Influence of malignant left large bowel obstruction in metastatic left-sided colon cancer patients during chemotherapy on survival: A Propensity Score Analysis

Influence of malignant left large bowel obstruction in metastatic left-sided colon cancer patients during chemotherapy on survival: A Propensity Score Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Influence of malignant left large bowel obstruction in metastatic left-sided colon cancer patients during chemotherapy on survival: A Propensity Score Analysis Jianlin Xiao, yu shen, Xuyang Yang, Hanjiang Zeng, Mingtian Wei, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3197254/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Chemotherapy was recommended to improve the long-term outcomes of metastatic colorectal cancer (mCRC). The process of chemotherapy may be interrupted by malignant large bowel obstruction (MLBO). The aim of this study was to find out the Oncologic outcomes for MLLBO in metastatic left-sided colon cancer (mLCC) patients during chemotherapy. Methods Consecutive mLCC patients who underwent chemotherapy from June 2009 to July 2021 in West China Hospital were divided into two groups according to whether MLLBO occurred during chemotherapy. Patients were propensity matched 1:2 into MLLBO and no-MLLBO groups and among the matched cohort, the univariable and multivariable Cox proportional hazards regression models were performed to identify predictors of survival. Potential variables were evaluated first with univariate and then multivariate analyses to identify the risk factors of tumor characteristics for MLLBO patients. Results Of 1638 mLCC patients diagnosed, 156 were identified in the matched cohort. The median overall survival was 34.0 months, 51.0 months in the non-MLLBO, and MLLBO groups, respectively (p= 0.020) and the corresponding median progression-free survival was 12.0 months, 23.0 months, respectively (p=0.018). Multivariable Cox regression analysis demonstrated that MLLBO was independently associated with reduced overall survival (hazard ratio [HR]= 1.473, 95% CI 1.186-1.812, P＜0.001) as well as progression-free survival (hazard ratio [HR]= 1.619, 95% CI 1.391-1.899, P＜0.001). In addition, Tumor length ≥ 10 cm (P=0.043) and TTI ≥ 1.5 cm (P＜0.001) were identified as independent risk factors of tumor characteristics for MLLBO patients. Conclusion No-MLLBO patients had better prognosis than MLLBO patients during chemotherapy. Prevention measures are recommended for mLCC patients with higher risk factors of MLLBO during chemotherapy. Metastatic colorectal cancer Malignant left large bowel obstruction Chemotherapy Propensity score matching Figures Figure 1 Figure 2 Figure 3 INTRODUCTION Colorectal cancer is one of the most common malignancies, accounting for 9.8% of all cancer cases, it is the third most common cancer reported worldwide and is the second most common cause of cancer death. [ 1 ] Initial clinical presentation as metastatic colorectal cancer (mCRC) occurs in approximately 20% of patients. Moreover, up to 50% of patients with localized disease eventually develop metastases. [ 2 , 3 ] According to the current guidelines, such as the NCCN, [ 4 ] ASCO, and ESMO guidelines, [ 5 , 6 ] systemic therapy is the first-line treatment for these cases. In the setting of current great advances in systemic treatment of mCRC, the risk of primary tumor-related emergency situations and the need for urgent surgical interventions are lower than before. [ 7 , 8 ] However, some researchers demonstrated that not all these patients could benefit from systemic chemotherapy and they unavoidably suffered from the adverse events linked to the primary tumor in the end. [ 9 , 10 ] A previous meta-analysis reported that when unresectable stage IV patients initially received chemotherapy, approximately 22% of these patients presented with primary tumor-related complications, such as malignant large bowel obstruction (MLBO). [ 11 ] MLBO occurs in roughly 15% of patients with colon cancer in the USA. [ 12 , 13 ] The majority of malignant large bowel obstructions are secondary to malignant left large bowel obstruction (MLLBO) and require urgent management. [ 14 , 15 ] MLLBO could cause colonic edema resulting in a poorer general condition of patients, which could lead to a series of serious complications such as water and electrolyte imbalance, acid-base imbalance, peritonitis, intestinal perforation, and septic shock. [ 16 ] There is still no consensus on whether MLLBO during chemotherapy will affect the survival outcome of patients with metastatic left-sided colon cancer (mLCC). Therefore, the purpose of this study is to analyze the difference in overall survival (OS) and progression-free survival (PFS) between MLLBO and no-MLLBO patients during chemotherapy by using PSM. In addition, we investigated the risk factors of tumor characteristics for MLLBO patients to predict clinical factors associated with the occurrence of MLLBO. PATIENTS AND METHODS Patients and study design This is a single-institution retrospective study, consecutive mLCC patients who underwent chemotherapy from June 2009 to July 2021 in West China Hospital were divided into two groups according to whether MLLBO occurred during chemotherapy. The inclusion criteria were: 1) patients newly diagnosed with mLCC without obstruction and accepted chemotherapy. Exclusion criteria were: 1) patients with recurrent CRC or primary cancer of other organs; 2) patients without baseline radiological evaluation records in our center before chemotherapy; 3) patients with LBO proved to be not mLCC related; 4) patients who lost to follow-up or gave up due to severe side effects of chemotherapy. Patients were then propensity matched 1:2 into MLLBO and no-MLLBO groups through the nearest neighbor method with a caliper of 0.1 times the standard deviation of the propensity score. No replacement was allowed, and patients were matched only once. Variables used for matching were as follows: age, sex, body mass index (BMI), Comorbidity, preoperative carcinoembryonic antigen (CEA) and albumin levels, metastatic sites, the number of metastatic sites, Eastern Cooperative Oncology Group (ECOG PS), chemotherapy regimen. The study was approved by the institutional review board of West China Hospital, Sichuan University. We confirm that we have obtained ethical approval to conduct the study as well as permission from the dataset, and the study was conducted in accordance with the provisions of the Declaration of Helsinki (as revised in Fortaleza, Brazil, October 2013). The obtained data were only collected and analyzed; however, detailed information was not released to the public, and information confidentiality regulations were strictly adhered to. Definitions Left-sided colon cancer was defined as carcinoma of the splenic flexure to the rectosigmoid junction. Large bowel obstruction is diagnosed by clinical symptoms (bloating, pain, and inability to pass stool or gas), clinical examination, endoscopy, abdominal plain radiography, and abdominal computed tomography (CT). The tumor stage was diagnosed according to the AJCC 8th Edition. [ 17 ] Overall survival (OS) was defined as the time from chemotherapy to death or the last follow-up. Progression-free survival (PFS) was defined as the period between the beginning of treatment and the onset of disease progression or the last follow-up date due to various causes in patients with mLCC. Data collection Demographic and clinical data were retrospectively extracted from the electronic clinical records. Including age, sex, body mass index (BMI), Comorbidity, preoperative CEA and albumin levels, metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, primary tumor location, primary and metastatic tumor response to chemotherapy (PR: partial response; SD: stable disease; PD: progressive disease), [ 18 ] tumor shape, treatment of MLLBO and ability to pass the colonoscope through the lesion. Enhanced CT imaging of included patients was performed using the 64-slice spiral CT (Philips Brilliance 64, Philips Medical Systems, Best, Netherlands), and 128-slice spiral CT (SOMATOM Definition AS+, Siemens Healthcare Forscheim, Germany). Traditionally, scanning parameters were set at a tube voltage of 100–120 kV and a tube current of 250–350 mAs. Non-ionic contrast agent (60–80 mL, iopamidol, 370 mg/mL, Bracco Sine Pharmaceutical Corp. Ltd, Shanghai, China) and saline flush (20 mL) were injected successively at a 2.5–3.5 mL/s flow rate. Collected radiological data were reconstructed with slice thickness of 2–5 mm. Radiological data were retrospectively obtained on the Syngo MultiModality Workplace and all the patients were scanned on a dual-source computed tomography (DSCT) scanner (SOMATOM Definition Flash; Siemens Healthcare, Forchheim, Germany). The enhanced CT data were first included for 3D reconstruction. A surgeon (Jianlin Xiao) and a radiologist (Hangjiang Zeng) were then blinded to the patients’ clinical diagnosis and reviewed the contrast-enhanced CT images of mLCC patients before chemotherapy respectively. The following radiological parameters were collected: 1) location of tumors; 2) thickness of tumor-involved intestinal canal (TTI); 3) degree of stenosis; 4) the max size of regional lymph nodes (short- and long-axis diameter of regional lymph nodes were measured); 5) whether lymph nodes were accompanied with fusion or necrosis on CT image. The degree of stenosis was measured by the ratio of the proximal and distal inner diameter of the involved large bowel. Study outcomes In our center, follow-ups (including CT review) were settled every two chemotherapy cycles according to routine follow-up protocol for colon cancer. [ 3 ] The primary endpoint was to compare the oncologic outcomes between MLLBO and no-MLLBO patients during chemotherapy. The secondary endpoint was to identify the risk factors of tumor characteristics for MLLBO. Statistical analysis SPSS for Windows, version 25 (IBM Corp, Armonk, NY) was used for data analysis. In this study, a 1:2 PSM analysis (without replacement) was conducted via the nearest neighbor method with a caliper of 0.1 times the standard deviation of the propensity score. Standardized differences were used to examine the balance across baseline covariates before and after matching, and a standardized difference below 10% was reliable enough to provide well-balanced covariates after matching. Next, χ2 statistics were utilized to compare patient and tumor characteristics in both matched and unmatched cohorts. In the matched population, univariable and multivariable Cox proportional hazards regression models were performed to identify the independent risk factors for MLLBO patients. Statistical significance was defined as a p -value smaller than 0.05. RESULTS Baseline characteristics in this study, 1638 patients diagnosed with mLCC between 2009 and 2021 met our selection criteria for additional analysis. Of those, 52 patients underwent MLLBO, whereas 1586 did not. A PSM analysis was then conducted and 156 patients were 1:2 matched, comprising a MLLBO and no-MLLBO cohort. (Fig. 1) Distribution of the baseline characteristics was well-balanced in the matched cohort (Table 1). Impact of MLLBO on overall survival The OS of the matched cohort was calculated by the Kaplan-Meier method. The results revealed a significant difference in survival between patients who underwent MLLBO and those who did not (log-rank p=0.020) (Fig. 2). The median OS for those who underwent MLLBO was 34.0 months (95% CI, 31.7 months–36.9 months) and 51.0 months (95% CI, 49.3 months–52.7 months) for those who did not. When performing a univariable Cox proportional hazards regression analysis in the matched population, all the baseline characteristics including sex, BMI, metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, MLLBO, primary tumor response to chemotherapy, metastatic tumor response to chemotherapy and treatment methods of MLLBO significantly correlated with these patients’ OS and these variables were all included in the following multivariate Cox analysis. After multivariable risk adjusting in the Cox proportional hazard regression analysis, MLLBO was a statistically significant risk factor for OS (hazard ratio [HR]= 1.473, 95% CI 1.186-1.812, P＜0.001). Besides, metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, metastatic tumor response to chemotherapy, and treatment methods of MLLBO were validated as independent risk or protective factors as well. (Table 2) Impact of MLLBO on progression-free survival Median PFS for those who underwent MLLBO was 12.0 months (95% CI, 10.1 months–13.9 months) and 23.0 months (95% CI, 22.3 months–24.7 months) for those who did not (Fig. 3). In the univariable Cox proportional hazards regression analysis, sex, BMI, metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, MLLBO, primary tumor response to chemotherapy, metastatic tumor response to chemotherapy and treatment methods of MLLBO were also correlated with PFS and they were further adjusted in the multivariate Cox regression. After multivariable analysis, MLLBO was a statistically significant risk factor for PFS (hazard ratio [HR]= 1.619, 95% CI 1.391-1.899, P＜0.001). Besides, other covariates including metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, metastatic tumor response to chemotherapy and primary tumor response to chemotherapy also proved to be independent prognostic factors for PFS. (Table 3) The univariate and multivariate analyses for MLLBO Potential variables (p<0.05 in the univariate analysis) were selected for further multivariable analysis, including primary tumor location (p=0.036), primary tumor response to chemotherapy (p=0.029), tumor length (p＜0.001), TTI (p＜0.001), degree of stenosis (p=0.032) and long-axis diameter of regional lymph node (p=0.047). In the multivariable logistic regression analysis, tumor length ≥ 10 cm (p=0.043) and TTI ≥ 1.5 cm (p＜0.001) were identified as independent risk factors of tumor characteristics for MLLBO patients. (Table 4) DISCUSSION Treatment decision-making for MLLBO during chemotherapy remains a challenging issue. The management of non-metastatic left-sided malignant colon obstruction includes emergency primary surgical resection with self-expandable metallic stent or decompressing stoma is a surgical bridge to select a strategy for transition to elective surgery. [ 16 ] For mLCC, we use self-expandable metallic stent or decompressing stoma to relieve the symptoms of MLLBO, to achieve the purpose of continuing systematic treatment or palliative treatment. [ 19 – 21 ] In this study, for the included patients with mLCC, we have compared the oncologic outcomes between MLLBO and no-MLLBO patients during chemotherapy. We advocate that no-MLLBO patients have better prognosis than MLLBO patients during chemotherapy for mLCC, the median OS and PFS of no-MLLBO patients were significantly higher than those of MLLBO patients. We analyzed the possible reasons as follows: 1) MLLBO interrupted systematic treatment and destroyed the continuity of therapy; 2) Patients with MLLBO were generally in poor physical condition, and the worse Eastern Cooperative Tumor Group (ECOG PS) status was independently associated with shorter median survival; [ 22 ] 3) The occurrence of MLLBO during chemotherapy may be a sign of the poor curative effect of systematic treatment. Surgical diversion is a common approach for MLLBO in clinical practice, however, current guidelines infrequently address its use. [ 23 ] In fact, some patients are not able to undergo surgical palliation due to their poor performance, and endoscopic palliation such as stent insertion can be an alternative method. However, limitation of endoscopic procedure still exists including approach failure, stent migration, or tumor ingrowth. [ 24 ] Preventing MLLBO is just important as treating it for mLCC patients. Preventing the occurrence of MLLBO can not only reduce emergency surgery but also ensure the completion of systematic treatment. Improving the completion rate of systematic treatment is almost the same as improving the rate of OS and PFS. Therefore, we identified independent risk factors for tumor characteristics in MLLBO patients, with tumor length ≥ 10 cm and TTI ≥ 1.5 cm, to predict the possibility of occurrence of MLLBO. One reason for this may be that longer and thicker tumor-involved bowel tube often indicates later tumor staging, and are frequently accompanied by worse enterocinesia. Both reasons weak the passage capacity of the bowel tube and result in the contents accumulating in the proximal bowel. [ 25 ] Another reason may be related to the role of inflammatory markers. Tumor growth has been proven to be related to many inflammatory markers such as cytokines and chemokines, which are stimulated by the tumor itself. [ 26 ] The previous study also verified that the preoperative neutrophil–lymphocyte ratio was a predictor of LBO due to tumor growth. [ 27 ] Larger tumors tend to activate more inflammatory effects than smaller ones, thus increasing the probability of obstruction. In addition, we also found that the tumor length ≥ 10 cm and TTI ≥ 1.5 cm may be associated factors. According to our study, 8 patients with tumor length ≥ 10 cm, 6 of those patients (75.0%) were along with TTI ≥ 1.5 cm and all of the patients developed MLLBO in the next six months to two years. So, we hypothesized that the presence of both tumor length ≥ 10 cm and TTI ≥ 1.5 cm were strong predictors of MLLBO in patients with mLCC. To prevent MLLBO, we need to take positive measures for mLCC patients with the above high-risk factors during chemotherapy, such as surgical diversion, self-expanding metal stents, and emergent oncologic resection. Of course, there are limitations in this present study. The major one is that it was a retrospective case-control study. Only 52 patients with MLLBO and 104 matched patients were included. This means all the conclusions were based on the small samples of our center. So, there is still a long way to go from limited inference to practical application. Another limitation of this study is in the process of matching and data extracting, despite the blind method, partial bias was still introduced by manual recognition. A prospective randomized controlled study with larger samples is needed to confirm our verdict and support our reasoning. In addition, there are fewer comorbidities including DM, COPD, etc. While these do not appear to reach significance, maybe the numbers of patients are too small to detect a significant difference. And we explored the risk factors of tumor characteristics for MLLBO patients, so we excluded general factors such as sex, age, BMI, etc. Therefore, it remains unknown whether there are other risk factors. In conclusion, we advocate that no-MLLBO patients have better prognosis than MLLBO patients during chemotherapy for mLCC, the median OS and PFS of no-MLLBO patients were significantly higher than those of MLLBO patients. In addition, Tumor length ≥ 10 cm and TTI ≥ 1.5 cm were identified as independent risk factors of tumor characteristics for MLLBO patients during chemotherapy. Attention should be paid to such patients and preventive measures should be taken. Declarations Funding: This study was supported by the Department of Science and Technology of Sichuan Province (Award Number 2021YFS0025); 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (No. 2019HXFH031; 20HXJS003) Author contributions: Jianlin Xiao: Resources; writing-original draft; writing-review and editing. Yu Shen: Writing-review and editing. Mingtian Wei & Xuyang Yang: Writing-review and editing. Hanjiang Zeng: Conceptualization; resources. Wenjian Meng: Conceptualization; resources; supervision. Ziqiang Wang: Conceptualization; methodology; writing-review and editing. Conflict of interest: The authors declare no conflict of interest. Ethics approval: The Institutional Review Committee of West China Hospital of Sichuan University approved this study. The study was registered at Chinese Clinical Trial Registry (Identifier: ChiCTR2200056134). The requirement for informed consent was waived due to the retrospective nature of the study. Availability of data and material : The datasets during and/or analysed during the current study are not publicly available due to the confidentiality of patient information but are available from the corresponding author on reasonable request. References SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA: a cancer journal for clinicians, 2021, 71(3): 209-49. 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Item Before 1:2 PSM After 1:2 PSM MLLBO (n=52) Non-MLLBO (n=1586) P MLLBO (n=52) Non-MLLBO (n=104) P Sex, n (%) 0.034 0.168 Male 28 (53.8) 694(43.8) 28(53.8) 62(59.6) Female 24 (46.2) 892(56.2) 24(46.2) 42(40.4) Age (years) 54.71±14.01 56.11±13.54 0.257 54.71±14.01 56.05±14.37 0.641 BMI (kg/m 2 ) 22.32±3.23 23.56±2.56 0.652 22.32±3.23 22.24±3.02 0.893 Comorbidity, n (%) DM 2(3.8) 159(10) 0.047 2(3.8) 5(4.8) 0.601 COPD 3(5.8) 37(2.3) 0.040 3(5.8) 5(4.8) 0.711 Smoking 22(42.3) 537(33.9) 0.613 22(42.3) 35(33.7) 0.241 Hypertension 3(5.8) 197(12.4) 0.086 3(5.8) 7(6.7) 0.812 Previous abdominal surgery 6(11.5) 125(7.9) 0.217 6(11.5) 11(10.6) 0.315 Albumin 41.16±3.67 37.17±2.77 0.241 41.16±3.67 41.55±4.06 0.796 Metastatic sites, n (%) Liver 33(63.5) 1072(67.6) 0.397 33(63.5) 74(71.2) 0.780 Liver only 25(48.1) 752(47.4) 25(48.1) 51(49) Lung 14(26.9) 467(29.4) 14(26.9) 35(32.7) Others 12(23.1) 97(6.1) 12(23.1) 16(15.4) No. of metastatic sites, n (%) 0.041 0.491 1 39(75) 974(61.4) 39(75) 82(78.8) ＞1 13(25) 612(38.6) 13(25) 22(21.2) ECOG PS, n (%) 0.037 0.276 0 6(11.5) 287(18.1) 6(11.5) 8(7.7) 1 14(26.9) 581(36.6) 14(26.9) 21(20.2) 2 23(44.2) 328(20.7) 23(44.2) 51(49) 3 8(15.4) 219(13.8) 8(15.4) 21(20.2) Other 1(1.9) 171(10.8) 1(1.9) 3(2.9) Chemotherapy regimen, n (%) 0.065 0.132 FOLFOX/XELOX 32(61.5) 1004(63.3) 32(61.5) 71(68.3) FOLFIRI 9(17.3) 311(19.6) 9(17.3) 18(17.3) FOLFOXIRI 9(17.3) 213(13.4) 9(17.3) 12(11.5) Use of molecular agent 21(40.4) 411(25.9) 21(40.4) 37(35.6) Others 2(3.8) 58(3.7) 2(3.8) 3(2.9) CEA mg/ml 110.24±224.84 248.37±352.16 0.003 110.24±224.84 127.24±263.77 0.601 MLLBO : malignant left large bowel obstruction ; PSM propensity score matching; BMI body mass index; DM diabetes; COPD chronic obstructive pulmonary disease; CEA carcinoembryonic antigen; ECOG PS Eastern Cooperative Oncology Group. *Data was shown as mean (SD). Table 2 Prognostic factors for overall survival of MLLBO. Variable Univariable Multivariable Crude HR 95 CI P Adjust HR 95 CI P Sex, n () Male [reference] Female 0.718 0.668-0.771 0.020 0.675 0.469-1.293 0.531 Age (years) 1.185 0.709-1.278 0.447 BMI (kg/m 2 ) 1.112 1.029-1.223 0.040 1.212 0.982-1.652 0.074 Comorbidity DM 1.344 0.765-1.939 0.298 COPD 1.765 0.653-2.885 0.073 Smoking 1.009 0.875-1.163 0.532 Hypertension 0.963 0.872-1.062 0.887 Previous abdominal surgery 1.332 0.554-2.204 0.175 Albumin 0.966 0.530-1.605 0.905 Metastatic sites Liver [reference] Liver only 1.875 1.526-2.065 ＜0.001 1.647 1.279-1.907 ＜0.001 Lung 1.246 1.080-1.766 0.015 1.101 1.015-1.227 0.028 Others 0.817 0.737-1.906 0.327 0.709 0.407-1.997 0.425 No. of metastatic sites 1 [reference] ＞1 1.977 1.686-2.318 ＜0.001 1.854 1.302-2.327 ＜0.001 ECOG PS 0 [reference] 1 0.588 0.556-0.621 ＜0.001 0.556 0.257-0.784 0.012 2 1.399 1.376-1.424 ＜0.001 1.232 1.011-1.594 0.041 3 1.819 0.686-2.387 0.058 1.917 1.505-2.371 0.049 Others 1.451 0.699-1.810 0.097 1.186 0.974-1.476 0.710 Chemotherapy regimen FOLFOX [reference] FOLFIRI 1.111 0.651-1.174 0.145 FOLFOXIRI 0.941 0.682-1.315 0.817 Use of molecular agent 0.408 0.153-0.787 0.041 0.620 0.417-0.898 0.023 Others 1.072 0.876-1.385 0.933 CEA mg/ml 1.143 0.985-1.570 0.508 MLLBO No [reference] Yes 1.807 1.382-2.434 ＜0.001 1.473 1.186-1.812 ＜0.001 Primary tumor location Splenic flexure [reference] Descending colon 1.131 0.821-1.337 0.092 Sigmoid colon 1.172 0.596-1.256 0.154 Rectosigmoid junction 0.960 0.843-1.093 0.753 Primary tumor response SD [reference] PR 0.539 0.198-0.811 0.017 0.751 0.470-1.908 0.426 PD 1.512 1.049-1.899 0.042 1.151 0.883-1.628 0.097 Metastatic tumor response SD [reference] PR 0.897 0.645-0.956 ＜0.001 0.611 0.379-0.906 ＜0.001 PD 1.298 1.077-1.564 0.037 1.237 1.001-1.587 ＜0.001 Tumor shape Fungating [reference] Non-fungating 1.443 0.511-1.876 0.648 Treatment of MLLBO emergency resection [reference] diverting stoma 1.013 0.679-1.254 0.146 1.179 0.601-1.659 0.649 using stent 0.806 0.635-1.031 0.646 0.982 0.646-1.667 0.731 conservative treatment 1.564 1.138-2.021 0.026 1.271 1.089-1.412 0.031 Passage of colonoscope 0.814 0.733-1.305 0.791 MLLBO : malignant left large bowel obstruction ; PSM propensity score matching; BMI body mass index; DM diabetes; COPD chronic obstructive pulmonary disease; CEA carcinoembryonic antigen; ECOG PS Eastern Cooperative Oncology Group; PR: partial response; SD: stable disease; PD: progressive disease; HR: hazard ratio; CI: confidence interval Table 3 Prognostic factors for progression-free survival of MLLBO. Variable Univariable Multivariable Crude HR 95 CI P Adjust HR 95 CI P Sex, n () Male [reference] Female 0.736 0.419-0.969 ＜0.001 0.781 0.599-1.907 0.247 Age (years) 1.043 0.917-1.186 0.522 BMI (kg/m 2 ) 1.161 1.078-1.250 0.032 1.073 0.816-1.351 0.516 Comorbidity DM 1.188 0.600-1.284 0.093 COPD 1.439 0.658-1.524 0.328 Smoking 1.122 0.960-1.188 0.673 Hypertension 0.959 0.867-1.061 0.413 Previous abdominal surgery 1.030 0.891-1.191 0.686 Albumin 0.996 0.717-1.384 0.983 Metastatic sites Liver [reference] Liver only 1.142 1.045-1.247 0.003 1.237 1.078-1.423 ＜0.001 Lung 1.403 1.062-1.885 ＜0.001 1.531 1.281-1.733 ＜0.001 Others 1.179 1.107-1.357 0.043 1.211 0.902-1.379 0.067 No of metastatic sites 1 [reference] ＞1 1.585 1.297-1.983 ＜0.001 1.239 1.127-1.491 ＜0.001 ECOG PS 0 [reference] 1 0.566 0.529-0.606 ＜0.001 0.861 0.623-0.901 0.003 2 1.027 1.003-1.195 ＜0.001 1.137 1.026-1.366 ＜0.001 3 1.347 1.257-1.444 0.021 1.536 1.289-1.699 0.031 Others 1.786 0.530-2.085 0.418 1.601 0.412-1.819 0.309 Chemotherapy regimen FOLFOX [reference] FOLFIRI 1.131 0.985-1.337 0.107 FOLFOXIRI 0.802 0.719-1.018 0.073 Use of molecular agent 0.582 0.550-0.616 0.013 0.517 0.384-0.793 0.037 Others 1.123 0.921-1.232 0.811 CEA mg/ml 1.269 0.737-1.469 0.097 MLLBO No [reference] Yes 1.901 1.677-2.429 ＜0.001 1.619 1.391-1.899 ＜0.001 Primary tumor location Splenic flexure [reference] Descending colon 1.806 0.866-2.389 0.397 Sigmoid colon 1.133 0.713-1.321 0.416 Rectosigmoid junction 0.714 0.542-1.071 0.712 Primary tumor response SD [reference] PR 0.917 0.819-0.983 ＜0.001 0.506 0.297-0.733 ＜0.001 PD 1.136 1.053-1.225 0.041 1.221 1.013-1.585 ＜0.001 Metastatic tumor response SD [reference] PR 0.799 0.579-0.905 ＜0.001 0.707 0.479-0.998 ＜0.001 PD 1.159 1.081-1.243 0.023 1.679 1.291-2.144 0.002 Tumor shape Fungating [reference] Non-fungating 1.281 0.612-1.597 0.316 Treatment of MLLBO emergency resection [reference] diverting stoma 1.104 0.720-1.195 0.571 1.163 0.612-1.466 0.856 using stent 0.885 0.799-1.980 0.612 0.735 0.489-1.655 0.310 conservative treatment 1.156 1.021-1.377 ＜0.001 1.270 0.909-1.445 0.056 Passage of colonoscope 0.947 0.731-1.328 0.560 MLLBO : malignant left large bowel obstruction ; PSM propensity score matching; BMI body mass index; DM diabetes; COPD chronic obstructive pulmonary disease; CEA carcinoembryonic antigen; ECOG PS Eastern Cooperative Oncology Group; PR: partial response; SD: stable disease; PD: progressive disease; HR: hazard ratio; CI: confidence interval Table 4 Univariate and multivariate analysis of tumor characteristics for MLLBO. MLLBO (n = 52) No-MLLBO (n = 104) Univariate p value Multivariate p value OR (95%CI) Previous abdominal surgery, n (%) 11(21.2) 26(25) 0.134 Primary tumor location, n (%) 0.036 0.154 1.096(0.845-1.636) Splenic flexure 8(15.4) 9(8.7) Descending colon 10(19.2) 31(29.8) Sigmoid colon 30(57.7) 54(51.9) Rectosigmoid junction 4(7.7) 10(9.6) Primary tumor response, n (%) 0.029 0.076 1.170 (0.743-1.593) PR 30(57.7) 56(53.8) SD 17(32.7) 31(29.8) PD 5(9.6) 17(16.3) Tumor shape, n (%) 0.790 Fungating 39(75) 91(87.5) Non-fungating 13(25) 13(12.5) Passage of colonoscope, n (%) 43(82.7) 91(87.5) 0.712 Tumor length, median (range) cm 6.02±6.27 5.3±7.19 Tumor length ≥ 10 cm, n (%) 12(23.1) 7(6.7) ＜0.001 0.043 1.523 (1.188-2.197) TTI, median (range) cm 2.19±0.91 1.42±0.34 TTI ≥ 1.5 cm, n (%) 44(84.6) 35(33.7) ＜0.001 ＜0.001 4.670(1.053-15.704) Degree of stenosis, median (range) 1.04±0.98 0.95±0.22 0.032 0.936 0.976(0.537-1.773) Reginal lymph node conditions Fusion or necrosis, n (%) 15(28.8) 21(20.2) 0.136 Long-axis diameter, median (range) cm 1.39±0.81 1.08±0.47 0.047 0.411 0.692(0.288-1.694) Short-axis diameter, median (range) cm 0.99±0.59 0.83±0.33 0.053 MLLBO : malignant left large bowel obstruction ; PSM propensity score matching; BMI body mass index; DM diabetes; COPD chronic obstructive pulmonary disease; CEA carcinoembryonic antigen; ECOG PS Eastern Cooperative Oncology Group; PR: partial response; SD: stable disease; PD: progressive disease; TTI thickness of tumor-involved intestinal tube; OR: odds ratio; CI: confidence interval. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3197254","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":220920596,"identity":"484ec002-6677-49b2-bc44-a63489d6bab1","order_by":0,"name":"Jianlin Xiao","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jianlin","middleName":"","lastName":"Xiao","suffix":""},{"id":220920597,"identity":"d31a2524-cd14-409c-ad81-d162dabea6f1","order_by":1,"name":"yu shen","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"yu","middleName":"","lastName":"shen","suffix":""},{"id":220920598,"identity":"a8e62c61-294d-436f-a6ee-81739c78840e","order_by":2,"name":"Xuyang Yang","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xuyang","middleName":"","lastName":"Yang","suffix":""},{"id":220920599,"identity":"ef7d5ba4-738e-4062-b49c-1bd9ce36e361","order_by":3,"name":"Hanjiang Zeng","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hanjiang","middleName":"","lastName":"Zeng","suffix":""},{"id":220920600,"identity":"bb9b8e26-415a-44f2-bc22-9ea2f31fe309","order_by":4,"name":"Mingtian Wei","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mingtian","middleName":"","lastName":"Wei","suffix":""},{"id":220920601,"identity":"d3d78366-4531-4ee8-9d43-42aef6aafeb6","order_by":5,"name":"Wenjian Meng","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Wenjian","middleName":"","lastName":"Meng","suffix":""},{"id":220920602,"identity":"44ff3e4f-20d7-4d86-b178-a714b77082de","order_by":6,"name":"Ziqiang Wang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA9UlEQVRIiWNgGAWjYNACAwYeIMn4AMJLIF4LswEJWiCATYIoLQbHzx5++aPAWoZ/dvu1yh81hxn42XMMGH7uwKPlTF6ahYRBOo/EnTNlt3mOHWaQ7HljwNh7BrcWswM5ZgYGBod5GG7kpN1mbDjMYHAjx4CZsQ2PlvNvzAwSgFrkgVoKfwK12BPUciPH+MEBoBaDG+nHGHhBtkgQ0GJ/440ZYwPQL4Y3cpileY4BPXXmWcHBXjxaJPtzjD/++GNtL3cj/eHHHzXWcvztyRsf/MSjhQESHcxAmgcck6A4ZTiAVwNQ+QeIFvYHBBSOglEwCkbBSAUAN9NRIhHStpoAAAAASUVORK5CYII=","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ziqiang","middleName":"","lastName":"Wang","suffix":""}],"badges":[],"createdAt":"2023-07-23 19:14:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3197254/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3197254/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":40663402,"identity":"8d33fe48-2eca-4892-8d7d-ab1397847a63","added_by":"auto","created_at":"2023-07-27 14:14:26","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":20442,"visible":true,"origin":"","legend":"\u003cp\u003eFlow diagram of patient selection\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eLBO\u003c/em\u003e large bowel obstruction; \u003cem\u003eCRC\u003c/em\u003e colorectal cancer; \u003cem\u003eMLLBO\u003c/em\u003e malignant left large bowel obstruction\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-3197254/v1/8f05290d95176bdaec9dcffe.png"},{"id":40663408,"identity":"42882da1-be53-4774-b7fb-5e70f9a664db","added_by":"auto","created_at":"2023-07-27 14:14:27","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":37796,"visible":true,"origin":"","legend":"\u003cp\u003eOverall survival for patients with and without MLLBO. Cens = censored.\u003c/p\u003e\n\u003cp\u003eLog rank, p = 0.020\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-3197254/v1/0f7289351775eae009dfbd19.png"},{"id":40663399,"identity":"e2c51802-5cc1-4ee1-9fb8-49b8a5c84865","added_by":"auto","created_at":"2023-07-27 14:14:26","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":35602,"visible":true,"origin":"","legend":"\u003cp\u003eProgression-free survival for patients with and without MLLBO, Cens = censored.\u003c/p\u003e\n\u003cp\u003eLog rank, p = 0.018\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-3197254/v1/1086c4ef42579f73bf745f1e.png"},{"id":40753636,"identity":"061d3d52-d792-4830-9299-47d79b50ad0c","added_by":"auto","created_at":"2023-07-29 07:52:36","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":382774,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3197254/v1/876ea646-bf1f-48df-98c8-4e9145e0a2bb.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Influence of malignant left large bowel obstruction in metastatic left-sided colon cancer patients during chemotherapy on survival: A Propensity Score Analysis","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eColorectal cancer is one of the most common malignancies, accounting for 9.8% of all cancer cases, it is the third most common cancer reported worldwide and is the second most common cause of cancer death.\u003csup\u003e[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]\u003c/sup\u003e Initial clinical presentation as metastatic colorectal cancer (mCRC) occurs in approximately 20% of patients. Moreover, up to 50% of patients with localized disease eventually develop metastases.\u003csup\u003e[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]\u003c/sup\u003e According to the current guidelines, such as the NCCN,\u003csup\u003e[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]\u003c/sup\u003e ASCO, and ESMO guidelines,\u003csup\u003e[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]\u003c/sup\u003e systemic therapy is the first-line treatment for these cases. In the setting of current great advances in systemic treatment of mCRC, the risk of primary tumor-related emergency situations and the need for urgent surgical interventions are lower than before.\u003csup\u003e[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]\u003c/sup\u003e However, some researchers demonstrated that not all these patients could benefit from systemic chemotherapy and they unavoidably suffered from the adverse events linked to the primary tumor in the end.\u003csup\u003e[\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]\u003c/sup\u003e A previous meta-analysis reported that when unresectable stage IV patients initially received chemotherapy, approximately 22% of these patients presented with primary tumor-related complications, such as malignant large bowel obstruction (MLBO).\u003csup\u003e[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]\u003c/sup\u003e MLBO occurs in roughly 15% of patients with colon cancer in the USA.\u003csup\u003e[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]\u003c/sup\u003e The majority of malignant large bowel obstructions are secondary to malignant left large bowel obstruction (MLLBO) and require urgent management.\u003csup\u003e[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]\u003c/sup\u003e MLLBO could cause colonic edema resulting in a poorer general condition of patients, which could lead to a series of serious complications such as water and electrolyte imbalance, acid-base imbalance, peritonitis, intestinal perforation, and septic shock. \u003csup\u003e[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eThere is still no consensus on whether MLLBO during chemotherapy will affect the survival outcome of patients with metastatic left-sided colon cancer (mLCC). Therefore, the purpose of this study is to analyze the difference in overall survival (OS) and progression-free survival (PFS) between MLLBO and no-MLLBO patients during chemotherapy by using PSM. In addition, we investigated the risk factors of tumor characteristics for MLLBO patients to predict clinical factors associated with the occurrence of MLLBO.\u003c/p\u003e"},{"header":"PATIENTS AND METHODS","content":"\u003cp\u003e \u003cb\u003ePatients and study design\u003c/b\u003e \u003c/p\u003e \u003cp\u003eThis is a single-institution retrospective study, consecutive mLCC patients who underwent chemotherapy from June 2009 to July 2021 in West China Hospital were divided into two groups according to whether MLLBO occurred during chemotherapy. The inclusion criteria were: 1) patients newly diagnosed with mLCC without obstruction and accepted chemotherapy. Exclusion criteria were: 1) patients with recurrent CRC or primary cancer of other organs; 2) patients without baseline radiological evaluation records in our center before chemotherapy; 3) patients with LBO proved to be not mLCC related; 4) patients who lost to follow-up or gave up due to severe side effects of chemotherapy.\u003c/p\u003e \u003cp\u003ePatients were then propensity matched 1:2 into MLLBO and no-MLLBO groups through the nearest neighbor method with a caliper of 0.1 times the standard deviation of the propensity score. No replacement was allowed, and patients were matched only once. Variables used for matching were as follows: age, sex, body mass index (BMI), Comorbidity, preoperative carcinoembryonic antigen (CEA) and albumin levels, metastatic sites, the number of metastatic sites, Eastern Cooperative Oncology Group (ECOG PS), chemotherapy regimen. The study was approved by the institutional review board of West China Hospital, Sichuan University. We confirm that we have obtained ethical approval to conduct the study as well as permission from the dataset, and the study was conducted in accordance with the provisions of the Declaration of Helsinki (as revised in Fortaleza, Brazil, October 2013). The obtained data were only collected and analyzed; however, detailed information was not released to the public, and information confidentiality regulations were strictly adhered to.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eDefinitions\u003c/strong\u003e \u003cp\u003eLeft-sided colon cancer was defined as carcinoma of the splenic flexure to the rectosigmoid junction. Large bowel obstruction is diagnosed by clinical symptoms (bloating, pain, and inability to pass stool or gas), clinical examination, endoscopy, abdominal plain radiography, and abdominal computed tomography (CT). The tumor stage was diagnosed according to the AJCC 8th Edition.\u003csup\u003e[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]\u003c/sup\u003e Overall survival (OS) was defined as the time from chemotherapy to death or the last follow-up. Progression-free survival (PFS) was defined as the period between the beginning of treatment and the onset of disease progression or the last follow-up date due to various causes in patients with mLCC.\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cb\u003eData collection\u003c/b\u003e \u003c/p\u003e \u003cp\u003eDemographic and clinical data were retrospectively extracted from the electronic clinical records. Including age, sex, body mass index (BMI), Comorbidity, preoperative CEA and albumin levels, metastatic sites, the number of metastatic sites, ECOG PS, chemotherapy regimen, primary tumor location, primary and metastatic tumor response to chemotherapy (PR: partial response; SD: stable disease; PD: progressive disease),\u003csup\u003e[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]\u003c/sup\u003e tumor shape, treatment of MLLBO and ability to pass the colonoscope through the lesion. Enhanced CT imaging of included patients was performed using the 64-slice spiral CT (Philips Brilliance 64, Philips Medical Systems, Best, Netherlands), and 128-slice spiral CT (SOMATOM Definition AS+, Siemens Healthcare Forscheim, Germany). Traditionally, scanning parameters were set at a tube voltage of 100\u0026ndash;120 kV and a tube current of 250\u0026ndash;350 mAs. Non-ionic contrast agent (60\u0026ndash;80 mL, iopamidol, 370 mg/mL, Bracco Sine Pharmaceutical Corp. Ltd, Shanghai, China) and saline flush (20 mL) were injected successively at a 2.5\u0026ndash;3.5 mL/s flow rate. Collected radiological data were reconstructed with slice thickness of 2\u0026ndash;5 mm. Radiological data were retrospectively obtained on the Syngo MultiModality Workplace and all the patients were scanned on a dual-source computed tomography (DSCT) scanner (SOMATOM Definition Flash; Siemens Healthcare, Forchheim, Germany). The enhanced CT data were first included for 3D reconstruction. A surgeon (Jianlin Xiao) and a radiologist (Hangjiang Zeng) were then blinded to the patients\u0026rsquo; clinical diagnosis and reviewed the contrast-enhanced CT images of mLCC patients before chemotherapy respectively. The following radiological parameters were collected: 1) location of tumors; 2) thickness of tumor-involved intestinal canal (TTI); 3) degree of stenosis; 4) the max size of regional lymph nodes (short- and long-axis diameter of regional lymph nodes were measured); 5) whether lymph nodes were accompanied with fusion or necrosis on CT image. The degree of stenosis was measured by the ratio of the proximal and distal inner diameter of the involved large bowel.\u003c/p\u003e \u003cp\u003e \u003cb\u003eStudy outcomes\u003c/b\u003e \u003c/p\u003e \u003cp\u003eIn our center, follow-ups (including CT review) were settled every two chemotherapy cycles according to routine follow-up protocol for colon cancer.\u003csup\u003e[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]\u003c/sup\u003e The primary endpoint was to compare the oncologic outcomes between MLLBO and no-MLLBO patients during chemotherapy. The secondary endpoint was to identify the risk factors of tumor characteristics for MLLBO.\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis\u003c/h2\u003e \u003cp\u003eSPSS for Windows, version 25 (IBM Corp, Armonk, NY) was used for data analysis. In this study, a 1:2 PSM analysis (without replacement) was conducted via the nearest neighbor method with a caliper of 0.1 times the standard deviation of the propensity score. Standardized differences were used to examine the balance across baseline covariates before and after matching, and a standardized difference below 10% was reliable enough to provide well-balanced covariates after matching. Next, χ2 statistics were utilized to compare patient and tumor characteristics in both matched and unmatched cohorts. In the matched population, univariable and multivariable Cox proportional hazards regression models were performed to identify the independent risk factors for MLLBO patients. Statistical significance was defined as a \u003cem\u003ep\u003c/em\u003e-value smaller than 0.05.\u003c/p\u003e \u003c/div\u003e"},{"header":"RESULTS","content":"\u003cp\u003eBaseline characteristics in this study, 1638 patients diagnosed with mLCC between 2009 and 2021 met our selection criteria for additional analysis. Of those, 52 patients underwent MLLBO, whereas 1586 did not. A PSM analysis was then conducted and 156 patients were 1:2 matched, comprising a MLLBO and no-MLLBO cohort. (Fig. 1) Distribution of the baseline characteristics was well-balanced in the matched cohort (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eImpact of MLLBO on overall survival\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe OS of the matched cohort was calculated by the Kaplan-Meier method. The results revealed a significant difference in survival between patients who underwent MLLBO and those who did not (log-rank p=0.020) (Fig. 2). The median OS for those who underwent MLLBO was 34.0 months (95% CI, 31.7 months\u0026ndash;36.9 months) and 51.0 months (95% CI, 49.3 months\u0026ndash;52.7 months) for those who did not. When performing a univariable Cox proportional hazards regression analysis in the matched population, all the baseline characteristics including sex, BMI, metastatic sites, the number of metastatic sites,\u0026nbsp;ECOG PS,\u0026nbsp;chemotherapy regimen, MLLBO,\u0026nbsp;primary tumor response to chemotherapy, metastatic tumor response to chemotherapy and treatment methods of MLLBO significantly correlated with these patients\u0026rsquo; OS and these variables were all included in the following multivariate Cox analysis. After multivariable risk adjusting in the Cox proportional hazard regression analysis, MLLBO was a statistically significant risk factor for OS (hazard ratio [HR]= 1.473, 95% CI 1.186-1.812, P＜0.001). Besides, metastatic sites, the number of metastatic sites,\u0026nbsp;ECOG PS,\u0026nbsp;chemotherapy regimen,\u0026nbsp;metastatic tumor response to chemotherapy, and treatment methods of MLLBO were validated as independent risk or protective factors as well. (Table 2)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eImpact of MLLBO on progression-free survival\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMedian PFS for those who underwent MLLBO was 12.0 months (95% CI, 10.1 months\u0026ndash;13.9 months) and 23.0 months (95% CI, 22.3 months\u0026ndash;24.7 months) for those who did not (Fig. 3). In the univariable Cox proportional hazards regression analysis, sex, BMI, metastatic sites, the number of metastatic sites,\u0026nbsp;ECOG PS,\u0026nbsp;chemotherapy regimen, MLLBO,\u0026nbsp;primary tumor response to chemotherapy, metastatic tumor response to chemotherapy and treatment methods of MLLBO were also correlated with PFS and they were further adjusted in the multivariate Cox regression. After multivariable analysis, MLLBO was a statistically significant risk factor for PFS (hazard ratio [HR]= 1.619, 95% CI 1.391-1.899, P＜0.001). Besides, other covariates including metastatic sites, the number of metastatic sites,\u0026nbsp;ECOG PS,\u0026nbsp;chemotherapy regimen,\u0026nbsp;metastatic tumor response to chemotherapy and primary tumor response to chemotherapy also proved to be independent prognostic factors for PFS. (Table 3)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe univariate and multivariate analyses for MLLBO\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePotential variables (p\u0026lt;0.05 in the univariate analysis) were selected for further multivariable analysis, including primary tumor location (p=0.036), primary tumor response to chemotherapy (p=0.029), tumor length (p＜0.001), TTI (p＜0.001), degree of stenosis (p=0.032) and long-axis diameter of regional lymph node (p=0.047). In the multivariable logistic regression analysis, tumor length \u0026ge; 10 cm (p=0.043) and TTI \u0026ge; 1.5 cm (p＜0.001) were identified as independent risk factors of tumor characteristics for MLLBO patients. (Table 4)\u003c/p\u003e"},{"header":"DISCUSSION","content":"\u003cp\u003eTreatment decision-making for MLLBO during chemotherapy remains a challenging issue. The management of non-metastatic left-sided malignant colon obstruction includes emergency primary surgical resection with self-expandable metallic stent or decompressing stoma is a surgical bridge to select a strategy for transition to elective surgery.\u003csup\u003e[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]\u003c/sup\u003e For mLCC, we use self-expandable metallic stent or decompressing stoma to relieve the symptoms of MLLBO, to achieve the purpose of continuing systematic treatment or palliative treatment.\u003csup\u003e[\u003cspan additionalcitationids=\"CR20\" citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]\u003c/sup\u003e In this study, for the included patients with mLCC, we have compared the oncologic outcomes between MLLBO and no-MLLBO patients during chemotherapy. We advocate that no-MLLBO patients have better prognosis than MLLBO patients during chemotherapy for mLCC, the median OS and PFS of no-MLLBO patients were significantly higher than those of MLLBO patients. We analyzed the possible reasons as follows: 1) MLLBO interrupted systematic treatment and destroyed the continuity of therapy; 2) Patients with MLLBO were generally in poor physical condition, and the worse Eastern Cooperative Tumor Group (ECOG PS) status was independently associated with shorter median survival;\u003csup\u003e[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]\u003c/sup\u003e 3) The occurrence of MLLBO during chemotherapy may be a sign of the poor curative effect of systematic treatment.\u003c/p\u003e \u003cp\u003e Surgical diversion is a common approach for MLLBO in clinical practice, however, current guidelines infrequently address its use.\u003csup\u003e[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]\u003c/sup\u003e In fact, some patients are not able to undergo surgical palliation due to their poor performance, and endoscopic palliation such as stent insertion can be an alternative method. However, limitation of endoscopic procedure still exists including approach failure, stent migration, or tumor ingrowth.\u003csup\u003e[\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]\u003c/sup\u003e Preventing MLLBO is just important as treating it for mLCC patients. Preventing the occurrence of MLLBO can not only reduce emergency surgery but also ensure the completion of systematic treatment. Improving the completion rate of systematic treatment is almost the same as improving the rate of OS and PFS. Therefore, we identified independent risk factors for tumor characteristics in MLLBO patients, with tumor length\u0026thinsp;\u0026ge;\u0026thinsp;10 cm and TTI\u0026thinsp;\u0026ge;\u0026thinsp;1.5 cm, to predict the possibility of occurrence of MLLBO. One reason for this may be that longer and thicker tumor-involved bowel tube often indicates later tumor staging, and are frequently accompanied by worse enterocinesia. Both reasons weak the passage capacity of the bowel tube and result in the contents accumulating in the proximal bowel.\u003csup\u003e[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]\u003c/sup\u003e Another reason may be related to the role of inflammatory markers. Tumor growth has been proven to be related to many inflammatory markers such as cytokines and chemokines, which are stimulated by the tumor itself.\u003csup\u003e[\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]\u003c/sup\u003e The previous study also verified that the preoperative neutrophil\u0026ndash;lymphocyte ratio was a predictor of LBO due to tumor growth.\u003csup\u003e[\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]\u003c/sup\u003e Larger tumors tend to activate more inflammatory effects than smaller ones, thus increasing the probability of obstruction. In addition, we also found that the tumor length\u0026thinsp;\u0026ge;\u0026thinsp;10 cm and TTI\u0026thinsp;\u0026ge;\u0026thinsp;1.5 cm may be associated factors. According to our study, 8 patients with tumor length\u0026thinsp;\u0026ge;\u0026thinsp;10 cm, 6 of those patients (75.0%) were along with TTI\u0026thinsp;\u0026ge;\u0026thinsp;1.5 cm and all of the patients developed MLLBO in the next six months to two years. So, we hypothesized that the presence of both tumor length\u0026thinsp;\u0026ge;\u0026thinsp;10 cm and TTI\u0026thinsp;\u0026ge;\u0026thinsp;1.5 cm were strong predictors of MLLBO in patients with mLCC. To prevent MLLBO, we need to take positive measures for mLCC patients with the above high-risk factors during chemotherapy, such as surgical diversion, self-expanding metal stents, and emergent oncologic resection.\u003c/p\u003e \u003cp\u003eOf course, there are limitations in this present study. The major one is that it was a retrospective case-control study. Only 52 patients with MLLBO and 104 matched patients were included. This means all the conclusions were based on the small samples of our center. So, there is still a long way to go from limited inference to practical application. Another limitation of this study is in the process of matching and data extracting, despite the blind method, partial bias was still introduced by manual recognition. A prospective randomized controlled study with larger samples is needed to confirm our verdict and support our reasoning. In addition, there are fewer comorbidities including DM, COPD, etc. While these do not appear to reach significance, maybe the numbers of patients are too small to detect a significant difference. And we explored the risk factors of tumor characteristics for MLLBO patients, so we excluded general factors such as sex, age, BMI, etc. Therefore, it remains unknown whether there are other risk factors.\u003c/p\u003e \u003cp\u003eIn conclusion, we advocate that no-MLLBO patients have better prognosis than MLLBO patients during chemotherapy for mLCC, the median OS and PFS of no-MLLBO patients were significantly higher than those of MLLBO patients. In addition, Tumor length\u0026thinsp;\u0026ge;\u0026thinsp;10 cm and TTI\u0026thinsp;\u0026ge;\u0026thinsp;1.5 cm were identified as independent risk factors of tumor characteristics for MLLBO patients during chemotherapy. Attention should be paid to such patients and preventive measures should be taken.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eThis study was supported by the Department of Science and Technology of Sichuan Province (Award Number 2021YFS0025); 1\u0026middot;3\u0026middot;5 project for disciplines of excellence, West China Hospital, Sichuan University (No. 2019HXFH031; 20HXJS003)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions:\u0026nbsp;\u003c/strong\u003eJianlin Xiao: Resources; writing-original draft; writing-review and editing.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eYu Shen: Writing-review and editing.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMingtian Wei \u0026amp; Xuyang Yang: Writing-review and editing.\u003c/p\u003e\n\u003cp\u003eHanjiang Zeng: Conceptualization; resources.\u003c/p\u003e\n\u003cp\u003eWenjian Meng: Conceptualization; resources; supervision.\u003c/p\u003e\n\u003cp\u003eZiqiang Wang: Conceptualization; methodology; writing-review and editing.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of interest: \u0026nbsp;\u003c/strong\u003eThe authors declare no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval:\u0026nbsp;\u003c/strong\u003eThe Institutional Review Committee of West China Hospital of Sichuan University approved this study. The study was\u0026nbsp;registered at Chinese Clinical Trial Registry (Identifier: ChiCTR2200056134).\u0026nbsp;The requirement for informed consent was waived due to the retrospective nature of the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e: The datasets during and/or analysed during the current study are not publicly available due to the confidentiality of patient information but are available from the corresponding author on reasonable request.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eSUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA: a cancer journal for clinicians, 2021, 71(3): 209-49.\u003c/li\u003e\n \u003cli\u003eCIARDIELLO F, CIARDIELLO D, MARTINI G, et al. Clinical management of metastatic colorectal cancer in the era of precision medicine [J]. CA: a Cancer Journal for Clinicians, 2022, 72(4): 372-401.\u003c/li\u003e\n \u003cli\u003eCERVANTES A, ADAM R, ROSELLO S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up [white star] [J]. Annals of Oncology, 2023, 34(1): 10-32.\u003c/li\u003e\n \u003cli\u003eBENSON A B, VENOOK A P, AL-HAWARY M M, et al. Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology [J]. Journal of the National Comprehensive Cancer Network, 2022, 20(10): 1139-67.\u003c/li\u003e\n \u003cli\u003eYOSHINO T, ARNOLD D, TANIGUCHI H, et al. Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer; A JSMO - ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS [J]. Annals of Oncology, 2018, 29(1): 44-70.\u003c/li\u003e\n \u003cli\u003eMORRIS V K M D, KENNEDY E B M, BAXTER N N M D P, et al. Treatment of Metastatic Colorectal Cancer: ASCO Guideline [J]. Journal of Clinical Oncology, 2023, 41(3): 678-700.\u003c/li\u003e\n \u003cli\u003ePOULTSIDES G A, SERVAIS E L, SALTZ L B, et al. Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment [J]. Journal of Clinical Oncology, 2009, 27(20): 3379.\u003c/li\u003e\n \u003cli\u003eLORIMER P D, MOTZ B M, KIRKS R C, et al. Frequency of unplanned surgery in patients with stage IV colorectal cancer receiving palliative chemotherapy with an intact primary: An analysis of SEER㎝edicare [J]. Journal of Surgical Oncology, 2019, 120(3):\u003c/li\u003e\n \u003cli\u003eBARTON, KAY M. Primary tumor location found to impact prognosis and response to therapy in patients with metastatic colorectal cancer [J]. CA: A Cancer Journal for Clinicians, 2017,\u003c/li\u003e\n \u003cli\u003eLEVENT K, ?ENOL C K H, FAYSAL D, et al. Kras-mutation influences outcomes for palliative primary tumor resection in advanced colorectal cancer- a Turkish Oncology Group Study [J]. Surgical Oncology, 2018, 27(3): 485-9.\u003c/li\u003e\n \u003cli\u003eSTILLWELL A P, BUETTNER P G, HO Y H. Meta-Analysis of Survival of Patients with Stage IV Colorectal Cancer Managed with Surgical Resection Versus Chemotherapy Alone [J]. World Journal of Surgery, 2010, 34(4): 797-807.\u003c/li\u003e\n \u003cli\u003eALVAREZ J A, BALDONEDO R F, BEAR I G, et al. Presentation, treatment, and multivariate analysis of risk factors for obstructive and perforative colorectal carcinoma [J]. American Journal of Surgery, 2005, 190(3): 376-82.\u003c/li\u003e\n \u003cli\u003eFRAGO, R., RAMIREZ, et al. Current management of acute malignant large bowel obstruction: a systematic review [J]. American Journal of Surgery, 2014,\u003c/li\u003e\n \u003cli\u003eMARKOGIANNAKIS H, BRAMIS I, MESSARIS E, et al. Acute mechanical bowel obstruction: clinical presentation, etiology, management and outcome [J]. 世界胃肠病学杂志:英文版(电子版), 2007, 13(003): 432-7.\u003c/li\u003e\n \u003cli\u003eTHANGASAMY, B. M. Oncological emergencies in colorectal carcinoma [J]. European Journal of Cancer, 2017, 72(S85-S.\u003c/li\u003e\n \u003cli\u003eZHANG J, DENG J, HU J, et al. Safety and feasibility of neoadjuvant chemotherapy as a surgical bridge for acute left-sided malignant colorectal obstruction: a retrospective study [J]. BMC Cancer, 2022, 22(1): 1-10.\u003c/li\u003e\n \u003cli\u003eYAO H, WU H, LIU Y. Improvement of prognostic and predictive network of colorectal cancer based upon the 8th edition of AJCC colorectal cancer staging system. [Chinese] [J]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2017, 20(1)(24-7.\u003c/li\u003e\n \u003cli\u003eSEYMOUR L, BOGAERTS J, PERRONE A, et al. iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics [J]. The Lancet Oncology, 2017, 18(3): e143-e52.\u003c/li\u003e\n \u003cli\u003eMALAKORN S, STEIN S L, LEE J H, et al. Urgent Management of Obstructing Colorectal Cancer: Divert, Stent, or Resect? [J]. Journal of Gastrointestinal Surgery, 2018, 23(\u003c/li\u003e\n \u003cli\u003eSAIDA Y. Short-Term Outcomes of Colorectal Stenting Using a Low Axial Force Self-Expandable Metal Stent for Malignant Colorectal Obstruction: A Japanese Multicenter Prospective Study [J]. Journal of Clinical Medicine, 2021, 10(\u003c/li\u003e\n \u003cli\u003eIKENNAH L. B, MD M, SEBASTIEN D, et al. Self-Expanding Metal Stents Do Not Adversely Affect Long-term Outcomes in Acute Malignant Large-Bowel Obstruction: A Retrospective Analysis [J]. Diseases of the Colon and Rectum, 2022, 2): 65.\u003c/li\u003e\n \u003cli\u003eWRIGHT FC C A, HELYER L, MORAVAN V, SELBY D. Predictors of survival in patients with non-curative stage IV cancer and malignant bowel obstruction [J]. Journal of Surgical Oncology, 2010, 101(5): 425-9.\u003c/li\u003e\n \u003cli\u003eVOGEL J D, ESKICIOGLU C, WEISER M R, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer [J]. Diseases of the Colon \u0026amp; Rectum, 2017, 60(10): 999.\u003c/li\u003e\n \u003cli\u003eKIM D H, KIM B, CHOI J H, et al. Tumor characteristics associated with malignant large bowel obstruction in stage IV colorectal cancer patients undergoing chemotherapy [J]. International Journal of Colorectal Disease, 2016, 31(11): 1767-74.\u003c/li\u003e\n \u003cli\u003eGRIGOREAN V T, ERCHID A, COMAN I S, et al. Colorectal Cancer-The \u0026quot;Parent\u0026quot; of Low Bowel Obstruction [J]. Medicina, 2023, 59(5): 02.\u003c/li\u003e\n \u003cli\u003eVELD J, UMANS D, VAN HALSEMA E, et al. Self-expandable metal stent (SEMS) placement or emergency surgery as palliative treatment for obstructive colorectal cancer: A systematic review and meta-analysis [J]. Critical Reviews in Oncology/Hematology, 2020, 155 (no pagination)(\u003c/li\u003e\n \u003cli\u003eETO S, KAWAHARA H, MATSUMOTO T, et al. Preoperative Neutrophil\u0026ndash;Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth [J]. Anticancer Research, 2019, 39(6): 3185-9.\u003cstrong\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003eTable 1. Baseline clinical characteristics of patients before PSM and after PSM.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"932\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eItem\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\"\u003e\n \u003cp\u003eBefore 1:2 PSM\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\"\u003e\n \u003cp\u003eAfter 1:2 PSM\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\"\u003e\n \u003cp\u003eMLLBO (n=52)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\"\u003e\n \u003cp\u003eNon-MLLBO (n=1586)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\"\u003e\n \u003cp\u003eMLLBO (n=52)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\"\u003e\n \u003cp\u003eNon-MLLBO (n=104)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eSex, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.168\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e28 (53.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e694(43.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e28(53.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e62(59.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e24 (46.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e892(56.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e24(46.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e42(40.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eAge (years)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e54.71\u0026plusmn;14.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e56.11\u0026plusmn;13.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.257\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e54.71\u0026plusmn;14.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e56.05\u0026plusmn;14.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.641\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e22.32\u0026plusmn;3.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e23.56\u0026plusmn;2.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.652\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e22.32\u0026plusmn;3.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e22.24\u0026plusmn;3.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.893\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eComorbidity, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eDM\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e2(3.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e159(10)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.047\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e2(3.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e5(4.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.601\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eCOPD\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e3(5.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e37(2.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.040\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e3(5.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e5(4.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.711\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eSmoking\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e22(42.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e537(33.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.613\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e22(42.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e35(33.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.241\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eHypertension\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e3(5.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e197(12.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.086\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e3(5.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e7(6.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.812\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003ePrevious abdominal surgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e6(11.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e125(7.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.217\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e6(11.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e11(10.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.315\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eAlbumin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e41.16\u0026plusmn;3.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e37.17\u0026plusmn;2.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.241\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e41.16\u0026plusmn;3.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e41.55\u0026plusmn;4.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.796\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eMetastatic sites, n (%)\u003c/p\u003e\n \u003cp\u003eLiver\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e33(63.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e1072(67.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.397\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e33(63.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e74(71.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.780\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp; Liver only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e25(48.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e752(47.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e25(48.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e51(49)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eLung\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e14(26.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e467(29.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e14(26.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e35(32.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp; Others\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e12(23.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e97(6.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e12(23.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e16(15.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eNo. of metastatic sites, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.491\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e39(75)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e974(61.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e39(75)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e82(78.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e＞1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e13(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e612(38.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e13(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e22(21.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eECOG PS, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.276\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e6(11.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e287(18.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e6(11.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e8(7.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e14(26.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e581(36.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e14(26.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e21(20.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e23(44.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e328(20.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e23(44.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e51(49)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e8(15.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e219(13.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e8(15.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e21(20.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e1(1.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e171(10.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e1(1.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e3(2.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eChemotherapy regimen, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.065\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.132\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOX/XELOX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e32(61.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e1004(63.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e32(61.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e71(68.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e9(17.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e311(19.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e9(17.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e18(17.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOXIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e9(17.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e213(13.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e9(17.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e12(11.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eUse of molecular agent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e21(40.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e411(25.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e21(40.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e37(35.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp; Others\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e2(3.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e58(3.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e2(3.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e3(2.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"20.92274678111588%\" valign=\"top\"\u003e\n \u003cp\u003eCEA mg/ml\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.450643776824034%\" valign=\"top\"\u003e\n \u003cp\u003e110.24\u0026plusmn;224.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"15.343347639484978%\" valign=\"top\"\u003e\n \u003cp\u003e248.37\u0026plusmn;352.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.725321888412017%\" valign=\"top\"\u003e\n \u003cp\u003e0.003\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e110.24\u0026plusmn;224.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.197424892703863%\" valign=\"top\"\u003e\n \u003cp\u003e127.24\u0026plusmn;263.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.163090128755364%\" valign=\"top\"\u003e\n \u003cp\u003e0.601\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003eMLLBO\u003c/em\u003e:\u0026nbsp;malignant left large bowel obstruction\u003cem\u003e; PSM\u003c/em\u003e propensity score matching;\u0026nbsp;\u003cem\u003eBMI\u003c/em\u003e body mass index; \u003cem\u003eDM\u003c/em\u003e diabetes; \u003cem\u003eCOPD\u003c/em\u003e chronic obstructive pulmonary disease;\u0026nbsp;\u003cem\u003eCEA\u0026nbsp;\u003c/em\u003ecarcinoembryonic antigen; \u003cem\u003eECOG PS\u003c/em\u003e Eastern Cooperative Oncology Group.\u003c/p\u003e\n\u003cp\u003e*Data was shown as mean (SD).\u003c/p\u003e\n\u003cp\u003eTable 2 Prognostic factors for overall survival of MLLBO.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"756\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\"\u003e\n \u003cp\u003eUnivariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003eMultivariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\"\u003e\n \u003cp\u003eCrude HR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\"\u003e\n \u003cp\u003e95 CI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003eAdjust HR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003e95 CI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSex, n ()\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.718\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.668-0.771\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.020\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.675\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.469-1.293\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.531\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eAge (years)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.185\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.709-1.278\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.447\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.112\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.029-1.223\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.040\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.212\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.982-1.652\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.074\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eComorbidity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eDM\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.344\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.765-1.939\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.298\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eCOPD\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.765\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.653-2.885\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.073\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSmoking\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.009\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.875-1.163\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.532\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eHypertension\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.963\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.872-1.062\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.887\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrevious abdominal surgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.332\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.554-2.204\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.175\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eAlbumin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.966\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.530-1.605\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.905\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMetastatic sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLiver\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLiver only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.875\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.526-2.065\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.647\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.279-1.907\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLung\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.246\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.080-1.766\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.015\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.101\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.015-1.227\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.028\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eOthers\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.817\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.737-1.906\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.327\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.709\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.407-1.997\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.425\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNo. of metastatic sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e＞1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.977\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.686-2.318\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.854\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.302-2.327\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eECOG PS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.588\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.556-0.621\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.556\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.257-0.784\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.012\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.399\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.376-1.424\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.232\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.011-1.594\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.819\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.686-2.387\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.058\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.917\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.505-2.371\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.049\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eOthers\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.451\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.699-1.810\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.097\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.186\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.974-1.476\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.710\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eChemotherapy regimen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.111\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.651-1.174\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.145\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOXIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.941\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.682-1.315\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.817\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eUse of molecular agent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.408\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.153-0.787\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.620\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.417-0.898\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.023\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp; Others\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.072\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.876-1.385\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.933\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eCEA mg/ml\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.143\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.985-1.570\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.508\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMLLBO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.807\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.382-2.434\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.473\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.186-1.812\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor location\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSplenic flexure\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eDescending colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.131\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.821-1.337\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.092\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSigmoid colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.172\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.596-1.256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.154\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eRectosigmoid junction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.960\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.843-1.093\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.753\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor response\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.539\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.198-0.811\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.017\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.751\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.470-1.908\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.426\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.512\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.049-1.899\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.042\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.151\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.883-1.628\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.097\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMetastatic tumor response\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.897\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.645-0.956\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.611\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.379-0.906\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.298\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.077-1.564\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.237\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.001-1.587\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eTumor shape\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNon-fungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.443\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.511-1.876\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.648\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eTreatment of MLLBO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eemergency resection\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003ediverting stoma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.013\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.679-1.254\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.146\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.179\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.601-1.659\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.649\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eusing stent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.806\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.635-1.031\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.646\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.982\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.646-1.667\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.731\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003econservative treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.564\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.138-2.021\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.026\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.271\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.089-1.412\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.031\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePassage of colonoscope\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.814\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.733-1.305\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.791\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003eMLLBO\u003c/em\u003e:\u0026nbsp;malignant left large bowel obstruction\u003cem\u003e; PSM\u003c/em\u003e propensity score matching;\u0026nbsp;\u003cem\u003eBMI\u003c/em\u003e body mass index; \u003cem\u003eDM\u003c/em\u003e diabetes; \u003cem\u003eCOPD\u003c/em\u003e chronic obstructive pulmonary disease;\u0026nbsp;\u003cem\u003eCEA\u0026nbsp;\u003c/em\u003ecarcinoembryonic antigen; \u003cem\u003eECOG PS\u003c/em\u003e Eastern Cooperative Oncology Group; \u003cem\u003ePR:\u003c/em\u003e partial response; \u003cem\u003eSD:\u0026nbsp;\u003c/em\u003estable disease; \u003cem\u003ePD:\u003c/em\u003e progressive disease;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eHR:\u0026nbsp;\u003c/em\u003ehazard ratio; \u003cem\u003eCI:\u003c/em\u003e confidence interval\u003c/p\u003e\n\u003cp\u003eTable 3 Prognostic factors for progression-free survival of MLLBO.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"756\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\"\u003e\n \u003cp\u003eUnivariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003eMultivariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\"\u003e\n \u003cp\u003eCrude HR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\"\u003e\n \u003cp\u003e95 CI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003eAdjust HR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\"\u003e\n \u003cp\u003e95 CI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSex, n ()\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.736\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.419-0.969\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.781\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.599-1.907\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.247\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eAge (years)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.043\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.917-1.186\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.522\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.161\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.078-1.250\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.032\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.073\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.816-1.351\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.516\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eComorbidity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eDM\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.188\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.600-1.284\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.093\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eCOPD\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.439\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.658-1.524\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.328\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSmoking\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.122\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.960-1.188\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.673\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eHypertension\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.959\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.867-1.061\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.413\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrevious abdominal surgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.030\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.891-1.191\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.686\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eAlbumin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.996\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.717-1.384\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.983\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMetastatic sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLiver\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLiver only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.142\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.045-1.247\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.003\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.237\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.078-1.423\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eLung\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.403\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.062-1.885\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.531\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.281-1.733\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eOthers\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.179\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.107-1.357\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.043\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.211\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.902-1.379\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.067\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNo of metastatic sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e＞1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.585\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.297-1.983\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.239\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.127-1.491\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eECOG PS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.566\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.529-0.606\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.861\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.623-0.901\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.003\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.027\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.003-1.195\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.137\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.026-1.366\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.347\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.257-1.444\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.021\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.536\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.289-1.699\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.031\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eOthers\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.786\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.530-2.085\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.418\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.601\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.412-1.819\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.309\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eChemotherapy regimen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOX\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.131\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.985-1.337\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.107\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFOLFOXIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.802\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.719-1.018\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.073\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eUse of molecular agent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.582\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.550-0.616\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.013\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.517\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.384-0.793\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp; Others\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.123\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.921-1.232\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.811\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eCEA mg/ml\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.269\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.737-1.469\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.097\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMLLBO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.901\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.677-2.429\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.619\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.391-1.899\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor location\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSplenic flexure\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eDescending colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.806\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.866-2.389\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.397\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSigmoid colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.133\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.713-1.321\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.416\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eRectosigmoid junction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.714\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.542-1.071\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.712\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor response\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.917\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.819-0.983\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.506\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.297-0.733\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.136\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.053-1.225\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.221\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.013-1.585\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eMetastatic tumor response\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eSD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.799\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.579-0.905\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.707\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.479-0.998\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.159\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.081-1.243\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.023\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.679\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.291-2.144\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.002\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eTumor shape\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eFungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003eNon-fungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.281\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.612-1.597\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.316\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eTreatment of MLLBO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eemergency resection\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e[reference]\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003ediverting stoma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.104\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.720-1.195\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.571\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.163\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.612-1.466\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.856\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003eusing stent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.885\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.799-1.980\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.612\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.735\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.489-1.655\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.310\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\"\u003e\n \u003cp\u003econservative treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e1.156\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e1.021-1.377\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e1.270\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e0.909-1.445\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e0.056\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"22.516556291390728%\" valign=\"top\"\u003e\n \u003cp\u003ePassage of colonoscope\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.258278145695364%\" valign=\"top\"\u003e\n \u003cp\u003e0.947\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"17.483443708609272%\" valign=\"top\"\u003e\n \u003cp\u003e0.731-1.328\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.066225165562914%\" valign=\"top\"\u003e\n \u003cp\u003e0.560\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.966887417218542%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.741721854304636%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003eMLLBO\u003c/em\u003e:\u0026nbsp;malignant left large bowel obstruction\u003cem\u003e; PSM\u003c/em\u003e propensity score matching;\u0026nbsp;\u003cem\u003eBMI\u003c/em\u003e body mass index; \u003cem\u003eDM\u003c/em\u003e diabetes; \u003cem\u003eCOPD\u003c/em\u003e chronic obstructive pulmonary disease;\u0026nbsp;\u003cem\u003eCEA\u0026nbsp;\u003c/em\u003ecarcinoembryonic antigen; \u003cem\u003eECOG PS\u003c/em\u003e Eastern Cooperative Oncology Group; \u003cem\u003ePR:\u003c/em\u003e partial response; \u003cem\u003eSD:\u0026nbsp;\u003c/em\u003estable disease; \u003cem\u003ePD:\u003c/em\u003e progressive disease;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003cem\u003eHR:\u0026nbsp;\u003c/em\u003ehazard ratio; \u003cem\u003eCI:\u0026nbsp;\u003c/em\u003econfidence interval\u003c/p\u003e\n\u003cp\u003eTable 4 Univariate and multivariate analysis of tumor characteristics for MLLBO.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"784\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\"\u003e\n \u003cp\u003eMLLBO\u003c/p\u003e\n \u003cp\u003e(n = 52)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\"\u003e\n \u003cp\u003eNo-MLLBO\u003c/p\u003e\n \u003cp\u003e(n = 104)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\"\u003e\n \u003cp\u003eUnivariate\u003c/p\u003e\n \u003cp\u003e\u003cem\u003ep\u003c/em\u003e value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\"\u003e\n \u003cp\u003eMultivariate\u003c/p\u003e\n \u003cp\u003e\u003cem\u003ep\u003c/em\u003e value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\"\u003e\n \u003cp\u003eOR (95%CI)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePrevious abdominal surgery, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e11(21.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e26(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.134\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor location, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.036\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e0.154\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e1.096(0.845-1.636)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eSplenic flexure\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e8(15.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e9(8.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eDescending colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e10(19.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e31(29.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eSigmoid colon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e30(57.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e54(51.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eRectosigmoid junction\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e4(7.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e10(9.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary tumor response, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.029\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e0.076\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e1.170 (0.743-1.593)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e30(57.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e56(53.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eSD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e17(32.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e31(29.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e5(9.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e17(16.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eTumor shape, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.790\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eFungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e39(75)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e91(87.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003eNon-fungating\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e13(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e13(12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\" valign=\"top\"\u003e\n \u003cp\u003ePassage of colonoscope, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e43(82.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e91(87.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.712\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003eTumor length, median (range) cm\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\"\u003e\n \u003cp\u003e6.02\u0026plusmn;6.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\"\u003e\n \u003cp\u003e5.3\u0026plusmn;7.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003e\u0026nbsp; Tumor length \u0026ge; 10 cm, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e12(23.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e7(6.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e0.043\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e1.523 (1.188-2.197)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003eTTI, median (range) cm\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e2.19\u0026plusmn;0.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e1.42\u0026plusmn;0.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003e\u0026nbsp; TTI \u0026ge; 1.5 cm, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e44(84.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e35(33.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e＜0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e4.670(1.053-15.704)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003eDegree of stenosis, median (range)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e1.04\u0026plusmn;0.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e0.95\u0026plusmn;0.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.032\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e0.936\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e0.976(0.537-1.773)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003eReginal lymph node conditions\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003e\u0026nbsp; Fusion or necrosis, n (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e15(28.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e21(20.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.136\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003e\u0026nbsp; Long-axis diameter, median (range) cm\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e1.39\u0026plusmn;0.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e1.08\u0026plusmn;0.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.047\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e0.411\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e0.692(0.288-1.694)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"27.678571428571427%\"\u003e\n \u003cp\u003e\u0026nbsp; Short-axis diameter, median (range) cm\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.26530612244898%\" valign=\"top\"\u003e\n \u003cp\u003e0.99\u0026plusmn;0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.41326530612245%\" valign=\"top\"\u003e\n \u003cp\u003e0.83\u0026plusmn;0.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.64795918367347%\" valign=\"top\"\u003e\n \u003cp\u003e0.053\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"11.73469387755102%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.260204081632654%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003eMLLBO\u003c/em\u003e:\u0026nbsp;malignant left large bowel obstruction\u003cem\u003e; PSM\u003c/em\u003e propensity score matching;\u0026nbsp;\u003cem\u003eBMI\u003c/em\u003e body mass index; \u003cem\u003eDM\u003c/em\u003e diabetes; \u003cem\u003eCOPD\u003c/em\u003e chronic obstructive pulmonary disease;\u0026nbsp;\u003cem\u003eCEA\u0026nbsp;\u003c/em\u003ecarcinoembryonic antigen; \u003cem\u003eECOG PS\u003c/em\u003e Eastern Cooperative Oncology Group; \u003cem\u003ePR:\u003c/em\u003e partial response; \u003cem\u003eSD:\u0026nbsp;\u003c/em\u003estable disease; \u003cem\u003ePD:\u003c/em\u003e progressive disease; \u003cem\u003eTTI\u003c/em\u003e thickness of tumor-involved intestinal tube; \u003cem\u003eOR:\u0026nbsp;\u003c/em\u003eodds ratio; \u003cem\u003eCI:\u0026nbsp;\u003c/em\u003econfidence interval.\u003c/p\u003e\n\u003cp\u003eData was shown as mean (SD).\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Metastatic colorectal cancer, Malignant left large bowel obstruction, Chemotherapy, Propensity score matching","lastPublishedDoi":"10.21203/rs.3.rs-3197254/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3197254/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e Chemotherapy was recommended to improve the long-term outcomes of metastatic colorectal cancer (mCRC). The process of chemotherapy may be interrupted by malignant large bowel obstruction (MLBO). The aim of this study was to find out the Oncologic outcomes for MLLBO in metastatic left-sided colon cancer (mLCC) patients during chemotherapy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods \u003c/strong\u003eConsecutive mLCC patients who underwent chemotherapy from June 2009 to July 2021 in West China Hospital were divided into two groups according to whether MLLBO occurred during chemotherapy. Patients were propensity matched 1:2 into MLLBO and no-MLLBO groups and among the matched cohort, the univariable and multivariable Cox proportional hazards regression models were performed to identify predictors of survival. Potential variables were evaluated first with univariate and then multivariate analyses to identify the risk factors of tumor characteristics for MLLBO patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003eOf 1638 mLCC patients diagnosed, 156 were identified in the matched cohort. The median overall survival was 34.0 months, 51.0 months in the non-MLLBO, and MLLBO groups, respectively (p= 0.020) and the corresponding median progression-free survival was 12.0 months, 23.0 months, respectively (p=0.018). Multivariable Cox regression analysis demonstrated that MLLBO was independently associated with reduced overall survival (hazard ratio [HR]= 1.473, 95% CI 1.186-1.812, P＜0.001) as well as progression-free survival (hazard ratio [HR]= 1.619, 95% CI 1.391-1.899, P＜0.001). In addition, Tumor length ≥ 10 cm (P=0.043) and TTI ≥ 1.5 cm (P＜0.001) were identified as independent risk factors of tumor characteristics for MLLBO patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion \u003c/strong\u003eNo-MLLBO patients had better prognosis than MLLBO patients during chemotherapy. Prevention measures are recommended for mLCC patients with higher risk factors of MLLBO during chemotherapy.\u003c/p\u003e","manuscriptTitle":"Influence of malignant left large bowel obstruction in metastatic left-sided colon cancer patients during chemotherapy on survival: A Propensity Score Analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-07-27 14:14:20","doi":"10.21203/rs.3.rs-3197254/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f6138123-67a9-4182-9a5a-4a85f9b900c8","owner":[],"postedDate":"July 27th, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-07-31T11:59:25+00:00","versionOfRecord":[],"versionCreatedAt":"2023-07-27 14:14:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3197254","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3197254","identity":"rs-3197254","version":["v1"]},"buildId":"rHA-KDH7Qsr4HCuvH75dn","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}