The genetic origins of ovarian failure

C A Bondy, Carolyn A. Bondy, Lawrence M. Nelson, L M Nelson, S N Kalantaridou, Sophia Kalantaridou
Journal of women's health · 1998 · vol. 7(10) , pp. 1225–1229 · doi:10.1089/jwh.1998.7.1225 · PMID:9929855 · W1980464364
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Experts discussed the genetic and physiologic origins of premature ovarian failure, identifying candidate murine genes and implicated human genes on the X chromosome that regulate ovarian function.

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Abstract

Premature ovarian failure (POF) is a condition characterized by cessation of ovarian function before the age of 40. The recent meeting at the National Institute of Child Health and Human Development brought together experts from diverse disciplines to share current perspectives on the genetic and physiologic origins of POF, with the idea that insights gained from these studies may provide important clues about the regulation of normal ovarian aging and perhaps aging processes in general. It was suggested that several murine genes, including Zfx, c = kit, and the kit ligand, should be fertile candidates for investigation of the etiology of POF in human families. The specific roles of the human DIA and FMR1 gene products in germ cell development need clarification in murine models, and there are more as yet unidentified genes residing on the long arm of the X chromosome that are also implicated in the regulation of human ovarian function. Genes acting at later stages of oocyte or ovarian follicle function, such as gonadotropin hormones and receptors, are responsible for POF in some women. POF has been found to be a heterogeneous disorder, the dissection of which offers promising insights into mechanisms governing germ cell origination, migration, and proliferation, meiotic mechanisms, and factors governing oocyte maturation and survival.

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MeSH descriptors

Gene Expression Regulation Oocytes Ovarian Follicle Primary Ovarian Insufficiency X Chromosome Adult Animals Autoimmunity Female Humans Mice Oocytes Ovarian Follicle Primary Ovarian Insufficiency Primary Ovarian Insufficiency Proteins Proteins Proteins Stem Cell Factor Stem Cell Factor

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References (19)

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organisms 4
human human human noordeloos 2009062

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