Expression of macrophage migration inhibitory factor and non-metastasis 23 in ovarian endometriosis

Objective:To explore the effect of macrophage migration inhibitory factor(MIF) and non-metastasis 23(nm23) on onset and development of ovarian endometriosis,expound the correlation between MIF,nm23 and ovarian endometriosis.Methods:The expression levels of MIF and nm23 in ectopic endometrium from 40 cases with ovarian endometriosis,eutopic endometrium from 35 cases with ovarian endometriosis and normal endometrium from 30 healthy women were detected by immunohistochemistry.Results:The expression rate of MIF in ectopic endometrium was 77.50%,which was higher than those in eutopic endometrium and normal endometrium,there was significantly difference among three groups(P0.05);the expression rate of nm23 in ectopic endometrium was 42.50%,which was significantly lower than those in eutopic endometrium and normal endometrium(P0.05),but there was no significant difference between eutopic endometrium and normal endometrium(P0.05);there was a negative correlation between MIF expression and nm23 expression in ectopic endometrium(γ=-0.385,P0.05).Conclusion:MIF and nm23 play important roles in the onset and development of ovarian endometriosis.