Investigation of vascular endothelial growth factor (VEGF) polymorphism in patients with idiopathic heavy menstrual bleeding

İkbal Kaygusuz, Nur Semerci Gündüz
In: Archives of Gynecology and Obstetrics · 2021 · vol. 305(1) , pp. 109–116 · doi:10.1007/s00404-021-06225-1 · PMID:34494138 · W3163890572
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VEGF polymorphisms at -2578C>A and -1154G>A were associated with increased risk of idiopathic heavy menstrual bleeding in the Turkish population.

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Abstract

PurposeTo investigate whether there is a relationship between the VEGF polymorphisms and idiopathic heavy menstrual bleeding (HMB-E)Query.MethodsSixty-five patients diagnosed with HMB-E according to the FIGO classification system and 65 female healthy volunteers were included in the study. The polymorphic regions rs699947 (- 2578C > A), rs1570360 (- 1154G > A), rs2010963 (+ 405G > C), rs3025039 (+ 936C > T), rs25648 (c534C > T) in the VEGF were detected using Next Generation DNA Sequencing method.ResultsThe - 2578C > A polymorphism CC genotype, CA + AA genotypes, and C allele, as well as the - 1154G > A polymorphism AA genotype, and A allele were associated with increased risk of HMB-E (p  C, + 936C > T, c534C > T polymorphic regions (p > 0.05 for all). While the - 2578/ - 1154/ + 405/c534 AGGC haplotype decreased the risk of HMB-E, the CAGC haplotype was found to increase the risk of HMB-E.ConclusionVEGF - 2578C > A and - 1154G > A polymorphisms were significantly associated with the risk of HMB-E in the Turkish population.

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