Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

We developed a novel method for production of no-carrier-added (n.c.a.) [ 188, 189, 191 Pt]Pt Ⅱ Cl 4 2- from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[Pt Ⅱ Cl 2 (NH 3 ) 2 ] ([*Pt]cisplatin) from [*Pt]Pt Ⅱ Cl 4 2- . [*Pt]Pt Ⅱ Cl 4 2- was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of Ir Ⅳ Cl 6 2- with ascorbic acid. The ligand-substitution reaction of Cl with NH 3 was promoted by treating n.c.a. [*Pt]Pt Ⅱ Cl 4 2- with excess NH 3 and heating the reaction mixture, and n.c.a [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99+% at the end of synthesis (EOS).