The Genetic Polymorphism of Alpha 2-Heremans Schmidt Glycoprotein (AHSG), and Antibody to AHSG in Patients with Endometriosis

In: Obstetrics & Gynecology Science · 2004 · vol. 47(5) , pp. 938–945 · W2405367160
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This study analyzed AHSG polymorphism and anti-AHSG antibodies in Korean women, finding that the proportion of noncarriers of the AHSG 2 allele was significantly higher in endometriosis patients.

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Abstract

Objective : To investigate the relationship among alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism, anti-AHSG antibody and endometriosis in Korean women. Methods : AHSG polymorphism was analyzed by restriction fragment length polymorphism and DNA sequencing in 79 women with endometriosis, and 105 women with normal pelviscopic finding. Anti-AHSG antibody was measured using enzyme linked immuosorbent assay. Results : The allele frequencies of AHSG 1 and AHSG 2 were 0.69 and 0.31 respectively. The proportion of noncarrier of AHSG 2 allele was significantly higher (p

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endometriosis

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