Clinical effect of levonorgestrel- releasing intrauterine system in the treatment of endometriosis

Objective To evaluate the safety of levonorgestrel- releasing intrauterine system( LNG- IUS) in the treatment of endometriosis( EM) for 5 years. Methods A total of 49 patients with endometriosis were included. The LNG- IUS was inserted into uterine cavity. The acne,facial pigmentation,mammary swelling,the body weight,the body hair and quality of life were scored and compared before and 6,12,36,and 60 months after the insertion of the LNG- IUS. Results Compared with prior treatment,the body weight and the scores of the body hair and facial pigmentation showed no marked change at each point of observation time( P 0. 05),and the scores of quality of life and mammary swelling dropped significantly( P 0. 05). Six months after insertion,the score of acne had no marked change( P 0. 05),but 12,36, and 60 months later, it decreased significantly( P 0. 05). Conclusion LNG- IUS is safe for long- term treatment of endometriosis.