias, a comparison between Italian and non-Italian centres has been performed. It showed that Italian surgeons were more prone to treat their patients with surgery in both periods with respect to their non-Italian counterparts (in 2019, 68.5% vs 48.7%, in 2020, 70.7% vs 42.6%, p=0.000). Furthermore, while non-Italian centres showed a small relative reduction of the surgical approach (from 48.7% of all treatments to 42.6%, variation=-12.6%) (and a contemporaneous increase of non-operative management), the attitude of Italian units showed a minimal relative increase in the surgical approach (from 68.5% of all treatments to 70.7%, variation=+3.2%), but this difference was not statistically significant.\u003c/p\u003e\n\u003cp\u003eIn the general series, some subspecialties had a more significant reduction (p=0.006). For instance, chest and abdominal wall surgery reduced more (respectively, -62.9% and -46.6%), while upper GI had a relative increase (-17.6%).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTotal length of stay was 7.8\u0026plusmn;10.5 days in the first period and 7.7\u0026plusmn;10.0 days in the second period (p=NS). The percent reduction of the reoperations was consistent with the overall reduction of cases (p=NS), but reduction of readmissions was significantly more than expected (-44.8%, p=0.059).\u003c/p\u003e\n\u003cp\u003eTable 3 examines the surgical access in the most common operations. Appendicectomies and cholecystectomies were performed by laparoscopy in the vast majority of cases (81.6% in 2019 and 83.0% in 2020 and 81.9% in 2019 and 76.4% in 2020, respectively). Hernia repairs, large bowel resections and small bowel resections have been more frequently performed by open surgery (92.2% vs 91.9%, 84.6% vs 87.4% and 96.5% vs 96.1%, respectively). There was no significant difference of approach between the two periods of the study.\u003c/p\u003e\n\u003cp\u003eTables 4 and 5 and Figure 1 deal with discharge diagnosis. The most frequent discharge diagnoses were acute appendicitis, acute cholecystitis and small bowel obstruction (SBO). The overall incidence of the different diagnoses changed significantly between the two study periods (p\u0026lt;0.0001). While the incidence of admission for \u0026ldquo;acute appendicitis\u0026rdquo; reduced by 41.5% (much more than expected) and for \u0026ldquo;acute diverticulitis\u0026rdquo; reduced by 49.6%, other diagnoses, such as \u0026ldquo;bowel ischaemia\u0026rdquo; and \u0026ldquo;haemorrhoids/rectal prolapse\u0026rdquo; reduced less significantly (respectively, -8.9% and -7.1%), thus showing a relative growth, and others even had an absolute increase (IBD +10%, stoma complications +168.8%, enteric fistulas +50%, oesophagogastric strictures +1050%). An analysis of the most frequent diagnoses (acute pancreatitis, hot gallbladder, acute appendicitis, diverticulitis and small bowel obstruction) whose results are depicted in Figure 1, did not showed any relative change.\u003c/p\u003e\n\u003cp\u003eThe treatment of acute pancreatitis, hot gallbladder, acute appendicitis and diverticulitis did not change significantly, but SBO was treated surgically much less frequently (63.6% in 2019, 55.2% in 2020 \u0026ndash; p=0.02324).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eCovid-19 is a worldwide pandemic affecting all Countries and taking by surprise every national healthcare system at its onset. Fortunately, due to immunization policies and containment guidelines, possibly helped by the natural weakening of the virus, the second and third waves of infection have been slightly less severe than the first and thankfully now the infection is reducing, at least in the western Countries. In most cases, social isolation has been used to control the spread of the virus. In some Countries, like the UK, this has meant an almost complete cessation of elective surgical work with significantly reduced capacity within primary care due to a combination of strict triage of patients and sickness within the workforce. Other governments and scientific societies have produced different guidelines, leading to different outcomes, mostly regarding the reduction of elective surgical operations. Sometimes, medical guidelines have been too drastic and widely controversial [1] also because with the aim of creating room for Covid-19 patients they reduced the capacity for elective and non-Covid emergency patients. On the contrary, we believe, in agreement with other Authors [2], that therapeutic indications should not change during this pandemic, because in our role of doctors in \u0026ldquo;developed\u0026rdquo; Countries we are morally bound to maintain high standards of care despite the pandemic [3]. It would be expected that this reduction in capacity would result in an increase in attendances across emergency services within secondary care, but this has failed to materialize with a reduction in attendances in all emergency departments including surgical emergency units.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOur audit demonstrated an overall reduction in surgical emergency admission of about 36%, while average age and gender distribution did not change significantly. Few Italian Authors have reported a much more significant reduction on the basis of their own local experience [4-6], while a study from Australia reported a minimal reduction in overall emergency cases of only 12%, and a subgroup analysis of the general surgery emergencies shows a variation of -14% [7]. These disparities can be due to the different national guidelines, but the variations between the pre-Covid era and the first months of the Covid outbreak always present with a minus sign.\u003c/p\u003e\n\u003cp\u003eThe reason for this general reduction of admissions, that reflects a general reduction of presentations to the Emergency Departments, is not utterly clear, but it may be due to the government policies of self-isolation with the aim to avoid overstretching the health system or probably just to the fear of being infected while attending the hospital [5]. However, it is not clear also if this reduction is associated with an actual decrease of the incidence of emergency pathologies \u0026ndash; possibly explained by a healthier lifestyle during lockdown \u0026ndash; or if it is because patients with fewer symptoms and no systemic illness decided to stay at home and possibly self-medicate. In this last case, we would expect that the admitted patients were in poorer general conditions. In fact, our data showed a significant reduction of ASA 1 patients (-52%), while ASA 5 patients did not reduce at all. Also in percentage, ASA 1 patients passed from 29% to 21% of all admitted patients, while ASA 3 and 4 patients passed from 29% and 8% to 32% and 10% respectively. Same results were found by analyzing the frailty score, where score 1-2 patients went from 54% to 48% and score \u0026gt;2 went from 46% to 53%. Expectedly, these findings confirm that patients in poorer general conditions were more likely to attend the hospital during lockdown with respect to healthier ones.\u003c/p\u003e\n\u003cp\u003eIt could be surely argued that the suggestion to \u0026ldquo;stay at home as much as possible\u0026rdquo; to save precious resources for more severe Covid patients might have caused the presentation of patients in more advanced stages of the disease. This may possibly be the case with acute cholecystitis and acute appendicitis [8] and more generally with peritonitis [9]. Our study did not consider the degree of severity of each of the analysed conditions, but if we take the therapeutic approach as an indirect index of severity, we could state that in our experience there was no difference in severity of the presentations between the pre-Covid and the Covid eras (Table 5).\u003c/p\u003e\n\u003cp\u003eThe indications for surgery did not change during the first lockdown, despite suggestions and guidelines. However, this may be a biased conclusion, because most of the patients included into the analysis are from Italy and in that Country the guidelines were not so restrictive as elsewhere, where they suggested conservative non-operative management as much as possible against surgery. In fact, our data suggest that Italian surgeons were more aggressive in that they tended to use surgery much more frequently than their non-Italian colleagues in both periods of the study, with no change of attitude during the pandemic, while non-Italian units became even more conservative. This difference is not statistically significant and does not affect the overall results of our audit but shows a different cultural approach to surgical emergencies in terms of different criteria of admissions \u0026ndash; where Italian surgeons tend to admit patients who more likely would need surgery \u0026ndash; or different choices of treatment strategy \u0026ndash; where non-Italian units, possibly considering local factors, prefer conservative management as much as possible.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eInteresting data came from the observation that patients with small bowel obstruction (SBO) were treated with surgery much less frequently during the pandemic, thus confirming the suggestion of evidence and guidelines [10]. While other diagnoses, such as appendicitis, are generally not a therapeutic dilemma, our audit showed that our treatment of patients with SBO may be too often too aggressive. In fact, while in the pre-Covid era patients with SBO were treated by surgery still in almost 64% of cases, during the Covid lockdown surgery was considered necessary in 55% of patients (Table 5). We believe that this percentage can be further reduced as soon as the above reported results are incorporated in new policies and guidelines on the treatment of SBO possibly reinforcing the role of non-operative management.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAlso, the kind of access (laparoscopic vs open vs laparoscopic converted to open) did not change significantly, but the comparative analysis showed that during the first Covid lockdown 40% were treated laparoscopically, against 43% of the pre-Covid period, showing a 5% relative reduction. Interestingly, there were less lap-to-open conversions during the Covid period, probably as an unwanted consequence of restricted indications to laparoscopy, as some hasty guidelines suggested. These results were confirmed also at the subgroup analysis by type of operation for the most common procedures (Table 3). \u0026nbsp;Many Authors suggested avoiding laparoscopy on the ground that it could be considered \u0026ldquo;unsafe\u0026rdquo; due to the risk of inhalation of surgical plume. We agree that the inhalation of surgical smoke can potentially be an occupational health issue due to chemical risk, but in the specific situation of the Covid pandemic, there is still no clear evidence suggesting transmission of viral particles through the surgical smoke [11].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eProbably a stricter selection of patient led to a reduced rate of readmission (overall -16%, from 9% to less than 8%), but this can also be due to the gradual introduction, during the first lockdown, of social restrictions in terms of more difficult access to hospital care, so that patients who previously would be admitted for a postoperative complication, were preferably treated at home during the Covid lockdown.\u003c/p\u003e\n\u003cp\u003eThe distribution of the various discharge diagnosis changed significantly during the Covid period with respect to the pre-Covid era (Table 4). Some of the changes we have highlighted during our audit can be due to normal variations, but some other are clearly not random but somehow related to the Covid pandemic or, better, to our response to it. This is for instance the case with acute appendicitis and acute diverticulitis, that had an absolute reduction of 42% and 50% respectively. As previously discussed, it is not clear if this reduction reflects a true fall of the incidence of these disorders or if it is due to a strict selection of the patients to be admitted, while less severe cases could be treated at home. This should open a frank discussion aimed at reviewing our criteria of surgical admission. In fact, if we could demonstrate that more patients can be easily treated at home with the same results of in-patients, we would introduce a huge improvement of resource utilization in our already very stretched national health systems. Initiative like the \u0026ldquo;Hospital At Home\u0026rdquo; scheme should be widely applied also to surgical emergency patients [12].\u003c/p\u003e\n\u003cp\u003eOther diseases likely reduced due to more people staying at home, and therefore hopefully having better diets and lifestyles, as it may be the case with symptomatic gallstones and gastro-oesophageal reflux, both reduced by more than 50%.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOn the contrary, other diagnoses became more frequent. We confirmed the common perception that the incidence of symptomatic haemorrhoids and rectal prolapse increased significantly during the first lockdown. This can be explained with the more sedentary life and the reduction of physical workout. On the contrary, the significant increase of stoma complications (+168.8%) demonstrated in our audit may be a direct consequence of the temporary closure of non-vital health services. A much more extensive investigation would be necessary to explain the relative increase of cases of bowel ischaemia as it is well known that Covid infection can cause microvascular thrombosis [13], but an increase of cases of unexplained bowel ischaemia during the Covid period has been demonstrated also in patients who resulted negative at naso-pharyngeal swab and broncho-alveolar lavage [14]. This in-depth analysis is beyond the scope of this work.\u003c/p\u003e\n\u003cp\u003eSignificant strength of this paper is its wide sample size, yielding clear and significant data on emergency surgical admissions during the first wave of Covid-19 pandemic as compared with the same period of the previous year. The characteristics of admitted patients have been reported and analysed thoroughly.\u003c/p\u003e\n\u003cp\u003eThis paper has also some limitations. First, it is supposed to give only a snapshot of the first two months of pandemic, but the Covid-19 infection did not break out at the same time in different Countries, therefore the choice of March-April may be arbitrary. Second, the fact that most of participating centres were in Italy might have introduced a selection bias linked to the different national policies and guidelines, but, as discussed above, this is not statistically significant.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn conclusion, this paper demonstrates a significant overall reduction of emergency surgical admissions during the first lockdown, with a minimal but significant change of the proportions of the single presentations and diagnoses. Further large studies may be necessary to find out if the reduction of surgical emergency admissions reflects a true reduction of incidence or it is just the evidence that more patients were treated non-operatively at home with the same results than during an hospital admission.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAssuming that the reduction of admissions is due to more patients being treated at home, this opens the door to new ways to manage surgical emergencies while reducing the pressure on the already stretched resources of our health systems. Clearly, new policies in this sense must be supported by a growing cooperation between patients (=customers), health professionals and policy-makers, all committed towards a more sustainable and evidence-based healthcare.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eACOI: Associazione dei Chirurghi Ospedalieri Italiani\u003c/p\u003e\n\u003cp\u003eANOVA: Analysis of Variance\u003c/p\u003e\n\u003cp\u003eASA: American Society of Anaesthesiologists\u003c/p\u003e\n\u003cp\u003eNS: not significant\u003c/p\u003e\n\u003cp\u003eGI: gastrointestinal\u003c/p\u003e\n\u003cp\u003eIBD: Inflammatory Bowel Disease\u003c/p\u003e\n\u003cp\u003ePI: Principal Investigator\u003c/p\u003e\n\u003cp\u003ePLI: Principal Local Investigator\u003c/p\u003e\n\u003cp\u003eSBO: small bowel obstruction\u003c/p\u003e\n\u003cp\u003eSC: Study Coordinator\u003c/p\u003e\n\u003cp\u003eWSES: World Society of Emergency Surgery\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eAuthors\u0026rsquo; contributions:\u003c/p\u003e\n\u003cp\u003eConceptualisation and study plan: GDT, MSM, MB, GBS, CL, RC, SDS, FC, MS and PM\u003c/p\u003e\n\u003cp\u003eStudy coordinator: GDT\u003c/p\u003e\n\u003cp\u003ePrincipal investigator: MB\u003c/p\u003e\n\u003cp\u003eLocal data collection and anonymisation: CovidICE-International Collaborative*\u003c/p\u003e\n\u003cp\u003eCentral data collection and analysis: GDT and MSM\u003c/p\u003e\n\u003cp\u003eInterpretation of data: GDT, MSM, MB, GBS, CL, RC, SDS, FC, MS and PM\u003c/p\u003e\n\u003cp\u003eWSES relationships: GDT, RC, SDS and FC\u003c/p\u003e\n\u003cp\u003eACOI relationships: GDT, MS and PM\u003c/p\u003e\n\u003cp\u003eManuscript drafting: GDT and MSM\u003c/p\u003e\n\u003cp\u003eManuscript final version approval: All Authors including the CovidICE-International Collaborative\u003c/p\u003e\n\u003cp\u003eFunding\u003c/p\u003e\n\u003cp\u003eNo funding was available for this study\u003c/p\u003e\n\u003cp\u003eAvailability of data and material:\u003c/p\u003e\n\u003cp\u003eThe dataset generated and analysed during the current study are available from the corresponding Author upon reasonable request\u003c/p\u003e\n\u003cp\u003eEthics approval and consent to participate\u003c/p\u003e\n\u003cp\u003eFormal ethical committee approval was not deemed to be necessary due to the retrospective nature and anonymised nature of the audit. However, the study was approved by the Comitato Etico ATS Sardegna on 22.12.2020 and was sponsored by the World Society of Emergency Surgery and by the Associazione dei Chirurghi Ospedalieri Italiani.\u003c/p\u003e\n\u003cp\u003eConsent for publication\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003eCompeting interests\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests. All authors certify that they have no affiliations with or involvement in any organisation or entity with any financial or non-financial interest in the subject matter or materials discussed in this manuscript.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1. Tebala GD, Bond-Smith G. Guidelines and recommendations during the Covid-19 pandemic: a word of caution. Am J Surg 2020;220:1526-1527\u003c/p\u003e\n\u003cp\u003e2. Aranda-Narvaez JM, Tallon-Aguilar L, Pareja-Ciur\u0026ograve; F, Martin-Martin G, Gonzales-Sanchez AJ, Rey-Simo I, Tamayo-Medel G, Yanez-Benitez C Costa-Navarro D, Monton-Condon S, Navarro-Soto S, Turegano-Fuentes F, Perez-Diaz MD, Ceballo-Esparragon J, Jover-Navalon JM, Balibrea JM, Morales-Conde S. Atencion dela urgencia quirurgica durante la pandemia COVID-19. Recomendaciones de la Asociation Espanola de Cirujanos. Cir Esp 2020;98:433-441\u003c/p\u003e\n\u003cp\u003e3. Tebala GD, Lami M, Bond-Smith G. Laparoscopic surgery and the coronavirus disease 2019 pandemic: a word from a different hymn-sheet. J Trauma Acute Care Surg 2021;89:e121\u003c/p\u003e\n\u003cp\u003e4. Castagneto-Gissey L, Casella G, Rossu MF, Del Corpo G, iodice A, Lattina I, Ferrari P, Iannone I, Mongoli A, La Torre F. Impact of COVID-19 outbreak on emergency surgery and emergency department admissions: an Italian level 2 emergency department experience. BJS 2020;107:e374-e375\u003c/p\u003e\n\u003cp\u003e5. Palisi M, Massucco P, Mineccia M, Celano C, Giovanardi F, Ferrero A. The disappearing of emergency surgery during the COVID 10 pandemic. Fact or fiction? BJS 2020;107:e508-e509\u003c/p\u003e\n\u003cp\u003e6. Tartaglia N, Pavone G, Lizzi V, Vovola F, Tricarico F, Pacilli M, Ambrosi A. How emergency surgery has changed during the COVID-19 pandemic: a cohort study. Ann Med Surg 2020;60:686-689\u003c/p\u003e\n\u003cp\u003e7. Fowler S, Zahir SF, Manning W, Kearney A, Sturgess D. Effect of the COVID-19 pandemic first wave and public policy on elective and emergency surgery provision in Southern Queensland. ANZ J Surg 2021;91:249-254\u003c/p\u003e\n\u003cp\u003e8. Nadell Farber O, Gomez GI, Titan AL, Fisher AT, Puntasecca CJ, Toro Arana V, Kempisky A, Wise CE, Bessoff KE, Hawn MT, Korndorffer JR, Forrester JD, Esquivel MM. Impact of COVID-19 presentation, management and outcomes of acute care surgery for gallbladder disease and acute appendicitis. WJGS 2021;13:859-870\u003c/p\u003e\n\u003cp\u003e9. Fallani G, Lombardi R, Masetti M, Chisari M, Zanini N, Cattaneo GM, Filosa M, Zanzi F, Guerra E, Bonilauri S, Di Donato L, Garulli G, Lucchi A, Grassia M, Ugolini G, Pasini F, Vetrone G, Benini C, Nicosia S, Jovine E. Urgent and emergency surgery for secondary peritonitis during the COVID-19 outbreak: an unseen burden of a healthcare crisis. Upd Surg 2021;73:753-762\u003c/p\u003e\n\u003cp\u003e10. De Simone B, Chouillard E, Di Saverio S, Pagani L, Sartelli M, Biffl WL, Coccolini F, Pieri A, Khan M, Borzellino G, Campanile FC, Ansaloni L, Catena F. Emergency surgery during the COVID-19 pandemic: what you need to know for practice. Ann R Coll Surg Engl 2020;102:323-332\u003c/p\u003e\n\u003cp\u003e11. Antunes D, Lami M, Chukwudi A, Dey A, Patel M, Shabana A, Shams M, Slack Z, Bond-Smith G, Tebala GD. COVID-19 infection risk by open and laparoscopic surgical smoke: a systematic review of the Literature. Surgeon 2021;3:S1479-666X(21)00041-X\u003c/p\u003e\n\u003cp\u003e12. Leong MQ, Lim CW, Lai YF. Comparison of Hospital-at-Home models: a systematic review of reviews. BMJ Open 2021;11:e043285\u003c/p\u003e\n\u003cp\u003e13. Ignat M, Philouze G, Aussenac-Belle L, Faucher V, Collange O, Mutter D, Pessaux P. Small bowel ischaemia and SARS -CoV-2 infection: an underdiagnosed distinct clinical entity. Surgery 2020;168:14-16\u003c/p\u003e\n\u003cp\u003e14. Norsa L, Valle C, Morotti D, Bonaffini PA, Indriolo A, Sonzogni A. Intestinal ischaemia in the COVID-19 era. Dig Liver Dis 2020;52:1090-1091\u003c/p\u003e"},{"header":"Tables","content":"\u003cp\u003eTable 1. Characteristics of the patients and variations between the two periods of the study.\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eFactor\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2019*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2020*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAbsolute variation \u0026sect;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eTOTAL\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e3810\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e2453\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-35.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e59.1\u0026plusmn;21.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e59.9\u0026plusmn;20.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e+1.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.11676\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eGender (F/M)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e1875/1935\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e1211/1242\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-35.4% / -35.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.90435\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePresentation\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eAbdominal pain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e2709 (71.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e1680 (68.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-38.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"21\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.00552\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eBowel obstruction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e183 (4.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e148 (6.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-19.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eGI bleeding\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e154 (4.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e142 (5.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-7.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eAnorexia/Weight loss\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e7 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-57.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eJaundice\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e113 (3.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e67 (2.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-40.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eDiarrhoea/Vomit\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e92 (2.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e63 (2.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-31.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eDysphagia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e9 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e10 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e+11.1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eNon-trauma haemoperitoneum\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e4 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eAnal pain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e114 (3.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e49 (2.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-57.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eFever\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e24 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e19 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-20.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eAnaemia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e15 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e4 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-73.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eHernia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e169 (4.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e94 (3.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-44.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eSkin issue\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e60 (1.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e51 (2.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-15.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eWound complications\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e10 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-80%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003ePostop complications\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e43 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e34 (1.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-20.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eBreast pain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e5 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e7 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e+40.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eChest pain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e40 (1.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e26 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-35%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eIschaemic limb\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e12 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e12 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eNon traumatic shock\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e17 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e17 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eAbnormal radiology\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-66.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e24 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e21 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-12.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSmoking\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e2616 (72.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e1428 (61.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-45.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e833 (23.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e599 (25.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-28.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eEx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e147 (4.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e296 (12.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e+101.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e214\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e130\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eASA\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e1007 (29.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e477 (20.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-52.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"5\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e1167 (33.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e834 (36.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-28.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e1004 (28.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e749 (32.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-25.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e277 (8.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e238 (10.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-14.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e16 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e16 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e339\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e139\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eFrailty score\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e1-2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e2060 (54.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e1165 (47.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-43.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003e\u0026gt;2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e1750 (45.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e1287 (52.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-26.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e1\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp id=\"isPasted\"\u003e*: values are reported as: total number (relative percentage in the column)\u003c/p\u003e\n\u003cp\u003e\u0026sect;: values represent the absolute variation of cases between March-April 2019 and March-April 2020\u003c/p\u003e\n\u003cp\u003eTable 2. Treatment of the patients and its outcome and variations between the two periods of the study.\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eFactor\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2019*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2020*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAbsolute variation \u0026sect;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eTreatment\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e1175 (30.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e808 (33.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-31.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.12282\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e2391 (62.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e1505 (61.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-37.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e244 (6.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e137 (5.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-43.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e3\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSurgical access\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e952 (42.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e559 (40.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-41.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.11324\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e1257 (56.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e818 (59.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-34.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eLap converted to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e19 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e6 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-68.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e171\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e107\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eLap-to-open conversion\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e19/971 (2.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e6/565 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-45.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.18140\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSurgical subspecialty\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eColorectal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e1307 (54.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e809 (53.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-38.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"9\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.00603\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eUpper GI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e85 (3.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e70 (4.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-17.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eHPB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e416 (17.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e256 (17.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-38.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eAbdominal wall\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e281 (11.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e150 (10.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-46.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eI\u0026amp;D of abscesses\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e138 (5.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e98 (6.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-29.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eChest\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e35 (1.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e13 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-62.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eVascular\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e21 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e11 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-47.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eUrology/Gynae\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e14 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e7 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e82 (3.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e87 (5.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e+6.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e12\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e4\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eLength of stay\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e7.8\u0026plusmn;10.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e7.7\u0026plusmn;10.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-1.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.65716\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eReoperation\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e3457 (96.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e2334 (96.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-32.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e0.93414\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e120 (3.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e82 (3.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-31.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e233\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e37\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cstrong\u003eReadmission\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e3398 (91.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e2247 (92.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e-33.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.05906\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"22.15686274509804%\"\u003e\n \u003cp\u003e335 (9.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.392156862745097%\"\u003e\n \u003cp\u003e185 (7.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"24.11764705882353%\"\u003e\n \u003cp\u003e-44.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u003cem\u003e77\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u003cem\u003e21\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"28.286189683860233%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.80199667221298%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"17.3044925124792%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"20.465890183028286%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.141430948419302%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;*: values are reported as: total number (relative percentage in the column)\u003c/p\u003e\n\u003cp\u003e\u0026sect;: values represent the absolute variation of cases between March-April 2019 and March-April 2020\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 3. Surgical access for the most common operations. * \u0026ldquo;Hernia repair\u0026rdquo; includes inguinal, femoral, umbilical, ventral and incisional hernias.\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAccess\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2019\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2020\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAppendicectomy\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e434 (81.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e249 (83.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.36888\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e91 (17.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e50 (16.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eLap to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e7 (1.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e1 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eCholecystectomy\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e321 (81.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e188 (76.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.24021\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e68 (17.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e56 (22.8%)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eLap to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e3 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e2 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eHernia repair*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e22 (7.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e12 (8.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.91902\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e259 (92.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e136 (91.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eLap to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eLarge bowel resection\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e40 (14.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e24 (11.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.49189\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e231 (84.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e180 (87.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eLap to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e2 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e2 (1.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSmall bowel resection\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eLaparoscopic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e3 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e4 (3.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.57322\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eOpen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e165 (96.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e122 (96.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eLap to open\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e3 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e1 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eTable 4. Discharge diagnosis in the two periods of the study.\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"38.308457711442784%\"\u003e\n \u003cp\u003e\u003cstrong\u003eDiagnosis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2019*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2020*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAbsolute variation \u0026sect;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cstrong\u003eP\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"38.308457711442784%\"\u003e\n \u003cp\u003eAcute appendicitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e609 (16.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e356 (14.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e-41.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"59\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;0.0001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAcute cholecystitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e445 (11.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e310 (12.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-30.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSmall bowel obstruction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e379 (9.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e232 (9.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-38.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eComplicated diverticulitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e268 (7.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e135 (5.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-49.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eComplicated inguinal hernia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e199 (5.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e110 (4.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-44.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAcute pancreatitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e174 (4.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e121 (4.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-30.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eComplicated colon cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e155 (4.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e114 (4.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-26.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eComplicated gastritis / peptic ulcer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e134 (3.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e88 (3.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-34.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eComplicated ventral hernia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e132 (3.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e84 (3.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-36.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eCBD stones\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e129 (3.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e76 (3.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-41.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eGallstones\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e124 (3.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e61 (2.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-50.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eNon-specific abdominal pain\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e112 (2.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e71 (2.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-36.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003ePerianal abscess/fistula/fissure\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e101 (2.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e69 (2.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-31.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSuperficial collection\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e66 (1.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e52 (2.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-21.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAdvanced cancer (any)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e62 (1.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e28 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-54.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eBowel ischaemia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e56 (1.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e51 (2.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-8.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eConstipation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e45 (1.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e9 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-80%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSmall bowel cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e38 (1.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e30 (1.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-21.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eUTI / orchitis / epididymitis / torsion\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e30 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e20 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-33.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003ePostop bleeding\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e30 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e1 (0.04%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-96.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eUpper GI cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e30 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e17 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-43.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eHaemorrhoids/Prolapse\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e28 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e26 (1.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-7.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eIschaemic limb\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e28 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e21 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-57.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSpontaneous PNX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e28 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e12 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-57.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003ePancreatic cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e25 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e8 (1.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-68.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAnastomotic leak\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e24 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e19 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-0.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSigmoid/Caecal volvulus\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e22 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e17 (0.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-22.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eGORD / Hiatus hernia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e22 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e11 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eGoitre\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e22 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e20 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-9.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAnaemia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e22 (0.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e21 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-4.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eIBD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e20 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e22 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+10.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eDeep SSI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e18 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-66.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAbdominal abscess\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e18 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e19 (0.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+5.6%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eStoma complication\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e16 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e43 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+168.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSpontaneous haemoperitoneum\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e16 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-62.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eIatrogenic GI perforation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e13 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e9 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-30.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eHepatobiliary cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e11 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e7 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-36.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eBenign large bowel obstruction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e10 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e10 (0.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eBiliary fistula\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e8 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-75.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSuperficial SSI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e8 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-25.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eKidney stone\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e8 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-62.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003ePID / Endometriosis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e8 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-62.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eMedical sepsis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e7 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-57.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eUnspecified peritonitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e5 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-60.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eBreast infection\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e5 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+20.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eAortic aneurysm\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eEnteric fistula\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eLiver abscess\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eGIST\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eOesophageal varices\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e4 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+33.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSmall bowel perforation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-100.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSmall bowel/large bowel bleeding\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e3 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eUpper GI stricture\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e23 (0.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+1050.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eMeckel\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e1 (0.04%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-50.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eSpleen/liver ischaemia, bleeding, cyst\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e6 (0.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-200.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eGallstone ileus\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e2 (0.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e-100.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eInfective colitis/enteritis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e1 (0.04%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+100.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eBladder perforation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e1 (0.04%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"45.294117647058826%\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e67 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e70 (2.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.235294117647058%\"\u003e\n \u003cp\u003e+4.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"38.308457711442784%\"\u003e\n \u003cp\u003e\u003cem\u003eMissing\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cem\u003e0\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"15.422885572139304%\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp id=\"isPasted\"\u003e*: values are reported as: total number (relative percentage in the column)\u003c/p\u003e\n\u003cp\u003e\u0026sect;: values represent the absolute variation of cases between March-April 2019 and March-April 2020\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 5. Treatment per diagnosis per year\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003e\u003cstrong\u003eTreatment\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2019\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003e2020\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAcute pancreatitis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e132 (75.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e96 (79.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.48247\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e27 (15.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e19 (15.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e15 (8.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e6 (5.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eHot gallbladder\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e202 (28.8%)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e136 (30.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.81865\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e401 (57.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e248 (55.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e98 (14.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e61 (13.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAcute appendicitis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e53 (8.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e32 (8.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.97813\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e567 (91.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e329 (90.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e2 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e1 (0.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eDiverticulitis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e159 (59.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e73 (54.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e0.49189\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e99 (36.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e58 (43.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e10 (3.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e4 (3.0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"31.3953488372093%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSmall bowel obstruction\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"18.770764119601328%\"\u003e\n \u003cp\u003eMedical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e131 (34.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e103 (44.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" valign=\"top\" width=\"16.611295681063122%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.02324\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eSurgical\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e241 (63.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e128 (55.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"36.10223642172524%\"\u003e\n \u003cp\u003eInterventional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e7 (1.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" width=\"31.94888178913738%\"\u003e\n \u003cp\u003e2 (0.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"world-journal-of-emergency-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"wjes","sideBox":"Learn more about [World Journal of Emergency Surgery](http://wjes.biomedcentral.com)","snPcode":"13017","submissionUrl":"https://submission.nature.com/new-submission/13017/3","title":"World Journal of Emergency Surgery","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"emergency surgery, Covid-19, admission","lastPublishedDoi":"10.21203/rs.3.rs-1106929/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1106929/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIntroduction\u003c/p\u003e\u003cp\u003eThe COVID-19 pandemic is having a deep impact on emergency surgical services, with a significant reduction of patients admitted into emergency surgical units world widely. Reliable figures of this reduction have not been produced yet. Our international audit aimed at giving a precise snapshot of the absolute and relative changes of emergency surgical admissions at the outbreak of the pandemic. \u003c/p\u003e\u003cp\u003eMaterials and methods\u003c/p\u003e\u003cp\u003eDatasets of patients admitted as general surgical emergencies into 45 internationally distributed emergency surgical units during the months of March and April 2020 (Covid-19 pandemic outbreak) were collected and compared with those of patients admitted into the same units during the months of March and April 2019 (pre-Covid-19). Primary endpoint was to evaluate the relative variation of the presentation symptoms and discharge diagnoses between the two study periods. Secondary endpoint was to identify the possible change of therapeutic strategy during the same two periods. \u003c/p\u003e\u003cp\u003eResults\u003c/p\u003e\u003cp\u003eForty-four centres participated sent their anonymised data to the study hub, for a total of 6263 patients. Of these, 3810 were admitted in the pre-Covid period and 2453 in the Covid period, for a 35.6% absolute reduction. The most common presentation was abdominal pain, whose incidence did not change between the two periods, but in the Covid period patients presented less frequently with anal pain, hernias, anaemia and weight loss. ASA 1 and low frailty patients were admitted less frequently, while ASA\u0026gt;1 and frail patients showed a relative increase. The type of surgical access did not change significantly, but lap-to-open conversion rate halved between the two study periods. Discharge diagnoses of appendicitis and diverticulitis reduced significantly, while bowel ischaemia and perianal ailments had a significant relative increase.\u003c/p\u003e\u003cp\u003eConclusions\u003c/p\u003e\u003cp\u003eOur audit demonstrates a significant overall reduction of emergency surgery admissions at the outbreak of the Covid-19 pandemic with a minimal change of the proportions of single presentations, diagnoses and treatments. These findings may open the door to new ways of managing surgical emergencies without engulfing the already busy hospitals.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Emergency Surgery Admissions and The COVID-19 Pandemic: Did The First Wave Really Change Our Practice? Results of An ACOI/WSES International Audit On 6263 Patients.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-11-30 16:49:57","doi":"10.21203/rs.3.rs-1106929/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2021-12-21T20:02:50+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-12-07T15:03:38+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"1eee6e9c-62d7-409c-8ea5-73f0ec34382f","date":"2021-12-05T09:14:35+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-12-04T11:06:12+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-11-24T12:58:38+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-11-24T10:44:21+00:00","index":"","fulltext":""},{"type":"submitted","content":"World Journal of Emergency Surgery","date":"2021-11-23T11:02:25+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"world-journal-of-emergency-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"wjes","sideBox":"Learn more about [World Journal of Emergency Surgery](http://wjes.biomedcentral.com)","snPcode":"13017","submissionUrl":"https://submission.nature.com/new-submission/13017/3","title":"World Journal of Emergency Surgery","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"fe043fc6-41b8-4a07-b0ca-e94550132616","owner":[],"postedDate":"November 30th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":8762798,"name":"Critical Care \u0026 Emergency Medicine"},{"id":8762799,"name":"Surgery"}],"tags":[],"updatedAt":"2022-01-09T12:29:09+00:00","versionOfRecord":[],"versionCreatedAt":"2021-11-30 16:49:57","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1106929","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1106929","identity":"rs-1106929","version":["v1"]},"buildId":"itB540yAGKdqaaUR3okzg","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}