Catalyst- and solvent-free synthesis, characterization, biological activity of Schiff bases and their metal (II) complexes derived from ferrocene

A novel efficient method for synthesizing ferrocene-based schiff bases and their metal (II) complexes was developed. The compounds were characterized by XRD and various spectroscopic techniques. In addition, their physicochemical studies were carried out using TGA-DTA analysis. The biological activities of ligands and their metal (II) complexes have been screened for in vitro antibacterial (such as S. aureus, B. cereus and E. coli ), antifungal properties (such as A. niger and A. fumigatus ). The results of these studies have revealed that Zn (II) complexes B11 was the most active against all bacterial strains, and antifungal activity was overall enhanced after complexation of the ligands.