Impact of NSAIDs use on osteoporotic fracture risk: Evidence from a large prospective population study

Impact of NSAIDs use on osteoporotic fracture risk: Evidence from a large prospective population study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL British Journal of Clinical Pharmacology This is a preprint and has not been peer reviewed. Data may be preliminary. 12 May 2026 V1 Latest version Share on Impact of NSAIDs use on osteoporotic fracture risk: Evidence from a large prospective population study Authors : Jie Huang [email protected] , Lu Xu [email protected] , Haofeng Hong [email protected] , Xuanqi Zheng [email protected] , Huan Wang [email protected] , Tong Wu [email protected] , Hao Liu [email protected] , Wanqiong Yuan [email protected] , Siyan Zhan [email protected] , Shengfeng Wang [email protected] , and Chunli Song 0000-0002-3690-9457 [email protected] Authors Info & Affiliations https://doi.org/10.22541/authorea.15003228/v1 8 views 3 downloads Contents Abstract Graphical Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aims: To investigate the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of osteoporotic fractures, and to determine whether this risk differs between aspirin and non-aspirin NSAIDs. Methods: Using data from UK Biobank, a cohort of 492,426 individuals aged 40-69 years from 2006-2010 was analysed. Participants were categorized as either NSAID users or nonusers and followed until the date of their first osteoporotic fracture, death, or 15th September 2021. The associations of aspirin and non‑aspirin NSAID use with osteoporotic fracture risk were assessed separately in both sexes. In addition, two‑sample Mendelian randomization (MR) was employed to evaluate the potential causal effects of aspirin and non‑aspirin NSAID use on osteoporotic fracture risk. Results: NSAID users had a greater hazard ratio (HR) of osteoporotic fracture risk than nonusers did (adjusted HR: 1.25, 95% CI: 1.10 to 1.42). The risk of osteoporotic fracture was greater among users of non-aspirin NSAIDs (adjusted HR: 1.48; 95% CI: 1.29 to 1.70) than among aspirin users (adjusted HR: 1.03, 95% CI: 0.87 to 1.22). Furthermore, employing two-sample Mendelian randomization analyses, we also demonstrated a significant causal association between non-aspirin NSAID use and an increased risk of osteoporotic fracture (odds ratio: 2.35, 95% CI: 1.28-4.34). Conversely, no evidence was found to support a causal relationship between aspirin use and osteoporotic fractures. Conclusion: Non-aspirin NSAIDs use, but not aspirin use, is causally associated with an increased risk of osteoporotic fractures. Graphical Abstract Supplementary Material File (supplemental data.xlsx) supplemental data Download 22.61 KB File (supplemental tables.docx) supplemental tables Download 15.26 KB Information & Authors Information Version history V1 Version 1 12 May 2026 Collection British Journal of Clinical Pharmacology Authors Affiliations Jie Huang [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Lu Xu [email protected] View all articles by this author Haofeng Hong [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Xuanqi Zheng [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Huan Wang [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Tong Wu [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Hao Liu [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Wanqiong Yuan [email protected] Peking University Third Hospital Department of Orthopaedics, Beijing, China, 100191 View all articles by this author Siyan Zhan [email protected] View all articles by this author Shengfeng Wang [email protected] View all articles by this author Chunli Song 0000-0002-3690-9457 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 8 views 3 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Jie Huang, Lu Xu, Haofeng Hong, et al. Impact of NSAIDs use on osteoporotic fracture risk: Evidence from a large prospective population study. Authorea . 12 May 2026. DOI: https://doi.org/10.22541/authorea.15003228/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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