A novel tumor-associated protein: clinical significance of serum levels in various clinical conditions with special reference to gynecological malignant diseases

M Nakai, Nakai M, Hirohito Kawauchi, H Kawauchi, Kawauchi H, Atsumi M, Masanori Atsumi, M Atsumi, Tsuneo Majima, Majima T, T Majima, M Ishikawa, Ishikawa M, Masakazu Ishikawa
European journal of obstetrics, gynecology, and reproductive biology · 1992 · vol. 43(2) , pp. 143–147 · doi:10.1016/0028-2243(92)90071-6 · PMID:1314200 · W2005486149
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This study identified a novel tumor-associated protein and evaluated its serum levels in various clinical conditions, with a particular focus on gynecological malignancies.

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Abstract

A novel tumor-associated protein (TAP), that was originally detected immunologically through the use of a monospecific antiserum against a placental antigen, was quantified by means of the rocket technique of Laurell. Four hundred and fifty-seven serum samples were obtained from healthy female subjects (55), and patients with leiomyomas (162), benign ovarian tumors (78), pelvic endometriosis (45), cervical cancer (73), endometrial cancer (18) and ovarian cancer (26), respectively. Statistical analysis showed that TAP exhibited the closest relationship in ovarian cancer patients in whom the appearance of TAP and its high level were most prominent. The present preliminary study suggests the clinical usefulness of this protein as a clinical adjunct for the management of ovarian cancer.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Differentiation, T-Lymphocyte Genital Neoplasms, Female Antigens, Differentiation, T-Lymphocyte Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometriosis Fallopian Tubes Fallopian Tubes Female Genital Neoplasms, Female Humans Hysterectomy Leiomyoma Leiomyoma Leiomyoma Ovarian Neoplasms Ovarian Neoplasms Ovariectomy

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Cites (1)

References (10)

Source provenance

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