Clinicalanamnestic aspects of patients with endometrial polips in postmenopause

The objective: to learn clinical-and-anamnestic aspects for patients with endometrial polips in postmenopause. Materials and methods. Research objects were become by 120 patients in postmenopause. From them 90 patients are with endometrial, including without malifnancy made I recurrent polips – basic group and II – control group 30 women without endometrial polips, but which are in a position of research of endometrium in postmenopause (serozometer, intrauterine synechias on a background age-old atrophy, artifacts at ultrasonic research which it appears during the conduct of hysteroscopy). In the process of work the modern methods of research are used: clinical (general and gynaecological examination), laboratory (biochemical analysis, cytological research, morphological, immunohistochemical research of scraping of the of mucous membrane of the uterine body, research of backterioscopy, polymerase chain reaction and microbiological research of mucous membrabe of cervical canal and cavity of uterus.Results. At the analysis of structure of diseases of organs of the reproductive system for the patients of basic group found out for certain higher frequency of inflammatory diseases, operative interferences, especially intrauterine manipulations as compared to the group of control. It is discovered that more frequent all there were inflammatory diseases of genital organs in anamnesis: vulvitis, salpingo-oophoritis, endometritis, which in two times more frequent was observed in the group of inspected with endometrial polips, what in the group of control and were 54 (60,0%) and 8 (26,7%) (p<0,01), respectively. It was rotined that risk of appearance of endometrial polips for women with inflammatory disease of genital organs for certain higher (RR=2,25; OR=4,13; 95% CI 1,21–4,17), here a sensitiveness was 87%, and specificity – 38%. The conducted research rotined that approximately in 10% inspected women, both with the polips of endometrium and healthy, in postmenopause took place bacterial vaginosis, which appeared absence of expressed leukocytosis (leucocytes to 20 in sight), by the presence of the extensive mixed flora by the exposure of «key» cells in the vaginal painting. However unlike the group of control in 30 patients with endometrial polips the expressed inflammatory process of vagina took place also. Conclusions. Complex analysis of clinical-and-anamnestic information found out the row of features which are a favourable background for development of endometrial polips in postmenopause. For patients with endometrial polips, by comparison to a control group, more frequent there were somatopathies, inflammatory diseases of genital organs, violation of the reproductive system, endometrial manipulations were conducted. Violation of microbiocenosis and local immunity of sexual ways results in development of chronic endometritis, that at presence of unfavorable factors on a background atrophy of endometrium in postmenopause serves as reason of decline of blood stream with development of hypoxia forming of polips of endometrium.