The relationship between cardiovascular diseases and the family history of Alzheimer’s disease: results from NHANES (1999-2004)

Patients with cardiovascular diseases (CVDs) have a notably high Alzheimer’s disease (AD) risk in the previous finding. Both CVDs and AD are genetic related disorders. While seldom data concerning the risk of CVDs in individuals with AD family history. The present study aimed to examine the relationship between CVDs and family history of AD. A total of 15019 participants were enrolled and analyzed. Logistic regression analysis indicated that individuals with AD family history had 0.173 higher odds of CVDs than those without AD relatives (OR = 1.173 (1.029-1.338), p < 0.05). The odds ratio of CVDs in the adjudged model was 1.184 (95%CI 0.987-1.421) for individuals with maternal line family history of AD after taking into account age, gender, BMI, race, education and family income. AD family history was positively associated with CVDs, while maternal origin AD family history is more likely to be a risk factor for CVDs than paternal origins. Further prospective studies are needed to confirm the relationship between AD family history and CVDs.