Heart rate variability is reduced during the menstrual phase in women with catamenial C1-type temporal lobe epilepsy

Fedele Dono, Giacomo Evangelista, Stefano Consoli, Giovanna Scorrano, Martina Di Pietro, Maria Vittoria De Angelis, Massimiliano Faustino, Raffaella Franciotti, Francesca Anzellotti, Marco Onofrj, Valério Frazzini, Catello Vollono, Stefano L. Sensi
In: Epilepsy & Behavior · 2021 · vol. 127 , pp. 108508 · doi:10.1016/j.yebeh.2021.108508 · PMID:34974372 · W4206129712
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Women with catamenial C1-type temporal lobe epilepsy exhibit significantly reduced heart rate variability during the menstrual phase compared to controls, indicating decreased vagal output and potential increased risk of cardiac dysfunction.

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Abstract

IntroductionTemporal lobe epilepsy (TLE) is the most frequent focal epilepsy in adulthood. Catamenial C1-type TLE, is characterized by a cyclic seizure exacerbation during the menstrual phase. The heart rate variability (HRV) analysis assesses cardiac autonomic control and may represent a biomarker for Sudden Unexpected Death in Epilepsy (SUDEP). It is plausible that female sex hormones can influence HRV. These changes might be more pronounced in patients suffering from catamenial C1-type TLE where hormonal changes also increase seizure susceptibility. To that aim, we evaluated HRV changes during the menstrual phase of women suffering from catamenial C1-type TLE.MethodsWe enrolled 12 adults with a diagnosis of catamenial C1-type TLE (Catamenial Group) and 12 age-, and seizure-frequency-matched controls with TLE (Non-Catamenial Group). Each patient underwent a 20-minute EEG + EKG recording in resting state during the menstrual phase. HRV parameters were calculated with a short-lasting analysis of EKG records. Time domain-related, frequency domain-related, as well as non-linear analysis parameters, were compared between the two groups.ResultCompared to the Non-Catamenial Group, the Catamenial Group showed significant reductions in SDNN (p-value = 0.01), RMSSD (p-value = 0.04), pNN50 (p-value = 0.001), LnLF ms2 (p-value = 0.05), LnHF ms2 (p-value = 0.007), SD1 (p-value = 0.02), and SD2 (p-value = 0.01). These results were independent from age, disease duration, numbers of ASM, and seizure etiology.ConclusionOur data provide experimental evidence that vagal output is reduced during the menstrual phase in patients with catamenial C1-type TLE. These results indicate that, during the menstrual phase, patients with catamenial C1-type TLE may be at a higher risk of developing cardiac dysfunctions and SUDEP.

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