Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making

Abstract Cortical circuits produce time-varying patterns of population and single neuron activity that play a fundamental role in perceptual and behavioral processes. However, the functional contributions of individual neuron activity to population dynamics and behavior remain unclear. Here we addressed this issue focusing on the mouse gustatory cortex (GC) and using a taste mixture-based decision-making task, high-density electrophysiology, and computational modeling. GC population dynamics represented stimuli linearly during taste sampling and choices categorically before decisions. Single neurons were classified by their linear and categorical activity patterns, revealing subpopulations encoding sensory, perceptual, and decisional variables. To test their functional role, we built a recurrent neural network model of GC. Model perturbations showed linear and categorical neurons were essential for driving normal population dynamics and behavioral performance, whereas many units with other activity patterns could be silenced without consequence. These results have implications that extend beyond GC, and demonstrate the role of linear and categorical coding neurons in cortical dynamics and behavior during perceptual decision-making. Competing Interest Statement The authors have declared no competing interest. Footnotes New analyses and simulations were performed to describe the contribution of constrained and unconstrained units to neural dynamics and behavior.