Interleukin-21 in cancer immunotherapy: Friend or foe?
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OA: gold
Abstract
Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer. Understanding the biology of IL-21 in these different situations is needed to ensure maximal therapeutic benefit.
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- last seen: 2026-10-11T09:27:45.537177+00:00