Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information

Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.18905/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 16 Nov, 2020 Read the published version in BMC Cancer → Version 3 posted 4 You are reading this latest preprint version Show more versions Abstract Background: Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a variety of epithelial cancers. In a cohort of patients with presumed resectable pancreatic and periampullary carcinoma, we evaluated the frequency and the potential prognostic impact of the preoperative presence of DTC, defined as cytokeratin-positive cells detected by immunocytochemistry (ICC). Methods: Preoperative BMsamples from 242 patients selected for surgical resection of presumed resectable pancreatic and periampullary carcinoma from 09/2009 to 12/2014, were analysed for presence of CK-positive cells by ICC. The median observation time was 21.5 months. Overall survival (OS) and disease-free survival (DFS) were calculated by Kaplan-Meier and Cox regression analysis. Results: Successful resections of malignant tumours were performed in 179 of the cases, 30 patients resected had benign pancreatic disease based on postoperative histology, and 33 were deemed inoperable intraoperatively due to advanced disease. Overall survival for patients with resected carcinoma was 21.1 months (95% CI: 18.0-24.1), for those with benign disease OS was 101 months (95% CI: 69.4-132) and for those with advanced disease OS was 8.8 months (95% CI: 4.3-13.3).The frequency of CK-positive cells was 6/168 (3.6%) in resected malignant cases, 2/31 (6.5%) in advanced disease and 4/29 (13.8%) in benign disease. The presence of CK-positive cells was not correlated to OS or DFS, neither in the entire cohort nor in the subgroup negative for circulating tumour cells (CTC). Conclusions: The results indicate that CK-positive cells may be present in both patients with malignant and benign diseases of the pancreas. Detection of CK-positive cells was not associated with differences in prognosis for the entire cohort or any of the subgroups analysed. Trial registration: clinicaltrials.gov (NCT01919151) Oncology Gastroenterology & Hepatology DTC disseminated tumour cells bone marrow pancreatic cancer periampullary cancer Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Background According to their anatomical origin, the main carcinoma types of the periampullary region are p ancreatic d uctal a denocar c inoma (PDAC), d istal b ile d uct c ancer (DBDC), ampu llary c ancer (AMPUC), and duod enal c ancer (DUODC). They constitute an entity of aggressive tumours, particularly PDAC and DBDC where 80% of the cases have either locally advanced or metastatic disease at the time of diagnosis (1,2). These tumours are potentially curable when diagnosed at an early, localised stage (3). Still, the results from state of the art “surgery first” strategy (4), with radical resection followed by adjuvant therapy, are dismal. The expected rate of relapse during the first year after surgical resection is 50% and 5-year survival rates below 10% (1,3). The BM is a known reservoir for dormant or slowly proliferating, disseminated tumour cells (DTCs) (5), being part of the metastatic cascade in malignancies of epithelial origin (6). The best validated DTC-detection method for BM-samples is based on density centrifugation and immunocytochemical (ICC) identification of a panel of Cytokeratins (CK). The morphological evaluation and categorization of the cells follows internationally standardized criteria by the ISHAGE-group (7-9). Beyond prognostic information, there is well established evidence for the clinical utility of DTC detection in the management of the early stages of both breast (10,11) and prostate cancer(5,12). There are several reports on the impact of DTC in pancreatic cancer in general, indicating an association of DTC with reduced survival (13-17). However, for the potential application as a predictive tool for presumed resectable periampullary cancers, the clinical relevance of DTC is unclear. A recent meta-analysis exploring the significance of CTC and DTC in PDAC-patients (18) revealed a significant association between DTC and survival for the entire cohort containing a mix of resectable and advanced cancers. In the subgroup of resected cancers only, the same study did not disclose a significant association, even though another study(13) had reported an association between DTC and impaired survival previously. The aim of the present study was to explore the frequency and the prognostic impact of preoperatively detected DTCs in a cohort of patients with presumed resectable pancreatic and other periampullary cancers. Methods Patients, Study design and Follow-up Between September 2009 and December 2014, patients referred to Oslo University Hospital, Norway with potentially resectable pancreatic and periampullary malignancy were included in a standardised preoperative workup and evaluation in a multidisciplinary tumour board as detailed previously (19). Clinical data were recorded prospectively in an Epi-Info 3.5.3 database (CDC; Atlanta, GA; USA). The follow up included clinical status, computed tomography (CT) of the chest and abdomen as well as CA19-9 assessment twice a year. The mortality was deducted from the Norwegian Cause of Death Registry, provided by the Norwegian Institute of Public Health. The same patient cohort was described previously (20), with the observation period further extended by 25 months to January, 31 st 2019. The study was undertaken in accordance to the STROBE(2014) and REMARK(2012) criteria for analysis and reporting. Detection of CK-positive cells in the bone marrow BM samples were collected under anaesthesia just prior to surgery, five ml BM from the anterior iliac crest bilaterally in syringes containing 200IE Heparin in 0.5ml NaCl. Samples were processed within 24h at the Micrometastasis Laboratory, Oslo University Hospital, Norway as previously described (21). BM mononuclear cells were isolated by density centrifugation over a Ficoll-Hypaque gradient (Lymphoprep ® , STEMCELL Technologies UK Ltd., Cambridge, UK) and cytospin-slides were prepared with 0.5x10 6 BM-MNC/slide. For each sample 4 slides ( i.e. 2x10 6 cells) were immunostained for CK-positive cells with a combination of the monoclonal mouse primary antibodies AE1 and AE3 (Prod.# MAB 1612 & 1611, Milipore), with a broad affinity for the acidic and basic cytokeratin types, namely CK 1-8, 10, 14-16 and 19. The APAAP method for detection used a rabbit anti-mouse secondary antibody (Dako, #Z0259) and an alkaline phosphatase-mouse-anti-alkaline phosphatase tertiary antibody(Dako, #D0651), followed by a colour reaction with New Fuchsin, staining positive cells red (22). Nuclear counterstaining was performed with haematoxylin. The cytospins were screened for ICC-positive cells in an automated Ariol SL50 analyser (Leica biosystems). Detected elements were reviewed by a trained research engineer (CBS) and candidate cells were classified by a dedicated pathologist (EB). The cytomorphological evaluation of detected ICC-positive cells was performed in accordance to the ISHAGE consensus guidelines(7,8).This protocol, originally validated for breast cancer samples, has become the de facto standard for DTC reporting, including pancreatic cancer studies(13). Based on this classification, and according to earlier practice(23), the ICC-positive cells are divided into 4 categories: tumour cells (TC), hematopoietic (ie “false positive”) cells (HC), QHC (questionable/probable HC) and uninterpretable cells (UIC). If cells classified as TC or UIC were detected, 4 additional cytospins were incubated with the non-reactive mouse monoclonal antibody MOPC21 (Prod# M9269, Sigma Aldrich) of the same Ig isotype as AE1AE3, and detected by APAAP as above, constituting a negative control for the ICC reaction. Samples harbouring cells classified as TC in AE1/AE3 slides and not in the corresponding negative control slides were classified as “DTC-positive”. Samples harbouring cells classified as TC in AE1/AE3 slides and in the corresponding negative control slides were interpreted as “not evaluable” (n.e.) and excluded from further analysis. Samples harbouring “UIC”, “HC” or “QHC” were interpreted as “DTC-negative”. Results were stored in a database at the Micrometastasis Laboratory, Dept. of Pathology, Oslo University Hospital and were not available to treating clinicians. Following closure of the observation period, the classification of ICC-positive cells was combined with the clinical data using a scripted tool upon import to SPSS. Characteristics of the patient cohort Patients were categorised into three distinct clinical groups. Patients who underwent surgical resection did either have confirmed malignancy (resectable cancer) or a non-malignant condition (benign disease). The third group consisted of advanced cancer patients who underwent exploratory laparotomy but did not undergo resection, either due to locally advanced tumour growth or overt metastases (advanced cancer). In addition to the presence of ICC-positive cells, the following clinical- and pathological parameters were recorded: age, gender, CA19-9, tumour size on CT-scan, AJCC/UICC-stage (7 th ed.), pTNM-staging including resection margin, cancer origin, grade of histopathological differentiation, histological subtype (predominantly intestinal or pancreatobiliary), vascular and perineural infiltration. Continuous variables were dichotomized at the following thresholds: CA19-9 ≥ 200kU/L and the size of the lesion on CT-scan ≥ 25mm (for results, see Table 1). Statistics Data were analysed in IBM SPSS, V25 (IBM Cooperation Analytics, Armonk, NY, USA) and STATA 15 (Stata Corp LLC, College Station, Texas, USA). Graphs were prepared in PRISM 8 (GraphPad Software Inc., La Jolla, CA, USA). The primary endpoints of the study were overall survival (OS), defined as survival until death by any cause and disease-free survival (DFS), defined as survival until signs of local relapse or metastasis were detected. Survival analyses were carried out with the Kaplan-Meier method, using the Log-rank test for difference of curve pairs. The association between TC-status and survival was quantified by a hazard ratio (HR) with a 95% confidence interval (CI) using Cox regression analysis. Statistical significance was assumed for p<0.05. Results Patient group characteristics 277 patients were assessed during the study period of whom 35 patients (12.6%) did not meet the inclusion criteria. Tumour resection with curative intent was performed in 86.4% of the patients (209/242), while in 13.6% (33/242) resection was not performed due to intraoperative detection of advanced disease. In patients deemed unresectable intraoperatively, a biliary or intestinal bypass procedure was performed in 24 patients and 9 received an explorative laparotomy. Of the cases with advanced disease, the tumour origin was the pancreatic head in 30 cases, the duodenum in two cases and in one case the distal bile duct. Of the 209 cases where a successful resection was performed, malignant tumours were confirmed in 85.6% (179/209), while 14.4% (30/209) a benign pancreatic disease was found. Thus, for the whole cohort, resected malignancies account for 74.0% (179/242), advanced disease 13.6% (33/242) and benign pancreatic disease for 12.4% (30/242). The 90-day mortality in operated patients was 2.1% (5/242), all due to rapid cancer progression because of advanced disease, in one case additionally complicated by an anastomotic failure. 84.6% (31/212) of all patients with malignant disease were alive at the date of last follow-up. Ten patients had died from other causes than cancer relapse. Further details on clinical features, distribution of procedures and histopathological diagnoses of the cohort are summarised in Table 1. Overall survival for patient groups The median observation time for the entire cohort was 21.5 months (range 1.5-110). Median overall survival (OS) was estimated to 101 months (95% CI: 69.4-132) in patients with a benign lesion, 21.1 months (95% CI: 18.0-24.1) in the resectable cancer group and 8.8 months (95% CI: 4.3-13.3) in patients with advanced cancer. Differences in OS between the subgroups were statistically significant (see also Figure 2). Bone marrow ICC-positive cell types and patient survival ICC-positive cells of the named subtypes were identified both in patients with resected malignant tumours, in those with advanced cancers as well as in patients with benign pancreatic disease. According to patient group, DTCs were present in 6/168 (3.6%) in resected cancers, 2/31 (6.5%) in advanced cancers and 4/29 (13.8%) in cases of benign pancreatic disease. The frequency of the other classes of ICC-positive cells in each prognostic group is presented in detail in Table 1. A per case specification of the distribution and frequency of all cell types together with the clinicopathological data are presented in Appendix Table 1. The low number of ICC-positive samples precludes subgroup analysis by tumour type. Survival analyses according to presence or absence of DTCs and the other ICC-positive cells are presented in Figure 3 and Figure 4, and in further detail in Table 2. DTC-positivity was associated with neither OS nor DFS. Furthermore, presence of other ICC-positive cells did not negatively impact on survival. The association between survival and presence of ICC-positive cells for benign disease was hampered by too few ICC-positive cases. To account for the effect of CTC status and nodal status, as well as the weaker effects of vascular infiltration and histological type on survival of resected patients(20), we performed survival analyses subgrouped by these factors(Figure 5). Patients with or without DTCs had similar outcome in those subgroups (Figure 5). Presence other any other of the bone marrow ICC-positive cell types did not affect survival among the CTC-megative patients (Appendix Figure 1). Among the CTC-positive patients, DTCs were not observed (Figure 5) and in only one patient a single ICC-positive cell (HC) was detected (Appendix Figure 1). Discussion DTC frequency A low frequency of DTCs was detected in both resected (3.6%) and advanced cancer patients (6.5%). These numbers are less than half the frequencies reported from the largest patient series prior to the present study (13) which reported 13.5% DTC-positivity for resected cancers and 13.9% for advanced cancers. Even higher positive rates of 38% to 57.1% were reported from earlier cohorts with smaller patient numbers and predominantly advanced stage cancers (14,15,17). Complementary to the data from ICC-based studies, there were two studies using RT-PCR for CK-20 (24) detecting 33% positive cases in a cohort of resectable PDAC (24) and CK-19 (25), detecting 67% positives in a cohort of mixed stage cases (25). In the absence of comparative studies between ICC and PCR-based detection, the seemingly higher positive rates for PCR-based assays targeting a single CK category versus ICC utilising broad spectrum antibodies against a range of class I and class II CK-subtypes remains unexplained, although different sensitivity and/or specificity may contribute. Survival prediction Among resected pancreatic cancer patients, five ICC-based studies (13-17) reported a significant association between DTCs and impaired survival in univariate analysis. In one of these studies(13), prognostic information was also retained in multivariate analysis (HR 2.755, p=0.022), while the four other studies did not test independent predictive value of DTC. There are two additional ICC-based studies on the same subject that did not discover an association between DTC status and survival (26,27). When weighing the evidence from these studies, several methodological differences have to be taken into consideration. The ISHAGE-group (7) established the first consensus on the cyto­morpho­logical criteria for the classification of ICC-positive cells in the BMfor breast cancer patients. These criteria were later underscored in consensus reports (8,9) but also used in additional studies (23,28) Several of the studies mentioned above have been conducted prior to this standardisation or do not disclose their adherence to the ISHAGE criteria (14,15,17). Furthermore, there is a lack of standardisation concerning the choice of CK-detection antibodies, only one group (27) used the same antibody combination as in the present study. While not validated separately for gastrointestinal cancer types, the broad reactivity of the AE1 and AE3 antibody combinations which covers a spectrum of both the basic and acidic categories of CKs makes the assumption reasonable that the assay employed in the present study detects CK-positive cells independent from the tissue-type dependent differences in CK-subtype expression. The comparison of our results with the aforementioned studies may also be affected by the small size of several of the studies and mixed cohorts with predominantly advanced cancer stages (14-17). Moreover, the substantial rate of surgical interventions performed outside established criteria for operability may have introduced a hidden stage migration (13). Concerning the association of UIC-type cells with an inferior OS in patients with benign disease, there are only two UIC-positive cases out of 30 patients, rendering the result inconclusive. Although there seemed to be an association of UIC with an improved DFS for UIC-positive patients in the resected group, no difference in overall survival was observed. Since DFS and OS are tightly linked in these patients the clinical relevance of this finding is questionable. ICC-positive cases in benign pancreatic disease In the present study, ICC-positive cells meeting the morphological criteria for DTC were detected in four out of 29 patients with benign pancreatic disease, for one more patient the analysis was inconclusive. The majority of ICC-based studies have excluded patients with benign pancreatic disease a priori from the analysis (13-15,17,26). Therefore, previous evidence on the validity of the results from the present cohort is limited. This observed rate of 13% is far above the established rate of 2-3.5% for false positive events for the ICC-based assay (7,15,27,29). The presence of occult malignancy in those patients as the source for those cells is unlikely since none of the patients were diagnosed with cancer later during the observation period and none had a previous history of malignancy. While the nature of those cells cannot be further determined in the present study, there are independent reports on cells of seemingly epithelial origin in the BM and peripheral blood of PDAC-patients. One ICC-based study reported results from four patients with benign disease, disclosing two ICC-positive cases (16). In their conclusion the authors deem their method unfit for clinical use in PDAC due to the unreliability of the assay. Also one of the PCR-based studies report a rate of 11% in cases with benign pancreatic disease, while reporting only one positive case in 20 healthy controls(30). In addition, there is one report disclosing the presence of epithelial cells in the bloodstream of patients with benign pancreatic disease (31). These cells could potentially enter the BMvia the bloodstream and could thereby be detected in BM-samples as well. Another possibility for the non-malignant origin of epithelial cells could be the shedding of epithelial cells from the pancreatic- and bile ducts or the duodenal wall during interventions, especially in the presence of inflammation (32). Interestingly, all of the four ICC-positive cases in benign pancreatic disease in the present study had undergone invasive procedures preoperatively, either ERCP, endoscopic biopsy or bile duct stenting. Conclusions The results from our study of a large cohort of patients with presumed resectable periampullary cancer show a low frequency of CK-positive cases in both resectable cancer, advanced cancer group and non-malignant pancreatic disease. No association with CK-status and survival was observed. For the UIC cell type, an association with disease free-survival was observed, but this was not supported by overall survival data and the relevance of the association is questionable. Cells satisfying predefined consensus criteria for DTC/CK-positive cells in the BM were detected both in patients with malignant as well as benign pancreatic disease. The combination of low frequency of CK-positive cells and their presence in benign pancreatic disease cases indicates that the ICC-based CK-detection method used in the present study does not reliably identify relevant cells of malignant origin for the type of cancers studied. Nevertheless, additional studies including further characterisation of the cells, preferably with single cell techniques are encouraged. Abbreviations AJCC/UICC: A merican J oint C ommittee on C ancer / U nion I nternationale C ontre le C ancere AMPUC: Ampu llary c ancer APAAP: A lkaline P hosphatase- A nti- A lkaline P hosphatase BM: B one m arrow CDC: C entre for D isease C ontrol CI: C onfidence i nterval CK C yto k eratin CT C omputed t omography X-ray CTC: C irculating t umour c ells DBDC: Distal b ile d uct c ancer DFS: D isease- f ree s urvival DTC: D isseminated t umour c ells DUODC: Duod enal c ancer HC: H ematopoietic c ells ICC: I mmuno- c yto c hemistry ISHAGE: I nternational S ociety of H ematotherapy a nd G raft E ngineering MNC: M ono n uclear c ells OS: O verall s urvival PDAC: P ancreatic d uctal a denocar c inoma pTNM P athological t umour stage, n odal status, m etastastis status QHC: Q uestionable/probable h ematopoietic cells REMARK: Re porting recommendations for tumour mark er prognostic studies STROBE: Str engthening the reporting of ob servational studies in e pidemiology TC: T umour c ells UIC: U n i nterpretable c ells Declarations Ethics approval and consent to participate All patients selected for surgery were offered participation in this prospective, observational study and asked for their written informed consent. Exclusion criteria were a history of other malignancies in the past ten years, failure to adhere to standard treatment and infrequent cancer types such as neuroendocrine carcinoma. The study protocol was approved by the Regional Ethical Committee (Helse Sør-Øst; Ref. 93-08172d 6.2008.540) in Oslo, Norway and registered at clinicaltrials.gov (NCT01919151). Clinical data were recorded prospectively in a database that was approved by and maintained as regulated by the Oslo University Hospital guidelines, supervised by the Data Protection Officer for Research. Consent for publication Not applicable Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request Competing interests None of the authors has any conflicting interest to disclose Funding This work was supported by a research grant from Helse Sør-Øst (Regional health-authority) to GW that covered the costs of laboratory analyses for the present study. HH had a part-time junior researcher position funded by Helse Sør-Øst over four years in the beginning of the study period. The funding entity was neither involved in the design of the present study nor were results disclosed previous to publication. Authors' contributions The concept of the present study was developed by GW, HH, KJL and BN. The acquisition of clinical data was performed by KJL, HH, LTS, the histopathological data by CSV. CTC analyses and the interpretation of results were performed by CBS, AR and EB. 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Tables Table 1: Clinical characteristics of the cohort according to patient groups including ICC-positive cell type status in bone marrow Resected cancers (n=179) Advanced cancers (n=33) Benign (n=30) Age, median [years] 69 (34-88) 63 (46-83) 69 (45-82) Sex, male 92 (51.4%) 19 (57.6%) 21 (70.0%) ICC-positivity: ≥ 1 ICC-positive cell / 2x 10 6 MNC (ICC-status numbers may differ due to varying number of inconclusive ICC-results per category) TC UIC HC QHC 6/168 (3.6%) 10/174 (5.7%) 16/169 (9.5%) 12/135 (8.8%) 2/31 (6.5%) 0/31 (0.0%) 2/30 (6.7%) 3/28 (7.9%) 4/29 (13.8%) 2/30 (6.7%) 3/29 (10.3%) 3/25 (12.0%) . Preoperative Risk Factors CA19-9 ≥ 200kU/l 51/127 (40.2%); 52 missing 17/28 (60.7%); 5 missing 0/20; 10 missing Tumour size> 25mm 71 (39.7%) 20 (60.6%) 10 (33.3%) Bilirubin > 50µmol/L 132/151 (87.4%); 28 missing 21/32 (65.6%); 1 missing 7/29 (24.1%); 1 missing Treatment Neoadjuvant chemotherapy GEMZ 6 (4.1%) FOLFIRINX 1 (0.7%) GEMZ 1 (3.0%) none Operation: PPPD PD Pancreatectomy 146 (82.6%) 25 (14.0%) 8 (4.5%) BDB 24 (72.7%) Exp . lap. 9 (27.3%) 29 (96.7%) 1 (3.3%) none Venous resection 49 (27.4%) n.a. 2 (6.7%) Adjuvant chemotherapy FLV : 91 (50.8%) GEMZ : 7 (3.9%) FLOX : 1 (0.7%) none: 80 (44.7%) Palliative chemotherapy 31 (93.9%) n.a. Histopathologic results Pancreatic cancer Malignant IPMN Distal bile duct ca. Ampullary cancer Duodenal cancer 101 (56.4%) 9 (5.0%) 31 (17.3%) 21 (11.7%) 17 (9.4%) 30 1 2 Pancreatobiliary type Intestinal type Mucinous type 146 (81.6%) 26 (14.5%) 7 (3.9%) 28 (84.8%) 5 (15.2%) IPMN 11 (36.7%) ben.Tu. 5 (16.6%) AIP 6 (20.0%) chr.Panc 4 (13.3%) inflam. 4 (13.4%) UICC-stage (V7): I II III IV 16 (10.6%) 150 (83.8%) 13 (7.3%) 7 (21.2%) 26 (78.8%) N1-status 120 (67.0%) R1-status 87 (48.6%) Vascular infiltration 108 (60.3%) Perineural infiltration 141 (78.8%) GEMZ: Gemzitabine , FLV, FLOX, FOLFIRINOX: chemotherapy regimens ; PD: pancreatico-duodenectomy, PPPD: pylorus preserving PD , BDB: biliodigestive bypass ; Ex.lap.: explorative laparotomy; IPMN : intraductal pancreatic mucinous neoplasia ; ben.tu.: benign tumour ; AIP: autoimmune pancreatitis ; chr. panc.: chronic pancreatitis ; inflam .: inflammation n.a.: not applicable; n.d.: not determined . Note: ICC-status numbers may differ due to varying number of inconclusive ICC-results per category. Table 2: Overall survival according to ICC-positive cell type status in bone marrow ICC-type Level N Incident cases Person months HR (95%CI) p-value Mean OS (95%CI) Overall survival, resected cancers TC Positive 6 5 217.5 1.1 (0.4-2.3) 0.865 36.2 (11.3-61.2) Negative 162 133 5293.6 37.1 (31.6-42.6) UIC Positive 10 7 488.1 0.6 (0.3-1.3) 0.197 52.5 (27.2-77.7) Negative 164 136 5144.0 35. 6 (30.2-40.9) HC Positive 16 14 431.6 1.3 (0.7-2.2) 0.386 29.6 (14.3-44.8) Negative 153 125 5006.5 37.3 (31.6-43.1) QHC Positive 12 10 419.0 0.9 (.5-1.8) 0.795 37.1 (18.1-56.0) Negative 123 102 3817.1 35.5 (29.2-41.8) Overall survival, advanced cancers TC Positive 2 2 7.9 3.4 (0.7-15.4) 0.114 3.9 (0.8-7.1)s Negative 29 29 298.8 10.3 (7.4-13.2) UIC Positive 0 0 - - Negative 31 31 306.6 9.9 (7.1-12.7) HC Positive 2 2 14.3 1.6 (0.4-7.2) 0.522 7.2 (4.0-10.3) Negative 28 28 266.6 9.5 (6.5-12.5) QHC Positive 3 3 16.6 2.1 (0.6-7.2) 0.262 5.5 (1.9-9.2) Negative 25 25 248.5 9.9 (6.5-13.4) Overall survival, benign disease TC Positive 4 2 256.1 4.0 (0.7-22.6) 0.114 65.3 (53.0-77.6) Negative 25 7 1929.4 92.2 (82.7-101.7) UIC Positive 2 2 143.0 5.7 (1.1-25.5) 0.039 71.5 (52.9-90.1) Negative 28 7 1796.9 92.6 (83.2-101.9) HC Positive 3 2 202.3 4.7 (0.9-25.7) 0.075 69.4 (43.1-95.7) Negative 26 6 1867.3 93.7 (84.3-103.2) QHC Positive 3 2 202.3 3.9 (0.7-21.6) 0.114 5.5 (1.9-9.2) Negative 22 5 1639.1 9.9 (6.5-13.4) Disease free survival, resected cancers TC Positive 6 6 112.4 1.3 (0.6-3.0) 0.525 18.7 (4.5-33.0) Negative 162 126 4022.2 32.2 (25.9-38.5) UIC Positive 10 5 441.8 0.4 (0.2-1.0) 0.040 62.1 (37.1-87.1) Negative 164 132 3785.8 29.4 (23.5-35.4) HC Positive 16 16 299.4 1.4 (0.8-2.5) 0.277 22.6 (5.7-39.5) Negative 153 120 3774.0 31.9 (25.5-38.3) QHC Positive 12 10 340.7 1.0 (0.5-1.9) 0.973 30.1 (10. 1-50.8) Negative 123 96 2825.6 30.8 (23.7-37.8) Detailed survival analysis for patients with (pos.) or without (neg.) ICC-positive cells in the bone marrow in the indicated morphological cell categories. HR and p-values were computed by Cox-regression analysis. The number of patients analysed may differ from group size for cases with inconclusive ICC-results. Table 3. Published studies on DTC status in the bone marrow for peri-ampullary adenocarcinomas, grouped by detection method. Authors Method/ Markers Detection limit DTC def. Pat. number Loc. / Adv. TC-rate false-pos. rate Prog. Comments Immunocytochemistry Effenberger 2012 (13) CK A45-B/B3 ≥1 / 2x10 6 MNC TC n=175 n=71 / n=104 13.7% (24/175) - Pos. 29 pat. resected despite advanced cancer stage Rehders 2012 (25) CK A45-B/B3 ≥1 / 1x10 6 MNC TC n=49 n=49 / - 27% (12/49) - Neg. No details on survival analysis disclosed Roder 1999 (17) CK 2; KL1; A45-B7B3 ≥1 / 5x10 5 MNC TC n=48 n=8 / n=40 52.1% (25/48) - Pos. Association with OS for resected patients van Heek 2001 (16) CK (8,18) ≥1 / 1x10 7 MNC TC n=35 n=14 / n=13 34.2% (12/35) 50% (2/4) Pos. 2/4 benign pat. false positive Vogel 1999 (14) panCK, mucin, CEA, Ca-19–9 ≥1 / 1.25x10 6 TC n=80 n=11 / n=60 38% (27/71) 6.6% (3/45) Pos. Thorban 1996 (15) CK A45-B/B3 ≥1 / 5x10 5 MNC TC n=42 n=24 / n=18 57.1% (24/42) - Pos. Association with metastatic and local relapse Z`Graggen 2001 (26) CK AE3/AE1 ≥1 / 5x10 6 MNC TC n=54 n=3 / n=51 24% (13/54) 4.1% (1/24) Neg. Nucleotide based detection Hoffmann 2007 (24) rt-PCR / CK-19 - n=37 n=7 / n=30 67% (25/37) - Neg. Soeth 2005 (23) rt-PCR / CK-20 - n=117 n=172 33.3% (45/135) 11% Neg. Survival data only for blood/BM combined. False positive rate 11% Prog: prognostic impact of DTC-status on survival Loc : Localised cancers; Adv : advanced cancers; MNC : mononuclear cells Supplementary Files AppendixFigure1BMCCaRev1.pdf AppendixTable2BMCCaRev1.docx AppendixTable1BMCCaRev1.docx Cite Share Download PDF Status: Published Journal Publication published 16 Nov, 2020 Read the published version in BMC Cancer → Version 3 posted Editorial decision: Accept 06 Oct, 2020 Editor assigned by journal 05 Oct, 2020 Submission checks completed at journal 04 Oct, 2020 Editor invited by journal 04 Oct, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9524","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":3101741,"identity":"48102b63-f17f-49a7-a253-732713be2a2d","order_by":0,"name":"Harald Hugenschmidt","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+UlEQVRIiWNgGAWjYBACAxDxgM0mAco/wMDGkIBTNUJLAlsaspZkuAQ+LYcRWhgIaTFnP/vwQ0LZ+TyD84uPPfxRcyeajz3/AHNBxR+cWix70o0lEs7dLja48SzdmOfYs9w2nscMzDPO4HHYgTQGicS224kbbpwxk2ZsOJzbJpHMwMzbhkfL+WfMPxLbzgG1nP8m+ROu5R8eLTfS2IC2HEjccL6HTYIXrqUBn5ZnbBYJ55ITZ95gM5PmOXYY5BeDwzzHjPE4LI35xocyu8S+84efSf6oOZw7vz3x4WOeGjmcWhBAIgHBPkCEeiDgJ1LdKBgFo2AUjDwAAJmHXdblgJX9AAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-1114-5366","institution":"Oslo Universitetssykehus","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Harald","middleName":"","lastName":"Hugenschmidt","suffix":""},{"id":3101742,"identity":"885d99b6-8383-4165-b9ed-209de248a370","order_by":1,"name":"Knut Jørgen Labori","email":"","orcid":"","institution":"Oslo universitetssykehus Rikshospitalet","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Knut","middleName":"Jørgen","lastName":"Labori","suffix":""},{"id":3101743,"identity":"39ed0d09-d12a-490f-bdf7-b906cb7b831d","order_by":2,"name":"Cathrine Brunborg","email":"","orcid":"","institution":"Universitetet i Oslo","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Cathrine","middleName":"","lastName":"Brunborg","suffix":""},{"id":3101744,"identity":"ad1a2ee7-04f6-4115-9b82-452aae6b6c52","order_by":3,"name":"Caroline Sophie Verbeke","email":"","orcid":"","institution":"Oslo universitetssykehus Rikshospitalet","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Caroline","middleName":"Sophie","lastName":"Verbeke","suffix":""},{"id":3101745,"identity":"a6fa862c-e9c0-4326-b59d-db69d0f3eeab","order_by":4,"name":"Lars Thomas Seeberg","email":"","orcid":"","institution":"Sykehuset i Vestfold HF","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lars","middleName":"Thomas","lastName":"Seeberg","suffix":""},{"id":3101746,"identity":"8dda4cf0-4516-4849-9878-341025a35ba9","order_by":5,"name":"Cecilie Bendigtsen Schirmer","email":"","orcid":"","institution":"Oslo Universitetssykehus","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Cecilie","middleName":"Bendigtsen","lastName":"Schirmer","suffix":""},{"id":3101747,"identity":"de5b0fde-4cf1-4f44-8ca2-08500bf5e6fa","order_by":6,"name":"Anne Renolen","email":"","orcid":"","institution":"Oslo Universitetssykehus","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Anne","middleName":"","lastName":"Renolen","suffix":""},{"id":3101748,"identity":"e91c66df-280d-4192-a1a7-beb52de68ff4","order_by":7,"name":"Elin Borgen","email":"","orcid":"","institution":"Oslo Universitetssykehus","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Elin","middleName":"","lastName":"Borgen","suffix":""},{"id":3101749,"identity":"1931d5da-d508-4d8a-ac34-d5ed4a77f8f8","order_by":8,"name":"Bjørn Naume","email":"","orcid":"","institution":"Oslo Universitetssykehus","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Bjørn","middleName":"","lastName":"Naume","suffix":""},{"id":3101750,"identity":"1656f2a8-e8cd-4b5c-80e5-4158507b5799","order_by":9,"name":"Gro Wiedswang","email":"","orcid":"","institution":"Oslo Universitetssykehus","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Gro","middleName":"","lastName":"Wiedswang","suffix":""}],"badges":[],"createdAt":"2019-12-12 11:58:48","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.2.18905/v3","doiUrl":"https://doi.org/10.21203/rs.2.18905/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12885-020-07510-z","type":"published","date":"2020-11-16T15:00:39+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":2957141,"identity":"480246d8-eed4-41c1-a32d-606c632ee06d","added_by":"auto","created_at":"2020-10-13 20:21:02","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":39153,"visible":true,"origin":"","legend":"Stratification of the patient cohort\nStudy overview, showing group distribution, specifying causes for exclusion, histologic types, reasons for advanced cancer status and benign diagnoses. AIP: autoimmune pancreatitis; IPMN: intraductal mucinous neoplasia\n","description":"","filename":"Figure1BMCCaRev1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/05b71fa39207bc2d54d11c2d.jpg"},{"id":2957143,"identity":"887115d7-71e2-4db1-ab65-440be6e641c9","added_by":"auto","created_at":"2020-10-13 20:21:02","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":29856,"visible":true,"origin":"","legend":"Overall- and disease free survival for patient groups\nKaplan-Meier curves, with 5-year survival and P values (log Rank) for pairwise comparison between patient groups. A, Overall survival. B, Disease-free survival for resected patients. DFS: disease-free survival; OS: overall survival.\n","description":"","filename":"Figure2BMCCaRev1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/c9ca080a0ea47e8013d986c0.jpg"},{"id":2957145,"identity":"818bca8d-c9e3-4fca-abbe-878d3a0dc99e","added_by":"auto","created_at":"2020-10-13 20:21:03","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":141765,"visible":true,"origin":"","legend":"Overall survival in disease groups according to ICC-positive cell type status\nOverall survival among patients with (pos.) or without (neg.) ICC-positive cells in the bone marrow within the indicated morphological cell categories. P values were computed by log-rank test, assuming p\u003c0.05 for significance. The number of cases with determined CK-status differs from group size due to cases of inconclusive ICC-results.\n","description":"","filename":"Figure3BMCCaRev1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/fed95e00c2759710d242f8f3.jpg"},{"id":2957146,"identity":"f16e125a-6d7f-49ac-8777-8e9c16ab9986","added_by":"auto","created_at":"2020-10-13 20:21:03","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":53015,"visible":true,"origin":"","legend":"Disease free survival among resected cancers according to ICC-positive cell type status\nDisease free survival among patients with (pos.) or without (neg.) CK-positive cells in the BMwithin the indicated morphological cell categories. P values were computed by log-rank test, assuming p\u003c0.05 for significance. The number of cases with determined CK-status differs from group size due to cases of inconclusive ICC-results.\n","description":"","filename":"Figure4BMCCaRev1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/be0a7cc8a1d59b377c035f1d.jpg"},{"id":2957147,"identity":"96780f2b-092c-43a6-9c9f-71e12dab23d1","added_by":"auto","created_at":"2020-10-13 20:21:03","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":117719,"visible":true,"origin":"","legend":"Cancer specific survival by prognostic subgroups in resected and advanced cancers according to TC-status\nOverall survival dependent on CTC-status for resected and advanced cancer patients with (pos.) or without (neg.) TC cells. P values were computed by log-rank test, assuming p\u003c0.05 for significance. The number of cases with determined CK-status differs from group size due to cases of inconclusive ICC-results.\n","description":"","filename":"Figure5BMCCaRev1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/38d2c02cc0ea4cee0d8a3a8a.jpg"},{"id":13601947,"identity":"7eaf8ee6-7457-4cea-bb16-a93dc1ffa92d","added_by":"auto","created_at":"2021-09-17 05:49:51","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1011052,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/f4489f96-2725-4476-b5c4-fad592ee1954.pdf"},{"id":2957140,"identity":"dc0000f8-19ff-4152-8e6c-607578a13c79","added_by":"auto","created_at":"2020-10-13 20:21:02","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":48726,"visible":true,"origin":"","legend":"","description":"","filename":"AppendixFigure1BMCCaRev1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/1a9b286c83d9fcb8ae7aad87.pdf"},{"id":2957142,"identity":"c243901e-c957-4740-b427-9ed88971aabe","added_by":"auto","created_at":"2020-10-13 20:21:02","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":26614,"visible":true,"origin":"","legend":"","description":"","filename":"AppendixTable2BMCCaRev1.docx","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/e35ba0c041f409ca4812d956.docx"},{"id":2957144,"identity":"8f4fc42e-4ee9-470d-bf5d-e0a0d657a568","added_by":"auto","created_at":"2020-10-13 20:21:03","extension":"docx","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":59712,"visible":true,"origin":"","legend":"","description":"","filename":"AppendixTable1BMCCaRev1.docx","url":"https://assets-eu.researchsquare.com/files/rs-9524/v3/2400fb1be100dd681c8a4e3e.docx"}],"financialInterests":"","formattedTitle":"Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information","fulltext":[{"header":"Background","content":"\u003cp\u003eAccording to their anatomical origin, the main carcinoma types of the periampullary region are \u003cu\u003ep\u003c/u\u003eancreatic \u003cu\u003ed\u003c/u\u003euctal \u003cu\u003ea\u003c/u\u003edenocar\u003cu\u003ec\u003c/u\u003einoma (PDAC), \u003cu\u003ed\u003c/u\u003eistal \u003cu\u003eb\u003c/u\u003eile \u003cu\u003ed\u003c/u\u003euct \u003cu\u003ec\u003c/u\u003eancer (DBDC), \u003cu\u003eampu\u003c/u\u003ellary \u003cu\u003ec\u003c/u\u003eancer (AMPUC), and \u003cu\u003eduod\u003c/u\u003eenal \u003cu\u003ec\u003c/u\u003eancer (DUODC). They constitute an entity of aggressive tumours, particularly PDAC and DBDC where 80% of the cases have either locally advanced or metastatic disease at the time of diagnosis (1,2). These tumours are potentially curable when diagnosed at an early, localised stage (3). Still, the results from state of the art \u0026ldquo;surgery first\u0026rdquo; strategy (4), with radical resection followed by adjuvant therapy, are dismal. The expected rate of relapse during the first year after surgical resection is 50% and 5-year survival rates below 10% (1,3).\u003c/p\u003e\n\u003cp\u003eThe BM is a known reservoir for dormant or slowly proliferating, disseminated tumour cells (DTCs) (5), being part of the metastatic cascade in malignancies of epithelial origin (6). The best validated DTC-detection method for BM-samples is based on density centrifugation and immunocytochemical (ICC) identification of a panel of Cytokeratins (CK). The morphological evaluation and categorization of the cells follows internationally standardized criteria by the ISHAGE-group (7-9). Beyond prognostic information, there is well established evidence for the clinical utility of DTC detection in the management of the early stages of both breast (10,11) and prostate cancer(5,12). There are several reports on the impact of DTC in pancreatic cancer in general, indicating an association of DTC with reduced survival (13-17). However, for the potential application as a predictive tool for presumed resectable periampullary cancers, the clinical relevance of DTC is unclear. A recent meta-analysis exploring the significance of CTC and DTC in PDAC-patients (18) revealed a significant association between DTC and survival for the entire cohort containing a mix of resectable and advanced cancers. In the subgroup of resected cancers only, the same study did not disclose a significant association, even though another study(13) had reported an association between DTC and impaired survival previously.\u003c/p\u003e\n\u003cp\u003eThe aim of the present study was to explore the frequency and the prognostic impact of preoperatively detected DTCs in a cohort of patients with presumed resectable pancreatic and other periampullary cancers.\u003c/p\u003e"},{"header":"Methods","content":"\u003ch2\u003ePatients, Study design and Follow-up\u003c/h2\u003e\n\u003cp\u003eBetween September 2009 and December 2014, patients referred to Oslo University Hospital, Norway with potentially resectable pancreatic and periampullary malignancy were included in a standardised preoperative workup and evaluation in a multidisciplinary tumour board as detailed previously (19). Clinical data were recorded prospectively in an Epi-Info 3.5.3 database (CDC; Atlanta, GA; USA). The follow up included clinical status, computed tomography (CT) of the chest and abdomen as well as CA19-9 assessment twice a year. The mortality was deducted from the Norwegian Cause of Death Registry, provided by the Norwegian Institute of Public Health. The same patient cohort was described previously (20), with the observation period further extended by 25 months to January, 31\u003csup\u003est\u003c/sup\u003e 2019. The study was undertaken in accordance to the STROBE(2014) and REMARK(2012) criteria for analysis and reporting.\u003c/p\u003e\n\u003ch2\u003eDetection of CK-positive cells in the bone marrow\u003c/h2\u003e\n\u003cp\u003eBM samples were collected under anaesthesia just prior to surgery, five ml BM from the anterior iliac crest bilaterally in syringes containing 200IE Heparin in 0.5ml NaCl. Samples were processed within 24h at the Micrometastasis Laboratory, Oslo University Hospital, Norway as previously described (21). BM mononuclear cells were isolated by density centrifugation over a Ficoll-Hypaque gradient (Lymphoprep\u003csup\u003e\u0026reg;\u003c/sup\u003e, STEMCELL Technologies UK Ltd., Cambridge, UK) and cytospin-slides were prepared with 0.5x10\u003csup\u003e6\u003c/sup\u003e BM-MNC/slide. For each sample 4 slides ( i.e. 2x10\u003csup\u003e6\u003c/sup\u003e cells) were immunostained for CK-positive cells with a combination of the monoclonal mouse primary antibodies AE1 and AE3 (Prod.# MAB 1612 \u0026amp; 1611, Milipore), with a broad affinity for the acidic and basic cytokeratin types, namely CK 1-8, 10, 14-16 and 19. The APAAP method for detection used a rabbit anti-mouse secondary antibody (Dako, #Z0259) and an alkaline phosphatase-mouse-anti-alkaline phosphatase tertiary antibody(Dako, #D0651), followed by a colour reaction with New Fuchsin, staining positive cells red (22). Nuclear counterstaining was performed with haematoxylin. The cytospins were screened for ICC-positive cells in an automated Ariol SL50 analyser (Leica biosystems). Detected elements were reviewed by a trained research engineer (CBS) and candidate cells were classified by a dedicated pathologist (EB). The cytomorphological evaluation of detected ICC-positive cells was performed in accordance to the ISHAGE consensus guidelines(7,8).This protocol, originally validated for breast cancer samples, has become the \u003cem\u003ede facto\u003c/em\u003e standard for DTC reporting, including pancreatic cancer studies(13). Based on this classification, and according to earlier practice(23), the ICC-positive cells are divided into 4 categories: tumour cells (TC), hematopoietic (ie \u0026ldquo;false positive\u0026rdquo;) cells (HC), QHC (questionable/probable HC) and uninterpretable cells (UIC). If cells classified as TC or UIC were detected, 4 additional cytospins were incubated with the non-reactive mouse monoclonal antibody MOPC21 (Prod# M9269, Sigma Aldrich) of the same Ig isotype as AE1AE3, and detected by APAAP as above, constituting a negative control for the ICC reaction. Samples harbouring cells classified as TC in AE1/AE3 slides and not in the corresponding negative control slides were classified as \u0026ldquo;DTC-positive\u0026rdquo;. Samples harbouring cells classified as TC in AE1/AE3 slides and in the corresponding negative control slides were interpreted as \u0026ldquo;not evaluable\u0026rdquo; (n.e.) and excluded from further analysis. Samples harbouring \u0026ldquo;UIC\u0026rdquo;, \u0026ldquo;HC\u0026rdquo; or \u0026ldquo;QHC\u0026rdquo; were interpreted as \u0026ldquo;DTC-negative\u0026rdquo;. Results were stored in a database at the Micrometastasis Laboratory, Dept. of Pathology, Oslo University Hospital and were not available to treating clinicians. Following closure of the observation period, the classification of ICC-positive cells was combined with the clinical data using a scripted tool upon import to SPSS.\u003c/p\u003e\n\u003ch2\u003eCharacteristics of the patient cohort\u003c/h2\u003e\n\u003cp\u003ePatients were categorised into three distinct clinical groups. Patients who underwent surgical resection did either have confirmed malignancy (resectable cancer) or a non-malignant condition (benign disease). The third group consisted of advanced cancer patients who underwent exploratory laparotomy but did not undergo resection, either due to locally advanced tumour growth or overt metastases (advanced cancer).\u003c/p\u003e\n\u003cp\u003eIn addition to the presence of ICC-positive cells, the following clinical- and pathological parameters were recorded: age, gender, CA19-9, tumour size on CT-scan, AJCC/UICC-stage (7\u003csup\u003eth\u003c/sup\u003e ed.), pTNM-staging including resection margin, cancer origin, grade of histopathological differentiation, histological subtype (predominantly intestinal or pancreatobiliary), vascular and perineural infiltration. Continuous variables were dichotomized at the following thresholds: CA19-9 \u0026ge; 200kU/L and the size of the lesion on CT-scan \u0026ge; 25mm (for results, see Table 1).\u003c/p\u003e\n\u003ch2\u003eStatistics\u003c/h2\u003e\n\u003cp\u003eData were analysed in IBM SPSS, V25 (IBM Cooperation Analytics, Armonk, NY, USA) and STATA 15 (Stata Corp LLC, College Station, Texas, USA). Graphs were prepared in PRISM 8 (GraphPad Software Inc., La Jolla, CA, USA). The primary endpoints of the study were overall survival (OS), defined as survival until death by any cause and disease-free survival (DFS), defined as survival until signs of local relapse or metastasis were detected. Survival analyses were carried out with the Kaplan-Meier method, using the Log-rank test for difference of curve pairs. The association between TC-status and survival was quantified by a hazard ratio (HR) with a 95% confidence interval (CI) using Cox regression analysis. Statistical significance was assumed for p\u0026lt;0.05.\u003c/p\u003e"},{"header":"Results","content":"\u003ch2\u003ePatient group characteristics\u003c/h2\u003e\n\u003cp\u003e277 patients were assessed during the study period of whom 35 patients (12.6%) did not meet the inclusion criteria. Tumour resection with curative intent was performed in 86.4% of the patients (209/242), while in 13.6% (33/242) resection was not performed due to intraoperative detection of advanced disease. In patients deemed unresectable intraoperatively, a biliary or intestinal bypass procedure was performed in 24 patients and 9 received an explorative laparotomy. Of the cases with advanced disease, the tumour origin was the pancreatic head in 30 cases, the duodenum in two cases and in one case the distal bile duct. Of the 209 cases where a successful resection was performed, malignant tumours were confirmed in 85.6% (179/209), while 14.4% (30/209) a benign pancreatic disease was found. Thus, for the whole cohort, resected malignancies account for 74.0% (179/242), advanced disease 13.6% (33/242) and benign pancreatic disease for 12.4% (30/242). The 90-day mortality in operated patients was 2.1% (5/242), all due to rapid cancer progression because of advanced disease, in one case additionally complicated by an anastomotic failure. 84.6% (31/212) of all patients with malignant disease were alive at the date of last follow-up. Ten patients had died from other causes than cancer relapse. Further details on clinical features, distribution of procedures and histopathological diagnoses of the cohort are summarised in Table 1.\u003c/p\u003e\n\u003ch2\u003eOverall survival for patient groups\u003c/h2\u003e\n\u003cp\u003eThe median observation time for the entire cohort was 21.5 months (range 1.5-110). Median overall survival (OS) was estimated to 101 months (95% CI: 69.4-132) in patients with a benign lesion, 21.1 months (95% CI: 18.0-24.1) in the resectable cancer group and 8.8 months (95% CI: 4.3-13.3) in patients with advanced cancer. Differences in OS between the subgroups were statistically significant (see also Figure 2).\u003c/p\u003e\n\u003ch2\u003eBone marrow ICC-positive cell types and patient survival\u003c/h2\u003e\n\u003cp\u003eICC-positive cells of the named subtypes were identified both in patients with resected malignant tumours, in those with advanced cancers as well as in patients with benign pancreatic disease. According to patient group, DTCs were present in 6/168 (3.6%) in resected cancers, 2/31 (6.5%) in advanced cancers and 4/29 (13.8%) in cases of benign pancreatic disease. The frequency of the other classes of ICC-positive cells in each prognostic group is presented in detail in Table 1. A per case specification of the distribution and frequency of all cell types together with the clinicopathological data are presented in Appendix Table 1. The low number of ICC-positive samples precludes subgroup analysis by tumour type. Survival analyses according to presence or absence of DTCs and the other ICC-positive cells are presented in Figure 3 and Figure 4, and in further detail in Table 2. DTC-positivity was associated with neither OS nor DFS. Furthermore, presence of other ICC-positive cells did not negatively impact on survival. The association between survival and presence of ICC-positive cells for benign disease was hampered by too few ICC-positive cases.\u003c/p\u003e\n\u003cp\u003eTo account for the effect of CTC status and nodal status, as well as the weaker effects of vascular infiltration and histological type on survival of resected patients(20), we performed survival analyses subgrouped by these factors(Figure 5). Patients with or without DTCs had similar outcome in those subgroups (Figure 5). Presence other any other of the bone marrow ICC-positive cell types did not affect survival among the CTC-megative patients (Appendix Figure 1). Among the CTC-positive patients, DTCs were not observed (Figure 5) and in only one patient a single ICC-positive cell (HC) was detected (Appendix Figure 1).\u003c/p\u003e"},{"header":"Discussion","content":"\u003ch2\u003eDTC frequency\u003c/h2\u003e\n\u003cp\u003eA low frequency of DTCs was detected in both resected (3.6%) and advanced cancer patients (6.5%). These numbers are less than half the frequencies reported from the largest patient series prior to the present study (13) which reported 13.5% DTC-positivity for resected cancers and 13.9% for advanced cancers. Even higher positive rates of 38% to 57.1% were reported from earlier cohorts with smaller patient numbers and predominantly advanced stage cancers (14,15,17). Complementary to the data from ICC-based studies, there were two studies using RT-PCR for CK-20 (24) detecting 33% positive cases in a cohort of resectable PDAC (24) and CK-19 (25), detecting 67% positives in a cohort of mixed stage cases (25). In the absence of comparative studies between ICC and PCR-based detection, the seemingly higher positive rates for PCR-based assays targeting a single CK category versus ICC utilising broad spectrum antibodies against a range of class I and class II CK-subtypes remains unexplained, although different sensitivity and/or specificity may contribute.\u003c/p\u003e\n\u003ch2\u003eSurvival prediction\u003c/h2\u003e\n\u003cp\u003eAmong resected pancreatic cancer patients, five ICC-based studies (13-17) reported a significant association between DTCs and impaired survival in univariate analysis. In one of these studies(13), prognostic information was also retained in multivariate analysis (HR 2.755, p=0.022), while the four other studies did not test independent predictive value of DTC. There are two additional ICC-based studies on the same subject that did not discover an association between DTC status and survival (26,27). When weighing the evidence from these studies, several methodological differences have to be taken into consideration. The ISHAGE-group (7) established the first consensus on the cyto\u0026shy;morpho\u0026shy;logical criteria for the classification of ICC-positive cells in the BMfor breast cancer patients. These criteria were later underscored in consensus reports (8,9) but also used in additional studies (23,28)\u003c/p\u003e\n\u003cp\u003eSeveral of the studies mentioned above have been conducted prior to this standardisation or do not disclose their adherence to the ISHAGE criteria (14,15,17). Furthermore, there is a lack of standardisation concerning the choice of CK-detection antibodies, only one group (27) used the same antibody combination as in the present study. While not validated separately for gastrointestinal cancer types, the broad reactivity of the AE1 and AE3 antibody combinations which covers a spectrum of both the basic and acidic categories of CKs makes the assumption reasonable that the assay employed in the present study detects CK-positive cells independent from the tissue-type dependent differences in CK-subtype expression. The comparison of our results with the aforementioned studies may also be affected by the small size of several of the studies and mixed cohorts with predominantly advanced cancer stages (14-17). Moreover, the substantial rate of surgical interventions performed outside established criteria for operability may have introduced a hidden stage migration (13). Concerning the association of UIC-type cells with an inferior OS in patients with benign disease, there are only two UIC-positive cases out of 30 patients, rendering the result inconclusive. Although there seemed to be an association of UIC with an improved DFS for UIC-positive patients in the resected group, no difference in overall survival was observed. Since DFS and OS are tightly linked in these patients the clinical relevance of this finding is questionable.\u003c/p\u003e\n\u003ch2\u003eICC-positive cases in benign pancreatic disease\u003c/h2\u003e\n\u003cp\u003eIn the present study, ICC-positive cells meeting the morphological criteria for DTC were detected in four out of 29 patients with benign pancreatic disease, for one more patient the analysis was inconclusive. The majority of ICC-based studies have excluded patients with benign pancreatic disease \u003cem\u003ea priori\u003c/em\u003e from the analysis (13-15,17,26). Therefore, previous evidence on the validity of the results from the present cohort is limited. This observed rate of 13% is far above the established rate of 2-3.5% for false positive events for the ICC-based assay (7,15,27,29). The presence of occult malignancy in those patients as the source for those cells is unlikely since none of the patients were diagnosed with cancer later during the observation period and none had a previous history of malignancy. While the nature of those cells cannot be further determined in the present study, there are independent reports on cells of seemingly epithelial origin in the BM and peripheral blood of PDAC-patients. One ICC-based study reported results from four patients with benign disease, disclosing two ICC-positive cases (16). In their conclusion the authors deem their method unfit for clinical use in PDAC due to the unreliability of the assay. Also one of the PCR-based studies report a rate of 11% in cases with benign pancreatic disease, while reporting only one positive case in 20 healthy controls(30). In addition, there is one report disclosing the presence of epithelial cells in the bloodstream of patients with benign pancreatic disease (31). These cells could potentially enter the BMvia the bloodstream and could thereby be detected in BM-samples as well. Another possibility for the non-malignant origin of epithelial cells could be the shedding of epithelial cells from the pancreatic- and bile ducts or the duodenal wall during interventions, especially in the presence of inflammation\u0026nbsp;\u0026nbsp; (32). Interestingly, all of the four ICC-positive cases in benign pancreatic disease in the present study had undergone invasive procedures preoperatively, either ERCP, endoscopic biopsy or bile duct stenting.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe results from our study of a large cohort of patients with presumed resectable periampullary cancer show a low frequency of CK-positive cases in both resectable cancer, advanced cancer group and non-malignant pancreatic disease. No association with CK-status and survival was observed. For the UIC cell type, an association with disease free-survival was observed, but this was not supported by overall survival data and the relevance of the association is questionable. Cells satisfying predefined consensus criteria for DTC/CK-positive cells in the BM were detected both in patients with malignant as well as benign pancreatic disease. The combination of low frequency of CK-positive cells and their presence in benign pancreatic disease cases indicates that the ICC-based CK-detection method used in the present study does not reliably identify relevant cells of malignant origin for the type of cancers studied. Nevertheless, additional studies including further characterisation of the cells, preferably with single cell techniques are encouraged.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAJCC/UICC: \u003cu\u003eA\u003c/u\u003emerican \u003cu\u003eJ\u003c/u\u003eoint \u003cu\u003eC\u003c/u\u003eommittee on \u003cu\u003eC\u003c/u\u003eancer / \u003cu\u003eU\u003c/u\u003enion \u003cu\u003eI\u003c/u\u003enternationale \u003cu\u003eC\u003c/u\u003eontre le \u003cu\u003eC\u003c/u\u003eancere\u003c/p\u003e\n\u003cp\u003eAMPUC: \u003cu\u003eAmpu\u003c/u\u003ellary \u003cu\u003ec\u003c/u\u003eancer\u003c/p\u003e\n\u003cp\u003eAPAAP: \u003cu\u003eA\u003c/u\u003elkaline \u003cu\u003eP\u003c/u\u003ehosphatase-\u003cu\u003eA\u003c/u\u003enti-\u003cu\u003eA\u003c/u\u003elkaline \u003cu\u003eP\u003c/u\u003ehosphatase\u003c/p\u003e\n\u003cp\u003eBM: \u003cu\u003eB\u003c/u\u003eone \u003cu\u003em\u003c/u\u003earrow\u003c/p\u003e\n\u003cp\u003eCDC: \u003cu\u003eC\u003c/u\u003eentre for \u003cu\u003eD\u003c/u\u003eisease \u003cu\u003eC\u003c/u\u003eontrol\u003c/p\u003e\n\u003cp\u003eCI: \u003cu\u003eC\u003c/u\u003eonfidence \u003cu\u003ei\u003c/u\u003enterval\u003c/p\u003e\n\u003cp\u003eCK \u003cu\u003eC\u003c/u\u003eyto\u003cu\u003ek\u003c/u\u003eeratin\u003c/p\u003e\n\u003cp\u003eCT \u003cu\u003eC\u003c/u\u003eomputed \u003cu\u003et\u003c/u\u003eomography X-ray\u003c/p\u003e\n\u003cp\u003eCTC: \u003cu\u003eC\u003c/u\u003eirculating \u003cu\u003et\u003c/u\u003eumour \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e\n\u003cp\u003eDBDC: Distal \u003cu\u003eb\u003c/u\u003eile \u003cu\u003ed\u003c/u\u003euct \u003cu\u003ec\u003c/u\u003eancer\u003c/p\u003e\n\u003cp\u003eDFS: \u003cu\u003eD\u003c/u\u003eisease-\u003cu\u003ef\u003c/u\u003eree \u003cu\u003es\u003c/u\u003eurvival\u003c/p\u003e\n\u003cp\u003eDTC: \u003cu\u003eD\u003c/u\u003eisseminated \u003cu\u003et\u003c/u\u003eumour \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e\n\u003cp\u003eDUODC: \u003cu\u003eDuod\u003c/u\u003eenal \u003cu\u003ec\u003c/u\u003eancer\u003c/p\u003e\n\u003cp\u003eHC: \u003cu\u003eH\u003c/u\u003eematopoietic \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e\n\u003cp\u003eICC: \u003cu\u003eI\u003c/u\u003emmuno-\u003cu\u003ec\u003c/u\u003eyto\u003cu\u003ec\u003c/u\u003ehemistry\u003c/p\u003e\n\u003cp\u003eISHAGE: \u003cu\u003eI\u003c/u\u003enternational \u003cu\u003eS\u003c/u\u003eociety of \u003cu\u003eH\u003c/u\u003eematotherapy \u003cu\u003ea\u003c/u\u003end \u003cu\u003eG\u003c/u\u003eraft \u003cu\u003eE\u003c/u\u003engineering\u003c/p\u003e\n\u003cp\u003eMNC: \u003cu\u003eM\u003c/u\u003eono\u003cu\u003en\u003c/u\u003euclear \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e\n\u003cp\u003eOS: \u003cu\u003eO\u003c/u\u003everall \u003cu\u003es\u003c/u\u003eurvival\u003c/p\u003e\n\u003cp\u003ePDAC: \u003cu\u003eP\u003c/u\u003eancreatic \u003cu\u003ed\u003c/u\u003euctal \u003cu\u003ea\u003c/u\u003edenocar\u003cu\u003ec\u003c/u\u003einoma\u003c/p\u003e\n\u003cp\u003epTNM \u003cu\u003eP\u003c/u\u003eathological \u003cu\u003et\u003c/u\u003eumour stage, \u003cu\u003en\u003c/u\u003eodal status, \u003cu\u003em\u003c/u\u003eetastastis status\u003c/p\u003e\n\u003cp\u003eQHC: \u003cu\u003eQ\u003c/u\u003euestionable/probable \u003cu\u003eh\u003c/u\u003eematopoietic cells\u003c/p\u003e\n\u003cp\u003eREMARK: \u003cu\u003eRe\u003c/u\u003eporting recommendations for tumour \u003cu\u003emark\u003c/u\u003eer prognostic studies\u003c/p\u003e\n\u003cp\u003eSTROBE: \u003cu\u003eStr\u003c/u\u003eengthening the reporting of \u003cu\u003eob\u003c/u\u003eservational studies in \u003cu\u003ee\u003c/u\u003epidemiology\u003c/p\u003e\n\u003cp\u003eTC: \u003cu\u003eT\u003c/u\u003eumour \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e\n\u003cp\u003eUIC: \u003cu\u003eU\u003c/u\u003en\u003cu\u003ei\u003c/u\u003enterpretable \u003cu\u003ec\u003c/u\u003eells\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch2\u003eEthics approval and consent to participate\u003c/h2\u003e\n\u003cp\u003eAll patients selected for surgery were offered participation in this prospective, observational study and asked for their written informed consent. Exclusion criteria were a history of other malignancies in the past ten years, failure to adhere to standard treatment and infrequent cancer types such as neuroendocrine carcinoma. The study protocol was approved by the Regional Ethical Committee (Helse S\u0026oslash;r-\u0026Oslash;st; Ref. 93-08172d 6.2008.540) in Oslo, Norway and registered at clinicaltrials.gov (NCT01919151). Clinical data were recorded prospectively in a database that was approved by and maintained as regulated by the Oslo University Hospital guidelines, supervised by the Data Protection Officer for Research.\u003c/p\u003e\n\u003ch2\u003eConsent for publication\u003c/h2\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003ch2\u003eAvailability of data and materials\u003c/h2\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request\u003c/p\u003e\n\u003ch2\u003eCompeting interests\u003c/h2\u003e\n\u003cp\u003eNone of the authors has any conflicting interest to disclose\u003c/p\u003e\n\u003ch2\u003eFunding\u003c/h2\u003e\n\u003cp\u003eThis work was supported by a research grant from Helse S\u0026oslash;r-\u0026Oslash;st (Regional health-authority) to GW that covered the costs of laboratory analyses for the present study. HH had a part-time junior researcher position funded by Helse S\u0026oslash;r-\u0026Oslash;st over four years in the beginning of the study period. The funding entity was neither involved in the design of the present study nor were results disclosed previous to publication.\u003c/p\u003e\n\u003ch2\u003eAuthors' contributions\u003c/h2\u003e\n\u003cp\u003eThe concept of the present study was developed by GW, HH, KJL and BN. The acquisition of clinical data was performed by KJL, HH, LTS, the histopathological data by CSV. CTC analyses and the interpretation of results were performed by CBS, AR and EB. Statistical analyses were performed by CB. All authors were involved in the interpretation of the data with full access to the primary data and have approved the submitted version. The authors have agreed to be personally accountable for their own contributions and to ensure that questions related to the integrity and accuracy of any part of the present work are appropriately investigated, resolved and the resolution documented in the literature.\u003c/p\u003e\n\u003ch2\u003eAcknowledgements\u003c/h2\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eS\u0026oslash;reide K, Aagnes B, M\u0026oslash;ller B, Westgaard A, Bray F. Epidemiology of pancreatic cancer in Norway: trends in incidence, basis of diagnosis and survival 1965-2007. Scand J Gastroenterol. 2010;45(1):82\u0026ndash;92.\u003c/li\u003e\n\u003cli\u003eLi D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet. 2004 Mar 27;363(9414):1049\u0026ndash;57.\u003c/li\u003e\n\u003cli\u003eHe J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA, et al. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford). 2014 Jan;16(1):83\u0026ndash;90.\u003c/li\u003e\n\u003cli\u003eTempero MA, Malafa MP, Al-Hawary M, Asbun H, Bain A, Behrman SW, et al. Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. Harborside Press, LLC; 2017 Aug;15(8):1028\u0026ndash;61.\u003c/li\u003e\n\u003cli\u003eMorrissey C, Vessella RL, Lange PH, Lam H-M. The biology and clinical implications of prostate cancer dormancy and metastasis. J Mol Med. 2016 Mar;94(3):259\u0026ndash;65.\u003c/li\u003e\n\u003cli\u003ePantel K, Alix-Panabi\u0026egrave;res C, Riethdorf S. Cancer micrometastases. 2009 Jun;6(6):339\u0026ndash;51.\u003c/li\u003e\n\u003cli\u003eBorgen E, Naume B, Nesland JM, Kvalheim G, Beiske K, Fodstad O, et al. Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells. Cytotherapy. 1999;1(5):377\u0026ndash;88.\u003c/li\u003e\n\u003cli\u003eFehm T, Braun S, M\u0026uuml;ller V, Janni W, Gebauer G, Marth C, et al. A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer. 2006 Sep 1;107(5):885\u0026ndash;92.\u003c/li\u003e\n\u003cli\u003eBorgen E, Pantel K, Schlimok G, M\u0026uuml;ller P, Otte M, Renolen A, et al. A European interlaboratory testing of three well-known procedures for immunocytochemical detection of epithelial cells in bone marrow. Results from analysis of normal bone marrow. Cytometry B Clin Cytom. John Wiley \u0026amp; Sons, Ltd; 2006 Nov 15;70(6):400\u0026ndash;9.\u003c/li\u003e\n\u003cli\u003eMignot F, Loirat D, Dureau S, Bataillon G, Caly M, Vincent-Salomon A, et al. Disseminated tumor cells predict efficacy of regional nodal irradiation in early stage breast cancer. Int J Radiat Oncol Biol Phys. 2018 Oct 3.\u003c/li\u003e\n\u003cli\u003eNaume B, Synnestvedt M, Falk RS, Wiedswang G, Weyde K, Risberg T, et al. Clinical outcome with correlation to disseminated tumor cell (DTC) status after DTC-guided secondary adjuvant treatment with docetaxel in early breast cancer. Journal of Clinical Oncology. 2014 Dec 1;32(34):3848\u0026ndash;57.\u003c/li\u003e\n\u003cli\u003eTodenh\u0026ouml;fer T, Hennenlotter J, Faber F, Wallwiener D, Schilling D, K\u0026uuml;hs U, et al. Significance of apoptotic and non-apoptotic disseminated tumor cells in the bone marrow of patients with clinically localized prostate cancer. Prostate. John Wiley \u0026amp; Sons, Ltd; 2015 May;75(6):637\u0026ndash;45.\u003c/li\u003e\n\u003cli\u003eEffenberger KE, Schroeder C, Eulenburg C, Reeh M, Tachezy M, Riethdorf S, et al. Disseminated tumor cells in pancreatic cancer-an independent prognosticator of disease progression and survival. Int J Cancer. 2012 Aug 15;131(4):E475\u0026ndash;83.\u003c/li\u003e\n\u003cli\u003eVogel I, Kr\u0026uuml;ger U, Marxsen J, Soeth E, Kalthoff H, Henne-Bruns D, et al. Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: a new prognostic factor. 1999 Mar;5(3):593\u0026ndash;9.\u003c/li\u003e\n\u003cli\u003eThorban S, Roder JD, Pantel K, Siewert JR. Epithelial tumour cells in bone marrow of patients with pancreatic carcinoma detected by immunocytochemical staining. European Journal of Cancer. 1996 Feb;32(2):363\u0026ndash;5.\u003c/li\u003e\n\u003cli\u003evan Heek NT, Tascilar M, van Beekveld JL, Drillenburg P, Offerhaus GJA, Gouma DJ. Micrometastases in bone marrow of patients with suspected pancreatic and ampullary cancer. 2001 Dec 1;27(8):740\u0026ndash;5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0748798301912090\u003c/li\u003e\n\u003cli\u003eRoder JD, Thorban S, Pantel K, Siewert JR. Micrometastases in bone marrow: prognostic indicators for pancreatic cancer. World J Surg. 1999 Sep;23(9):888\u0026ndash;91.\u003c/li\u003e\n\u003cli\u003eStephenson D, Nahm C, Chua T, Gill A, Mittal A, de Reuver P, et al. Circulating and disseminated tumor cells in pancreatic cancer and their role in patient prognosis: a systematic review and meta-analysis. Oncotarget. Impact Journals; 2017 Dec 5;8(63):107223\u0026ndash;36.\u003c/li\u003e\n\u003cli\u003eLabori KJ, Katz MH, Tzeng CW, Bj\u0026oslash;rnbeth BA, Cvancarova M, Edwin B, et al. Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study. Acta Oncol. 2016;55(3):265\u0026ndash;77.\u003c/li\u003e\n\u003cli\u003eHugenschmidt H, Labori KJ, Brunborg C, Verbeke CS, Seeberg LT, Schirmer CB, et al. Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma. Ann Surg. 2020 Mar;271(3):549\u0026ndash;58.\u003c/li\u003e\n\u003cli\u003eWiedswang G, Borgen E, K\u0026aring;resen R, Kvalheim G, Nesland JM, Qvist H, et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol. American Society of Clinical Oncology; 2003 Sep 15;21(18):3469\u0026ndash;78.\u003c/li\u003e\n\u003cli\u003eCordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984 Feb;32(2):219\u0026ndash;29.\u003c/li\u003e\n\u003cli\u003eSynnestvedt M, Borgen E, Schlichting E, Schirmer CB, Renolen A, Giercksky KE, et al. Disseminated tumour cells in the bone marrow in early breast cancer: morphological categories of immunocytochemically positive cells have different impact on clinical outcome. Breast Cancer Res Treat. Springer US; 2013 Apr;138(2):485\u0026ndash;97.\u003c/li\u003e\n\u003cli\u003eSoeth E, Grigoleit U, Moellmann B, R\u0026ouml;der C, Schniewind B, Kremer B, et al. Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival. J Cancer Res Clin Oncol. 2005 Oct;131(10):669\u0026ndash;76.\u003c/li\u003e\n\u003cli\u003eHoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, et al. Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol. 2007 Jan 14;13(2):257\u0026ndash;63.\u003c/li\u003e\n\u003cli\u003eRehders A, Stoecklein NH, G\u0026uuml;ray A, Riediger R, Alexander A, Knoefel WT. Vascular invasion in pancreatic cancer: tumor biology or tumor topography? Surgery [Internet]. 2012 Sep;152(3 Suppl 1):S143\u0026ndash;51. Available from: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed\u0026amp;id=22766363\u0026amp;retmode=ref\u0026amp;cmd=prlinks\u003c/li\u003e\n\u003cli\u003eZ'graggen K, Centeno BA, Fernandez-del Castillo C, Jimenez RE, Werner J, Warshaw AL. Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients. Surgery. 2001 May 1;129(5):537\u0026ndash;46.\u003c/li\u003e\n\u003cli\u003eBidard F-C, Vincent-Salomon A, Gomme S, Nos C, de Rycke Y, Thiery JP, et al. Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse. Clin Cancer Res. American Association for Cancer Research; 2008 Jun 1;14(11):3306\u0026ndash;11.\u003c/li\u003e\n\u003cli\u003eSchlimok G, Funke I, Holzmann B, G\u0026ouml;ttlinger G, Schmidt G, H\u0026auml;user H, et al. Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. Proc Natl Acad Sci USA. National Academy of Sciences; 1987 Dec;84(23):8672\u0026ndash;6.\u003c/li\u003e\n\u003cli\u003eSoeth E, Vogel I, R\u0026ouml;der C, Juhl H, Marxsen J, Kr\u0026uuml;ger U, et al. Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR. Cancer Res. 1997 Aug 1;57(15):3106\u0026ndash;10.\u003c/li\u003e\n\u003cli\u003eRosenbaum MW, Cauley CE, Kulemann B, Liss AS, Castillo CF-D, Warshaw AL, et al. Cytologic characteristics of circulating epithelioid cells in pancreatic disease. Cancer. 2017 May;125(5):332\u0026ndash;40.\u003c/li\u003e\n\u003cli\u003eLiu JJ, Wong K, Thiesen AL, Mah SJ, Dieleman LA, Claggett B, et al. Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters. Gastrointestinal Endoscopy. 2011 Jun;73(6):1174\u0026ndash;80.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin:0in;line-height:150%;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;'\u003e\u003cspan style=\"font-size: 13px; line-height: 150%; color: rgb(0, 0, 0);\"\u003eTable 1:\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:150%;font-weight:normal;\"\u003eClinical characteristics of the cohort according to patient groups including ICC-positive cell type status in bone marrow\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:115.5pt;border-top:solid windowtext 1.0pt;border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;margin:0in;text-align:center;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 21.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height: 115%;\"\u003eResected cancers\u003cbr\u003e\u0026nbsp;(n=179)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.55pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eAdvanced cancers\u003cbr\u003e\u0026nbsp;(n=33)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:115.55pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;margin:0in;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eBenign\u003cbr\u003e\u0026nbsp;(n=30)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 12.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eAge, median [years]\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 12.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e69 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (34-88)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 12.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e63 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (46-83)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 12.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e69 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (45-82)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eSex, male\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 15.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e92 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (51.4%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 15.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e19 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (57.6%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e21 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (70.0%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 462.15pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 19.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; ICC-positivity: \u0026ge; 1 ICC-positive cell / 2x 10\u003csup\u003e6\u0026nbsp;\u003c/sup\u003eMNC\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:14px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (ICC-status numbers may differ due to varying number of inconclusive ICC-results per category)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 13px; line-height: 115%;\"\u003eTC\u003cbr\u003e UIC\u003cbr\u003e HC\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eQHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; line-height: 115%;\"\u003e6/168 \u0026nbsp; \u0026nbsp;(3.6%) \u003cbr\u003e 10/174 (5.7%)\u003cbr\u003e 16/169 (9.5%)\u003cbr\u003e\u0026nbsp;12/135 \u0026nbsp;(8.8%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; line-height: 115%;\"\u003e2/31 \u0026nbsp; \u0026nbsp; \u0026nbsp;(6.5%)\u003cbr\u003e 0/31 (0.0%)\u003cbr\u003e 2/30 (6.7%)\u003cbr\u003e\u0026nbsp;3/28 \u0026nbsp; \u0026nbsp; \u0026nbsp;(7.9%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 13px; line-height: 115%;\"\u003e4/29 \u0026nbsp; \u0026nbsp; \u0026nbsp;(13.8%)\u003cbr\u003e 2/30 (6.7%)\u003cbr\u003e 3/29 (10.3%)\u003cbr\u003e\u0026nbsp;3/25 \u0026nbsp; \u0026nbsp; \u0026nbsp;(12.0%)\u003c/span\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 462.15pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Preoperative Risk Factors\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eCA19-9 \u0026ge; 200kU/l\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e51/127 (40.2%); \u003cem\u003e52 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e17/28 \u0026nbsp; \u0026nbsp;(60.7%); \u003cem\u003e5 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e0/20; \u003cem\u003e10 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eTumour size\u0026gt; 25mm\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e71 (39.7%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e20 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (60.6%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e10 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (33.3%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eBilirubin \u0026gt; 50\u0026micro;mol/L\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e132/151 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(87.4%); \u003cem\u003e28 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e21/32 \u0026nbsp; \u0026nbsp;(65.6%); \u003cem\u003e1 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e7/29 \u0026nbsp; \u0026nbsp; \u0026nbsp;(24.1%); \u003cem\u003e1 missing\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 462.15pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 8.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Treatment\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 7.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eNeoadjuvant chemotherapy\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 7.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eGEMZ \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e6 (4.1%)\u003cbr\u003e \u003cstrong\u003eFOLFIRINX\u003c/strong\u003e 1 (0.7%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 7.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eGEMZ\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp;1 (3.0%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 7.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003enone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 20.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eOperation: \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;PPPD\u003cbr\u003e PD\u003cbr\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Pancreatectomy\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 20.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e146 \u0026nbsp; \u0026nbsp; \u0026nbsp; (82.6%)\u003cbr\u003e 25 (14.0%)\u003cbr\u003e\u0026nbsp;8 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(4.5%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 20.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eBDB\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;24 (72.7%)\u003cbr\u003e \u003cstrong\u003eExp\u003c/strong\u003e.\u003cstrong\u003elap.\u003c/strong\u003e 9 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(27.3%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 20.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e29 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(96.7%) \u003cbr\u003e 1 (3.3%) \u003cbr\u003e\u0026nbsp;none\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eVenous resection\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e49 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (27.4%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003en.a.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e2 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(6.7%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eAdjuvant chemotherapy\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eFLV\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e: \u0026nbsp; \u0026nbsp; 91 (50.8%)\u003cbr\u003e \u003cstrong\u003eGEMZ\u003c/strong\u003e: 7 (3.9%)\u003cbr\u003e \u003cstrong\u003eFLOX\u003c/strong\u003e: 1 (0.7%)\u003cbr\u003e \u003cstrong\u003enone:\u003c/strong\u003e 80 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(44.7%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003ePalliative chemotherapy\u003cbr\u003e\u0026nbsp;31 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(93.9%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003en.a.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 462.15pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Histopathologic results\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003ePancreatic cancer\u003cbr\u003e Malignant IPMN\u003cbr\u003e Distal bile duct ca.\u003cbr\u003e Ampullary cancer\u003cbr\u003e\u0026nbsp;Duodenal cancer\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e101 \u0026nbsp; \u0026nbsp; \u0026nbsp; (56.4%)\u003cbr\u003e 9 (5.0%)\u003cbr\u003e 31 (17.3%)\u003cbr\u003e 21 (11.7%)\u003cbr\u003e\u0026nbsp;17 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (9.4%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border: none;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e30\u003cbr\u003e \u003cbr\u003e 1\u003cbr\u003e \u003cbr\u003e\u0026nbsp;2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003ePancreatobiliary type\u003cbr\u003e Intestinal type\u003cbr\u003e\u0026nbsp;Mucinous type\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e146 \u0026nbsp; \u0026nbsp; \u0026nbsp; (81.6%)\u003cbr\u003e 26 (14.5%)\u003cbr\u003e\u0026nbsp;7 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(3.9%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e28 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(84.8%)\u003cbr\u003e\u0026nbsp;5 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(15.2%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 42.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eIPMN\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;line-height: 115%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;11 (36.7%)\u003cbr\u003e \u003cstrong\u003eben.Tu. \u0026nbsp;\u003c/strong\u003e5 (16.6%)\u003cbr\u003e \u003cstrong\u003eAIP\u003c/strong\u003e 6 (20.0%)\u003cbr\u003e \u003cstrong\u003echr.Panc\u003c/strong\u003e 4 (13.3%)\u003cbr\u003e \u003cstrong\u003einflam. \u0026nbsp;\u003c/strong\u003e4 (13.4%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 8.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eUICC-stage (V7): \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;I\u003cbr\u003e II\u003cbr\u003e III\u003cbr\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;IV\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 8.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e16 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (10.6%)\u003cbr\u003e 150 (83.8%)\u003cbr\u003e 13 (7.3%)\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 8.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u003cbr\u003e \u003cbr\u003e 7 (21.2%)\u003cbr\u003e\u0026nbsp;26 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (78.8%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 8.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eN1-status\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e120 \u0026nbsp; \u0026nbsp; \u0026nbsp; (67.0%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 13.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eR1-status\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 13.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e87 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; (48.6%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 13.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 13.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 6.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003eVascular infiltration\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 6.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e108 \u0026nbsp; \u0026nbsp; \u0026nbsp; (60.3%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;padding: 0in 5.4pt;height: 6.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 6.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 115.5pt;border-top: none;border-left: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 4.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003ePerineural infiltration\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 4.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e141 \u0026nbsp; \u0026nbsp; \u0026nbsp; (78.8%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 4.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 115.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 4.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:115%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 462.15pt;border: none;padding: 0in 5.4pt;height: 35.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:left;line-height:115%;font-size:13px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003eGEMZ:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003eGemzitabine\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e, FLV, FLOX, FOLFIRINOX:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003echemotherapy regimens\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; PD:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003epancreatico-duodenectomy,\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e\u0026nbsp;PPPD:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003epylorus preserving PD\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e, BDB:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 115%;\"\u003ebiliodigestive bypass\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; Ex.lap.:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003eexplorative laparotomy;\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e\u0026nbsp;IPMN\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003e: intraductal pancreatic mucinous neoplasia\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; ben.tu.:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003ebenign tumour\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; AIP:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003eautoimmune pancreatitis\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; chr. panc.:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003echronic\u0026nbsp;pancreatitis\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e; inflam\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003e.:\u0026nbsp;inflammation\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e\u0026nbsp;n.a.:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003enot applicable;\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e\u0026nbsp;n.d.:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height:115%;\"\u003enot determined\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003e.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 115%;\"\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height:115%;\"\u003eNote:\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:14px;line-height:115%;\"\u003eICC-status numbers may differ due to varying number of inconclusive ICC-results per category.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.0e+2pt;border: none;margin-left:.5pt;border-collapse:collapse;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"13\" style=\"width:495.65pt;border:none;border-bottom: solid windowtext 1.0pt;padding:4.0pt 4.0pt 4.0pt 4.0pt;height:13.65pt;\"\u003e\n \u003cp style='margin:0in;line-height:150%;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height: 150%;\"\u003eTable 2:\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:13px;line-height: 150%;font-weight:normal;\"\u003eOverall survival according to ICC-positive cell type status in bone marrow\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 48.35pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003eICC-type\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.9pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003eLevel\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.3pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;margin-right:5.65pt;text-align: center;text-indent:-7.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003eN\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 55.9pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;margin-right:5.65pt;text-align: center;text-indent:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003eIncident\u003cbr\u003e\u0026nbsp;cases\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 55.25pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;margin-right:5.65pt;text-align: center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003ePerson months\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 79.45pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;margin-right:5.65pt;text-align: center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003eHR\u003cbr\u003e\u0026nbsp;(95%CI)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 47.05pt;border: none;padding: 1pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:13px;font-family:\"Helvetica Neue\";color:black;border:none;font-weight:bold;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Helvetica\",sans-serif;'\u003ep-value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 112.45pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 20.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica Neue\";'\u003eMean OS\u003cbr\u003e\u0026nbsp;(95%CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"12\" style=\"width:447.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;margin-top:12.0pt;margin-right: 5.65pt;margin-bottom:.0001pt;margin-left:0in;text-align: center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eOverall survival, resected cancers\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border-top:solid windowtext 1.0pt;border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border: none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eTC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;border:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e217.5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.1\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.4-2.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.865\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:4.45pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e36.2\u0026nbsp; \u0026nbsp; \u0026nbsp;(11.3-61.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e162\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e133\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e5293.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e37.1\u0026nbsp; \u0026nbsp; \u0026nbsp;(31.6-42.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eUIC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e488.1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.6\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.3-1.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.197\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e52.5\u0026nbsp; \u0026nbsp; \u0026nbsp;(27.2-77.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e164\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e136\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e5144.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e35. 6\u0026nbsp; \u0026nbsp;\u0026nbsp;(30.2-40.9)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e431.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.3\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.7-2.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.386\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e29.6\u0026nbsp; \u0026nbsp; \u0026nbsp;(14.3-44.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e153\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e125\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e5006.5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e37.3\u0026nbsp; \u0026nbsp; \u0026nbsp;(31.6-43.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eQHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e419.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.9\u0026nbsp; \u0026nbsp;\u0026nbsp;(.5-1.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.795\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:8.35pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e37.1\u0026nbsp; \u0026nbsp; \u0026nbsp;(18.1-56.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e123\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e102\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3817.1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e35.5\u0026nbsp; \u0026nbsp; \u0026nbsp;(29.2-41.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"12\" style=\"width:447.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;margin-top:12.0pt;margin-right: 5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;text-align: center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eOverall survival, advanced cancers\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border-top:solid windowtext 1.0pt;border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eTC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;border:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e7.9\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3.4\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.7-15.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.114\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3.9\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(0.8-7.1)s\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e298.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e10.3\u0026nbsp; \u0026nbsp; \u0026nbsp;(7.4-13.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eUIC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e31\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e31\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e306.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 47.05pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e9.9\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(7.1-12.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e14.3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.6 \u0026nbsp; \u0026nbsp;(0.4-7.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.522\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e7.2\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(4.0-10.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e266.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 47.05pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e9.5\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(6.5-12.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eQHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e16.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2.1\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.6-7.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.262\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5.5\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(1.9-9.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e248.5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.05pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:109.0pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e9.9\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(6.5-13.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"12\" style=\"width:447.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;margin-top:12.0pt;margin-right: 5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;text-align: center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eOverall survival, benign disease\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border-top:solid windowtext 1.0pt;border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eTC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;border:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e256.1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e4.0\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.7-22.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.114\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e65.3\u0026nbsp; \u0026nbsp; \u0026nbsp;(53.0-77.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e1929.4\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 50pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-9.55pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e92.2\u0026nbsp; \u0026nbsp; \u0026nbsp;(82.7-101.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eUIC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e143.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5.7\u0026nbsp; \u0026nbsp;\u0026nbsp;(1.1-25.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.039\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e71.5\u0026nbsp; \u0026nbsp; \u0026nbsp;(52.9-90.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e1796.9\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-2.45pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e92.6\u0026nbsp; \u0026nbsp; \u0026nbsp;(83.2-101.9)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e202.3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e4.7\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.9-25.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.075\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e69.4\u0026nbsp; \u0026nbsp; \u0026nbsp;(43.1-95.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e26\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e1867.3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 50pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e93.7\u0026nbsp; \u0026nbsp; \u0026nbsp;(84.3-103.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eQHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e202.3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e3.9\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.7-21.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.114\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5.5\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(1.9-9.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1639.1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e9.9\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;(6.5-13.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:right;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"12\" style=\"width:447.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:12.0pt;margin-right:5.65pt;margin-bottom:.0001pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eDisease free survival, resected cancers\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border-top:solid windowtext 1.0pt;border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003eTC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;border:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e112.4\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.3\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.6-3.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;border:none;border-top:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.525\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e18.7\u0026nbsp; \u0026nbsp; \u0026nbsp;(4.5-33.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e162\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e126\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e4022.2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 50pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e32.2\u0026nbsp; \u0026nbsp; \u0026nbsp;(25.9-38.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003eUIC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e441.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.4\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.2-1.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.040\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e62.1\u0026nbsp; \u0026nbsp; \u0026nbsp;(37.1-87.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e164\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e132\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e3785.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 50pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e29.4\u0026nbsp; \u0026nbsp; \u0026nbsp;(23.5-35.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border:none;border-left:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003eHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e299.4\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.4\u0026nbsp; \u0026nbsp;\u0026nbsp;(0.8-2.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.277\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e22.6\u0026nbsp; \u0026nbsp; \u0026nbsp;(5.7-39.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:0in;margin-bottom: 6.0pt;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e153\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:5.65pt;margin-bottom: 6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003e3774.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 77.75pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:0in;margin-right:-5.3pt;margin-bottom:6.0pt;margin-left:0in;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 50pt;padding: 1pt;height: 7.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-bottom:6.0pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e31.9\u0026nbsp; \u0026nbsp; \u0026nbsp;(25.5-38.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.35pt;border-top:none;border-left:solid windowtext 1.0pt;border-bottom:solid windowtext 1.0pt;border-right:none;padding: 0in 5.4pt 0in 5.4pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;border:none;margin-right:5.65pt;text-align:center;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family: \"Helvetica\",sans-serif;'\u003eQHC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.9pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e340.7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e1.0 (0.5-1.9)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e0.973\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border:none;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e30.1\u0026nbsp; \u0026nbsp; \u0026nbsp;(10. 1-50.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-left:2.85pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.3pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e123\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:59.55pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e96\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:5.65pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e2825.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:77.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-right:-5.3pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.05pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:7.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Helvetica\",sans-serif;'\u003e30.8\u0026nbsp; \u0026nbsp; \u0026nbsp;(23.7-37.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"13\" style=\"width:495.65pt;border:none;padding:1.0pt 1.0pt 1.0pt 1.0pt;height:12.2pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:6.0pt;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;line-height:150%;font-family:\"Helvetica\",sans-serif;'\u003eDetailed survival analysis for patients with (pos.) or without (neg.) ICC-positive cells in the bone marrow in the indicated morphological cell categories. HR and p-values were computed by Cox-regression analysis. The number of patients analysed may differ from group size for cases with inconclusive ICC-results.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:left;font-size:8px;font-family:\"Helvetica Neue\";color:black;border:none;margin-top:6.0pt;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:150%;font-size:16px;font-family:\"Helvetica\",sans-serif;color:black;font-weight:bold;margin-left:-28.35pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;line-height:150%;\"\u003eTable 3.\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:13px;line-height:150%;font-weight:normal;\"\u003ePublished studies on DTC status in the bone marrow for peri-ampullary adenocarcinomas, grouped by detection method.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003ctable style=\"width: 5.2e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: 1pt solid windowtext;border-left: 1pt solid windowtext;border-bottom: none;border-right: none;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eAuthors\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eMethod/ Markers\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eDetection limit\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eDTC def.\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003ePat. number\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eLoc. / Adv.\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eTC-rate\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003efalse-pos. rate\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eProg.\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: none;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 25.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eComments\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"10\" style=\"width: 513.95pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 17.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Immunocytochemistry\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eEffenberger 2012\u003csup\u003e(13)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK A45-B/B3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 2x10\u003csup\u003e6\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=175\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=71 / n=104\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e13.7% (24/175)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ePos.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e29 pat. resected despite advanced cancer stage\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eRehders\u003cbr\u003e 2012\u003csup\u003e(25)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK A45-B/B3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 1x10\u003csup\u003e6\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=49\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=49 /\u003cbr\u003e\u0026nbsp;-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e27% (12/49)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eNeg.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eNo details on survival analysis disclosed\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eRoder\u003cbr\u003e 1999\u003csup\u003e(17)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK 2; KL1; A45-B7B3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 5x10\u003csup\u003e5\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=48\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=8 / n=40\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e52.1% (25/48)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ePos.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eAssociation with OS for resected patients\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003evan Heek\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e2001\u003csup\u003e(16)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK (8,18)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 1x10\u003csup\u003e7\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=35\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=14 / n=13\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e34.2% (12/35)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e50%\u003cbr\u003e\u0026nbsp;(2/4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ePos.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e2/4 benign pat. false positive\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eVogel\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e1999\u003csup\u003e(14)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003epanCK, mucin, CEA, Ca-19\u0026ndash;9\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 1.25x10\u003csup\u003e6\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=80\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=11 /\u003cbr\u003e\u0026nbsp;n=60\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e38%\u003cbr\u003e\u0026nbsp;(27/71)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e6.6%\u003cbr\u003e\u0026nbsp;(3/45)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ePos.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eThorban\u003cbr\u003e 1996\u003csup\u003e(15)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK A45-B/B3\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 5x10\u003csup\u003e5\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=42\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=24 / n=18\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e57.1% (24/42)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ePos.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eAssociation with metastatic and local relapse\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eZ`Graggen\u003cbr\u003e\u0026nbsp;2001\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;\"\u003e(26)\u003c/span\u003e\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eCK AE3/AE1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026ge;1 / 5x10\u003csup\u003e6\u0026nbsp;\u003c/sup\u003eMNC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eTC\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=54\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=3 /\u003cbr\u003e\u0026nbsp;n=51\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e24% (13/54)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e4.1%\u003cbr\u003e\u0026nbsp;(1/24)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eNeg.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"10\" style=\"width: 513.95pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 17.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Nucleotide based detection\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 58.1pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;\"\u003eHoffmann\u003cbr\u003e 2007\u003csup\u003e(24)\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ert-PCR / CK-19\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=37\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=7 /\u003cbr\u003e\u0026nbsp;n=30\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e67%\u003cbr\u003e\u0026nbsp;(25/37)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003ert-PCR / CK-20\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.6pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=117\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.15pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003en=172\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.2pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e33.3%\u003cbr\u003e\u0026nbsp;(45/135)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003e11%\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38.55pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eNeg.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;font-size:11px;font-family:\"Helvetica\",sans-serif;color:black;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size:13px;\"\u003eSurvival data only for blood/BM combined. False positive rate 11%\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;border-bottom:solid windowtext 1.0pt;\"\u003e\n \u003cp style='margin:0in;line-height:200%;font-size:16px;font-family:\"Helvetica\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width: 514.95pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 75.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:-5.2pt;text-align:justify;line-height: normal;font-size:13px;font-family:\"Helvetica\",sans-serif;color:black;text-indent:-.35pt;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eProg:\u003c/strong\u003e prognostic impact of DTC-status on survival \u003cstrong\u003eLoc\u003c/strong\u003e: Localised cancers; \u003cstrong\u003eAdv\u003c/strong\u003e: advanced cancers; \u003cstrong\u003eMNC\u003c/strong\u003e: mononuclear cells\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"DTC, disseminated tumour cells, bone marrow, pancreatic cancer, periampullary cancer","lastPublishedDoi":"10.21203/rs.2.18905/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.18905/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a variety of epithelial cancers. In a cohort of patients with presumed resectable pancreatic and periampullary carcinoma, we evaluated the frequency and the potential prognostic impact of the preoperative presence of DTC, defined as cytokeratin-positive cells detected by immunocytochemistry (ICC). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u0026nbsp;\u003c/strong\u003ePreoperative BMsamples from 242 patients selected for surgical resection of presumed resectable pancreatic and periampullary carcinoma from 09/2009 to 12/2014, were analysed for presence of CK-positive cells by ICC.\u0026nbsp;The\u0026nbsp;median observation time was 21.5 months. Overall survival (OS) and disease-free survival (DFS) were calculated by Kaplan-Meier and Cox regression analysis. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e\u0026nbsp;Successful resections of malignant tumours were performed in 179\u0026nbsp;of the cases, 30 patients resected had benign pancreatic disease based on postoperative histology, and 33 were deemed inoperable intraoperatively due to advanced disease.\u0026nbsp;Overall survival for patients with resected carcinoma was 21.1 months (95% CI: 18.0-24.1), for those with benign disease OS was 101 months (95% CI: 69.4-132) and for those with advanced disease OS was 8.8 months (95% CI: 4.3-13.3).The frequency of CK-positive cells was 6/168 (3.6%) in resected malignant cases, 2/31 (6.5%) in advanced disease and 4/29 (13.8%) in benign disease. The presence of CK-positive cells was not correlated to OS or DFS, neither in the entire cohort nor in the subgroup negative for circulating tumour cells (CTC).\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e\u0026nbsp;The results indicate that CK-positive cells may be present in both patients with malignant and benign diseases of the pancreas. Detection of CK-positive cells was not associated with differences in prognosis for the entire cohort or any of the subgroups analysed. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eTrial registration:\u003c/strong\u003e\u0026nbsp;clinicaltrials.gov (NCT01919151)\u003c/p\u003e","manuscriptTitle":"Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-10-13 20:21:00","doi":"10.21203/rs.2.18905/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2020-10-06T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-10-05T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-04T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-04T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-09-08 17:22:46","doi":"10.21203/rs.2.18905/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-09-29T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-24T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe authors responded to all of comments from the reviewers and updated the manuscript well. The authors analyze frequency of disseminated tumor cells (DTC) in bone marrow (BM) by cytokeratin immunocytochemistry (ICC) and evaluate potential as a prognosis marker with pancreatic and periampullary cancer patients. The frequency of DTC in bone marrow is very low, and there is no significance between prognosis and cytokeratin-positive cells in bone marrow in this study, but the authors well discussed about the results. Overall, this study shows an important data for future study.\nSince the positive rate and specific of cytokeratin positive cells in BM depends on the methods (ICC or PCR), combination with different methodology or using other approach such as a single cell sequence might provide valuable information that may help with survival advantage for patients. It might be worth considering about it in future study.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-04T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-09-02T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-02T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-02T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThe authors have sufficiently revised their original submission, I have no further comments* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorAssigned","content":"","date":"2020-09-01T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-31T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-31T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2019-12-16 22:38:47","doi":"10.21203/rs.2.18905/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2020-08-04T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nPancreatic and periampullary carcinomas can be challenging to diagnose and evaluate pre-operative burden. In this study, Hugenschmidt et al. analyze frequency of disseminated tumor cells (DTC) in bone marrow with the goal to evaluate potential utility for prognosis. The authors conclude that evaluation of DTC in bone marrow does not lend useful information that may help with identification of survival advantage for patients. The manuscript is overall well-written and clear, may benefit from minor adjustment.\nMinor essential revisions.\n1. The results could be discussed in more detail, currently this particular section simply refers the reader to Figures. \n2. Given that this cohort of patients was previously also analyzed for blood CTC, it would be interesting to see the correlation of circulating with presumed disseminated tumor cells from the same patient - is there additional information gained by bone marrow biopsy? Similarly, is there a trend to higher frequency of DTC in patients with more advanced disease as opposed to resectable or benign?\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"decision","content":"Minor revision","date":"2020-08-04T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-08-03T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-04-02T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nIn this study, Hugenschmidt, et al. presented an interesting data on the relationship between cytokeratin-positive cells in bone marrow and prognostic information. Specially, the authors detected DTCs by sensitive cytokeratin-19 antibody and internationally standardized ISHAGE criteria in 242 patient's bone marrow samples. And also, the authors observed their prognosis for long period. Contrary to previous reports, there are no significance between prognosis and cytokeratin-positive cells in bone marrow, but the authors well discussed about the results. Overall, this study shows an important data for future study. While this manuscript is interesting and potentially significant, there are several questions as follows to be addressed. \n\n1. The authors used AE1 and AE3 combination antibody and ISHAGE criteria to detected cytokeratin 19 positive cells in bone marrow more rigorously than previous methods. As a result, a low percentage of cytokeratin 19 positive cells were detected in both resected cancer (3.6%) and advanced cancer (6.5%), but on the contrary, high percentage of false positive cells (13.8%) are detected.\n As the authors described in discussion session, positive rate and specific of cytokeratin positive cells seems depends on antibody (A45-B/B3 or AE1/AE3), methods (ICC or PCR) and classification criteria (ISHAGE or not). However, in actual fact, to compare the impact of these factors, the authors should analyze the same patient sample at same time by different methods. Do the authors have any plan to compare them?\n \n2. In other studies, cytokeratin-19 positive cells in blood, bone marrow and /or peritoneal lavage were investigated to evaluate the diagnostic potential of cytokeratin-19 positive cells (26). Do the authors think the cytokeratin positive cells could be a prognostic indicator, if it is analyzed combination with some other factors?\n\n3. All the results included all pancreatic and periampullary malignancy disease. Are there any difference, if the results are classified by primary lesion, especially pancreas? Because, resected cancers included 56.4% of pancreatic cancer, and all of Benign are pancreas disease.\n Also, the authors classified the resected cancer into \" High risk\" and \"Low risk\" group in previous paper (20). Are there any difference if the authors classify the resected cancer into these two groups?\n\n4. Why the number of TC, UIC, HC and QHC are not equal to total number (ex. Resected cancer n=179. TC positive n=6, TC negative n=162)?\n\n5. Total number of Resected Cancers are 179, but some of the numbers are not match as follows (Table 1). \nPancreatic cancer 101 + Malignant IPMN 9 + Distal bile duct 31 + cancer 21 =162.\nPancreatobillary type 148 + Intestin type 26 + Mucinous type 7 =181.\nUICC-stage I 19 + II 150 + III 13 = 182\n\n6. There are no information of primary lesion in \"Advanced cancers\" in Table 1. Pancreatibillary type (PANBIL) includes disorders of the gall bladder, biliary ducts and pancreas. The authors should add the information of primary lesion.* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: **\nI agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-01-17T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-12-21T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-12-16T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-12-12T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-12-12T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f41431e8-bb54-4809-8868-ee484313315a","owner":[],"postedDate":"October 13th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":463348,"name":"Oncology"},{"id":463349,"name":"Gastroenterology \u0026 Hepatology"}],"tags":[],"updatedAt":"2020-11-22T15:02:46+00:00","versionOfRecord":{"articleIdentity":"rs-9524","link":"https://doi.org/10.1186/s12885-020-07510-z","journal":{"identity":"bmc-cancer","isVorOnly":false,"title":"BMC Cancer"},"publishedOn":"2020-11-16 15:00:39","publishedOnDateReadable":"November 16th, 2020"},"versionCreatedAt":"2020-10-13 20:21:00","video":"","vorDoi":"10.1186/s12885-020-07510-z","vorDoiUrl":"https://doi.org/10.1186/s12885-020-07510-z","workflowStages":[]},"version":"v3","identity":"rs-9524","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-9524","version":["v3"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}