Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases

preprint OA: closed
📄 Open PDF Full text JSON View at publisher

Abstract

Withdrawal Statement The authors have withdrawn this preprint because the co-authors were not in agreement about posting the work in its current form. The authors request that this work not be cited. Please contact the corresponding author (Dr. Xunlei Kang, [email protected] ) with questions.
Full text 10,747 characters · extracted from preprint-html · click to expand
WITHDRAWN: Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases | bioRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-M677548'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search Withdrawn WITHDRAWN: Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases Yi Pan , XiaDuo Meng , Chen Wang , WenXuan Zhou , Qin Zhou , Jingshu Chi , Breton Barrier , Luis Martinez-Lemus , De-Pei Li , Zhenguo Liu , XunLei Kang doi: https://doi.org/10.1101/2025.11.23.690015 Yi Pan 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 2 Ellis Fischel Cancer Center at MU Health Care, University of Missouri , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site XiaDuo Meng 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 2 Ellis Fischel Cancer Center at MU Health Care, University of Missouri , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Chen Wang 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 2 Ellis Fischel Cancer Center at MU Health Care, University of Missouri , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site WenXuan Zhou 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 2 Ellis Fischel Cancer Center at MU Health Care, University of Missouri , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Qin Zhou 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 5 Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 8 Department of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital , Chengdu 610091, PR China 9 Department of Cardiology, Children’s Hospital of Chongqing Medical University , Chongqing, 400014, P.R. China Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jingshu Chi 10 Internal Medicine Cardiovascular medicine, University of Nebraska Medical Center . Omaha,NE 68106 Find this author on Google Scholar Find this author on PubMed Search for this author on this site Breton Barrier 4 Department of Obstetrics & Gynecology and Women’s Health, University of Missouri School of Medicine , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Luis Martinez-Lemus 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 6 Dalton Cardiovascular Research Center, University of Missouri , Columbia, Missouri 7 Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine , Columbia, Missouri Find this author on Google Scholar Find this author on PubMed Search for this author on this site De-Pei Li 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 5 Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Zhenguo Liu 10 Internal Medicine Cardiovascular medicine, University of Nebraska Medical Center . Omaha,NE 68106 Find this author on Google Scholar Find this author on PubMed Search for this author on this site XunLei Kang 1 Center for Precision Medicine, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA 2 Ellis Fischel Cancer Center at MU Health Care, University of Missouri , Columbia, MO 65212, USA 3 Division of Hematology and Oncology, Department of Medicine, University of Missouri School of Medicine , Columbia, MO 65212, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: kangxu{at}health.missouri.edu Abstract Info/History Metrics Preview PDF Withdrawal Statement The authors have withdrawn this preprint because the co-authors were not in agreement about posting the work in its current form. The authors request that this work not be cited. Please contact the corresponding author (Dr. Xunlei Kang, kangxu{at}health.missouri.edu ) with questions. Competing Interest Statement The authors have declared no competing interest. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . View the discussion thread. Back to top Previous Next Posted March 11, 2026. Download PDF Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following WITHDRAWN: Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share WITHDRAWN: Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases Yi Pan , XiaDuo Meng , Chen Wang , WenXuan Zhou , Qin Zhou , Jingshu Chi , Breton Barrier , Luis Martinez-Lemus , De-Pei Li , Zhenguo Liu , XunLei Kang bioRxiv 2025.11.23.690015; doi: https://doi.org/10.1101/2025.11.23.690015 Share This Article: Copy Citation Tools WITHDRAWN: Clonal Hematopoiesis Associated with TP53 and DNMT3A Mutations Promotes Tissue Repair in Acute Cardiovascular Diseases Yi Pan , XiaDuo Meng , Chen Wang , WenXuan Zhou , Qin Zhou , Jingshu Chi , Breton Barrier , Luis Martinez-Lemus , De-Pei Li , Zhenguo Liu , XunLei Kang bioRxiv 2025.11.23.690015; doi: https://doi.org/10.1101/2025.11.23.690015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Cell Biology Subject Areas All Articles Animal Behavior and Cognition (7635) Biochemistry (17690) Bioengineering (13892) Bioinformatics (41936) Biophysics (21451) Cancer Biology (18588) Cell Biology (25499) Clinical Trials (138) Developmental Biology (13378) Ecology (19899) Epidemiology (2067) Evolutionary Biology (24320) Genetics (15609) Genomics (22506) Immunology (17736) Microbiology (40394) Molecular Biology (17181) Neuroscience (88603) Paleontology (666) Pathology (2832) Pharmacology and Toxicology (4824) Physiology (7641) Plant Biology (15152) Scientific Communication and Education (2045) Synthetic Biology (4294) Systems Biology (9825) Zoology (2271)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00