The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study

There is no national or international consensus on the effect of smoking on blood uric acid levels and the risk of hyperuricemia (HUA). By collecting and analyzing clinical data of 3,196 patients with undiagnosed HUA at baseline in Dalian Municipal Central Hospital between January 1, 2010, and January 1, 2021, patients were grouped according to baseline smoking status and smoking index, and Cox regression analysis was applied to the univariate and multifactor analysis of factors that may influence the occurrence of HUA, and further stratified analysis was performed. A total of 485 (15.2%) patients developed HUA. The incidence of HUA was significantly higher in the smoking group than in the nonsmoking group (P<0.05). And there was a statistically significant difference in the incidence of HUA between the smoking index 1-4 groups and the smoking index 0 group (P<0.05). Smoking is an independent risk factor for the occurrence of HUA and is independent of gender, whether a woman is menopausal, BMI, and alcohol consumption. The Smoking index≥601 was an independent risk factor for the occurrence of HUA. However, further prospective studies involving rigorous large samples are needed to further confirm the association between smoking and HUA.