Epstein Barr Virus Enhance Risk Development of Gastric Cancer in Young Adults with H. pylori Infection

Gastric cancer (GC) is a global health concern, the majority of GC are H. pylori inflammation-related cancers. The H. pylori infection as well as bacterial virulence factors are not sufficient in predicting risk development of gastric cancer (GC) among populations with high prevalence of H. pylori infection such as East Asia. Among H. pylori infectious patients in Vietnam, compared to gastritis group, among gastric cancer patients the prevalence of EBV was significantly greater. The coinfection with EBV and CMV was highest in gastric cancer (46,7%) follows by peptic ulcer (16,7%) and gastritis (15.2%). This difference becomes even more evident in the younger group. Therefor EBV showed a certain role in the development of GC in Vietnam, especially in young patients positive for H. pylori.