Involvement of MMP-2 activity in ovarian endometriosis.

Sayantan Jana (3190551), Kasturi Chatterjee (3190545), Amlan K. Ray (3190548), Pramathes DasMahapatra (3190542), Snehasikta Swarnakar (232461)
2016 · doi:10.1371/journal.pone.0163540.g003 · W6922895792
other OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-17 · read from full text ⓘ

The study investigated the role of Matrix Metalloproteinase-2 (MMP-2) activity in ovarian endometriosis by comparing eutopic endometrium, serum levels, and ectopic tissues from patients across different disease stages. Researchers analyzed samples from women with and without endometriosis to determine how MMP-2 status correlates with lesion severity and angiogenesis. The findings indicated that MMP-2 activity is significantly altered in both serum and ectopic ovarian endometriotic tissues, particularly showing higher levels in advanced stages compared to early-stage disease or controls. This paper is centrally about endometriosis — specifically examining the involvement of MMP-2 activity in ovarian endometriosis lesions.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

(A,B) Status of MMP-2 activity in eutopic endometrium (n = 15 samples/group) between women with and without endometriosis. (C,D) Serum MMP-2 status in different stages of ovarian endometriosis patients. (E-G) Status of MMP-2 activity in ectopic ovarian endometriotic tissues. (F,G) Representative zymography profile for pro and active MMP-2 in ectopic ovarian endometriosis. Number of patients for stage I (n = 19), stage II (n = 14), stage III (n = 24), stage IV (n = 31). Means ± SEM. p<0.05 was accepted as level of significance; *** p < 0.001; ** p < 0.01; * p 0.05.
Full text 760 characters · extracted from oa-doi-fallback · click to expand
Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis Fig 3 Involvement of MMP-2 activity in ovarian endometriosis. (A,B) Status of MMP-2 activity in eutopic endometrium (n = 15 samples/group) between women with and without endometriosis. (C,D) Serum MMP-2 status in different stages of ovarian endometriosis patients. (E-G) Status of MMP-2 activity in ectopic ovarian endometriotic tissues. (F,G) Representative zymography profile for pro and active MMP-2 in ectopic ovarian endometriosis. Number of patients for stage I (n = 19), stage II (n = 14), stage III (n = 24), stage IV (n = 31). Means ± SEM. p<0.05 was accepted as level of significance; *** p < 0.001; ** p < 0.01; * p 0.05.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-11T08:38:43.053463+00:00
License: CC0 · commercial use OK