Expression of IGF-1 and TNF-ɑ and their significance in adenomyosis
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Immunohistochemical analysis revealed that IGF-1 and TNF-α expression levels are significantly elevated in adenomyosis uterine samples compared to healthy controls, with a positive correlation between the two proteins across different uterine regions.
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Abstract
Objective
To investigate the expression of tumor necrosis factor- ɑ(TNF-ɑ) and IGF-1 in the different position of the uterus, and investigate its effect in adenomyosis.
Methods
A total of 30 adenpmyosis cases were sellected as experiment group; meanwhile, 30 healthy cases were sellected as control group.Immunohistochemical method was used to detect the expression levels of TNF-ɑ and IGF-1 in different position of the uterus(including endometrium, endometrial-myometrial border and outer myometrium) in experiment group and control group.
Results
TNF-ɑ and IGF-1 expression were higher in experiment group than that in control group in uteru samples (all P 0.05). The expression intensity of TNF-ɑ was correlated with IGF-1 in experiment group(r=0.523, 0.862, 0.447, P all<0.05).
Conclusions
IGF-1 and TNF-ɑ may act by changing structure and function of the endometrial-myometrial border; IGF-1 and TNF-ɑ may have some kind of synergistic effect in adenomyosis.
Key words:
Adenomyosis; IGF-1; Tumor necrosis factor-ɑ; Immunohistochemistry
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
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