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This study investigated the therapeutic potential of bazedoxifene, a selective estrogen receptor modulator, in a rat model of surgically induced endometriosis. The researchers administered the drug to evaluate its effects on lesion size and associated inflammatory markers compared to control groups. Results indicated that bazedoxifene treatment led to significant regression of endometriotic lesions, demonstrating its efficacy in reducing disease burden in this experimental setting. This paper is centrally about endometriosis — specifically evaluating a pharmacological intervention using a selective estrogen receptor modulator in an animal model of the condition.
Abstract
Aim: The only factor that is proved on the pathogenesis of endometriosis is estrogen. The aim of this study is to investigate the effect of bazedoxifene, a third generation selective estrogen receptor modulator, on the endometriotic implants in the rat endometriosis model by using histopathological examination and immunohistochemical assays. Materials and Method: This randomized, placebocontrolled, experimental study was conducted in the Animal Research Laboratory at Ankara Education and Research Hospital. The study was performed on 20 Wistar female albino rats. Experimental endometriosis model was constituted with implantation of autologous endometrial tissue on the right side of the pelvic wall. The endometriotic implants were examined by second laparatomy after 30 days, and the rats were divided randomly into two groups. Group 1 received 3 mg/ kg Bazedoxifene (n =10) per oral, once a day, for 30 more days. Group 2 (n =10) was the control group and did not receive any medical treatment. After 30 days of treatment period, the third laparatomy was performed, endometriotic lesions volumes were measured, and endometriotic foci were extracted for histopatological and immunohistochemical evaluation. Histopathological scoring was evaluated according to preservation of epithelial layer. In addition, endometrial implants were evaluated immunohistochemically for VEGF, MMP-2 and MMP-9. Results: The volumes of the lesions were smaller in the group which was treated with bazedoxifene than the ones in the control group which was statistically significant (p 0.05). Conclusion: Bazedoxifene treatment was seen to have a regressive effect on the volumes and histopathological structure of endometriotic implants. Bazedoxifene could be regarded as a new alternative in the treatment of endometriosis.
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SELEKTİF ESTROJEN RESEPTÖR MODÜLATÖRÜ OLAN BAZEDOKSİFENİN RAT MODELİNDE OLUŞTURULAN ENDOMETRİOZİS TEDAVİSİNDEKİ ROLÜ
Öz
Anahtar Kelimeler
Kaynakça
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- Taylor E, Williams C. Surgical treatment of endometriosis: location and patterns of disease at reoperation. Fertil Steril 2010; 93:57-61.
- Kulak J Jr, Fischer C, Komm B, Taylor HS. Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model. Endocrinology 152(8):3226-32. 2011doi: 10.1210/en.2010-1010. Epub 2011 May 17.
- Komm BS, Kharode YP, Modine PV, Harris HA, Miller CP, Lyttle CR. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 2005;146:3999-4008.
- Ronkin S, Northington R, Baracat E, et al. Endometrial effects of bazedoxifene acetate, a novel selective estrogen receptor modulator, in postmenopausal women. Obstet Gynecol 2005;105(6):1397-404.
- Morello KC, Wurz GT, DeGregorio MW. Pharmacokinetics of selective estrogen receptor modulators. Clin Pharmacokinet 2003;42:361-72.
- Chris P. Spencer, MD, Edward P. Morris and Janice M. Selective estrogen receptor modulators: Women’s panacea for the next millennium? Am J Obstet Gynecol 1999; 180: 763-70.
- Maeda K, Ohkura S, Tsukamura H. Physiology of the reproduction. In: Krinke GJ, editor. The laboratory rat (Handbook of experimental animals) London:Academic Press; 2000.p.148-149
Ayrıntılar
Birincil Dil
Türkçe
Konular
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Bölüm
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Yazarlar
Senem Mine Keskin
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Hacer Cavidan Gülerman
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Özlem Uzunlar
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Şebnem Özyer
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Ayla Aktulay
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Muzaffer Çaydere
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Yayımlanma Tarihi
1 Temmuz 2013
Gönderilme Tarihi
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Kabul Tarihi
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Yayımlandığı Sayı
Yıl 2013 Cilt: 10 Sayı: 39
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