Episodic Memory in Prodromal Alzheimer’s: TYM-MCI Spanish Validation

Background: Building on the validation of the Your Memory test for mild cognitive impairment in English speakers, this study adapted and validated the Memory Test for Mild Cognitive Impairment (TYM-MCI) for Spanish-speaking older adults, highlighting its potential for early detection of Alzheimer's disease (AD). Methods: A total of 151 independently functioning adults aged 60 or older (Barthel Index 9-10) completed the TYM-MCI, the Addenbrooke's Cognitive Examination-Revised (ACE-R-Ch), the Mini-Mental State Examination, and the original TYM. Analyses included ROC curves, correlation matrices, and principal component analysis (PCA). Results: The TYM-MCI exhibited strong psychometric properties (Cronbach's α = 0.832; sensitivity = 81.7%; specificity = 47.8%). The optimal cut-off score was ≥ 24.5/30. Scores between 19 and 24.5 suggested probable mild cognitive impairment (MCI). Conclusions: The episodic memory components of this test are key cognitive features that help differentiate the progression of potential cognitive decline related to dementia and are straightforward to administer. Notably, it specifically assesses visual and verbal episodic memory. It can be used alongside other assessments, such as the ACE-R or MMSE, to evaluate cognitive function in older adults. Clinically, it offers a foundation for early assessment and intervention in cases of cognitive decline, aiding in the prevention or delay of MCI or dementia diagnoses.